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The map label for this gene is fruA [H]

Identifier: 152976110

GI number: 152976110

Start: 2480574

End: 2482430

Strand: Reverse

Name: fruA [H]

Synonym: Bcer98_2394

Alternate gene names: 152976110

Gene position: 2482430-2480574 (Counterclockwise)

Preceding gene: 152976111

Following gene: 152976109

Centisome position: 60.74

GC content: 38.23

Gene sequence:

>1857_bases
ATGAAAATTACAGAATTGCTAAAAAAAGATACCATTATTATGGATTTGACAGCTTCAGATAAAGAAGCTGTCATTGATGA
ATTAGTAGAACGGTTGGAGAAAGCAGGAAGGTTAAATAGTCAAGCGGAATTTAAAGAAGCCATTTTAAAGCGAGAGGCAC
AAAGTACAACAGGAATTGGAGAAGGGATTGCAATCCCGCATGCGAAAACAAAAGCAGTTAAAGAACCTGCCATTTGTTTT
GGAAGAAGTGTAAGCGGTATCAATTATGAATCTCTTGATGGACAACCTGCACACTTGTTTTTTATGATTGCTGCAAGTGA
AGGGGCGAATAATACACACTTAGAAACTTTATCCTGTTTATCTACGTTATTAATGGATGAAGAATTTCGAAAACAACTAT
TAGAAGCGACAAGTCAAGAGGAACTTCTTCGTTTATTCGATGAGAAAGAGAATGAAAAAGAAGAGCATGTTGAGAATGTG
AAACTTAAGAAAGATGAACCATATGTATTGGCAGTAACTGCTTGTCCGACTGGTATCGCTCACACATATATGGCTGCAGA
TAGTTTGAAAGCAAAAGCAGCGGAGTTAGGGATTGCGATAAAAGTAGAAACAAACGGCTCAACAGGTGTTAAAAATGCTT
TAACAAAAGAAGATATTGAGCGAGCAACAGCTATTATTGTTGCAGCTGATAAACAAGTGGAAATGAATCGTTTCACTGGA
AAATATGTAATACAAGTGCCGGTTGCAGATGGAATTCGGAAATCAGAACAACTCATTCAACGTGCGATTAAACAAGATGC
ACCGGTTTTCCAAGGAGTAAAAGATAGTAGAAACGCTGAAAAGACGGAAGAAGAACAAGGATTTGGTATATATAAGCACT
TAATGAATGGCGTAAGCAATATGTTACCGTTTGTAGTTGGCGGCGGTATATTAATTGCATTAGCGTTTTCCTTTGGAGGA
ATTAAAGCGGAAGGACCTATAGCAGAGATGTTAATGAGTATTGGCGGCGGGAAAACGGGTGCGTTTCTATTTCTCGTTCC
AATATTAGCAGGATTTATTGCGAGTTCTATTGCTGATCGTCCTGGATTTATGCCAGGGATTGTCGGTGGATTTCTAGCAG
CACAAGCAAATGCTGGTTTTCTTGGTGGACTAATTGCGGGTTTTTTAGCAGGATATGTTGTTCTTGGTTTGAAAAAGGCA
TTTGCGAATTTACCAGTTCAGTTAGAAGGGATTAAGCCAGTTTTACTATATCCAGTCTTTGGACTATTAATTACAGGAAT
TTTGATGACGAAAGTTGTAAACCCACCTGTAGTTGCGCTGAATGAAGTTTTAACAAATTGGTTAAATAGTTTAGGTGGAA
CAAATGCTATCTTACTAGGGCTTATTTTAGGTGGTATGATGGCTATTGATATGGGTGGTCCAATTAATAAAGCTGCATTT
ACATTCGGAATCGCAGCAATTGAAGCTGGGAACTCTGGGATACATTCAGCTGTTATGGCTGGGGGAATGGTTCCTCCGCT
TGCAATTGCACTTGCGACAACAATTTTTAAAGCAAAATATACAGAGGCAGAGCGTAAATCAGGGCTTACTAATTACATTA
TGGGAGCATCGTTTATTACGGAAGGTGCAATTCCGTTTGCAGCTGCAGATCCAATTCGTGTTATTGTAAGTTGTGTAGTT
GGTTCAAGTATGGCTGGTGCATTATCGATGTTATTTCATATTACATTGCCCGCTCCTCATGGTGGCTTATTTGTTATTAT
GTTAGTGAATAAGCCCCTGTTATATATTCTGTCTATTGCAATTGGATCTATGATTTCTGCTCTTATGATGGGAATATGGA
AAAAGAAAATACAATAA

Upstream 100 bases:

>100_bases
AGGAAGTGCAACCGCGTTCTCAGCAGACTTATGTACGAAAGACAAGGTAGAAACATTATTATCGCAAGTAATCGTTACAA
AACGATAGGGGGAACAGTAT

Downstream 100 bases:

>100_bases
AAAATGTAAAGAACGGCTATCTAGTAGGTAGCCGTTCTTTTTTATAACGGTATATGTAATATTACCTTTTTAATTTGTAA
TAAAAAGGTAATATTATTTT

Product: PTS system, fructose subfamily, IIC subunit

Products: NA

Alternate protein names: EIIABC-Fru; Fructose-specific phosphotransferase enzyme IIA component; EII-Fru; PTS system fructose-specific EIIA component; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MKITELLKKDTIIMDLTASDKEAVIDELVERLEKAGRLNSQAEFKEAILKREAQSTTGIGEGIAIPHAKTKAVKEPAICF
GRSVSGINYESLDGQPAHLFFMIAASEGANNTHLETLSCLSTLLMDEEFRKQLLEATSQEELLRLFDEKENEKEEHVENV
KLKKDEPYVLAVTACPTGIAHTYMAADSLKAKAAELGIAIKVETNGSTGVKNALTKEDIERATAIIVAADKQVEMNRFTG
KYVIQVPVADGIRKSEQLIQRAIKQDAPVFQGVKDSRNAEKTEEEQGFGIYKHLMNGVSNMLPFVVGGGILIALAFSFGG
IKAEGPIAEMLMSIGGGKTGAFLFLVPILAGFIASSIADRPGFMPGIVGGFLAAQANAGFLGGLIAGFLAGYVVLGLKKA
FANLPVQLEGIKPVLLYPVFGLLITGILMTKVVNPPVVALNEVLTNWLNSLGGTNAILLGLILGGMMAIDMGGPINKAAF
TFGIAAIEAGNSGIHSAVMAGGMVPPLAIALATTIFKAKYTEAERKSGLTNYIMGASFITEGAIPFAAADPIRVIVSCVV
GSSMAGALSMLFHITLPAPHGGLFVIMLVNKPLLYILSIAIGSMISALMMGIWKKKIQ

Sequences:

>Translated_618_residues
MKITELLKKDTIIMDLTASDKEAVIDELVERLEKAGRLNSQAEFKEAILKREAQSTTGIGEGIAIPHAKTKAVKEPAICF
GRSVSGINYESLDGQPAHLFFMIAASEGANNTHLETLSCLSTLLMDEEFRKQLLEATSQEELLRLFDEKENEKEEHVENV
KLKKDEPYVLAVTACPTGIAHTYMAADSLKAKAAELGIAIKVETNGSTGVKNALTKEDIERATAIIVAADKQVEMNRFTG
KYVIQVPVADGIRKSEQLIQRAIKQDAPVFQGVKDSRNAEKTEEEQGFGIYKHLMNGVSNMLPFVVGGGILIALAFSFGG
IKAEGPIAEMLMSIGGGKTGAFLFLVPILAGFIASSIADRPGFMPGIVGGFLAAQANAGFLGGLIAGFLAGYVVLGLKKA
FANLPVQLEGIKPVLLYPVFGLLITGILMTKVVNPPVVALNEVLTNWLNSLGGTNAILLGLILGGMMAIDMGGPINKAAF
TFGIAAIEAGNSGIHSAVMAGGMVPPLAIALATTIFKAKYTEAERKSGLTNYIMGASFITEGAIPFAAADPIRVIVSCVV
GSSMAGALSMLFHITLPAPHGGLFVIMLVNKPLLYILSIAIGSMISALMMGIWKKKIQ
>Mature_618_residues
MKITELLKKDTIIMDLTASDKEAVIDELVERLEKAGRLNSQAEFKEAILKREAQSTTGIGEGIAIPHAKTKAVKEPAICF
GRSVSGINYESLDGQPAHLFFMIAASEGANNTHLETLSCLSTLLMDEEFRKQLLEATSQEELLRLFDEKENEKEEHVENV
KLKKDEPYVLAVTACPTGIAHTYMAADSLKAKAAELGIAIKVETNGSTGVKNALTKEDIERATAIIVAADKQVEMNRFTG
KYVIQVPVADGIRKSEQLIQRAIKQDAPVFQGVKDSRNAEKTEEEQGFGIYKHLMNGVSNMLPFVVGGGILIALAFSFGG
IKAEGPIAEMLMSIGGGKTGAFLFLVPILAGFIASSIADRPGFMPGIVGGFLAAQANAGFLGGLIAGFLAGYVVLGLKKA
FANLPVQLEGIKPVLLYPVFGLLITGILMTKVVNPPVVALNEVLTNWLNSLGGTNAILLGLILGGMMAIDMGGPINKAAF
TFGIAAIEAGNSGIHSAVMAGGMVPPLAIALATTIFKAKYTEAERKSGLTNYIMGASFITEGAIPFAAADPIRVIVSCVV
GSSMAGALSMLFHITLPAPHGGLFVIMLVNKPLLYILSIAIGSMISALMMGIWKKKIQ

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=452, Percent_Identity=44.2477876106195, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1786951, Length=634, Percent_Identity=33.7539432176656, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI87082348, Length=475, Percent_Identity=33.4736842105263, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI1790386, Length=312, Percent_Identity=39.1025641025641, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI1788729, Length=404, Percent_Identity=26.980198019802, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790387, Length=94, Percent_Identity=40.4255319148936, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789597, Length=156, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788730, Length=88, Percent_Identity=40.9090909090909, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788726, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI2367327, Length=139, Percent_Identity=23.021582733813, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 65564; Mature: 65564

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITELLKKDTIIMDLTASDKEAVIDELVERLEKAGRLNSQAEFKEAILKREAQSTTGIG
CCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
EGIAIPHAKTKAVKEPAICFGRSVSGINYESLDGQPAHLFFMIAASEGANNTHLETLSCL
CCCCCCCHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHH
STLLMDEEFRKQLLEATSQEELLRLFDEKENEKEEHVENVKLKKDEPYVLAVTACPTGIA
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCEECCCCEEEEEECCCCCHH
HTYMAADSLKAKAAELGIAIKVETNGSTGVKNALTKEDIERATAIIVAADKQVEMNRFTG
HHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHEEEEECCCCCHHHHCCC
KYVIQVPVADGIRKSEQLIQRAIKQDAPVFQGVKDSRNAEKTEEEQGFGIYKHLMNGVSN
EEEEEEECHHCCHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
MLPFVVGGGILIALAFSFGGIKAEGPIAEMLMSIGGGKTGAFLFLVPILAGFIASSIADR
HHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
PGFMPGIVGGFLAAQANAGFLGGLIAGFLAGYVVLGLKKAFANLPVQLEGIKPVLLYPVF
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHH
GLLITGILMTKVVNPPVVALNEVLTNWLNSLGGTNAILLGLILGGMMAIDMGGPINKAAF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCCHHHH
TFGIAAIEAGNSGIHSAVMAGGMVPPLAIALATTIFKAKYTEAERKSGLTNYIMGASFIT
HHHHHHEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EGAIPFAAADPIRVIVSCVVGSSMAGALSMLFHITLPAPHGGLFVIMLVNKPLLYILSIA
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHEECCCCCCCEEEEEECCCCHHHHHHHH
IGSMISALMMGIWKKKIQ
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKITELLKKDTIIMDLTASDKEAVIDELVERLEKAGRLNSQAEFKEAILKREAQSTTGIG
CCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
EGIAIPHAKTKAVKEPAICFGRSVSGINYESLDGQPAHLFFMIAASEGANNTHLETLSCL
CCCCCCCHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHH
STLLMDEEFRKQLLEATSQEELLRLFDEKENEKEEHVENVKLKKDEPYVLAVTACPTGIA
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCEECCCCEEEEEECCCCCHH
HTYMAADSLKAKAAELGIAIKVETNGSTGVKNALTKEDIERATAIIVAADKQVEMNRFTG
HHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHEEEEECCCCCHHHHCCC
KYVIQVPVADGIRKSEQLIQRAIKQDAPVFQGVKDSRNAEKTEEEQGFGIYKHLMNGVSN
EEEEEEECHHCCHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
MLPFVVGGGILIALAFSFGGIKAEGPIAEMLMSIGGGKTGAFLFLVPILAGFIASSIADR
HHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
PGFMPGIVGGFLAAQANAGFLGGLIAGFLAGYVVLGLKKAFANLPVQLEGIKPVLLYPVF
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHH
GLLITGILMTKVVNPPVVALNEVLTNWLNSLGGTNAILLGLILGGMMAIDMGGPINKAAF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCCHHHH
TFGIAAIEAGNSGIHSAVMAGGMVPPLAIALATTIFKAKYTEAERKSGLTNYIMGASFIT
HHHHHHEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EGAIPFAAADPIRVIVSCVVGSSMAGALSMLFHITLPAPHGGLFVIMLVNKPLLYILSIA
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHEECCCCCCCEEEEEECCCCHHHHHHHH
IGSMISALMMGIWKKKIQ
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]