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The map label for this gene is mdmC [H]

Identifier: 153002937

GI number: 153002937

Start: 74009

End: 74686

Strand: Reverse

Name: mdmC [H]

Synonym: Anae109_0058

Alternate gene names: 153002937

Gene position: 74686-74009 (Counterclockwise)

Preceding gene: 153002940

Following gene: 153002935

Centisome position: 1.42

GC content: 76.99

Gene sequence:

>678_bases
ATGGGATCTCCCCCGGTGAAGGGGTTCGGGCAGGGCGACCCCGCGCTCGCGGCGTGGGCGGAGTCGGTGTACGCGCCGGA
GGACGAGGTGCTGCGCGAGATCCGGGCGCGGAGCGACGCGGCCGGCCTCCCGCCCATCCACGTGGGCCGCTTCGACGGGC
TCCACCTCGAGGTGCTCGCCCGCGCCTGCGCCGCGCGCCGGATCGTCGAGATCGGCACGCTCGCCGGGTACAGCGGCGTC
TGCCTCGCGCGGGCGCTCCCGGAGGACGGCGTGCTCCACACGTTCGAGCTGCTCGAGCGGCACGCCGCGCTCGCGCGGGC
CGCGTTCGCGCGCGCGGGCGTGGCGGGCCGCGTCCGGGTCCACGTCGGCCCCGCCCTGGAGCGGCTGCGGGAGGTGGAGG
GCGAGGGCCCCTTCGACCTGGTCTTCGTGGACGCCGACAAGGGCGGCTACCCCGCCTACCTCGCCTGGGCGGAGGAGCAC
CTGCGCGTGGGCGGCGTCCTGCTCGCCGACAACACCTTCGGCTTCGGCCACGTGCACGAGCCCGCCTCGGCCGGCGAGGA
CGCCGCCGCGATGGAGCCGCTGCGGCGCTTCAGCGAGCGGCTCGCCCGCGGCGGCCGCTTCCGCGCGACGATGCTCCCGA
CGGCGGAGGGGCTATCGCTCGGAGTGAAGGTGCGCTGA

Upstream 100 bases:

>100_bases
GCGCTCGCCGGAGCGCCGCGCCTGCCTCGCGCCGATCGCCCCACCCGCCCGGCACGTGCGACCCGCGCCGGGGACGGTAA
CTCGCTCCGCGGAGGACAGG

Downstream 100 bases:

>100_bases
GCCCGCTACAGCAATTCCAGCTGCATGTGCTCGCGCAACGGCTCCGACCGCACGCCCTCCTTGCGGAGCGCGGCGGAGAG
CGCGTCGGCGTGGCCGTGCA

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MGSPPVKGFGQGDPALAAWAESVYAPEDEVLREIRARSDAAGLPPIHVGRFDGLHLEVLARACAARRIVEIGTLAGYSGV
CLARALPEDGVLHTFELLERHAALARAAFARAGVAGRVRVHVGPALERLREVEGEGPFDLVFVDADKGGYPAYLAWAEEH
LRVGGVLLADNTFGFGHVHEPASAGEDAAAMEPLRRFSERLARGGRFRATMLPTAEGLSLGVKVR

Sequences:

>Translated_225_residues
MGSPPVKGFGQGDPALAAWAESVYAPEDEVLREIRARSDAAGLPPIHVGRFDGLHLEVLARACAARRIVEIGTLAGYSGV
CLARALPEDGVLHTFELLERHAALARAAFARAGVAGRVRVHVGPALERLREVEGEGPFDLVFVDADKGGYPAYLAWAEEH
LRVGGVLLADNTFGFGHVHEPASAGEDAAAMEPLRRFSERLARGGRFRATMLPTAEGLSLGVKVR
>Mature_224_residues
GSPPVKGFGQGDPALAAWAESVYAPEDEVLREIRARSDAAGLPPIHVGRFDGLHLEVLARACAARRIVEIGTLAGYSGVC
LARALPEDGVLHTFELLERHAALARAAFARAGVAGRVRVHVGPALERLREVEGEGPFDLVFVDADKGGYPAYLAWAEEHL
RVGGVLLADNTFGFGHVHEPASAGEDAAAMEPLRRFSERLARGGRFRATMLPTAEGLSLGVKVR

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=169, Percent_Identity=36.6863905325444, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI72001127, Length=230, Percent_Identity=26.0869565217391, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565612, Length=179, Percent_Identity=26.2569832402235, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23977; Mature: 23845

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSPPVKGFGQGDPALAAWAESVYAPEDEVLREIRARSDAAGLPPIHVGRFDGLHLEVLA
CCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHH
RACAARRIVEIGTLAGYSGVCLARALPEDGVLHTFELLERHAALARAAFARAGVAGRVRV
HHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
HVGPALERLREVEGEGPFDLVFVDADKGGYPAYLAWAEEHLRVGGVLLADNTFGFGHVHE
EECHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEHHHHHHHHCCCEEEECCCCCCCCCCC
PASAGEDAAAMEPLRRFSERLARGGRFRATMLPTAEGLSLGVKVR
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEC
>Mature Secondary Structure 
GSPPVKGFGQGDPALAAWAESVYAPEDEVLREIRARSDAAGLPPIHVGRFDGLHLEVLA
CCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHH
RACAARRIVEIGTLAGYSGVCLARALPEDGVLHTFELLERHAALARAAFARAGVAGRVRV
HHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
HVGPALERLREVEGEGPFDLVFVDADKGGYPAYLAWAEEHLRVGGVLLADNTFGFGHVHE
EECHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEHHHHHHHHCCCEEEECCCCCCCCCCC
PASAGEDAAAMEPLRRFSERLARGGRFRATMLPTAEGLSLGVKVR
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]