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The map label for this gene is stp [H]

Identifier: 153002910

GI number: 153002910

Start: 39892

End: 41343

Strand: Reverse

Name: stp [H]

Synonym: Anae109_0031

Alternate gene names: 153002910

Gene position: 41343-39892 (Counterclockwise)

Preceding gene: 153002912

Following gene: 153002909

Centisome position: 0.78

GC content: 78.65

Gene sequence:

>1452_bases
ATGGACGGGACGCTGCGCTACGGCAGCCGGGCGGGGAGGGGCGTCTTGCTCGTCGCCGTCCTCGGCTCGGGGCTCGCGTT
CCTCGACGCGACGGTGGTGAACGTCATCCTGCCCGTGCTGGGGCGGGAGCTCGGCGCGAGCCTGGGCGCGCTGCAGTGGA
CCCTCGACGCCTACCTCCTCACGCTCTCGGCGCTGCTGCTCCCCGCGGGCGCCCTCGGCGACCGTCACGGCCGCCGGCGC
GTGTTCACCGTGGGTCTCGTCTGGTTCGCGCTCGCGTCCCTCCTCTGCGGGATCGCCCCCAGCGCCGGCGCGCTGGTCGC
GGCGCGGGCGGTGCAGGGCATCGGCGCGGCCCTGCTCGTCCCCGGCAGCCTGGCCCTCATCCGCAGCTGCTTCGCCCCGG
AGGACCAGGGGCGCGCGATCGGCGCGTGGGCCGGGCTCTCCGGCGTGACGACGGCGCTCGGCCCGCTCCTCGGCGGCTGG
CTCGCGGACGCGGTCTCGTGGCGCGCGGTGTTCCTCGTGAACCCGCCGCTCGCGGCGCTGGGCGTCTGGGCGGCGGTGCG
GTTCGTGCCCGAGTCGCGCGGGCGGCGGGGGGCGCGGCTCGACCTGGCCGGAGCGGCGCTCGCCGCCGTCGGTCTCGGCG
CGCTCACCTTCGCGCTCATCGAGGCCACCGGCGGCGCCGCGCGTTCACCCCGCGTCCTGGTCGGCGCGGCGGGCGGCCTC
GCGGCGCTCGCCGCGTTCGCCCTCGTCGAGCGTCGGAGCGCCGCCCCCATGCTCCCGCCATCGCTCTTCCGCTCGCGCCA
GTTCACCGGCGTGAACGCGGCCACCCTCGCCCTCTACTTCGGCCTCGGGGGCGCCACCTTCCTCCTCGCGCTCCAGCTGC
AGCGCGGCCTCGGCTGGTCCCCGCTCGCGGCCGGTGCGGCCCTCCTCCCCCTCACCTTCTGCATCCTCGTGCTGTCGCCC
TGGTCGGGCCGCCTCGCCGCGCGCGTCGGGAACCGCCCGCCCATGGCGGCGGGCGCGCTCGTCGCCGGGGCCGGGCTCGC
GCTCCTCGCCCGCGTGACGCCGGGGGCCGCGTACCTCCCCGACGTCTTCCCCGGCGTGGCGACGCTCGGCGTGGGGCTCG
GCCTCGCCATCGCGCCGCTCACCTCGGCGGCCCTCTCGGCGGTGGGGGTGGAGCGGGCCGGGGTGGCCTCCGCCGTGAAC
AACGCCGTCGCCCGGGTCGCGGGGCTGCTCGCGGTGGCCGTCCTGCCCCTGGCCGCCGGGATCGCCCCCGCCGAGGTGGC
CTCCGGGAGCTTCACCTCCGGGTTCCAGCGAGCGATGACGATCTCCGCGGCGCTGTGCGCCCTGGGCGGCGTCACCGCGT
GGGCCACGGTCGAGCGCGGACGCCGCGCGACGCCTCCGCACCGTGCGCTCGGCGAGGCCACCGGGCCCATCGCGCCCGGA
CGGGTCCGCTGA

Upstream 100 bases:

>100_bases
CCCGGCCGGGCGAGCGCCTGGCGCGGGGGAGCGTGGGGGAGAGGACGGGGCCGCGCGGCGCCAGGCCGCGCGCCGGCCGC
GCGCGGCTTAGGTCTCTGCG

Downstream 100 bases:

>100_bases
GGCGCGGAGGCCGTAGGACCCCAACCGACCGCGGACGTGCGCGTCCGACCTCGGCCTACTCGGTCGCCCTCCGACCTGGA
AGGGAACAGTTCGCCCGGAC

Product: EmrB/QacA family drug resistance transporter

Products: NA

Alternate protein names: Spectinomycin tetracycline efflux pump [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MDGTLRYGSRAGRGVLLVAVLGSGLAFLDATVVNVILPVLGRELGASLGALQWTLDAYLLTLSALLLPAGALGDRHGRRR
VFTVGLVWFALASLLCGIAPSAGALVAARAVQGIGAALLVPGSLALIRSCFAPEDQGRAIGAWAGLSGVTTALGPLLGGW
LADAVSWRAVFLVNPPLAALGVWAAVRFVPESRGRRGARLDLAGAALAAVGLGALTFALIEATGGAARSPRVLVGAAGGL
AALAAFALVERRSAAPMLPPSLFRSRQFTGVNAATLALYFGLGGATFLLALQLQRGLGWSPLAAGAALLPLTFCILVLSP
WSGRLAARVGNRPPMAAGALVAGAGLALLARVTPGAAYLPDVFPGVATLGVGLGLAIAPLTSAALSAVGVERAGVASAVN
NAVARVAGLLAVAVLPLAAGIAPAEVASGSFTSGFQRAMTISAALCALGGVTAWATVERGRRATPPHRALGEATGPIAPG
RVR

Sequences:

>Translated_483_residues
MDGTLRYGSRAGRGVLLVAVLGSGLAFLDATVVNVILPVLGRELGASLGALQWTLDAYLLTLSALLLPAGALGDRHGRRR
VFTVGLVWFALASLLCGIAPSAGALVAARAVQGIGAALLVPGSLALIRSCFAPEDQGRAIGAWAGLSGVTTALGPLLGGW
LADAVSWRAVFLVNPPLAALGVWAAVRFVPESRGRRGARLDLAGAALAAVGLGALTFALIEATGGAARSPRVLVGAAGGL
AALAAFALVERRSAAPMLPPSLFRSRQFTGVNAATLALYFGLGGATFLLALQLQRGLGWSPLAAGAALLPLTFCILVLSP
WSGRLAARVGNRPPMAAGALVAGAGLALLARVTPGAAYLPDVFPGVATLGVGLGLAIAPLTSAALSAVGVERAGVASAVN
NAVARVAGLLAVAVLPLAAGIAPAEVASGSFTSGFQRAMTISAALCALGGVTAWATVERGRRATPPHRALGEATGPIAPG
RVR
>Mature_483_residues
MDGTLRYGSRAGRGVLLVAVLGSGLAFLDATVVNVILPVLGRELGASLGALQWTLDAYLLTLSALLLPAGALGDRHGRRR
VFTVGLVWFALASLLCGIAPSAGALVAARAVQGIGAALLVPGSLALIRSCFAPEDQGRAIGAWAGLSGVTTALGPLLGGW
LADAVSWRAVFLVNPPLAALGVWAAVRFVPESRGRRGARLDLAGAALAAVGLGALTFALIEATGGAARSPRVLVGAAGGL
AALAAFALVERRSAAPMLPPSLFRSRQFTGVNAATLALYFGLGGATFLLALQLQRGLGWSPLAAGAALLPLTFCILVLSP
WSGRLAARVGNRPPMAAGALVAGAGLALLARVTPGAAYLPDVFPGVATLGVGLGLAIAPLTSAALSAVGVERAGVASAVN
NAVARVAGLLAVAVLPLAAGIAPAEVASGSFTSGFQRAMTISAALCALGGVTAWATVERGRRATPPHRALGEATGPIAPG
RVR

Specific function: Contributes to spectinomycin and tetracycline resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=387, Percent_Identity=30.4909560723514, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI1790195, Length=457, Percent_Identity=27.7899343544858, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1789042, Length=401, Percent_Identity=27.930174563591, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788710, Length=400, Percent_Identity=26.75, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788392, Length=333, Percent_Identity=32.7327327327327, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790146, Length=135, Percent_Identity=28.1481481481481, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082312, Length=212, Percent_Identity=31.1320754716981, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324954, Length=461, Percent_Identity=23.8611713665944, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323520, Length=455, Percent_Identity=23.7362637362637, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323735, Length=291, Percent_Identity=28.1786941580756, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48095; Mature: 48095

Theoretical pI: Translated: 12.13; Mature: 12.13

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGTLRYGSRAGRGVLLVAVLGSGLAFLDATVVNVILPVLGRELGASLGALQWTLDAYLL
CCCCCCCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
TLSALLLPAGALGDRHGRRRVFTVGLVWFALASLLCGIAPSAGALVAARAVQGIGAALLV
HHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEC
PGSLALIRSCFAPEDQGRAIGAWAGLSGVTTALGPLLGGWLADAVSWRAVFLVNPPLAAL
CCHHHHHHHHCCCCCCCCEEEEHHCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHH
GVWAAVRFVPESRGRRGARLDLAGAALAAVGLGALTFALIEATGGAARSPRVLVGAAGGL
HHHHHHHHCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHH
AALAAFALVERRSAAPMLPPSLFRSRQFTGVNAATLALYFGLGGATFLLALQLQRGLGWS
HHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCC
PLAAGAALLPLTFCILVLSPWSGRLAARVGNRPPMAAGALVAGAGLALLARVTPGAAYLP
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
DVFPGVATLGVGLGLAIAPLTSAALSAVGVERAGVASAVNNAVARVAGLLAVAVLPLAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IAPAEVASGSFTSGFQRAMTISAALCALGGVTAWATVERGRRATPPHRALGEATGPIAPG
CCHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHCCCCCCCCCC
RVR
CCC
>Mature Secondary Structure
MDGTLRYGSRAGRGVLLVAVLGSGLAFLDATVVNVILPVLGRELGASLGALQWTLDAYLL
CCCCCCCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
TLSALLLPAGALGDRHGRRRVFTVGLVWFALASLLCGIAPSAGALVAARAVQGIGAALLV
HHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEC
PGSLALIRSCFAPEDQGRAIGAWAGLSGVTTALGPLLGGWLADAVSWRAVFLVNPPLAAL
CCHHHHHHHHCCCCCCCCEEEEHHCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHH
GVWAAVRFVPESRGRRGARLDLAGAALAAVGLGALTFALIEATGGAARSPRVLVGAAGGL
HHHHHHHHCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHH
AALAAFALVERRSAAPMLPPSLFRSRQFTGVNAATLALYFGLGGATFLLALQLQRGLGWS
HHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCC
PLAAGAALLPLTFCILVLSPWSGRLAARVGNRPPMAAGALVAGAGLALLARVTPGAAYLP
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
DVFPGVATLGVGLGLAIAPLTSAALSAVGVERAGVASAVNNAVARVAGLLAVAVLPLAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IAPAEVASGSFTSGFQRAMTISAALCALGGVTAWATVERGRRATPPHRALGEATGPIAPG
CCHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHCCCCCCCCCC
RVR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]