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The map label for this gene is yclK [H]

Identifier: 152977461

GI number: 152977461

Start: 3854760

End: 3856190

Strand: Reverse

Name: yclK [H]

Synonym: Bcer98_3793

Alternate gene names: 152977461

Gene position: 3856190-3854760 (Counterclockwise)

Preceding gene: 152977462

Following gene: 152977460

Centisome position: 94.35

GC content: 39.76

Gene sequence:

>1431_bases
ATGTCGTTAAAACGAAATATGGTGTTTGGCATTGTCGGATTGTTGATTCCGATTCTTTGTCTTTTATATACAGTGATTTA
TATTGCGCTTGAGAAGAATATGTATCGTAATGCAGCGGCTTCCTTAGAGAAGCTAAGTGTAGAAGCGCAAATGTATACGA
TGAATTATATAGAGAAGGAAGCAGAAGTAGAGAAAATCGGACAAAGTTCTCTTCTAGTGGCATCTTATTTAGCAAAACGC
ATGGATGTCCGCGTGCAGATGATTGGGAGAAATGGAGACGTTGTGGCAGATACGGAGAAAGGGGCATTGCTTCATAAGAA
CGTCGATATTGAGAAGTCATTACAAGGAAAGAAAGCGTATGTGTTTGAAGATAATGAACCAGCGCCGCTCCTTTTATTTT
CAAGTCCGGTTTATTATGGAAACGATGTCATTGGCTCCATTCGCTTTATTAGTGAGCTAAAGGATGAGAAGGAGATTTTA
ACAAATGTGAGCTGGACGTTTCTTATGACATCGCTTTGTTTAGTTGCAGGAGGAATTTTCTTTGCGATTCGATTAGCAAA
TTCACTTCATAAGCCAATTGATCAGTTACGGCAAATGGCGCAGCGGCTCGCAAATGGCGATTATCAAAGTAAGATTGAGC
TGAATGAATATGTAGAAATTGCGCAGCTTTCTGCGTCCTTTAATGCGATGGCGGATGGGATTGAACTTCATATATCGCAG
CTGAAGGAAGAGAAGGAAAAGCAAAAGGATTTCTTAGACCGAATTACACATGAGTTAAAAACACCCCTTACAGCGATTAT
TGGGTATGTCGATTTAATTCCAAAGTTAAAATCAAGGGAAGATATAAAGGAGAGTCTCCGTTATGTTTCGGTGGAAAGTC
ATCGATTATTATCGCTTGTGGAGGAACTCTTGCAATCATCAAAATACGGAACGAGTACGTTTGAAGTGTCGCCAACGATT
GTGAATATAAAGGAGTTAGCAGACGAAGCCATTTCCATTGTTACTCCGCGCCTGCAGCAATTTGAAATTGAGGTAATTCA
TGAATTACCGGAAATATATGTTGTGGCGGATTTTGATAAGACAAAGCAGATTTTCTTAAATGTGCTTGATAATGCGATTA
AGTATAGTGATGCTTCAAAGATAAGTTTGAGTGTTACGATGAATGAACGGGAAGCAAAAGTAAGGATGTATGATGACGGA
ATTGGCATGGATGAAGAAGTGCTAGCTGAATGGAATCGCTCTTCAAAAGGGACAAAGCTTACTTCTAGTTATGGAAATGG
CTATGGCTTATCCATTTGCCAGGAGATTATGAATAAGCAAGGCGGAAGCATGCAGATTGAAAGCAGCGCGGAAGTGGGAA
CGATTGTGACGCTGACATTTTTATTGCCAAGGCATATGGAAGATATAAAAAACTTGAAAGCGGTTGAATGA

Upstream 100 bases:

>100_bases
ATATTATGGTGCAGCGCCTTAGAAAGAAACTTAAGGCAAGTGGTGAGCATATTAAGACAATTTACGGTGTTGGATATAAG
CTGGATTGTTAGGTGATGAG

Downstream 100 bases:

>100_bases
TACATTTATGAAACAATTATGCGGTATTTTCGAAACAACGTTTTTTTATCTTGGAGGTAGGCAGAAATGAAAAGGCTATC
ATTTCAAATTCTTTTCTTTG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSLKRNMVFGIVGLLIPILCLLYTVIYIALEKNMYRNAAASLEKLSVEAQMYTMNYIEKEAEVEKIGQSSLLVASYLAKR
MDVRVQMIGRNGDVVADTEKGALLHKNVDIEKSLQGKKAYVFEDNEPAPLLLFSSPVYYGNDVIGSIRFISELKDEKEIL
TNVSWTFLMTSLCLVAGGIFFAIRLANSLHKPIDQLRQMAQRLANGDYQSKIELNEYVEIAQLSASFNAMADGIELHISQ
LKEEKEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKSREDIKESLRYVSVESHRLLSLVEELLQSSKYGTSTFEVSPTI
VNIKELADEAISIVTPRLQQFEIEVIHELPEIYVVADFDKTKQIFLNVLDNAIKYSDASKISLSVTMNEREAKVRMYDDG
IGMDEEVLAEWNRSSKGTKLTSSYGNGYGLSICQEIMNKQGGSMQIESSAEVGTIVTLTFLLPRHMEDIKNLKAVE

Sequences:

>Translated_476_residues
MSLKRNMVFGIVGLLIPILCLLYTVIYIALEKNMYRNAAASLEKLSVEAQMYTMNYIEKEAEVEKIGQSSLLVASYLAKR
MDVRVQMIGRNGDVVADTEKGALLHKNVDIEKSLQGKKAYVFEDNEPAPLLLFSSPVYYGNDVIGSIRFISELKDEKEIL
TNVSWTFLMTSLCLVAGGIFFAIRLANSLHKPIDQLRQMAQRLANGDYQSKIELNEYVEIAQLSASFNAMADGIELHISQ
LKEEKEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKSREDIKESLRYVSVESHRLLSLVEELLQSSKYGTSTFEVSPTI
VNIKELADEAISIVTPRLQQFEIEVIHELPEIYVVADFDKTKQIFLNVLDNAIKYSDASKISLSVTMNEREAKVRMYDDG
IGMDEEVLAEWNRSSKGTKLTSSYGNGYGLSICQEIMNKQGGSMQIESSAEVGTIVTLTFLLPRHMEDIKNLKAVE
>Mature_475_residues
SLKRNMVFGIVGLLIPILCLLYTVIYIALEKNMYRNAAASLEKLSVEAQMYTMNYIEKEAEVEKIGQSSLLVASYLAKRM
DVRVQMIGRNGDVVADTEKGALLHKNVDIEKSLQGKKAYVFEDNEPAPLLLFSSPVYYGNDVIGSIRFISELKDEKEILT
NVSWTFLMTSLCLVAGGIFFAIRLANSLHKPIDQLRQMAQRLANGDYQSKIELNEYVEIAQLSASFNAMADGIELHISQL
KEEKEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKSREDIKESLRYVSVESHRLLSLVEELLQSSKYGTSTFEVSPTIV
NIKELADEAISIVTPRLQQFEIEVIHELPEIYVVADFDKTKQIFLNVLDNAIKYSDASKISLSVTMNEREAKVRMYDDGI
GMDEEVLAEWNRSSKGTKLTSSYGNGYGLSICQEIMNKQGGSMQIESSAEVGTIVTLTFLLPRHMEDIKNLKAVE

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=288, Percent_Identity=26.7361111111111, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1788713, Length=275, Percent_Identity=25.8181818181818, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789149, Length=334, Percent_Identity=21.8562874251497, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=27.2, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=24.1071428571429, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=22.5108225108225, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787894, Length=282, Percent_Identity=24.822695035461, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=241, Percent_Identity=26.9709543568465, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=23.7068965517241, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790861, Length=263, Percent_Identity=25.4752851711027, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790346, Length=280, Percent_Identity=25, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53629; Mature: 53497

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKRNMVFGIVGLLIPILCLLYTVIYIALEKNMYRNAAASLEKLSVEAQMYTMNYIEKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEVEKIGQSSLLVASYLAKRMDVRVQMIGRNGDVVADTEKGALLHKNVDIEKSLQGKKAY
HHHHHHCCHHHHHHHHHHHHHCEEEEEECCCCCEEEECCCCEEEECCCCHHHCCCCCEEE
VFEDNEPAPLLLFSSPVYYGNDVIGSIRFISELKDEKEILTNVSWTFLMTSLCLVAGGIF
EEECCCCCEEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FAIRLANSLHKPIDQLRQMAQRLANGDYQSKIELNEYVEIAQLSASFNAMADGIELHISQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKEEKEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKSREDIKESLRYVSVESHRLLSLV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHH
EELLQSSKYGTSTFEVSPTIVNIKELADEAISIVTPRLQQFEIEVIHELPEIYVVADFDK
HHHHHCCCCCCCEEEECCCEEEHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCH
TKQIFLNVLDNAIKYSDASKISLSVTMNEREAKVRMYDDGIGMDEEVLAEWNRSSKGTKL
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHCCCCCCCEE
TSSYGNGYGLSICQEIMNKQGGSMQIESSAEVGTIVTLTFLLPRHMEDIKNLKAVE
ECCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLKRNMVFGIVGLLIPILCLLYTVIYIALEKNMYRNAAASLEKLSVEAQMYTMNYIEKE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEVEKIGQSSLLVASYLAKRMDVRVQMIGRNGDVVADTEKGALLHKNVDIEKSLQGKKAY
HHHHHHCCHHHHHHHHHHHHHCEEEEEECCCCCEEEECCCCEEEECCCCHHHCCCCCEEE
VFEDNEPAPLLLFSSPVYYGNDVIGSIRFISELKDEKEILTNVSWTFLMTSLCLVAGGIF
EEECCCCCEEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FAIRLANSLHKPIDQLRQMAQRLANGDYQSKIELNEYVEIAQLSASFNAMADGIELHISQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKEEKEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKSREDIKESLRYVSVESHRLLSLV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHH
EELLQSSKYGTSTFEVSPTIVNIKELADEAISIVTPRLQQFEIEVIHELPEIYVVADFDK
HHHHHCCCCCCCEEEECCCEEEHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCH
TKQIFLNVLDNAIKYSDASKISLSVTMNEREAKVRMYDDGIGMDEEVLAEWNRSSKGTKL
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHCCCCCCCEE
TSSYGNGYGLSICQEIMNKQGGSMQIESSAEVGTIVTLTFLLPRHMEDIKNLKAVE
ECCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]