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The map label for this gene is norM [H]

Identifier: 153934879

GI number: 153934879

Start: 95285

End: 96622

Strand: Reverse

Name: norM [H]

Synonym: CLC_0120

Alternate gene names: 153934879

Gene position: 96622-95285 (Counterclockwise)

Preceding gene: 153935868

Following gene: 153936920

Centisome position: 2.57

GC content: 28.33

Gene sequence:

>1338_bases
TTGAAAATTAATAGGGAAAATATTAAAACTGTACTTTCTTTAGCTCTTCCTGCTGTTGGAGAAATGATTTTATATATGAT
GATTTGGGTTCTTGATACTATGATGGTTGGACAATACGGCGGTCAAATTGCTGTAAGCACTGTAGGATTAAGTTCAGAAA
TAATATATACTTTTACAAATATATTTATAGCTGTTGGACTATCTATTGGCATAACATCTATAGTAGCTAGATCCTATGGT
AGTGATAATTTACACTTAGCTGAAGAGTATGCTTCCATAGGATTATCTATAGGAATTTTAATAGCCTTTTTTATTTCTAT
TATACTATTTATTTTTCCTAAAACTATACTTAGCCTTGCTAATGCTAAAGAAGCTGTATTAATAAACGGAACAATATATA
TGAAAATAATTTCTCTTGGAATATTCTTTAGTATGTTAACTAGCTTAATGAATTCTATAGTTAGAGGATATGGTAATACC
AAGACTCCTTTATTTATCTCCATATTAATTAACATAGTAAATTTAACTTTAGATTATGGACTTATATTTGGTAAATTGGG
GTTTCCAGAATTAGGAATAAGGGGTGCTGCTATCGCAACTTCTATAGCTAACCTATCTGGTTTTATGTTTGCTATATACT
ATTTATTTACTAAATCTAAAATTAAACCTAAAATAAAATATATTAAGAACATTAATATAAGTCGTTTCAAATACCTAATA
AGATTGTCTATCCCATCATCACTGCAAGAAGCTTCATTAAGTGTAAGTAAATTAATTAATACATTTATGATAATGCATTT
AGGAACTGTAGCTTTTGCCTCTAATCAGATAGCTCTTACTGTAGAATCAATATCTTTTATGCCTGGTTGGGGTTTTGCCG
TAGCAGCTACTACACTAACAGGTCATAAAATAGGAGAAAAAAATATTGAAAAAGCTAGAGATTATTCACATACTTGTACA
TTTTTAGGGATTTGTATAATGGGAATAACAGGTCTTATTTTTCTTATATTTCCATCATTTATAATAAAATTATTTATAAC
AAATTCTGAAAAACAAGTTATCACCTTAGGTAGCCGTTGCCTTATGATTGCTTCTTTAGAACAAATTCCTATGGCTATAT
CCATGATATTAGGAGGATCATTAAAAGGATTTGGCGATACTAAAACGCCATTTTTAGTTTCCTTTATTTCCAGTTGGCTT
CTTAGACTTCCTTTAATGTTTTATTTTATATATATAGTTAAATCTTCTGTAACTTATGTTTGGTGGATAACTTCTATTCA
ATGGATATTTGAAGCTATATGCTTAATAATACTTTCTAGGAAAAAATTTAATAAATAA

Upstream 100 bases:

>100_bases
TTAATTTTACCATATAAACATATCTTTATTAACTATATTGCTTTATTTAATGCTATAAGTTACTATTAAATTGCTAGTAT
TTTGGAGTGGGGGAATTTTA

Downstream 100 bases:

>100_bases
AATATTAACCTATAATAATGCTATAGGCAATCAAATAGTCTACGGCCTAAAAGAGGATGTCTCAAAATAGCCTTAATTTT
AAAACCGTAAATATAAATAA

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKINRENIKTVLSLALPAVGEMILYMMIWVLDTMMVGQYGGQIAVSTVGLSSEIIYTFTNIFIAVGLSIGITSIVARSYG
SDNLHLAEEYASIGLSIGILIAFFISIILFIFPKTILSLANAKEAVLINGTIYMKIISLGIFFSMLTSLMNSIVRGYGNT
KTPLFISILINIVNLTLDYGLIFGKLGFPELGIRGAAIATSIANLSGFMFAIYYLFTKSKIKPKIKYIKNINISRFKYLI
RLSIPSSLQEASLSVSKLINTFMIMHLGTVAFASNQIALTVESISFMPGWGFAVAATTLTGHKIGEKNIEKARDYSHTCT
FLGICIMGITGLIFLIFPSFIIKLFITNSEKQVITLGSRCLMIASLEQIPMAISMILGGSLKGFGDTKTPFLVSFISSWL
LRLPLMFYFIYIVKSSVTYVWWITSIQWIFEAICLIILSRKKFNK

Sequences:

>Translated_445_residues
MKINRENIKTVLSLALPAVGEMILYMMIWVLDTMMVGQYGGQIAVSTVGLSSEIIYTFTNIFIAVGLSIGITSIVARSYG
SDNLHLAEEYASIGLSIGILIAFFISIILFIFPKTILSLANAKEAVLINGTIYMKIISLGIFFSMLTSLMNSIVRGYGNT
KTPLFISILINIVNLTLDYGLIFGKLGFPELGIRGAAIATSIANLSGFMFAIYYLFTKSKIKPKIKYIKNINISRFKYLI
RLSIPSSLQEASLSVSKLINTFMIMHLGTVAFASNQIALTVESISFMPGWGFAVAATTLTGHKIGEKNIEKARDYSHTCT
FLGICIMGITGLIFLIFPSFIIKLFITNSEKQVITLGSRCLMIASLEQIPMAISMILGGSLKGFGDTKTPFLVSFISSWL
LRLPLMFYFIYIVKSSVTYVWWITSIQWIFEAICLIILSRKKFNK
>Mature_445_residues
MKINRENIKTVLSLALPAVGEMILYMMIWVLDTMMVGQYGGQIAVSTVGLSSEIIYTFTNIFIAVGLSIGITSIVARSYG
SDNLHLAEEYASIGLSIGILIAFFISIILFIFPKTILSLANAKEAVLINGTIYMKIISLGIFFSMLTSLMNSIVRGYGNT
KTPLFISILINIVNLTLDYGLIFGKLGFPELGIRGAAIATSIANLSGFMFAIYYLFTKSKIKPKIKYIKNINISRFKYLI
RLSIPSSLQEASLSVSKLINTFMIMHLGTVAFASNQIALTVESISFMPGWGFAVAATTLTGHKIGEKNIEKARDYSHTCT
FLGICIMGITGLIFLIFPSFIIKLFITNSEKQVITLGSRCLMIASLEQIPMAISMILGGSLKGFGDTKTPFLVSFISSWL
LRLPLMFYFIYIVKSSVTYVWWITSIQWIFEAICLIILSRKKFNK

Specific function: Multidrug efflux pump [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=438, Percent_Identity=23.2876712328767, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI48994890, Length=402, Percent_Identity=24.3781094527363, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI226510954, Length=432, Percent_Identity=24.0740740740741, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49282; Mature: 49282

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINRENIKTVLSLALPAVGEMILYMMIWVLDTMMVGQYGGQIAVSTVGLSSEIIYTFTN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
IFIAVGLSIGITSIVARSYGSDNLHLAEEYASIGLSIGILIAFFISIILFIFPKTILSLA
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NAKEAVLINGTIYMKIISLGIFFSMLTSLMNSIVRGYGNTKTPLFISILINIVNLTLDYG
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LIFGKLGFPELGIRGAAIATSIANLSGFMFAIYYLFTKSKIKPKIKYIKNINISRFKYLI
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHEEEEE
RLSIPSSLQEASLSVSKLINTFMIMHLGTVAFASNQIALTVESISFMPGWGFAVAATTLT
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHH
GHKIGEKNIEKARDYSHTCTFLGICIMGITGLIFLIFPSFIIKLFITNSEKQVITLGSRC
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEECCHH
LMIASLEQIPMAISMILGGSLKGFGDTKTPFLVSFISSWLLRLPLMFYFIYIVKSSVTYV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
WWITSIQWIFEAICLIILSRKKFNK
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKINRENIKTVLSLALPAVGEMILYMMIWVLDTMMVGQYGGQIAVSTVGLSSEIIYTFTN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
IFIAVGLSIGITSIVARSYGSDNLHLAEEYASIGLSIGILIAFFISIILFIFPKTILSLA
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NAKEAVLINGTIYMKIISLGIFFSMLTSLMNSIVRGYGNTKTPLFISILINIVNLTLDYG
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LIFGKLGFPELGIRGAAIATSIANLSGFMFAIYYLFTKSKIKPKIKYIKNINISRFKYLI
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHEEEEE
RLSIPSSLQEASLSVSKLINTFMIMHLGTVAFASNQIALTVESISFMPGWGFAVAATTLT
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHH
GHKIGEKNIEKARDYSHTCTFLGICIMGITGLIFLIFPSFIIKLFITNSEKQVITLGSRC
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEECCHH
LMIASLEQIPMAISMILGGSLKGFGDTKTPFLVSFISSWLLRLPLMFYFIYIVKSSVTYV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
WWITSIQWIFEAICLIILSRKKFNK
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]