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The map label for this gene is tipA [H]

Identifier: 153935389

GI number: 153935389

Start: 991299

End: 992063

Strand: Reverse

Name: tipA [H]

Synonym: CLC_0965

Alternate gene names: 153935389

Gene position: 992063-991299 (Counterclockwise)

Preceding gene: 153936721

Following gene: 153937433

Centisome position: 26.38

GC content: 27.45

Gene sequence:

>765_bases
TTGCACTATAAAATAAAAGAAGTTGCTGACATGGCCGGCATAAGTGTACGCATGCTTCATCATTATGACAAGATAGGATT
ACTTGATCCAGAGTCTGTAAGTGATGCAGGTTATAGACTTTATTCAGATGAAAATCTTGATAGATTGCAACAAATTCTGT
TTTTTAAAGAACTGAATTTTCCCCTCCAAGAAATAAAAATTATCTTGGACAGTCCAAATTTTAACAAAAAAGAAGCTTTA
GAAACTCATAAACAATTGCTTTTAGAGAAAAAAATAAGACTTGAAAAAATTATACAATCTGTGGATAAAACTATAAGTAG
TATGGAAGGAGAATTTAAAATGAATAAAAAAGAAGTGCTTGGAGCATTTGATATGACTGAAATAGAAGAACATCAAAAGA
AATATTCAGAGGAAGTAAAAAATAAATATGGAAACACCTCTGCTTATAAGGAAAGTAATGAAAAAACTTCTAAATATACA
AAAGAAGATTGGAATAATATAATGAAAGATTGGGATATTATTTATAAAAAACTAGCAAATCTTATGGACAAAAATCCAGA
TGATAAAGAAGTTCAAGAATATATACACCAATTTAGAGAGCATATTTCAAAAAACTTTTATGATTGTACTCCTGAAATAT
TTAGAGGGCTTGGAGAACTTTATGTTAATGATGAAAGATTTACTGCTAATATAGATAAATATAAAACTGGTCTTTCTAAA
TTTTTAAGGGAAGCTATTAATGTTTATTGTGACAATATAAAATAA

Upstream 100 bases:

>100_bases
TTGTCTTTAATATTATGCTATAGGTTATTATAAAAAACTAAAATAAGTATTGACCCTGACACTGTGTTATAGGCTACTAT
AAATATGGAGGTGATAAACA

Downstream 100 bases:

>100_bases
TAATTATATGCTATTTTAAATATTATCTAAAATAGCTAGTATTTATTATACAAAAATAAGGTGATTCAAAATAAATTAAA
TCTATTTTGAAATACCTTAT

Product: transcriptional activator TipA

Products: NA

Alternate protein names: Multidrug transporter activation protein [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MHYKIKEVADMAGISVRMLHHYDKIGLLDPESVSDAGYRLYSDENLDRLQQILFFKELNFPLQEIKIILDSPNFNKKEAL
ETHKQLLLEKKIRLEKIIQSVDKTISSMEGEFKMNKKEVLGAFDMTEIEEHQKKYSEEVKNKYGNTSAYKESNEKTSKYT
KEDWNNIMKDWDIIYKKLANLMDKNPDDKEVQEYIHQFREHISKNFYDCTPEIFRGLGELYVNDERFTANIDKYKTGLSK
FLREAINVYCDNIK

Sequences:

>Translated_254_residues
MHYKIKEVADMAGISVRMLHHYDKIGLLDPESVSDAGYRLYSDENLDRLQQILFFKELNFPLQEIKIILDSPNFNKKEAL
ETHKQLLLEKKIRLEKIIQSVDKTISSMEGEFKMNKKEVLGAFDMTEIEEHQKKYSEEVKNKYGNTSAYKESNEKTSKYT
KEDWNNIMKDWDIIYKKLANLMDKNPDDKEVQEYIHQFREHISKNFYDCTPEIFRGLGELYVNDERFTANIDKYKTGLSK
FLREAINVYCDNIK
>Mature_254_residues
MHYKIKEVADMAGISVRMLHHYDKIGLLDPESVSDAGYRLYSDENLDRLQQILFFKELNFPLQEIKIILDSPNFNKKEAL
ETHKQLLLEKKIRLEKIIQSVDKTISSMEGEFKMNKKEVLGAFDMTEIEEHQKKYSEEVKNKYGNTSAYKESNEKTSKYT
KEDWNNIMKDWDIIYKKLANLMDKNPDDKEVQEYIHQFREHISKNFYDCTPEIFRGLGELYVNDERFTANIDKYKTGLSK
FLREAINVYCDNIK

Specific function: Global transcriptional regulator that activates transcription of bmr and blt by binding directly to their promoter. Stimulates also the expression of the mta gene itself, ydfK and ymfE [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 30153; Mature: 30153

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYKIKEVADMAGISVRMLHHYDKIGLLDPESVSDAGYRLYSDENLDRLQQILFFKELNF
CCCCHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHCC
PLQEIKIILDSPNFNKKEALETHKQLLLEKKIRLEKIIQSVDKTISSMEGEFKMNKKEVL
CHHHHEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
GAFDMTEIEEHQKKYSEEVKNKYGNTSAYKESNEKTSKYTKEDWNNIMKDWDIIYKKLAN
HHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMDKNPDDKEVQEYIHQFREHISKNFYDCTPEIFRGLGELYVNDERFTANIDKYKTGLSK
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FLREAINVYCDNIK
HHHHHHHHHHCCCC
>Mature Secondary Structure
MHYKIKEVADMAGISVRMLHHYDKIGLLDPESVSDAGYRLYSDENLDRLQQILFFKELNF
CCCCHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHCC
PLQEIKIILDSPNFNKKEALETHKQLLLEKKIRLEKIIQSVDKTISSMEGEFKMNKKEVL
CHHHHEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
GAFDMTEIEEHQKKYSEEVKNKYGNTSAYKESNEKTSKYTKEDWNNIMKDWDIIYKKLAN
HHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMDKNPDDKEVQEYIHQFREHISKNFYDCTPEIFRGLGELYVNDERFTANIDKYKTGLSK
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FLREAINVYCDNIK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9150240; 9384377 [H]