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The map label for this gene is uraA [H]

Identifier: 153002935

GI number: 153002935

Start: 71234

End: 72538

Strand: Reverse

Name: uraA [H]

Synonym: Anae109_0056

Alternate gene names: 153002935

Gene position: 72538-71234 (Counterclockwise)

Preceding gene: 153002937

Following gene: 153002927

Centisome position: 1.37

GC content: 69.2

Gene sequence:

>1305_bases
ATGAAAGCGGAGCAGCGCACCGTCGACGTGGGAGAGCGGCTCCCGCTCTTGCAGAGCATCCCCCTCTCGCTGCAGCACCT
GTTCGCGATGTTCGGCGCGACGGTGCTCGTGCCGTACCTCGTCGGCCTCGACACCTCGGTGACGCTCTTCACCTCCGGCG
TCGGCACGCTGCTCTACATCTTCGTGACGAAGGGGAAGATCCCCGCCTACCTCGGGTCGTCCTTCGCCTTCATCGCCGCG
TTCATCGGCCTGCTCGGCGCCAAGGCGGGAGAGCTCGCCTCGCCCGACCGCATCGCGGTCGCCATGGGCGGCTGCGTGGT
GGTGGGCCTCGTCTACATCGTCGTGGCGGCCATCATCGGCAAGTTCGGCACCGGCTGGATCGACCGGCTGCTGCCGCCCG
TGGTCATCGGCTCGGTGGTGATGGTCATCGGCCTCGGCCTCGCCCGCACCGCGGTGGTGACGATGGCGATGGAGGGCGGC
ACGGGGACCTATCACCCCGAGTACTTCGCGGTGGCCCTCTCCGCGCTCGCGATCGCCATCCTGGCGGCGGTGTTCCTGAA
GGGGTTCCTCGGCGTCATCCCCATCCTGATCGGCATCGTGGGCGGCTACCTCGTGGCGCTCCTCGCCGGGCAGGTGAGCT
TCGACGCGGTGAGGTCCGCCGCGCCGGTCGCGCTGCCCCCCTTCGTGCCGCCGAAGTTCACCTGGGGCGCGATCCTCACG
CTCGCCCCGATCTCGCTCGTCGTCATCACCGAGCACATCGGCCACCTCATCGTCACGAACAACATCGTGGGGCGCGACTT
CGTGAAGGATCCGGGCCTCCACCGCTCGCTCGCGGGCGACGGCGTGGCCACCGCCTTCGCGGGCCTCCTGGGCGGCCCGC
CCAACACCACCTACGGCGAGAACATCGGGGTCATGGCGATCACGCGGGTGTTCAGCGTGTGGGTCATCGGCGGCGCGGCC
GTGATCGCCATCGTGATGTCGTTCTTCCCGCCGGTGGGCGCGCTCATCCGCACCATCCCGACCCACGTGATGGGCGGCAT
CTGCATCCTGCTCTTCGGGATCATCGCCTCCGCCGGCATCCGCATGCTGGTCGAGGCCGGCATCGACTTCTCCCAGAAGC
GCAACCTCATCATCGCCTCGGTGGTGCTCGTCATCGGCATCGGCGGCGCGAAGCTGCACATCGGCGGCATCGAGTTCGGC
GAGATGTCCCTCGCCGCCTACGTCGGCATGCTGCTGAACCTGATCCTGCCCCGCGCCATGGAGAAGGGCGCCGGCGAGGC
GGCCGGCGAGGCGGCGGACGTCTAG

Upstream 100 bases:

>100_bases
GTCAGCCCCCTCTGGCATCATGCGCGCCGCCATGGCCCTACCTCTTCGAAGAGACACCGAGCCCGCCCGCAGGGACGTGG
GCTCCCCCCGGGAGGCGAAG

Downstream 100 bases:

>100_bases
ATCCCCGAGCGGCGGCGAATCCTCGGCGCCCGGTCCCGCCCGCGCGGGGCCGGGCGCTTCTACTTCAGGAGCAGGTAGTA
GAGCCGCCCCGGCTGCTTCA

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MKAEQRTVDVGERLPLLQSIPLSLQHLFAMFGATVLVPYLVGLDTSVTLFTSGVGTLLYIFVTKGKIPAYLGSSFAFIAA
FIGLLGAKAGELASPDRIAVAMGGCVVVGLVYIVVAAIIGKFGTGWIDRLLPPVVIGSVVMVIGLGLARTAVVTMAMEGG
TGTYHPEYFAVALSALAIAILAAVFLKGFLGVIPILIGIVGGYLVALLAGQVSFDAVRSAAPVALPPFVPPKFTWGAILT
LAPISLVVITEHIGHLIVTNNIVGRDFVKDPGLHRSLAGDGVATAFAGLLGGPPNTTYGENIGVMAITRVFSVWVIGGAA
VIAIVMSFFPPVGALIRTIPTHVMGGICILLFGIIASAGIRMLVEAGIDFSQKRNLIIASVVLVIGIGGAKLHIGGIEFG
EMSLAAYVGMLLNLILPRAMEKGAGEAAGEAADV

Sequences:

>Translated_434_residues
MKAEQRTVDVGERLPLLQSIPLSLQHLFAMFGATVLVPYLVGLDTSVTLFTSGVGTLLYIFVTKGKIPAYLGSSFAFIAA
FIGLLGAKAGELASPDRIAVAMGGCVVVGLVYIVVAAIIGKFGTGWIDRLLPPVVIGSVVMVIGLGLARTAVVTMAMEGG
TGTYHPEYFAVALSALAIAILAAVFLKGFLGVIPILIGIVGGYLVALLAGQVSFDAVRSAAPVALPPFVPPKFTWGAILT
LAPISLVVITEHIGHLIVTNNIVGRDFVKDPGLHRSLAGDGVATAFAGLLGGPPNTTYGENIGVMAITRVFSVWVIGGAA
VIAIVMSFFPPVGALIRTIPTHVMGGICILLFGIIASAGIRMLVEAGIDFSQKRNLIIASVVLVIGIGGAKLHIGGIEFG
EMSLAAYVGMLLNLILPRAMEKGAGEAAGEAADV
>Mature_434_residues
MKAEQRTVDVGERLPLLQSIPLSLQHLFAMFGATVLVPYLVGLDTSVTLFTSGVGTLLYIFVTKGKIPAYLGSSFAFIAA
FIGLLGAKAGELASPDRIAVAMGGCVVVGLVYIVVAAIIGKFGTGWIDRLLPPVVIGSVVMVIGLGLARTAVVTMAMEGG
TGTYHPEYFAVALSALAIAILAAVFLKGFLGVIPILIGIVGGYLVALLAGQVSFDAVRSAAPVALPPFVPPKFTWGAILT
LAPISLVVITEHIGHLIVTNNIVGRDFVKDPGLHRSLAGDGVATAFAGLLGGPPNTTYGENIGVMAITRVFSVWVIGGAA
VIAIVMSFFPPVGALIRTIPTHVMGGICILLFGIIASAGIRMLVEAGIDFSQKRNLIIASVVLVIGIGGAKLHIGGIEFG
EMSLAAYVGMLLNLILPRAMEKGAGEAAGEAADV

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788843, Length=412, Percent_Identity=49.5145631067961, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI87081818, Length=426, Percent_Identity=42.2535211267606, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI87082181, Length=405, Percent_Identity=27.1604938271605, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790087, Length=408, Percent_Identity=27.4509803921569, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI87082178, Length=406, Percent_Identity=27.3399014778325, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356175, Length=433, Percent_Identity=25.4041570438799, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44662; Mature: 44662

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAEQRTVDVGERLPLLQSIPLSLQHLFAMFGATVLVPYLVGLDTSVTLFTSGVGTLLYI
CCCCCCHHCHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
FVTKGKIPAYLGSSFAFIAAFIGLLGAKAGELASPDRIAVAMGGCVVVGLVYIVVAAIIG
HEECCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
KFGTGWIDRLLPPVVIGSVVMVIGLGLARTAVVTMAMEGGTGTYHPEYFAVALSALAIAI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHH
LAAVFLKGFLGVIPILIGIVGGYLVALLAGQVSFDAVRSAAPVALPPFVPPKFTWGAILT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
LAPISLVVITEHIGHLIVTNNIVGRDFVKDPGLHRSLAGDGVATAFAGLLGGPPNTTYGE
HHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCC
NIGVMAITRVFSVWVIGGAAVIAIVMSFFPPVGALIRTIPTHVMGGICILLFGIIASAGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLVEAGIDFSQKRNLIIASVVLVIGIGGAKLHIGGIEFGEMSLAAYVGMLLNLILPRAM
HHHHHHCCCHHHHCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
EKGAGEAAGEAADV
HCCCCCCCCCCCCC
>Mature Secondary Structure
MKAEQRTVDVGERLPLLQSIPLSLQHLFAMFGATVLVPYLVGLDTSVTLFTSGVGTLLYI
CCCCCCHHCHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
FVTKGKIPAYLGSSFAFIAAFIGLLGAKAGELASPDRIAVAMGGCVVVGLVYIVVAAIIG
HEECCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
KFGTGWIDRLLPPVVIGSVVMVIGLGLARTAVVTMAMEGGTGTYHPEYFAVALSALAIAI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHH
LAAVFLKGFLGVIPILIGIVGGYLVALLAGQVSFDAVRSAAPVALPPFVPPKFTWGAILT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
LAPISLVVITEHIGHLIVTNNIVGRDFVKDPGLHRSLAGDGVATAFAGLLGGPPNTTYGE
HHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCC
NIGVMAITRVFSVWVIGGAAVIAIVMSFFPPVGALIRTIPTHVMGGICILLFGIIASAGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLVEAGIDFSQKRNLIIASVVLVIGIGGAKLHIGGIEFGEMSLAAYVGMLLNLILPRAM
HHHHHHCCCHHHHCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
EKGAGEAAGEAADV
HCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]