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The map label for this gene is dut [H]

Identifier: 152976324

GI number: 152976324

Start: 2706672

End: 2707166

Strand: Reverse

Name: dut [H]

Synonym: Bcer98_2612

Alternate gene names: 152976324

Gene position: 2707166-2706672 (Counterclockwise)

Preceding gene: 152976325

Following gene: 152976323

Centisome position: 66.24

GC content: 42.42

Gene sequence:

>495_bases
ATGAACCTGCGAGTGAAAATTAAAAGGTTGAAAGATGTGGACCTCCCGCGATATGCGAGGTTTGGAGATGCTGGGTTTGA
TCTAATGGCAGCGGAGGACGTAATTATTAAGCCAGGAGAAACAAAAGTCATTCCTATAGGATTAGCTTTTGAAATTCCGC
CAGGTTACGAGCTTCAAGTAAGGCCAAGAAGTGGGATTTCAAGAAGAACAAAGTTAAGGGTAATTCTTGGAACGGTGGAT
AGTGGTTTTAGAGGAGAGGTTGGCGTGATTATTGAAAATACCTCTCCTAAAGGTAACGAAGATTACGGATGCAACGATAT
TCATGGTGAGCCGGAATTTTATGAAAGTACAGCGTATCAAATATTAAAAGGAGACCGTATTGCACAGGGCGTAATAGCGC
CAGTGCAAACAGCTCTTTTTGTGGAAGTAGACAAACTACCTGATAGTGAGCGAGGAATCAATGGTTTTGGAAGTACAGGG
ATTCGCGATGAGTAA

Upstream 100 bases:

>100_bases
TTTACAATAATTTTACAAAAGGAGTGTGCTACATGAAAGCGATGGAACATGGCGCGTATGAAATTACTTTATTGATCAGC
GAAGCGAAAGGGGAAAAACG

Downstream 100 bases:

>100_bases
GTACGGAAATAAAAAAGTTGAGCTAGATGGTCATGTTTTTGATAGCAAAGCTGAGGCTGATTACTACGAGGGGTTAAAAG
TTCGCCAAGCTGCAGGTGAG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase Dut

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MNLRVKIKRLKDVDLPRYARFGDAGFDLMAAEDVIIKPGETKVIPIGLAFEIPPGYELQVRPRSGISRRTKLRVILGTVD
SGFRGEVGVIIENTSPKGNEDYGCNDIHGEPEFYESTAYQILKGDRIAQGVIAPVQTALFVEVDKLPDSERGINGFGSTG
IRDE

Sequences:

>Translated_164_residues
MNLRVKIKRLKDVDLPRYARFGDAGFDLMAAEDVIIKPGETKVIPIGLAFEIPPGYELQVRPRSGISRRTKLRVILGTVD
SGFRGEVGVIIENTSPKGNEDYGCNDIHGEPEFYESTAYQILKGDRIAQGVIAPVQTALFVEVDKLPDSERGINGFGSTG
IRDE
>Mature_164_residues
MNLRVKIKRLKDVDLPRYARFGDAGFDLMAAEDVIIKPGETKVIPIGLAFEIPPGYELQVRPRSGISRRTKLRVILGTVD
SGFRGEVGVIIENTSPKGNEDYGCNDIHGEPEFYESTAYQILKGDRIAQGVIAPVQTALFVEVDKLPDSERGINGFGSTG
IRDE

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=137, Percent_Identity=33.5766423357664, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI4503423, Length=159, Percent_Identity=30.8176100628931, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI70906441, Length=159, Percent_Identity=30.8176100628931, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1790071, Length=155, Percent_Identity=30.9677419354839, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71988561, Length=149, Percent_Identity=34.2281879194631, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319729, Length=159, Percent_Identity=30.188679245283, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583610, Length=140, Percent_Identity=34.2857142857143, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI19921126, Length=140, Percent_Identity=34.2857142857143, Blast_Score=76, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 18050; Mature: 18050

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRVKIKRLKDVDLPRYARFGDAGFDLMAAEDVIIKPGETKVIPIGLAFEIPPGYELQV
CCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEECCCCCEEEEEEEEEECCCCCEEEE
RPRSGISRRTKLRVILGTVDSGFRGEVGVIIENTSPKGNEDYGCNDIHGEPEFYESTAYQ
ECCCCCCCCEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
ILKGDRIAQGVIAPVQTALFVEVDKLPDSERGINGFGSTGIRDE
HHCCCCHHHCCHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNLRVKIKRLKDVDLPRYARFGDAGFDLMAAEDVIIKPGETKVIPIGLAFEIPPGYELQV
CCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEECCCCCEEEEEEEEEECCCCCEEEE
RPRSGISRRTKLRVILGTVDSGFRGEVGVIIENTSPKGNEDYGCNDIHGEPEFYESTAYQ
ECCCCCCCCEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
ILKGDRIAQGVIAPVQTALFVEVDKLPDSERGINGFGSTGIRDE
HHCCCCHHHCCHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA