Click here to switch to the map view.

The map label for this gene is menB [H]

Identifier: 152977175

GI number: 152977175

Start: 3550241

End: 3551059

Strand: Reverse

Name: menB [H]

Synonym: Bcer98_3491

Alternate gene names: 152977175

Gene position: 3551059-3550241 (Counterclockwise)

Preceding gene: 152977176

Following gene: 152977174

Centisome position: 86.89

GC content: 42.0

Gene sequence:

>819_bases
ATGGCTATCGAATGGATAAAAGAAGGCAATTACGAAGATATTATTTATTCCACATACAATGGTATCGCAAAGATTTCGAT
TAATCGCCCTGAAGTACATAACGCATTCCGTCCTGAAACGGTAATGGAGTTAATCGATGCTTTTGCACATGCGCGTGATG
ATGAAAATATCGGCGTTATCATTTTAACTGGTGAAGGTGGACGTGCATTCTGTTCTGGCGGCGACCAAAAAGTTCGCGGT
CATGGTGGATATGTAGGAGGAGACAAAATTCCTCGATTAAACGTATTAGACTTACAACGTTTAATCCGTGCAATTCCGAA
ACCAGTTATCGCAATGGTAGCAGGTTATGCAATTGGTGGTGGACACGTACTTCATATTGTATGTGATTTAACAATTGCGG
CAGACAACGCAGTATTTGGACAAACTGGTCCGAAAGTAGGAAGCTTTGATGGTGGATACGGTGCTGGTTATTTAGCTCGC
ATGGTAGGTCATAAGAAAGCTCGTGAAATTTGGTATTTATGTCGCCAATATAACGCACAAGAAGCGCTTGATATGGGCTT
AATTAATACAGTTGTACCACTAGATCAATTAGAAGAAGAAACAGTAAAATGGGCAGAAGAAATTTTAGAAAAGAGCCCAA
TGGCATTACGTTTCTTAAAAGCTGCATTCAACGCAGACACGGACGGCCTAGCTGGTATTCAACAACTAGCGGGAGACGCA
ACGTTATTGTATTACACAACTGACGAAGCAAAAGAAGGTCGTGACGCGTTCAAAGAAAAACGCCGTCCAGACTTCGGACA
ATTCCCTCGTTTCCCTTGA

Upstream 100 bases:

>100_bases
GGTACAATAGTAGAGGGATTTTTAAAAACCATACGGTGATGCTTTCTTTTTTTAGAGAAAGTTGAACTTATATTAGCACA
ACAAAAAGGAGGTAAGAGTA

Downstream 100 bases:

>100_bases
TCAAAAGCGGAATCGAATGTCTATCCCTGACGGCTAATGTTCTTTCGCATGAAGAGTAATTTTTACTTTCCCATGCGGAA
GTAGCTCGTTCAGAATAAGA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MAIEWIKEGNYEDIIYSTYNGIAKISINRPEVHNAFRPETVMELIDAFAHARDDENIGVIILTGEGGRAFCSGGDQKVRG
HGGYVGGDKIPRLNVLDLQRLIRAIPKPVIAMVAGYAIGGGHVLHIVCDLTIAADNAVFGQTGPKVGSFDGGYGAGYLAR
MVGHKKAREIWYLCRQYNAQEALDMGLINTVVPLDQLEEETVKWAEEILEKSPMALRFLKAAFNADTDGLAGIQQLAGDA
TLLYYTTDEAKEGRDAFKEKRRPDFGQFPRFP

Sequences:

>Translated_272_residues
MAIEWIKEGNYEDIIYSTYNGIAKISINRPEVHNAFRPETVMELIDAFAHARDDENIGVIILTGEGGRAFCSGGDQKVRG
HGGYVGGDKIPRLNVLDLQRLIRAIPKPVIAMVAGYAIGGGHVLHIVCDLTIAADNAVFGQTGPKVGSFDGGYGAGYLAR
MVGHKKAREIWYLCRQYNAQEALDMGLINTVVPLDQLEEETVKWAEEILEKSPMALRFLKAAFNADTDGLAGIQQLAGDA
TLLYYTTDEAKEGRDAFKEKRRPDFGQFPRFP
>Mature_271_residues
AIEWIKEGNYEDIIYSTYNGIAKISINRPEVHNAFRPETVMELIDAFAHARDDENIGVIILTGEGGRAFCSGGDQKVRGH
GGYVGGDKIPRLNVLDLQRLIRAIPKPVIAMVAGYAIGGGHVLHIVCDLTIAADNAVFGQTGPKVGSFDGGYGAGYLARM
VGHKKAREIWYLCRQYNAQEALDMGLINTVVPLDQLEEETVKWAEEILEKSPMALRFLKAAFNADTDGLAGIQQLAGDAT
LLYYTTDEAKEGRDAFKEKRRPDFGQFPRFP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=262, Percent_Identity=32.824427480916, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI31542718, Length=262, Percent_Identity=32.0610687022901, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4502327, Length=263, Percent_Identity=31.9391634980989, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI45643119, Length=217, Percent_Identity=27.6497695852535, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI260275230, Length=217, Percent_Identity=27.6497695852535, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI260274832, Length=217, Percent_Identity=27.6497695852535, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI68989263, Length=227, Percent_Identity=28.1938325991189, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI70995211, Length=229, Percent_Identity=28.3842794759825, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788597, Length=274, Percent_Identity=68.6131386861314, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1787659, Length=262, Percent_Identity=32.824427480916, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87082183, Length=264, Percent_Identity=29.5454545454545, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI221142681, Length=265, Percent_Identity=30.188679245283, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1787660, Length=259, Percent_Identity=30.8880308880309, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788682, Length=202, Percent_Identity=26.2376237623762, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=246, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI25145438, Length=252, Percent_Identity=32.9365079365079, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17540714, Length=210, Percent_Identity=30.4761904761905, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17549921, Length=216, Percent_Identity=26.3888888888889, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17560910, Length=188, Percent_Identity=32.9787234042553, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17534483, Length=280, Percent_Identity=26.7857142857143, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=218, Percent_Identity=29.3577981651376, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17535521, Length=248, Percent_Identity=24.1935483870968, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI20129971, Length=245, Percent_Identity=35.9183673469388, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653477, Length=245, Percent_Identity=35.9183673469388, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653139, Length=255, Percent_Identity=30.1960784313725, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21357171, Length=189, Percent_Identity=32.8042328042328, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922422, Length=270, Percent_Identity=23.3333333333333, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650670, Length=207, Percent_Identity=29.951690821256, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 29920; Mature: 29789

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEWIKEGNYEDIIYSTYNGIAKISINRPEVHNAFRPETVMELIDAFAHARDDENIGVI
CCCEEECCCCCCCEEEECCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHCCCCCCEEEE
ILTGEGGRAFCSGGDQKVRGHGGYVGGDKIPRLNVLDLQRLIRAIPKPVIAMVAGYAIGG
EEECCCCEEEECCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCC
GHVLHIVCDLTIAADNAVFGQTGPKVGSFDGGYGAGYLARMVGHKKAREIWYLCRQYNAQ
CEEEEEEEEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
EALDMGLINTVVPLDQLEEETVKWAEEILEKSPMALRFLKAAFNADTDGLAGIQQLAGDA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCC
TLLYYTTDEAKEGRDAFKEKRRPDFGQFPRFP
EEEEEECCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AIEWIKEGNYEDIIYSTYNGIAKISINRPEVHNAFRPETVMELIDAFAHARDDENIGVI
CCEEECCCCCCCEEEECCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHCCCCCCEEEE
ILTGEGGRAFCSGGDQKVRGHGGYVGGDKIPRLNVLDLQRLIRAIPKPVIAMVAGYAIGG
EEECCCCEEEECCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCC
GHVLHIVCDLTIAADNAVFGQTGPKVGSFDGGYGAGYLARMVGHKKAREIWYLCRQYNAQ
CEEEEEEEEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
EALDMGLINTVVPLDQLEEETVKWAEEILEKSPMALRFLKAAFNADTDGLAGIQQLAGDA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCC
TLLYYTTDEAKEGRDAFKEKRRPDFGQFPRFP
EEEEEECCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]