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The map label for this gene is comEC [H]

Identifier: 152976755

GI number: 152976755

Start: 3098160

End: 3100502

Strand: Reverse

Name: comEC [H]

Synonym: Bcer98_3051

Alternate gene names: 152976755

Gene position: 3100502-3098160 (Counterclockwise)

Preceding gene: 152976756

Following gene: 152976754

Centisome position: 75.86

GC content: 36.96

Gene sequence:

>2343_bases
TTGCGTAGGCAATGGGGCTATATTGCAATTTCTTTTGTAATAGGAATTGCAATTGCCTGTTCTTCGTCCCAATTATTGGG
TACGATTTTATTTGGGTGCTATTTTTTATTCTGCACATACCGTACTTCGCGTCAAACCCTCATGTTCTGTATAGTAGCGT
GTCTTAGTAGTTTTCTTTATACATCATATATTGAACAGGAAAATAAGCCTTCTATACGTTATGATTTAGAATCCATAACG
GGTGTGATTCTAAATACTCCTCTTATTAATGGGAATCGCCTCTCTTTTCAAATAGAAGATAACTCAAAAAATAAAGTGCA
GCTATTTTATAACATGCAGTCAGAGAAGGAAAAGAATGTGCTGCGCGGGTTACGTGTGGGGATGGTATGTACTTTTAGAG
GAGCGTTAAAGGAACCGCCAAGCGCTCGGAATTTTTATGGATTTGATTATAAAAATTACTTGTACAAACAAAGGATTCAT
TTTTTGTTTGAGGCAACCGCAATAATGGATTGTAGCAACAATCATGTTACATTTGTAAATTGGCTTTTTCAATTGAGACA
AAAAGCAACGTTGGCAGTTGCAGAAATGTTTCCCGAACAATCGGGTGCATTTATGAATGCACTATTATTTGGAGACCGCC
AATTCATGTCATATGAAGTGGAACAACAATATCAACAGTTTGGTTTGATTCACTTGCTTGCTATTTCAGGTTCACACATT
GTATTACTATCGGCAATTGTATATTTTGTTTTGCTTCGAATTGGTGTAACAAGGGAAAGAACAACAACTGCTCTTATAAT
TTGTATCCCGCTGTATATGTTTTTTGCGGGGGCATCTCCTTCTGTTATGCGAGCTTCTATTATGGGTACTTTATTGCTCA
TAGGGGTGATGCATTCCTTTCGTTTATTCAGTATAGATGCGATTAGTGTAACAGCTATATTCATGCTCATATATGATCCA
TACATGCTTTTTGATATTGGATTTCAATTTTCGTTTATTGGTAGTTTGGCGTTATTGTTATCTGCAAATACATTGTTACA
GCATAACCGCGGAGTGATTCAAAATGCAATCATCCTTTCTCTTATTTCACAACTTGCCAGTATCCCGATTACGCTCTATC
ATTTCGGTTATTTTTCTCCATACAGTATTCCCCTCAATTTGATTTATGTTCCATTCCTGTCTTGTATTGTATTACCGTGT
AGCATCATTATTTTTTTATGTATGATGATTTTCCCTCCGCTGGCAAAAGGAATTGCACATCTACTATCTATATGTTTACG
CATGTCTAATGATGTTTTGCAGTATTGTGAAGCCTTTCCTTTTGTACGGTTTACGTTTGGACAAACTCCTCCATTTCTTG
TAGTGCTTTATTCCTTTAGTATCATTATTATATGTATCGTGTGGGAAAGAGCGATTAGGAAAATATTTTTATATTTCGCC
TTTGGTATCTTCTTTTTTTTATGTATGTGTCATTATCTATCTCCATATTTTCGCGCAAGTGGCAGCGTGACATTTATTGA
TGTGGGACAAGGTGATGCGATATTGATTCGCCTTCCGTATGATAAAGAAGTGTATCTTATTGATACAGGAGGGACAATTC
CGATAAAAAAAGAACATTGGCAACAGAAGAAACATGAATTTTCTATTGGGGATGATGTGCTCATTCCTTTTTTACAAAAG
CAAGGAATTCGCACGATTGATAAGTTGATTGTGACACATGGTGATGTCGATCATATGGGAGCGGCTAAAGAGGTAGTAGC
AGCTCTTGATGTAAAAGAAATTATATTTGGAAAAAAGAGAAAAGATTCTGTATTAGAAGCTGAATTGAAGTACCTTGCGC
AGAAAAAAGACATGCGAATCAATAAGGTGAAAGAAGGCGACGGATGGAAAGTTGATGAAGTGGAATTTAGAGTATTATCA
CCAGAGGGAAGCGAAACAAGTGATAATGATTCTTCTATTGTTCTATGGGCGAAAATAGGAGAATTTACATGGTTGTTTAC
AGGAGATTTAGAAGAAAAGGGTGAGGAACGTATAGTAAAACAATATCCAAACTTGCGAGCGGACATACTAAAAGTTGGGC
ATCATGGGAGCAAGACATCTTCTACTGCCCCGTTTTTGCGGCTTATTCAGCCGAAGAAAGCGATTATTTCGGTAGGAGAG
CATAATCGATATGGACATCCGCATGACCAAGTATTAAAGCGCCTTGAGGAAATGCAAGTGGAAGTGTGGCGGACAGATAG
GGAAGGAGCCATTTTGTATACTTTTCAAGGAAAGAATGGAACATTTCAAAGCAAATTAACATATGATGAAACACAGAAAA
GGATGAAAAAAGACCGCAAGTAG

Upstream 100 bases:

>100_bases
AAGAACTGTTTTCTTCGTTAGAAAAAGAAGATTTAACAATGGACGAACTACAACGAGTATTCACAAAAGCGAAACAAATG
CTATAAGGAGTGAGAATGAG

Downstream 100 bases:

>100_bases
CGGTCTTTAGGAACCTATAAATTTAATGATTGTTGCAATAATAAAAAGTGTTGCGAAAAAACCAAATGAGACGATAAATC
CTACCCCTGAATCAACAGCA

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MRRQWGYIAISFVIGIAIACSSSQLLGTILFGCYFLFCTYRTSRQTLMFCIVACLSSFLYTSYIEQENKPSIRYDLESIT
GVILNTPLINGNRLSFQIEDNSKNKVQLFYNMQSEKEKNVLRGLRVGMVCTFRGALKEPPSARNFYGFDYKNYLYKQRIH
FLFEATAIMDCSNNHVTFVNWLFQLRQKATLAVAEMFPEQSGAFMNALLFGDRQFMSYEVEQQYQQFGLIHLLAISGSHI
VLLSAIVYFVLLRIGVTRERTTTALIICIPLYMFFAGASPSVMRASIMGTLLLIGVMHSFRLFSIDAISVTAIFMLIYDP
YMLFDIGFQFSFIGSLALLLSANTLLQHNRGVIQNAIILSLISQLASIPITLYHFGYFSPYSIPLNLIYVPFLSCIVLPC
SIIIFLCMMIFPPLAKGIAHLLSICLRMSNDVLQYCEAFPFVRFTFGQTPPFLVVLYSFSIIIICIVWERAIRKIFLYFA
FGIFFFLCMCHYLSPYFRASGSVTFIDVGQGDAILIRLPYDKEVYLIDTGGTIPIKKEHWQQKKHEFSIGDDVLIPFLQK
QGIRTIDKLIVTHGDVDHMGAAKEVVAALDVKEIIFGKKRKDSVLEAELKYLAQKKDMRINKVKEGDGWKVDEVEFRVLS
PEGSETSDNDSSIVLWAKIGEFTWLFTGDLEEKGEERIVKQYPNLRADILKVGHHGSKTSSTAPFLRLIQPKKAIISVGE
HNRYGHPHDQVLKRLEEMQVEVWRTDREGAILYTFQGKNGTFQSKLTYDETQKRMKKDRK

Sequences:

>Translated_780_residues
MRRQWGYIAISFVIGIAIACSSSQLLGTILFGCYFLFCTYRTSRQTLMFCIVACLSSFLYTSYIEQENKPSIRYDLESIT
GVILNTPLINGNRLSFQIEDNSKNKVQLFYNMQSEKEKNVLRGLRVGMVCTFRGALKEPPSARNFYGFDYKNYLYKQRIH
FLFEATAIMDCSNNHVTFVNWLFQLRQKATLAVAEMFPEQSGAFMNALLFGDRQFMSYEVEQQYQQFGLIHLLAISGSHI
VLLSAIVYFVLLRIGVTRERTTTALIICIPLYMFFAGASPSVMRASIMGTLLLIGVMHSFRLFSIDAISVTAIFMLIYDP
YMLFDIGFQFSFIGSLALLLSANTLLQHNRGVIQNAIILSLISQLASIPITLYHFGYFSPYSIPLNLIYVPFLSCIVLPC
SIIIFLCMMIFPPLAKGIAHLLSICLRMSNDVLQYCEAFPFVRFTFGQTPPFLVVLYSFSIIIICIVWERAIRKIFLYFA
FGIFFFLCMCHYLSPYFRASGSVTFIDVGQGDAILIRLPYDKEVYLIDTGGTIPIKKEHWQQKKHEFSIGDDVLIPFLQK
QGIRTIDKLIVTHGDVDHMGAAKEVVAALDVKEIIFGKKRKDSVLEAELKYLAQKKDMRINKVKEGDGWKVDEVEFRVLS
PEGSETSDNDSSIVLWAKIGEFTWLFTGDLEEKGEERIVKQYPNLRADILKVGHHGSKTSSTAPFLRLIQPKKAIISVGE
HNRYGHPHDQVLKRLEEMQVEVWRTDREGAILYTFQGKNGTFQSKLTYDETQKRMKKDRK
>Mature_780_residues
MRRQWGYIAISFVIGIAIACSSSQLLGTILFGCYFLFCTYRTSRQTLMFCIVACLSSFLYTSYIEQENKPSIRYDLESIT
GVILNTPLINGNRLSFQIEDNSKNKVQLFYNMQSEKEKNVLRGLRVGMVCTFRGALKEPPSARNFYGFDYKNYLYKQRIH
FLFEATAIMDCSNNHVTFVNWLFQLRQKATLAVAEMFPEQSGAFMNALLFGDRQFMSYEVEQQYQQFGLIHLLAISGSHI
VLLSAIVYFVLLRIGVTRERTTTALIICIPLYMFFAGASPSVMRASIMGTLLLIGVMHSFRLFSIDAISVTAIFMLIYDP
YMLFDIGFQFSFIGSLALLLSANTLLQHNRGVIQNAIILSLISQLASIPITLYHFGYFSPYSIPLNLIYVPFLSCIVLPC
SIIIFLCMMIFPPLAKGIAHLLSICLRMSNDVLQYCEAFPFVRFTFGQTPPFLVVLYSFSIIIICIVWERAIRKIFLYFA
FGIFFFLCMCHYLSPYFRASGSVTFIDVGQGDAILIRLPYDKEVYLIDTGGTIPIKKEHWQQKKHEFSIGDDVLIPFLQK
QGIRTIDKLIVTHGDVDHMGAAKEVVAALDVKEIIFGKKRKDSVLEAELKYLAQKKDMRINKVKEGDGWKVDEVEFRVLS
PEGSETSDNDSSIVLWAKIGEFTWLFTGDLEEKGEERIVKQYPNLRADILKVGHHGSKTSSTAPFLRLIQPKKAIISVGE
HNRYGHPHDQVLKRLEEMQVEVWRTDREGAILYTFQGKNGTFQSKLTYDETQKRMKKDRK

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=587, Percent_Identity=22.1465076660988, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 89190; Mature: 89190

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRQWGYIAISFVIGIAIACSSSQLLGTILFGCYFLFCTYRTSRQTLMFCIVACLSSFLY
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TSYIEQENKPSIRYDLESITGVILNTPLINGNRLSFQIEDNSKNKVQLFYNMQSEKEKNV
HHHHHCCCCCCCEEEHHHHCCHHEECCEECCCEEEEEEECCCCCEEEEEEECCCHHHHHH
LRGLRVGMVCTFRGALKEPPSARNFYGFDYKNYLYKQRIHFLFEATAIMDCSNNHVTFVN
HHHHHHHHEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHH
WLFQLRQKATLAVAEMFPEQSGAFMNALLFGDRQFMSYEVEQQYQQFGLIHLLAISGSHI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCHH
VLLSAIVYFVLLRIGVTRERTTTALIICIPLYMFFAGASPSVMRASIMGTLLLIGVMHSF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
RLFSIDAISVTAIFMLIYDPYMLFDIGFQFSFIGSLALLLSANTLLQHNRGVIQNAIILS
HEEEEHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LISQLASIPITLYHFGYFSPYSIPLNLIYVPFLSCIVLPCSIIIFLCMMIFPPLAKGIAH
HHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSICLRMSNDVLQYCEAFPFVRFTFGQTPPFLVVLYSFSIIIICIVWERAIRKIFLYFA
HHHHHHHHCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGIFFFLCMCHYLSPYFRASGSVTFIDVGQGDAILIRLPYDKEVYLIDTGGTIPIKKEHW
HHHHHHHHHHHHHCHHHHCCCCEEEEEECCCCEEEEEECCCCEEEEEECCCCCCCCHHHH
QQKKHEFSIGDDVLIPFLQKQGIRTIDKLIVTHGDVDHMGAAKEVVAALDVKEIIFGKKR
HHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHCCCCC
KDSVLEAELKYLAQKKDMRINKVKEGDGWKVDEVEFRVLSPEGSETSDNDSSIVLWAKIG
CHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEC
EFTWLFTGDLEEKGEERIVKQYPNLRADILKVGHHGSKTSSTAPFLRLIQPKKAIISVGE
CEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHEECCC
HNRYGHPHDQVLKRLEEMQVEVWRTDREGAILYTFQGKNGTFQSKLTYDETQKRMKKDRK
CCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRRQWGYIAISFVIGIAIACSSSQLLGTILFGCYFLFCTYRTSRQTLMFCIVACLSSFLY
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TSYIEQENKPSIRYDLESITGVILNTPLINGNRLSFQIEDNSKNKVQLFYNMQSEKEKNV
HHHHHCCCCCCCEEEHHHHCCHHEECCEECCCEEEEEEECCCCCEEEEEEECCCHHHHHH
LRGLRVGMVCTFRGALKEPPSARNFYGFDYKNYLYKQRIHFLFEATAIMDCSNNHVTFVN
HHHHHHHHEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHH
WLFQLRQKATLAVAEMFPEQSGAFMNALLFGDRQFMSYEVEQQYQQFGLIHLLAISGSHI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCHH
VLLSAIVYFVLLRIGVTRERTTTALIICIPLYMFFAGASPSVMRASIMGTLLLIGVMHSF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
RLFSIDAISVTAIFMLIYDPYMLFDIGFQFSFIGSLALLLSANTLLQHNRGVIQNAIILS
HEEEEHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LISQLASIPITLYHFGYFSPYSIPLNLIYVPFLSCIVLPCSIIIFLCMMIFPPLAKGIAH
HHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSICLRMSNDVLQYCEAFPFVRFTFGQTPPFLVVLYSFSIIIICIVWERAIRKIFLYFA
HHHHHHHHCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGIFFFLCMCHYLSPYFRASGSVTFIDVGQGDAILIRLPYDKEVYLIDTGGTIPIKKEHW
HHHHHHHHHHHHHCHHHHCCCCEEEEEECCCCEEEEEECCCCEEEEEECCCCCCCCHHHH
QQKKHEFSIGDDVLIPFLQKQGIRTIDKLIVTHGDVDHMGAAKEVVAALDVKEIIFGKKR
HHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHCCCCC
KDSVLEAELKYLAQKKDMRINKVKEGDGWKVDEVEFRVLSPEGSETSDNDSSIVLWAKIG
CHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEC
EFTWLFTGDLEEKGEERIVKQYPNLRADILKVGHHGSKTSSTAPFLRLIQPKKAIISVGE
CEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHEECCC
HNRYGHPHDQVLKRLEEMQVEVWRTDREGAILYTFQGKNGTFQSKLTYDETQKRMKKDRK
CCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]