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The map label for this gene is uvrD [H]

Identifier: 153935329

GI number: 153935329

Start: 2154186

End: 2155967

Strand: Reverse

Name: uvrD [H]

Synonym: CLC_2031

Alternate gene names: 153935329

Gene position: 2155967-2154186 (Counterclockwise)

Preceding gene: 153937844

Following gene: 153936158

Centisome position: 57.33

GC content: 26.6

Gene sequence:

>1782_bases
ATGAGTAATACGGAGTATGAAACAATTACTTCAGACCAATTAATTGATATAAATACAAATTTTAAAATCATAGCTGGTCC
TGGTGCAGGTAAAACGTATTGGCTAGTACGACATATTAAGCACGTACTAGAAGAATCGAAAATATTAAAATCAGCTTCAA
AAATAGCGTGCATTACTTATACTACAGTAGCTGCTGAAGAAATAAATAATAGACTAAAGGCAAATAGTGATAGAGTAGAA
ATATCTACTATACATAGCTTTTTATATAATAACGTAATAAAGCCATATATTTACTTGTTAAAGGATGAAAATGAAAAATG
TATTGTGAATTATATTAAACTTGATGGACATGTTGAAAATGTTCCAAGCAATGGCAAAATAATTCAATGGAAGAAAATAA
ATAATTTATTCCACTTTAAAGATGACAATAAGATTAAGAAATGTTTGATGGATTTAGATTGGAGTTTAAAAGACCAAGAA
TTATTATTGAAAGTACGAAAAGATTATAATAGAAAAGTAGGAAGATATTATATCAAAGAAGAATGTTTTCCTTCATATAA
GCAGTTGTTTTGGGATGAAGGAATAATACATCATGAGGATGTTTTATATTTTTCATTTAATTTATTAGAACAATATCCAA
TGATAAAAGAGTTTCTTTCTGCAAAATATCCTTATATTTTCCTTGATGAATTTCAAGACACAAATCCAATACAGACCCAA
ATTATTAAATGGTTAGGAGAAGCGGGAAGTTTGACAGGGGTTATAGGCGACCCTGCTCAGTCAATTTACAAATTTCAAGG
TGCTTCAAGAAAAGATTTTCTAGAATTTAATCTTTTAAATCAAAAGAACTATAAAATAGAGAAAAACAGAAGAAGCACGG
AAAATATTATTAAAATATTAAATCATTTGAGGAATGGAGATAACATAAATCAGAGTTGTTATAGAGCGAATTTAGGGAAT
GATGTGTTGTACATTGTATCTAATGATACAAATTATATTATTAATAAATTTAAGGAAGTAAGAAAAGCGATAGGTTGTTA
TAAAGACTATTGCATTATTACAAGAAAAAATGACGATGTAATAAAATTAAAGAATGGTGATAAAAGTTGTGATTGTAAAC
TATGGGACAAAGTATTTGAATGTGATTTTTCAAGGGGAAGATTTTTAAAAAATTTATTTACTGCTCAAGAATTGGCTGTT
GAAGACAGATATGAGATGGCAATAAAAGAGGTATTAAAATTATTTAAAAGTAATAGAGATGGTAAATTAAGAGAACCTTT
CAAATCAACTATAGAAATTACTAATTTACAAAAAAGAAGTTATGCAGTTAGTATATTAGAGCATTTGTTAAATAATAGAG
AAGGTAATATGAATGTAAAATTATTAGACTTCTATAATCGATTGAATAATGATGTTTTAGAAAGTTTAAATTTACAGATT
TCAAAAGTTGGATCTAGAGGGAAAGCTAAAACTTGTTATGAATCTGTAATATTAAAAGACCTAATAAGTAATTTAAAGTT
AGACGAAGAAAAAGAAAGTAAAATAAGAACTATACATAAAACTAAAGGTACAGAATTTGAATCTGTTTTAGTTTGTATAG
AAAGCAATGATGATATTGAAAATATTATATCACCTAATATTGAAAATGAGGAAGATGATTGCAGGCTTTATTATGTTGCA
TCAAGTAGAGCAAAAGATCTTTTATGTATTGCTGTACCAGAAGGAAGTCAAGAAAAAAAATTAAAGGAAATAGGTTTAGT
TTCTATGATAGATAATATATAA

Upstream 100 bases:

>100_bases
GAGAAAATTAGAAGTGAGGAAATAAATATTAAATTACCGAATCATATCCAAAAAGCATTTAACTGGGTGTGCTACATGGA
TGATGAGGAGGTAAAAGAGG

Downstream 100 bases:

>100_bases
AACGAGTTATTAGCAACAAAAACTGTTTCAGTTTTTGTAAGGGTTCAGACCCTTTACAAAGATTGGAAATGAAACGAACA
GGCTTTGTTGCTAAAAATTA

Product: ATP-dependent DNA helicase UvrD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MSNTEYETITSDQLIDINTNFKIIAGPGAGKTYWLVRHIKHVLEESKILKSASKIACITYTTVAAEEINNRLKANSDRVE
ISTIHSFLYNNVIKPYIYLLKDENEKCIVNYIKLDGHVENVPSNGKIIQWKKINNLFHFKDDNKIKKCLMDLDWSLKDQE
LLLKVRKDYNRKVGRYYIKEECFPSYKQLFWDEGIIHHEDVLYFSFNLLEQYPMIKEFLSAKYPYIFLDEFQDTNPIQTQ
IIKWLGEAGSLTGVIGDPAQSIYKFQGASRKDFLEFNLLNQKNYKIEKNRRSTENIIKILNHLRNGDNINQSCYRANLGN
DVLYIVSNDTNYIINKFKEVRKAIGCYKDYCIITRKNDDVIKLKNGDKSCDCKLWDKVFECDFSRGRFLKNLFTAQELAV
EDRYEMAIKEVLKLFKSNRDGKLREPFKSTIEITNLQKRSYAVSILEHLLNNREGNMNVKLLDFYNRLNNDVLESLNLQI
SKVGSRGKAKTCYESVILKDLISNLKLDEEKESKIRTIHKTKGTEFESVLVCIESNDDIENIISPNIENEEDDCRLYYVA
SSRAKDLLCIAVPEGSQEKKLKEIGLVSMIDNI

Sequences:

>Translated_593_residues
MSNTEYETITSDQLIDINTNFKIIAGPGAGKTYWLVRHIKHVLEESKILKSASKIACITYTTVAAEEINNRLKANSDRVE
ISTIHSFLYNNVIKPYIYLLKDENEKCIVNYIKLDGHVENVPSNGKIIQWKKINNLFHFKDDNKIKKCLMDLDWSLKDQE
LLLKVRKDYNRKVGRYYIKEECFPSYKQLFWDEGIIHHEDVLYFSFNLLEQYPMIKEFLSAKYPYIFLDEFQDTNPIQTQ
IIKWLGEAGSLTGVIGDPAQSIYKFQGASRKDFLEFNLLNQKNYKIEKNRRSTENIIKILNHLRNGDNINQSCYRANLGN
DVLYIVSNDTNYIINKFKEVRKAIGCYKDYCIITRKNDDVIKLKNGDKSCDCKLWDKVFECDFSRGRFLKNLFTAQELAV
EDRYEMAIKEVLKLFKSNRDGKLREPFKSTIEITNLQKRSYAVSILEHLLNNREGNMNVKLLDFYNRLNNDVLESLNLQI
SKVGSRGKAKTCYESVILKDLISNLKLDEEKESKIRTIHKTKGTEFESVLVCIESNDDIENIISPNIENEEDDCRLYYVA
SSRAKDLLCIAVPEGSQEKKLKEIGLVSMIDNI
>Mature_592_residues
SNTEYETITSDQLIDINTNFKIIAGPGAGKTYWLVRHIKHVLEESKILKSASKIACITYTTVAAEEINNRLKANSDRVEI
STIHSFLYNNVIKPYIYLLKDENEKCIVNYIKLDGHVENVPSNGKIIQWKKINNLFHFKDDNKIKKCLMDLDWSLKDQEL
LLKVRKDYNRKVGRYYIKEECFPSYKQLFWDEGIIHHEDVLYFSFNLLEQYPMIKEFLSAKYPYIFLDEFQDTNPIQTQI
IKWLGEAGSLTGVIGDPAQSIYKFQGASRKDFLEFNLLNQKNYKIEKNRRSTENIIKILNHLRNGDNINQSCYRANLGND
VLYIVSNDTNYIINKFKEVRKAIGCYKDYCIITRKNDDVIKLKNGDKSCDCKLWDKVFECDFSRGRFLKNLFTAQELAVE
DRYEMAIKEVLKLFKSNRDGKLREPFKSTIEITNLQKRSYAVSILEHLLNNREGNMNVKLLDFYNRLNNDVLESLNLQIS
KVGSRGKAKTCYESVILKDLISNLKLDEEKESKIRTIHKTKGTEFESVLVCIESNDDIENIISPNIENEEDDCRLYYVAS
SRAKDLLCIAVPEGSQEKKLKEIGLVSMIDNI

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=360, Percent_Identity=23.6111111111111, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322369, Length=393, Percent_Identity=23.1552162849873, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 69031; Mature: 68900

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTEYETITSDQLIDINTNFKIIAGPGAGKTYWLVRHIKHVLEESKILKSASKIACITY
CCCCCCCEECCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
TTVAAEEINNRLKANSDRVEISTIHSFLYNNVIKPYIYLLKDENEKCIVNYIKLDGHVEN
HHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHEEEEEECCCCEEEEEEEEECCEEEC
VPSNGKIIQWKKINNLFHFKDDNKIKKCLMDLDWSLKDQELLLKVRKDYNRKVGRYYIKE
CCCCCCEEEEEECCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
ECFPSYKQLFWDEGIIHHEDVLYFSFNLLEQYPMIKEFLSAKYPYIFLDEFQDTNPIQTQ
HCCHHHHHHHHCCCCEECCCEEEEEHHHHHHCHHHHHHHCCCCCEEEEECCCCCCHHHHH
IIKWLGEAGSLTGVIGDPAQSIYKFQGASRKDFLEFNLLNQKNYKIEKNRRSTENIIKIL
HHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCCEEEEEECCCCCEECCCCCHHHHHHHHH
NHLRNGDNINQSCYRANLGNDVLYIVSNDTNYIINKFKEVRKAIGCYKDYCIITRKNDDV
HHHCCCCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCE
IKLKNGDKSCDCKLWDKVFECDFSRGRFLKNLFTAQELAVEDRYEMAIKEVLKLFKSNRD
EEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GKLREPFKSTIEITNLQKRSYAVSILEHLLNNREGNMNVKLLDFYNRLNNDVLESLNLQI
CCCHHHHHHHEEHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCHHHHHHHCCEE
SKVGSRGKAKTCYESVILKDLISNLKLDEEKESKIRTIHKTKGTEFESVLVCIESNDDIE
EECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHH
NIISPNIENEEDDCRLYYVASSRAKDLLCIAVPEGSQEKKLKEIGLVSMIDNI
HHCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNTEYETITSDQLIDINTNFKIIAGPGAGKTYWLVRHIKHVLEESKILKSASKIACITY
CCCCCCEECCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
TTVAAEEINNRLKANSDRVEISTIHSFLYNNVIKPYIYLLKDENEKCIVNYIKLDGHVEN
HHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHEEEEEECCCCEEEEEEEEECCEEEC
VPSNGKIIQWKKINNLFHFKDDNKIKKCLMDLDWSLKDQELLLKVRKDYNRKVGRYYIKE
CCCCCCEEEEEECCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
ECFPSYKQLFWDEGIIHHEDVLYFSFNLLEQYPMIKEFLSAKYPYIFLDEFQDTNPIQTQ
HCCHHHHHHHHCCCCEECCCEEEEEHHHHHHCHHHHHHHCCCCCEEEEECCCCCCHHHHH
IIKWLGEAGSLTGVIGDPAQSIYKFQGASRKDFLEFNLLNQKNYKIEKNRRSTENIIKIL
HHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCCEEEEEECCCCCEECCCCCHHHHHHHHH
NHLRNGDNINQSCYRANLGNDVLYIVSNDTNYIINKFKEVRKAIGCYKDYCIITRKNDDV
HHHCCCCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCE
IKLKNGDKSCDCKLWDKVFECDFSRGRFLKNLFTAQELAVEDRYEMAIKEVLKLFKSNRD
EEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GKLREPFKSTIEITNLQKRSYAVSILEHLLNNREGNMNVKLLDFYNRLNNDVLESLNLQI
CCCHHHHHHHEEHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCHHHHHHHCCEE
SKVGSRGKAKTCYESVILKDLISNLKLDEEKESKIRTIHKTKGTEFESVLVCIESNDDIE
EECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHH
NIISPNIENEEDDCRLYYVASSRAKDLLCIAVPEGSQEKKLKEIGLVSMIDNI
HHCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]