Click here to switch to the map view.

The map label for this gene is frr

Identifier: 153934708

GI number: 153934708

Start: 2409033

End: 2409587

Strand: Reverse

Name: frr

Synonym: CLC_2279

Alternate gene names: 153934708

Gene position: 2409587-2409033 (Counterclockwise)

Preceding gene: 153937211

Following gene: 153937234

Centisome position: 64.08

GC content: 28.29

Gene sequence:

>555_bases
GTGATAAAAGAAATATTAAAAAAAGCAGATGAAAAAATGGGTAAAACTATTGTAGCTTTAAAAAAAGAATTAGCTTCAAT
GAAAGCTGGTAGAGCTAATCCAGCTATGCTTGATAGAATAGAAGCAGAATATTATGGTTCTATGACTCCACTAAATCAAT
TAGGAAATATATCTGTACCAGAAGCAAGGGTTCTTTTAATACAACCTTGGGATAAAGGTGCTTTATCAGCTATAGAGAAA
GCTATATTAAAATCAGATTTAGGCTTAAATCCTTCTAATGATGGTACTGTAATAAGACTTGTTATACCAGAATTAACAGA
AGAAACAAGAAAAAACATAGTTAAAACTGTGAAAAAAACTGGAGAGGAAGCAAAAGTAGCTATAAGATCTATAAGAAGAG
ATTGTAATGATGATGTTAAGAATCTAAAAAAAGATGACGTTTCAGAAGATGATATTAAAAAAGCAGAAGATGATATCCAA
AAGAAAACAGATAAATATATAAAAGAAATAGATTCTATAATAAGTGCAAAAGAAAAGGAAATACTATCTATATAA

Upstream 100 bases:

>100_bases
AGTTTTTGGATTAGATGAACCTTGCAATATAATAAAAGCTGTAACTGGAGAAGAAATAGGTACTCTAGTTTCAAATTCAA
AATAAGGGGAGGTTATTTAA

Downstream 100 bases:

>100_bases
ACATTATAACCTGCTTATTAGCAGGTTTTTTAATAATTTAGAGTAAATATGTTGGGGGTAACTTTATGAAAAATTTTTTT
TCAAGTAACAAAAAAGCTAG

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MIKEILKKADEKMGKTIVALKKELASMKAGRANPAMLDRIEAEYYGSMTPLNQLGNISVPEARVLLIQPWDKGALSAIEK
AILKSDLGLNPSNDGTVIRLVIPELTEETRKNIVKTVKKTGEEAKVAIRSIRRDCNDDVKNLKKDDVSEDDIKKAEDDIQ
KKTDKYIKEIDSIISAKEKEILSI

Sequences:

>Translated_184_residues
MIKEILKKADEKMGKTIVALKKELASMKAGRANPAMLDRIEAEYYGSMTPLNQLGNISVPEARVLLIQPWDKGALSAIEK
AILKSDLGLNPSNDGTVIRLVIPELTEETRKNIVKTVKKTGEEAKVAIRSIRRDCNDDVKNLKKDDVSEDDIKKAEDDIQ
KKTDKYIKEIDSIISAKEKEILSI
>Mature_184_residues
MIKEILKKADEKMGKTIVALKKELASMKAGRANPAMLDRIEAEYYGSMTPLNQLGNISVPEARVLLIQPWDKGALSAIEK
AILKSDLGLNPSNDGTVIRLVIPELTEETRKNIVKTVKKTGEEAKVAIRSIRRDCNDDVKNLKKDDVSEDDIKKAEDDIQ
KKTDKYIKEIDSIISAKEKEILSI

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=179, Percent_Identity=33.5195530726257, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI291042689, Length=148, Percent_Identity=34.4594594594595, Blast_Score=77, Evalue=8e-15,
Organism=Escherichia coli, GI1786368, Length=185, Percent_Identity=45.945945945946, Blast_Score=172, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24661488, Length=185, Percent_Identity=27.027027027027, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_CLOB1 (A7FPZ5)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001384607.1
- ProteinModelPortal:   A7FPZ5
- SMR:   A7FPZ5
- STRING:   A7FPZ5
- GeneID:   5394554
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_2296
- eggNOG:   COG0233
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- ProtClustDB:   PRK00083
- BioCyc:   CBOT441770:CLB_2296-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20547; Mature: 20547

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKEILKKADEKMGKTIVALKKELASMKAGRANPAMLDRIEAEYYGSMTPLNQLGNISVP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCC
EARVLLIQPWDKGALSAIEKAILKSDLGLNPSNDGTVIRLVIPELTEETRKNIVKTVKKT
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHC
GEEAKVAIRSIRRDCNDDVKNLKKDDVSEDDIKKAEDDIQKKTDKYIKEIDSIISAKEKE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSI
HHCC
>Mature Secondary Structure
MIKEILKKADEKMGKTIVALKKELASMKAGRANPAMLDRIEAEYYGSMTPLNQLGNISVP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCC
EARVLLIQPWDKGALSAIEKAILKSDLGLNPSNDGTVIRLVIPELTEETRKNIVKTVKKT
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHC
GEEAKVAIRSIRRDCNDDVKNLKKDDVSEDDIKKAEDDIQKKTDKYIKEIDSIISAKEKE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSI
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA