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The map label for this gene is prs [H]

Identifier: 153003002

GI number: 153003002

Start: 152287

End: 153252

Strand: Reverse

Name: prs [H]

Synonym: Anae109_0125

Alternate gene names: 153003002

Gene position: 153252-152287 (Counterclockwise)

Preceding gene: 153003003

Following gene: 153003001

Centisome position: 2.9

GC content: 68.84

Gene sequence:

>966_bases
ATGGAATTTCACGGAATTCGGCCCGATTACCGGGTCTTCTCTGGCAACTCGAACCGGAAGCTCGCCGAGGCGATGTGCAA
GGAGCTCGGCCGGCCGCTCGCGCACGCGACGGTGGGGCGGTTCTCGGACGGCGAGATCCAGGTCGAGATCGGCGAGAACG
TCCGCGGCCTCGACACCTACGTCGTGCAGTCCACCTCGCCCGACGCGAACACCAACCTGATGGAGCTCCTCATCATGATC
GACGCGCTGAAGCGCGCGTCGGCGGGCTCCATCACGGCGGTGCTCCCCTACTACGGCTACGCCCGCCAGGACCGGAAGAG
CGCGCCGCGCGTGCCCATCACCGCGAAGCTCATCGCCGACCTCATCGAGGCCGCCGGCGCGACCCGCGTCGTCTCGATGG
ACATGCACGCCGGGCAGATCCAGGGCTTCTTCAACGTCCCCTTCGACCACCTCTACGCCGCGCCCGTGCTGCTCGAGCAC
ATGCGCAAGCGCTTCGACGGCGACGCGCAGAACGTCGTCATCGTCTCGCCCGACGCGGGCGGCGTGGAGCGCGCCCGCGC
CTACTCGAAGCGGCTCGGCTCGACCCTCGGCATCGTGGACAAGCGGCGCACGAAGCCGAACGTCGCGGAGATCATGAACG
TCATCGGCGAGGTGCAGGGGAAGATCGCCGTGCTCCTCGACGACATGATCGACACCGCCGGCACGCTCACCCAGGCCGCC
AACGCGCTCATGGACAAGGGCGCGGTGAAGGTCTACGCGTACGCCACGCACGCGGTGCTGTCCGGCCCCGCCGTCGAGCG
GATCGTGAAGAGCCCCATCGAGGAGGTGGTGGTGACCGACACGATCGCGCTCGGGCCCGCGGCGGAGGCCTGCCGCAAGA
TCCGCTCGCTCACGATCGCCGGCCTGCTCGCCGAGGCCGTCCGCCGCATCCACTCCGCGGACTCCCTCTCGAGCCTGTTC
GTTTAG

Upstream 100 bases:

>100_bases
GTTGGGTCTGTCGGGCGGTTCCGGTATATGTGGCGCCGCCGGTGGCCTCGGCACCCCCGGGCCGCCCTCTCCTCCTCGCG
GGACCACGCCGGAGCGCTCG

Downstream 100 bases:

>100_bases
ACGGGGGCTGCGCCCCCGCCTGCTTCCGCGCGGAACCCTTGACTACCCGGGGGGTTTCGGGTAATCACCCGCGCTCCCGT
GGCTCCCGGATGGTCGGGGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MEFHGIRPDYRVFSGNSNRKLAEAMCKELGRPLAHATVGRFSDGEIQVEIGENVRGLDTYVVQSTSPDANTNLMELLIMI
DALKRASAGSITAVLPYYGYARQDRKSAPRVPITAKLIADLIEAAGATRVVSMDMHAGQIQGFFNVPFDHLYAAPVLLEH
MRKRFDGDAQNVVIVSPDAGGVERARAYSKRLGSTLGIVDKRRTKPNVAEIMNVIGEVQGKIAVLLDDMIDTAGTLTQAA
NALMDKGAVKVYAYATHAVLSGPAVERIVKSPIEEVVVTDTIALGPAAEACRKIRSLTIAGLLAEAVRRIHSADSLSSLF
V

Sequences:

