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The map label for this gene is pth

Identifier: 153003000

GI number: 153003000

Start: 150799

End: 151377

Strand: Reverse

Name: pth

Synonym: Anae109_0123

Alternate gene names: 153003000

Gene position: 151377-150799 (Counterclockwise)

Preceding gene: 153003001

Following gene: 153002999

Centisome position: 2.87

GC content: 73.06

Gene sequence:

>579_bases
TTGAAGCTCGTCGTCGGTCTTGGGAACCCGGGCCCCGAGTACGCGCGCACGCGCCACAACGTCGGCTTCCTCGTGGCCGA
CCGGCTCGCGCTCGCCCTCCGGGCCGAGTTCACCCTCCGCAAGTTCGCCTCCGAGCTCGCGGAGGGGCGGGCCGGCGGCG
AGCGCGTCTGGATCATGAAGCCCCAGACCTACATGAACCACTCCGGCGAGTCCGTCGGGTCCGCGCTCCACTTCTGGAAG
CTCGGCCTCGAGGACCTCGTCGTGGTCCACGACGATCTCGAGCTCGAGCCGTTCCGGGTCCAGCTCAAGGTCGGCGGCGG
CCACGGCGGCCACAACGGCCTGAAGAGCGTGAACGCCCACGTGGGCGGCCCCGACTACGCGCGCGTGCGCGTCGGGGTGG
GCCGGCCGCCGCCGCGGATGGATCCGGCCGACTACGTGCTCGGCCGCTTCGCCAAGGCCGACGAGGCGCCGCTCGAGGAG
TGCCTCGTCCGCGCCACCGAGGCGGCCCGGCTCGCGATCGAGCTGGGCGCGGCGAAGGCGATGAACCAGGTGAACCGGCG
CGCGAGCGCCGCTGGCTGA

Upstream 100 bases:

>100_bases
CCGCGGCGGGTGCGCCTGCCGCCGGCGCCGCTCCGGCCGCGGGTGGCGAGGCCGCCAAGAAGGCTCCCGAGGCGAAGGGC
GCCAAGAAGTAGGGGCGCCC

Downstream 100 bases:

>100_bases
GAGCTGCTGCAGCACTCGTCCTCCGGCATGGGGCCGGGCGGGCGAAACGGAAGAGCGGACTCCTCGCGGCGGGCGAACCG
CCGCTTTCAGACCCGAGGGG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MKLVVGLGNPGPEYARTRHNVGFLVADRLALALRAEFTLRKFASELAEGRAGGERVWIMKPQTYMNHSGESVGSALHFWK
LGLEDLVVVHDDLELEPFRVQLKVGGGHGGHNGLKSVNAHVGGPDYARVRVGVGRPPPRMDPADYVLGRFAKADEAPLEE
CLVRATEAARLAIELGAAKAMNQVNRRASAAG

Sequences:

>Translated_192_residues
MKLVVGLGNPGPEYARTRHNVGFLVADRLALALRAEFTLRKFASELAEGRAGGERVWIMKPQTYMNHSGESVGSALHFWK
LGLEDLVVVHDDLELEPFRVQLKVGGGHGGHNGLKSVNAHVGGPDYARVRVGVGRPPPRMDPADYVLGRFAKADEAPLEE
CLVRATEAARLAIELGAAKAMNQVNRRASAAG
>Mature_192_residues
MKLVVGLGNPGPEYARTRHNVGFLVADRLALALRAEFTLRKFASELAEGRAGGERVWIMKPQTYMNHSGESVGSALHFWK
LGLEDLVVVHDDLELEPFRVQLKVGGGHGGHNGLKSVNAHVGGPDYARVRVGVGRPPPRMDPADYVLGRFAKADEAPLEE
CLVRATEAARLAIELGAAKAMNQVNRRASAAG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=36.9047619047619, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1787455, Length=187, Percent_Identity=37.4331550802139, Blast_Score=105, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321983, Length=183, Percent_Identity=32.2404371584699, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_ANADF (A7H6J5)

Other databases:

- EMBL:   CP000769
- RefSeq:   YP_001377325.1
- ProteinModelPortal:   A7H6J5
- SMR:   A7H6J5
- STRING:   A7H6J5
- GeneID:   5374514
- GenomeReviews:   CP000769_GR
- KEGG:   afw:Anae109_0123
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20711; Mature: 20711

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVVGLGNPGPEYARTRHNVGFLVADRLALALRAEFTLRKFASELAEGRAGGERVWIMK
CEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PQTYMNHSGESVGSALHFWKLGLEDLVVVHDDLELEPFRVQLKVGGGHGGHNGLKSVNAH
CHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCHHHCCCC
VGGPDYARVRVGVGRPPPRMDPADYVLGRFAKADEAPLEECLVRATEAARLAIELGAAKA
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MNQVNRRASAAG
HHHHHHHHCCCC
>Mature Secondary Structure
MKLVVGLGNPGPEYARTRHNVGFLVADRLALALRAEFTLRKFASELAEGRAGGERVWIMK
CEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PQTYMNHSGESVGSALHFWKLGLEDLVVVHDDLELEPFRVQLKVGGGHGGHNGLKSVNAH
CHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCHHHCCCC
VGGPDYARVRVGVGRPPPRMDPADYVLGRFAKADEAPLEECLVRATEAARLAIELGAAKA
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MNQVNRRASAAG
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA