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The map label for this gene is lytC [H]

Identifier: 153934774

GI number: 153934774

Start: 427501

End: 428589

Strand: Direct

Name: lytC [H]

Synonym: CLC_0432

Alternate gene names: 153934774

Gene position: 427501-428589 (Clockwise)

Preceding gene: 153936450

Following gene: 153935088

Centisome position: 11.37

GC content: 33.88

Gene sequence:

>1089_bases
ATGTTAAAGAAAAATAAAAAAATTCTTTCGGTTATAACTGCTACTTTAGTAATGGCAATAGGAATTTCTTTCACTAATGT
ACAAGCAGCTTCTATAAAAAGAATGAATGGAAGTAATAGAATAGATACAGCTAACAAAACAGCAAAAGAAATATTCCAAA
AATCAGAAGCGGTTATTTTAGTAAATGGTACAGGCTACGCAGATGCAGTAAGTTCAGCACCACTTTCAAAACTATTAAAT
GCTCCAATACTTTTAACTGAAAATAAAGGTGCATTAGAATCAGATGTGTTAAAAACTATAAATGACTTACAAAACGTTAA
AAAAATATATATAGTTGGTGGTACTGGAGTTGTATCTACAACTATGGAAAATTCATTAAAGAGCAAGGGATTCCAAGTTA
TACGTTACGATGGACAGAAATATGGGGATAAAACAAGATATGGAACTAACGCTAGAGTGGCAGAAGAAATATTAAAATTA
AGTCCTAAATCAAAGACAGGGATTCTGGTAAATGGACAAGATGGATATGCAGATGCATTATCTGTAGCTTCAGTAGCAGC
AACCAATGGTTATCCGGTATTGTTTGGGAACACTCAGAATGTACCAAATGTAATAAAAAATAATATAATATCAAAAAACA
AATTACAGATTCTTGCGGTAGGTGGTAACGGAGTGTTGCCTTCTTCTGTGGTTAGCTCTGTAAGTGGTAAAAAGATAACT
TCAGATGCTCAATCTAAAAATAGATTTCAAACTAATCTAGCCGTGCTAGAATATTTTAAAGGTAAAGGCGGTTTAGATTT
TAGTAATGTATATATAGCAGCAGGAGGACAAGCCGGAAAAGCTGGACAAAGTCAATTTGCAGATGCTCTAGTAGCTTCAG
CAGCAGCAGCTAAAACAGGCTCACCATTAGTTCTAAGTGGATTAGGAGCAGGTACAACAGAAATAGCTAATGCGGAAAAA
TTTATTGAAACCAATATAGAGGACGAGGGTAGCTTAGTTATTGTTGGAGGAAAAGCTTCAGTATCCGAATCAGTGGAACA
AAAATTAGATGAAAAAGTGGGGGACTTTAGAATATTAGATATATTTTAA

Upstream 100 bases:

>100_bases
AACAAAAGATTTTGTACGAATATTATATAGAATGTGCAAATAAGAATTAATTTAGTATATAATCATAAATATAGAAAATT
ATATAAATGGAGGAGAACTA

Downstream 100 bases:

>100_bases
GAAAGAGTATAGAGTATAGAGTATAGAGTATAGAAAAAAGAGTTAAGTAAATAAATTTACTTAACTCTTTTATTTAATGA
TCAATAATCAATTAGTAATG

Product: amidase domain-containing protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MLKKNKKILSVITATLVMAIGISFTNVQAASIKRMNGSNRIDTANKTAKEIFQKSEAVILVNGTGYADAVSSAPLSKLLN
APILLTENKGALESDVLKTINDLQNVKKIYIVGGTGVVSTTMENSLKSKGFQVIRYDGQKYGDKTRYGTNARVAEEILKL
SPKSKTGILVNGQDGYADALSVASVAATNGYPVLFGNTQNVPNVIKNNIISKNKLQILAVGGNGVLPSSVVSSVSGKKIT
SDAQSKNRFQTNLAVLEYFKGKGGLDFSNVYIAAGGQAGKAGQSQFADALVASAAAAKTGSPLVLSGLGAGTTEIANAEK
FIETNIEDEGSLVIVGGKASVSESVEQKLDEKVGDFRILDIF

Sequences:

>Translated_362_residues
MLKKNKKILSVITATLVMAIGISFTNVQAASIKRMNGSNRIDTANKTAKEIFQKSEAVILVNGTGYADAVSSAPLSKLLN
APILLTENKGALESDVLKTINDLQNVKKIYIVGGTGVVSTTMENSLKSKGFQVIRYDGQKYGDKTRYGTNARVAEEILKL
SPKSKTGILVNGQDGYADALSVASVAATNGYPVLFGNTQNVPNVIKNNIISKNKLQILAVGGNGVLPSSVVSSVSGKKIT
SDAQSKNRFQTNLAVLEYFKGKGGLDFSNVYIAAGGQAGKAGQSQFADALVASAAAAKTGSPLVLSGLGAGTTEIANAEK
FIETNIEDEGSLVIVGGKASVSESVEQKLDEKVGDFRILDIF
>Mature_362_residues
MLKKNKKILSVITATLVMAIGISFTNVQAASIKRMNGSNRIDTANKTAKEIFQKSEAVILVNGTGYADAVSSAPLSKLLN
APILLTENKGALESDVLKTINDLQNVKKIYIVGGTGVVSTTMENSLKSKGFQVIRYDGQKYGDKTRYGTNARVAEEILKL
SPKSKTGILVNGQDGYADALSVASVAATNGYPVLFGNTQNVPNVIKNNIISKNKLQILAVGGNGVLPSSVVSSVSGKKIT
SDAQSKNRFQTNLAVLEYFKGKGGLDFSNVYIAAGGQAGKAGQSQFADALVASAAAAKTGSPLVLSGLGAGTTEIANAEK
FIETNIEDEGSLVIVGGKASVSESVEQKLDEKVGDFRILDIF

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 37931; Mature: 37931

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKNKKILSVITATLVMAIGISFTNVQAASIKRMNGSNRIDTANKTAKEIFQKSEAVIL
CCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHEECCCCCCCCCCHHHHHHHHHCCCEEEE
VNGTGYADAVSSAPLSKLLNAPILLTENKGALESDVLKTINDLQNVKKIYIVGGTGVVST
EECCCCHHHHHCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCHHHH
TMENSLKSKGFQVIRYDGQKYGDKTRYGTNARVAEEILKLSPKSKTGILVNGQDGYADAL
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHH
SVASVAATNGYPVLFGNTQNVPNVIKNNIISKNKLQILAVGGNGVLPSSVVSSVSGKKIT
HHHHHHCCCCEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEC
SDAQSKNRFQTNLAVLEYFKGKGGLDFSNVYIAAGGQAGKAGQSQFADALVASAAAAKTG
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
SPLVLSGLGAGTTEIANAEKFIETNIEDEGSLVIVGGKASVSESVEQKLDEKVGDFRILD
CCEEEECCCCCCHHHHCHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEE
IF
EC
>Mature Secondary Structure
MLKKNKKILSVITATLVMAIGISFTNVQAASIKRMNGSNRIDTANKTAKEIFQKSEAVIL
CCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHEECCCCCCCCCCHHHHHHHHHCCCEEEE
VNGTGYADAVSSAPLSKLLNAPILLTENKGALESDVLKTINDLQNVKKIYIVGGTGVVST
EECCCCHHHHHCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCHHHH
TMENSLKSKGFQVIRYDGQKYGDKTRYGTNARVAEEILKLSPKSKTGILVNGQDGYADAL
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHH
SVASVAATNGYPVLFGNTQNVPNVIKNNIISKNKLQILAVGGNGVLPSSVVSSVSGKKIT
HHHHHHCCCCEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEC
SDAQSKNRFQTNLAVLEYFKGKGGLDFSNVYIAAGGQAGKAGQSQFADALVASAAAAKTG
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
SPLVLSGLGAGTTEIANAEKFIETNIEDEGSLVIVGGKASVSESVEQKLDEKVGDFRILD
CCEEEECCCCCCHHHHCHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEE
IF
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]