>Translated_321_residues
MEFHGIRPDYRVFSGNSNRKLAEAMCKELGRPLAHATVGRFSDGEIQVEIGENVRGLDTYVVQSTSPDANTNLMELLIMI
DALKRASAGSITAVLPYYGYARQDRKSAPRVPITAKLIADLIEAAGATRVVSMDMHAGQIQGFFNVPFDHLYAAPVLLEH
MRKRFDGDAQNVVIVSPDAGGVERARAYSKRLGSTLGIVDKRRTKPNVAEIMNVIGEVQGKIAVLLDDMIDTAGTLTQAA
NALMDKGAVKVYAYATHAVLSGPAVERIVKSPIEEVVVTDTIALGPAAEACRKIRSLTIAGLLAEAVRRIHSADSLSSLF
V
>Mature_321_residues
MEFHGIRPDYRVFSGNSNRKLAEAMCKELGRPLAHATVGRFSDGEIQVEIGENVRGLDTYVVQSTSPDANTNLMELLIMI
DALKRASAGSITAVLPYYGYARQDRKSAPRVPITAKLIADLIEAAGATRVVSMDMHAGQIQGFFNVPFDHLYAAPVLLEH
MRKRFDGDAQNVVIVSPDAGGVERARAYSKRLGSTLGIVDKRRTKPNVAEIMNVIGEVQGKIAVLLDDMIDTAGTLTQAA
NALMDKGAVKVYAYATHAVLSGPAVERIVKSPIEEVVVTDTIALGPAAEACRKIRSLTIAGLLAEAVRRIHSADSLSSLF
V

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=313, Percent_Identity=46.0063897763578, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI4506129, Length=313, Percent_Identity=45.6869009584665, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI84875539, Length=316, Percent_Identity=45.253164556962, Blast_Score=295, Evalue=5e-80,
Organism=Homo sapiens, GI28557709, Length=313, Percent_Identity=44.7284345047923, Blast_Score=291, Evalue=6e-79,
Organism=Homo sapiens, GI194018537, Length=347, Percent_Identity=36.8876080691643, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=37.1014492753623, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=31.2925170068027, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=31.2925170068027, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=31.2925170068027, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=31.2925170068027, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=51.7460317460318, Blast_Score=336, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI25149168, Length=313, Percent_Identity=45.6869009584665, Blast_Score=303, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI17554702, Length=313, Percent_Identity=45.6869009584665, Blast_Score=302, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI71989924, Length=313, Percent_Identity=45.6869009584665, Blast_Score=301, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=45.9546925566343, Blast_Score=298, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17570245, Length=336, Percent_Identity=35.1190476190476, Blast_Score=203, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=42.9487179487179, Blast_Score=261, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6319403, Length=315, Percent_Identity=42.8571428571429, Blast_Score=257, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6321776, Length=311, Percent_Identity=42.1221864951768, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6322667, Length=197, Percent_Identity=41.6243654822335, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=109, Percent_Identity=38.5321100917431, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21355239, Length=318, Percent_Identity=46.8553459119497, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI45551540, Length=341, Percent_Identity=43.6950146627566, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=35.4929577464789, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=35.4929577464789, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=35.4929577464789, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=35.4929577464789, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=33.6898395721925, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=33.6898395721925, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=33.6898395721925, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34584; Mature: 34584

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFHGIRPDYRVFSGNSNRKLAEAMCKELGRPLAHATVGRFSDGEIQVEIGENVRGLDTY
CCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCCEEE
VVQSTSPDANTNLMELLIMIDALKRASAGSITAVLPYYGYARQDRKSAPRVPITAKLIAD
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHCCCCCCCHHHHHHHH
LIEAAGATRVVSMDMHAGQIQGFFNVPFDHLYAAPVLLEHMRKRFDGDAQNVVIVSPDAG
HHHHCCCCEEEEECCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GVERARAYSKRLGSTLGIVDKRRTKPNVAEIMNVIGEVQGKIAVLLDDMIDTAGTLTQAA
CHHHHHHHHHHHCCHHCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
NALMDKGAVKVYAYATHAVLSGPAVERIVKSPIEEVVVTDTIALGPAAEACRKIRSLTIA
HHHHHCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GLLAEAVRRIHSADSLSSLFV
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEFHGIRPDYRVFSGNSNRKLAEAMCKELGRPLAHATVGRFSDGEIQVEIGENVRGLDTY
CCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCCEEE
VVQSTSPDANTNLMELLIMIDALKRASAGSITAVLPYYGYARQDRKSAPRVPITAKLIAD
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHCCCCCCCHHHHHHHH
LIEAAGATRVVSMDMHAGQIQGFFNVPFDHLYAAPVLLEHMRKRFDGDAQNVVIVSPDAG
HHHHCCCCEEEEECCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GVERARAYSKRLGSTLGIVDKRRTKPNVAEIMNVIGEVQGKIAVLLDDMIDTAGTLTQAA
CHHHHHHHHHHHCCHHCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
NALMDKGAVKVYAYATHAVLSGPAVERIVKSPIEEVVVTDTIALGPAAEACRKIRSLTIA
HHHHHCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GLLAEAVRRIHSADSLSSLFV
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA