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The map label for this gene is gcvPA [H]

Identifier: 153934481

GI number: 153934481

Start: 775830

End: 777170

Strand: Direct

Name: gcvPA [H]

Synonym: CLC_0752

Alternate gene names: 153934481

Gene position: 775830-777170 (Clockwise)

Preceding gene: 153936781

Following gene: 153937289

Centisome position: 20.63

GC content: 31.69

Gene sequence:

>1341_bases
ATGTTTCCATATATTCCAAACACAGAAAAAGAAACAAAAGAAATTTTAGATTTTCTTTCAATAAAATCTGTATATGAATT
ATTTAGTGATATACCAGATAATCTGAAGTTGAATAGGGAGTTAGACCTAGAGAGTTCTTTATCAGAACTAGAGGTTGAAA
AAAGATTAAAAGCCTTAGCTTTAAAAAATAAATCTATGGAAGATATGACATGTTTCTTAGGGGCTGGAATTTATGATCAT
TATATACCTTCTGTAATTAAACATATAACAGGAAGATCAGAATTTTATACAGCATATACACCTTACCAACCAGAGGTAAG
TCAAGGAACACTTCAAGCTATATTTGAATATCAAAGTATGATTTGCGCTTTAACAGGCATGGAAGTTTCAAACTCTTCTA
TGTATGATGGAGCAACAGCAACAGCTGAGGCAGCTATACTTTCTATTGTTAGTACTAAAAGAAATACTATTATAGTTTCT
AAATCAGTAAATCTTGATACAAGAAAAGTGCTTAAAACTTACTTAAAGTACAGAGGATACAATATGGTAGAGGTTGATTT
AGAAGATGGTACTACAGATGTAGATAAAGTTATCAATAGCTTAGATAAAAATGTAGCTGCAGTTATAATTCAAAGTCCAA
ACTTCCTTGGCTTAGTTGAAGATGTAGAAAATATGGTAGATGCTATTCATAAAAATAAGTCACTATTAATAATGAATGTA
GACCCAATATCATTAGGTATATTAAAGAGTCCAGGAGAATTAGGTGCAGATATTGTTGTTGGTGATGGGCAATGTTTAGG
TGCCAACATGAGTTATGGTGGCCCAGGTTTTGGATTTATGAACACTACAAAAAAACTTATGAGAAAAATGCCAGGCAGGA
TAGTTGGCGAAACTGAAGATGTTGAAGGAAAACGAGGCTTTGTTTTAACACTTCAAGCTAGAGAACAACATATAAGGAGA
GAAAAAGCAACTTCTAATATTTGTTCAGACCAAACAGCAGTAGCAATAGGTGCAGCTGTTTATATGGCTACTTTAGGAAA
AGAGGGAATAAAGGAAGTAGCAAAACAATGTGTAGCTAAATCACACTATGCATACAATGAGTTAATTAAATCTGGAAAAT
ACAAGCCTGCATTTAATAAACCATTCTTTAAGGAATTTGTAGTAAAGGGAGAAACTTCACCTTGTGAAATTAATGATAAA
TTATTAGAAAATAATATTTTAGGTGGATATGATTTAGGAAAAGTTTACTCAGAGTATGAAAATTCTATGTTACTTTGTGT
TACAGAGAAAAGGACAAGGGAAGATATAGATAATTTAGTAAAAGTGATGGAGGCGATATAA

Upstream 100 bases:

>100_bases
TTGCTGCAATAGAGATGTCAGATAAAAGTGAATTAGAAGAATTAATAAAACCAGAAGTTTATGAGAAAATATGTGAAGAG
TTAGATAAGGAGGCATAATT

Downstream 100 bases:

>100_bases
TGAAAGATTATAATAAAGTTATATTTGAGCTGTCATCAGAAGGTAGAAAAGGCTATAGACTTCCTAATTTAGATGTACCA
GAAGTAGAACTTTCAGAATT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MFPYIPNTEKETKEILDFLSIKSVYELFSDIPDNLKLNRELDLESSLSELEVEKRLKALALKNKSMEDMTCFLGAGIYDH
YIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSMICALTGMEVSNSSMYDGATATAEAAILSIVSTKRNTIIVS
KSVNLDTRKVLKTYLKYRGYNMVEVDLEDGTTDVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVDAIHKNKSLLIMNV
DPISLGILKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETEDVEGKRGFVLTLQAREQHIRR
EKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCVAKSHYAYNELIKSGKYKPAFNKPFFKEFVVKGETSPCEINDK
LLENNILGGYDLGKVYSEYENSMLLCVTEKRTREDIDNLVKVMEAI

Sequences:

>Translated_446_residues
MFPYIPNTEKETKEILDFLSIKSVYELFSDIPDNLKLNRELDLESSLSELEVEKRLKALALKNKSMEDMTCFLGAGIYDH
YIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSMICALTGMEVSNSSMYDGATATAEAAILSIVSTKRNTIIVS
KSVNLDTRKVLKTYLKYRGYNMVEVDLEDGTTDVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVDAIHKNKSLLIMNV
DPISLGILKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETEDVEGKRGFVLTLQAREQHIRR
EKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCVAKSHYAYNELIKSGKYKPAFNKPFFKEFVVKGETSPCEINDK
LLENNILGGYDLGKVYSEYENSMLLCVTEKRTREDIDNLVKVMEAI
>Mature_446_residues
MFPYIPNTEKETKEILDFLSIKSVYELFSDIPDNLKLNRELDLESSLSELEVEKRLKALALKNKSMEDMTCFLGAGIYDH
YIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSMICALTGMEVSNSSMYDGATATAEAAILSIVSTKRNTIIVS
KSVNLDTRKVLKTYLKYRGYNMVEVDLEDGTTDVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVDAIHKNKSLLIMNV
DPISLGILKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETEDVEGKRGFVLTLQAREQHIRR
EKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCVAKSHYAYNELIKSGKYKPAFNKPFFKEFVVKGETSPCEINDK
LLENNILGGYDLGKVYSEYENSMLLCVTEKRTREDIDNLVKVMEAI

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=416, Percent_Identity=34.6153846153846, Blast_Score=240, Evalue=2e-63,
Organism=Escherichia coli, GI1789269, Length=351, Percent_Identity=33.9031339031339, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535605, Length=369, Percent_Identity=38.2113821138211, Blast_Score=242, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6323843, Length=426, Percent_Identity=34.5070422535211, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24645648, Length=359, Percent_Identity=36.4902506963788, Blast_Score=241, Evalue=9e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49544; Mature: 49544

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPYIPNTEKETKEILDFLSIKSVYELFSDIPDNLKLNRELDLESSLSELEVEKRLKALA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHH
LKNKSMEDMTCFLGAGIYDHYIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSM
HCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
ICALTGMEVSNSSMYDGATATAEAAILSIVSTKRNTIIVSKSVNLDTRKVLKTYLKYRGY
HHHHHCCEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCC
NMVEVDLEDGTTDVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVDAIHKNKSLLIMNV
CEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEC
DPISLGILKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETED
CCCEEEEECCCCCCCCEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCC
VEGKRGFVLTLQAREQHIRREKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCVAK
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SHYAYNELIKSGKYKPAFNKPFFKEFVVKGETSPCEINDKLLENNILGGYDLGKVYSEYE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHC
NSMLLCVTEKRTREDIDNLVKVMEAI
CCEEEEEECHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MFPYIPNTEKETKEILDFLSIKSVYELFSDIPDNLKLNRELDLESSLSELEVEKRLKALA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHH
LKNKSMEDMTCFLGAGIYDHYIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSM
HCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
ICALTGMEVSNSSMYDGATATAEAAILSIVSTKRNTIIVSKSVNLDTRKVLKTYLKYRGY
HHHHHCCEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCC
NMVEVDLEDGTTDVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVDAIHKNKSLLIMNV
CEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEC
DPISLGILKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETED
CCCEEEEECCCCCCCCEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCC
VEGKRGFVLTLQAREQHIRREKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCVAK
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SHYAYNELIKSGKYKPAFNKPFFKEFVVKGETSPCEINDKLLENNILGGYDLGKVYSEYE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHC
NSMLLCVTEKRTREDIDNLVKVMEAI
CCEEEEEECHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]