Click here to switch to the map view.

The map label for this gene is yclK [H]

Identifier: 153934959

GI number: 153934959

Start: 862217

End: 863479

Strand: Direct

Name: yclK [H]

Synonym: CLC_0843

Alternate gene names: 153934959

Gene position: 862217-863479 (Clockwise)

Preceding gene: 153935783

Following gene: 153934921

Centisome position: 22.93

GC content: 23.59

Gene sequence:

>1263_bases
TTGTTAAAATATTTTAGAAATCCTGAAATTAAAGAATTAACTTTTAAATTTAGCATAATATTTATTTTATTTGCTACATT
AACTACAATTTTTATAAAAGGAGAACTTAATAAATTAAATAAAGATTACATAAATCAAAATACCTTGATAGTAGGAAATA
TACTATCAAAACATCCAGAACTGGAAGAAGAAATAATACTTTCTTTAAAGAGTAATGAGGATGCAATATATAATGAAGAA
AAAAATTATAAAATAGGAAAAAATATTTTAGAAAAATATTCATATGATGAAAATTTAGACATTTATAAAAATCCAGTATT
AAAGAACTTTAGCATAAATTTTATATATAGAACCATAATTTATTTTGGTGTAGCTATTATTATTATATATATCATAATAT
ATGATAAGTTTAAGTATTTTTATAAAAAAGCGGAAGTGTTTACTAAAGCATCAGAAGAAATAATGGATGGCCATTTTAAT
AAATTTGTAGATGAAAATAGAGAAGGAGATTTTTATGTTCTTTCTTCTAAATTTAATTTAATGTCAAATAGACTAGAGGA
ATCTTTATTAAACTTAAAAAAAGAAAAAATATTTTTAAAAAACATAATATCAGATATTTCTCATCAATTAAAAACACCAC
TATCCTCTTTAATAATGTTTAATGAATTAATGAAGGATGAAAATATGCCAATGGAAGATAGAAAAAATTTTTTAAAACTT
AGCGATGAACAGTTAAGAAGAATGGAATGGCTTATTATAAATCTTTTAAAAATAGGCAGACTAGAGGCTGGAGTAGTGGA
ATTTAGAAGAGAAAATAATCCTTTGTATGTTACGGTAAACAAAGCATTAGCAGGTCTTAGTGAGAAAGCTAAAGAAAAAT
CACAACAGGTAATAGTTAATATAGATGAAGATGTATATTTTAAGCATGATATGGATTGGACAGCAGAAGCTATTTCCAAT
ATTATAAAAAATTCTATAGAACATACAGATAATTATGGACAAATAAAAATAAGTTGTGAAGAAACACCAATATCTTTAAC
TATAAGTATAAAAGATAACGGAGAAGGAATACCAGAAAAATTACAAAATAAAATATTTGAAAGATTTTATAAAGGAGAAA
ACTCAGTTAATCCTTCTAGTATAGGAATAGGGCTTTCCCTTACCAAATCCATAATAGAATCTCAAAATGGAAGTATAATT
GTAGAAAGTGAAATGGGAGAAGGAACGGAATTTATAATAACATTCTTAAAAACTATAGTATAA

Upstream 100 bases:

>100_bases
ACTCAGTGCAAAGTAGATTGTGGAATTTTCAGTAGATAGTTACTACATAAATATTTAATTAATTTTTACAAATTAATTTA
GAATACTAAGGGGGATAATT

Downstream 100 bases:

>100_bases
AAGATATAAGAGATATTAAAATTAAATCTATTTTAGATATTTTTAAGTGAAATAGTAAAATTTAATAGTGAAGATGGTTC
ATTCTTACTTAGAATTTGAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MLKYFRNPEIKELTFKFSIIFILFATLTTIFIKGELNKLNKDYINQNTLIVGNILSKHPELEEEIILSLKSNEDAIYNEE
KNYKIGKNILEKYSYDENLDIYKNPVLKNFSINFIYRTIIYFGVAIIIIYIIIYDKFKYFYKKAEVFTKASEEIMDGHFN
KFVDENREGDFYVLSSKFNLMSNRLEESLLNLKKEKIFLKNIISDISHQLKTPLSSLIMFNELMKDENMPMEDRKNFLKL
SDEQLRRMEWLIINLLKIGRLEAGVVEFRRENNPLYVTVNKALAGLSEKAKEKSQQVIVNIDEDVYFKHDMDWTAEAISN
IIKNSIEHTDNYGQIKISCEETPISLTISIKDNGEGIPEKLQNKIFERFYKGENSVNPSSIGIGLSLTKSIIESQNGSII
VESEMGEGTEFIITFLKTIV

Sequences:

>Translated_420_residues
MLKYFRNPEIKELTFKFSIIFILFATLTTIFIKGELNKLNKDYINQNTLIVGNILSKHPELEEEIILSLKSNEDAIYNEE
KNYKIGKNILEKYSYDENLDIYKNPVLKNFSINFIYRTIIYFGVAIIIIYIIIYDKFKYFYKKAEVFTKASEEIMDGHFN
KFVDENREGDFYVLSSKFNLMSNRLEESLLNLKKEKIFLKNIISDISHQLKTPLSSLIMFNELMKDENMPMEDRKNFLKL
SDEQLRRMEWLIINLLKIGRLEAGVVEFRRENNPLYVTVNKALAGLSEKAKEKSQQVIVNIDEDVYFKHDMDWTAEAISN
IIKNSIEHTDNYGQIKISCEETPISLTISIKDNGEGIPEKLQNKIFERFYKGENSVNPSSIGIGLSLTKSIIESQNGSII
VESEMGEGTEFIITFLKTIV
>Mature_420_residues
MLKYFRNPEIKELTFKFSIIFILFATLTTIFIKGELNKLNKDYINQNTLIVGNILSKHPELEEEIILSLKSNEDAIYNEE
KNYKIGKNILEKYSYDENLDIYKNPVLKNFSINFIYRTIIYFGVAIIIIYIIIYDKFKYFYKKAEVFTKASEEIMDGHFN
KFVDENREGDFYVLSSKFNLMSNRLEESLLNLKKEKIFLKNIISDISHQLKTPLSSLIMFNELMKDENMPMEDRKNFLKL
SDEQLRRMEWLIINLLKIGRLEAGVVEFRRENNPLYVTVNKALAGLSEKAKEKSQQVIVNIDEDVYFKHDMDWTAEAISN
IIKNSIEHTDNYGQIKISCEETPISLTISIKDNGEGIPEKLQNKIFERFYKGENSVNPSSIGIGLSLTKSIIESQNGSII
VESEMGEGTEFIITFLKTIV

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=216, Percent_Identity=28.2407407407407, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788393, Length=261, Percent_Identity=22.9885057471264, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=27.3972602739726, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790861, Length=302, Percent_Identity=25.1655629139073, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=23.2456140350877, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787374, Length=216, Percent_Identity=23.6111111111111, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=247, Percent_Identity=24.2914979757085, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=22.0883534136546, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=25.3112033195021, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790346, Length=278, Percent_Identity=21.5827338129496, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=20, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787894, Length=298, Percent_Identity=23.1543624161074, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=216, Percent_Identity=25.9259259259259, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48887; Mature: 48887

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKYFRNPEIKELTFKFSIIFILFATLTTIFIKGELNKLNKDYINQNTLIVGNILSKHPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECHHHHCCHHHCCCCCEEEEHHHHCCCC
LEEEIILSLKSNEDAIYNEEKNYKIGKNILEKYSYDENLDIYKNPVLKNFSINFIYRTII
CCHHHHEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHH
YFGVAIIIIYIIIYDKFKYFYKKAEVFTKASEEIMDGHFNKFVDENREGDFYVLSSKFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHH
MSNRLEESLLNLKKEKIFLKNIISDISHQLKTPLSSLIMFNELMKDENMPMEDRKNFLKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
SDEQLRRMEWLIINLLKIGRLEAGVVEFRRENNPLYVTVNKALAGLSEKAKEKSQQVIVN
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEHHHHHCHHHHHHHCCCEEEEE
IDEDVYFKHDMDWTAEAISNIIKNSIEHTDNYGQIKISCEETPISLTISIKDNGEGIPEK
CCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCCHH
LQNKIFERFYKGENSVNPSSIGIGLSLTKSIIESQNGSIIVESEMGEGTEFIITFLKTIV
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MLKYFRNPEIKELTFKFSIIFILFATLTTIFIKGELNKLNKDYINQNTLIVGNILSKHPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECHHHHCCHHHCCCCCEEEEHHHHCCCC
LEEEIILSLKSNEDAIYNEEKNYKIGKNILEKYSYDENLDIYKNPVLKNFSINFIYRTII
CCHHHHEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHH
YFGVAIIIIYIIIYDKFKYFYKKAEVFTKASEEIMDGHFNKFVDENREGDFYVLSSKFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHH
MSNRLEESLLNLKKEKIFLKNIISDISHQLKTPLSSLIMFNELMKDENMPMEDRKNFLKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
SDEQLRRMEWLIINLLKIGRLEAGVVEFRRENNPLYVTVNKALAGLSEKAKEKSQQVIVN
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEHHHHHCHHHHHHHCCCEEEEE
IDEDVYFKHDMDWTAEAISNIIKNSIEHTDNYGQIKISCEETPISLTISIKDNGEGIPEK
CCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCCHH
LQNKIFERFYKGENSVNPSSIGIGLSLTKSIIESQNGSIIVESEMGEGTEFIITFLKTIV
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]