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The map label for this gene is thlA [H]

Identifier: 152976434

GI number: 152976434

Start: 2809361

End: 2810536

Strand: Reverse

Name: thlA [H]

Synonym: Bcer98_2722

Alternate gene names: 152976434

Gene position: 2810536-2809361 (Counterclockwise)

Preceding gene: 152976435

Following gene: 152976433

Centisome position: 68.77

GC content: 42.43

Gene sequence:

>1176_bases
ATGCAGAATGTTGTGATTACAGCAGCAGTTCGTTCACCAATCGGAACTTTCGGAGGAGCGCTCAAAAATATAACACCAGT
AGAATTAGTGGTTCCTGTACTTCAAGAAGCTGTAAAGCAAGGTGGAGTAGAGCCACATGAAGTGGATGAAGTCATTTTAG
GACACTGCATTCAACGAACGGATGAGGCAAATACAGCGCGAACAGCTGCATTAGCAGCAGGATTTCCAGAAACAGTTACA
GGCTATACGATTCAGCGTCAATGTTCTTCAGGGATGCAAGCGATTATGTCTGCAGCAATGCAAATTCAGTTAGGTATTAG
TGATGTTGTCGTTGCAGGCGGAGTAGAGGCGATGAGCTCTAGCCCCTATGCGTTAAAACAGCACCGCTGGGGACAGCGTC
TTCAGCACGGCGAAATTCGTGATACGGTGTGGGAAGTTTTAGAAGACCCTCTTCATCATATGATGATGGGTGAAACGGCA
GAAAATTTAGTGGAACAATATAACATTACAAGAGAGGAACAAGATGAAATTGCGCTGCGTAGCCATCGGCTAGCTCTTCA
AGCTATTGAATCTGGTTATTTTGATAAACAAATTGTGCCGATTACAATAAAGGAACGAAGAAAAGAAGTTGTGTTTTCGA
AGGATGAACATCCGCGTGCTGATATTACAGCGGAAAAGCTAGCAAATTTAAAACCAGCATTTCGTAAAGGCGGTTCTGTA
ACGGCCGGAAATGCATCAGGTATTAATGATGGTAGCGCCGTTTTAGTAGTAATGAGTGAAGAGAAAGCGAAAGAAAAAGG
ATTGCAACCATTAGCGAAAGTTGTAGGATATTCAGTAGCCGGAGTAGATCCTAAAATTATGGGAATTGGTCCAGCGCCAG
CAATTCGTAAAGGATTAAAAAAAGTGAATTGGTCGCTGGAAGATGCCGACTTACTAGAAATTAATGAAGCTTTTGCGGCT
CAATATTTGGCGGTCGAAAAGGAACTCGGTTTAAATCGTGAAAAAGTAAATGTGAATGGTAGTGGTGTAGGTCTTGGTCA
TCCAATTGGATGCACAGGAGCACGCATTACGGTAAGCTTAATTCATGAATTAAAAAGGCGAGGTCTTAAAAAGGGAATTG
CTTCCCTTTGTGTTGGTGGCGGTATTGGCGTAGCATTATTTATAGAAGCATTATAA

Upstream 100 bases:

>100_bases
ATTTTTATGAGGTGTTTATAGTATAATACATACAGATAGGCATCTTATGTTATTCCATCTAAAAATTTATGAGGATACAT
AAGAGAGGGGTAAGTATAAG

Downstream 100 bases:

>100_bases
AAAAGAAGCGGCGGTGACCGCTTCTTTTTTATGGTTGAAATAATCGCTCACGATTTTCGAAAAAGAGTTTCATTCTTTGA
TCATGTTCAGTTTCTTCTTA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MQNVVITAAVRSPIGTFGGALKNITPVELVVPVLQEAVKQGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPETVT
GYTIQRQCSSGMQAIMSAAMQIQLGISDVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPLHHMMMGETA
ENLVEQYNITREEQDEIALRSHRLALQAIESGYFDKQIVPITIKERRKEVVFSKDEHPRADITAEKLANLKPAFRKGGSV
TAGNASGINDGSAVLVVMSEEKAKEKGLQPLAKVVGYSVAGVDPKIMGIGPAPAIRKGLKKVNWSLEDADLLEINEAFAA
QYLAVEKELGLNREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLKKGIASLCVGGGIGVALFIEAL

Sequences:

>Translated_391_residues
MQNVVITAAVRSPIGTFGGALKNITPVELVVPVLQEAVKQGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPETVT
GYTIQRQCSSGMQAIMSAAMQIQLGISDVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPLHHMMMGETA
ENLVEQYNITREEQDEIALRSHRLALQAIESGYFDKQIVPITIKERRKEVVFSKDEHPRADITAEKLANLKPAFRKGGSV
TAGNASGINDGSAVLVVMSEEKAKEKGLQPLAKVVGYSVAGVDPKIMGIGPAPAIRKGLKKVNWSLEDADLLEINEAFAA
QYLAVEKELGLNREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLKKGIASLCVGGGIGVALFIEAL
>Mature_391_residues
MQNVVITAAVRSPIGTFGGALKNITPVELVVPVLQEAVKQGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPETVT
GYTIQRQCSSGMQAIMSAAMQIQLGISDVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPLHHMMMGETA
ENLVEQYNITREEQDEIALRSHRLALQAIESGYFDKQIVPITIKERRKEVVFSKDEHPRADITAEKLANLKPAFRKGGSV
TAGNASGINDGSAVLVVMSEEKAKEKGLQPLAKVVGYSVAGVDPKIMGIGPAPAIRKGLKKVNWSLEDADLLEINEAFAA
QYLAVEKELGLNREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLKKGIASLCVGGGIGVALFIEAL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=43.3673469387755, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=43.4447300771208, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=39.8477157360406, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=38.5390428211587, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=33.411214953271, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=30.0771208226221, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=48.8549618320611, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=45.8974358974359, Blast_Score=340, Evalue=9e-95,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=41.1471321695761, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=39.4472361809045, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1788683, Length=401, Percent_Identity=29.925187032419, Blast_Score=181, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=49.7422680412371, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=34.6055979643766, Blast_Score=241, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=37.4683544303797, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=31.6901408450704, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=28.2442748091603, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=38.5, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=36.1596009975062, Blast_Score=227, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=46.4285714285714, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=44.7837150127226, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=40.2035623409669, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=35.6132075471698, Blast_Score=212, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41928; Mature: 41928

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNVVITAAVRSPIGTFGGALKNITPVELVVPVLQEAVKQGGVEPHEVDEVILGHCIQRT
CCCEEEEEEHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
DEANTARTAALAAGFPETVTGYTIQRQCSSGMQAIMSAAMQIQLGISDVVVAGGVEAMSS
CCCCHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHCC
SPYALKQHRWGQRLQHGEIRDTVWEVLEDPLHHMMMGETAENLVEQYNITREEQDEIALR
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SHRLALQAIESGYFDKQIVPITIKERRKEVVFSKDEHPRADITAEKLANLKPAFRKGGSV
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCE
TAGNASGINDGSAVLVVMSEEKAKEKGLQPLAKVVGYSVAGVDPKIMGIGPAPAIRKGLK
ECCCCCCCCCCCEEEEEECCHHHHHHCHHHHHHHHCCHHCCCCCEEEECCCCHHHHHHHH
KVNWSLEDADLLEINEAFAAQYLAVEKELGLNREKVNVNGSGVGLGHPIGCTGARITVSL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHH
IHELKRRGLKKGIASLCVGGGIGVALFIEAL
HHHHHHHHHHHHHHHHHHCCCCEEHHHEECC
>Mature Secondary Structure
MQNVVITAAVRSPIGTFGGALKNITPVELVVPVLQEAVKQGGVEPHEVDEVILGHCIQRT
CCCEEEEEEHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
DEANTARTAALAAGFPETVTGYTIQRQCSSGMQAIMSAAMQIQLGISDVVVAGGVEAMSS
CCCCHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHCC
SPYALKQHRWGQRLQHGEIRDTVWEVLEDPLHHMMMGETAENLVEQYNITREEQDEIALR
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SHRLALQAIESGYFDKQIVPITIKERRKEVVFSKDEHPRADITAEKLANLKPAFRKGGSV
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCE
TAGNASGINDGSAVLVVMSEEKAKEKGLQPLAKVVGYSVAGVDPKIMGIGPAPAIRKGLK
ECCCCCCCCCCCEEEEEECCHHHHHHCHHHHHHHHCCHHCCCCCEEEECCCCHHHHHHHH
KVNWSLEDADLLEINEAFAAQYLAVEKELGLNREKVNVNGSGVGLGHPIGCTGARITVSL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHH
IHELKRRGLKKGIASLCVGGGIGVALFIEAL
HHHHHHHHHHHHHHHHHHCCCCEEHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]