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The map label for this gene is pbp [H]

Identifier: 152975715

GI number: 152975715

Start: 2060551

End: 2062635

Strand: Reverse

Name: pbp [H]

Synonym: Bcer98_1955

Alternate gene names: 152975715

Gene position: 2062635-2060551 (Counterclockwise)

Preceding gene: 152975716

Following gene: 152975714

Centisome position: 50.47

GC content: 44.22

Gene sequence:

>2085_bases
ATGGAAAATAAACGATTTGGGGTGTTAGTTGCTACCTTGGCTCTAACGATGATTCTACCAACAGGAGCGATAGCGTCTTC
TAGTACTAAGACTCCGATTGTAGCTAGCCAAGAAGTTGCTAGCAAAGAATTGGAGAAGATTGCTGCAGAGAACGCTGCGC
TACTCACGAAGTCCTATGAGACGACTAGCGTGCAGTATGCGCTAATTGATAATGGTAAACTTATTTTATCGGATCAGACA
GGCAAGAATGATATGGAAGGGAAACAGCCGCTGACCAAAGATACTCTATACGGGATTGGTTCAACCAGTAAAGTATATAC
AGCTGCGGCTGTTATGAAATTGGTCGATGAAGGAAAAGTCGATTTGGATACTCCTGTCGTTCGCTATATTCCTGAGTTCA
AGATGAAAGATAAGCGATACAAGCGCATTACAACGCGTATGCTATTGAACCACTCCTCCGGTTTGCAAGGTACCACGTTA
AATAATTCATTTTTATTTAAAGATAATGATACCTATACCCATGATATCTTGTTGCGGCAACTATCCACCCAAAGTTTGAA
GGCGGACCCTGGCGCGTTTTCGGTATACTGTAACGACGGTTTTACGCTGGCCGAGATTTTGGTAGAAAGAGTCAGCGGTA
TGAGTTTTACTGAATTTCTACATCAACAGTTTACAAAGCCATTAAAACTGAATCATACGAAAACGCCACAGGATAAATGG
GAGGACGAAAAGCGGGCTGGACTTTATTTTCCGACGTACCAAGGACAGCTTCCCATTGAAACGGTGAATGTGATTGGTAC
GGGAGGAATCTCTTCCACGGCAGAAGATGTGGTACGATTCTCACAATTATTTATGGGACAGGGAAAAGGAATCCTTTCTA
ATAAGGCAGTCAAGGAGATGGAGCAAGAGGAATATAAAAAAGGAATGTGGCCGGGGGCTGGAGATTATGTGTTCAACTAT
GGTCTTGGCTGGGATAGTGTGAAGCTATATCCATTCAATAGATATGGGATAAAGGCCTTGGCTAAGGGCGGCGACACGTT
ACTGCAACACGCTGCATTGGTCGTGCTTCCAGAGCAGAAGATGGCCGCAGCGGTGTTGTCATCTGGCGGAAGCAGCATGA
CAAATCAACTGTTGGCAACTAAATTACTGCTCGCCGCGCTTAAAGAGAAGGGGACAATTAAGGATATAAAGCCGGACAAA
TCTTTTGGCAAGCCAGTCAAGGCTAAGATGCCTCAAGCTGTGGCAAAGAAAGCGGGCTTTTACGGCAATAGCTACAGTCA
TTTTAAAATAGAAATTACGAAGAAGGGAGAACTGTTCTTACCATCTAATCGAGAAGAAAAGTATGTATATACTGCAGATG
GAAGCTTTATTAATGAGAAGGGCACCTCCAAGCTCAACTTTGTTACCGAGAAGAATGGAAGAACTTATTTGATGGAGAGC
ACATATAAATCAACACCAGGTTTAGGGCAAGATGTGCTGACTCACTATTTAGCTGAGAAACTAGAAGACAACGTGCTATC
GAAGAAAACTGCTGCCGTATGGACGGATCGGGAAGGTGGCAAGTTCTATCTCGTGAACGAGAAATTTAGTTCTATGGACT
ATCTCGTACAACTGATACCTCTTACTAAACAAATTACTCGCCAAGAGGGCCTAAAAGGCTATTGGGATGGCAGAAAAATT
ACAGGTCCGAACACGGCGGCGCATCAAATCCAGATCCCTGTGATGGATGGGCGCGATACGACGGAAGCTCGTTTCTATAC
AGAGGGTGGTAAGGAATATATGCAGATAGACAGCTCGTTATACGTCAGCGAATCCAACGTAAAACCACTTGAGACAGGTC
AATCATCGAAAGTTACACTGCAATCAAATGGGCATGCGAAATGGTTTACGATCCCGTATGCGGCAGCAGGGAAAACGATG
ACCGTGGAGTTACCATCGAAGAGTTCGTTTGCGGTGTATGATGAGAAGGGAGTATGCGTCAACTTTACCGTTGTGAGCAA
CAATAACAAAGTAAAACTGCCAAAGAACGGAACGGTTGTATTTGCTGGCGCGCCGAACTCGGAATTTACAGTTACGTTGA
ACTAG

Upstream 100 bases:

>100_bases
TAGCCGGTAGGGATAAAGACGGAATAGTAATTTATGTGATGTTTGTAATTGAACAAATAAGAGATGAAATCGATCATTTA
TCTAAGGAGGCATTTCTCTT

Downstream 100 bases:

>100_bases
CTACAATTCAAGATGAACTTCAACAAAACCAGCAAAACATTTTTCTATGTCGTGCTGGTTTTGTTTGTATTTTACGTATT
ACCTTTACGAAGAGGCTTTC

Product: beta-lactamase

Products: NA

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 694; Mature: 694

Protein sequence:

>694_residues
MENKRFGVLVATLALTMILPTGAIASSSTKTPIVASQEVASKELEKIAAENAALLTKSYETTSVQYALIDNGKLILSDQT
GKNDMEGKQPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKVDLDTPVVRYIPEFKMKDKRYKRITTRMLLNHSSGLQGTTL
NNSFLFKDNDTYTHDILLRQLSTQSLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQQFTKPLKLNHTKTPQDKW
EDEKRAGLYFPTYQGQLPIETVNVIGTGGISSTAEDVVRFSQLFMGQGKGILSNKAVKEMEQEEYKKGMWPGAGDYVFNY
GLGWDSVKLYPFNRYGIKALAKGGDTLLQHAALVVLPEQKMAAAVLSSGGSSMTNQLLATKLLLAALKEKGTIKDIKPDK
SFGKPVKAKMPQAVAKKAGFYGNSYSHFKIEITKKGELFLPSNREEKYVYTADGSFINEKGTSKLNFVTEKNGRTYLMES
TYKSTPGLGQDVLTHYLAEKLEDNVLSKKTAAVWTDREGGKFYLVNEKFSSMDYLVQLIPLTKQITRQEGLKGYWDGRKI
TGPNTAAHQIQIPVMDGRDTTEARFYTEGGKEYMQIDSSLYVSESNVKPLETGQSSKVTLQSNGHAKWFTIPYAAAGKTM
TVELPSKSSFAVYDEKGVCVNFTVVSNNNKVKLPKNGTVVFAGAPNSEFTVTLN

Sequences:

>Translated_694_residues
MENKRFGVLVATLALTMILPTGAIASSSTKTPIVASQEVASKELEKIAAENAALLTKSYETTSVQYALIDNGKLILSDQT
GKNDMEGKQPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKVDLDTPVVRYIPEFKMKDKRYKRITTRMLLNHSSGLQGTTL
NNSFLFKDNDTYTHDILLRQLSTQSLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQQFTKPLKLNHTKTPQDKW
EDEKRAGLYFPTYQGQLPIETVNVIGTGGISSTAEDVVRFSQLFMGQGKGILSNKAVKEMEQEEYKKGMWPGAGDYVFNY
GLGWDSVKLYPFNRYGIKALAKGGDTLLQHAALVVLPEQKMAAAVLSSGGSSMTNQLLATKLLLAALKEKGTIKDIKPDK
SFGKPVKAKMPQAVAKKAGFYGNSYSHFKIEITKKGELFLPSNREEKYVYTADGSFINEKGTSKLNFVTEKNGRTYLMES
TYKSTPGLGQDVLTHYLAEKLEDNVLSKKTAAVWTDREGGKFYLVNEKFSSMDYLVQLIPLTKQITRQEGLKGYWDGRKI
TGPNTAAHQIQIPVMDGRDTTEARFYTEGGKEYMQIDSSLYVSESNVKPLETGQSSKVTLQSNGHAKWFTIPYAAAGKTM
TVELPSKSSFAVYDEKGVCVNFTVVSNNNKVKLPKNGTVVFAGAPNSEFTVTLN
>Mature_694_residues
MENKRFGVLVATLALTMILPTGAIASSSTKTPIVASQEVASKELEKIAAENAALLTKSYETTSVQYALIDNGKLILSDQT
GKNDMEGKQPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKVDLDTPVVRYIPEFKMKDKRYKRITTRMLLNHSSGLQGTTL
NNSFLFKDNDTYTHDILLRQLSTQSLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQQFTKPLKLNHTKTPQDKW
EDEKRAGLYFPTYQGQLPIETVNVIGTGGISSTAEDVVRFSQLFMGQGKGILSNKAVKEMEQEEYKKGMWPGAGDYVFNY
GLGWDSVKLYPFNRYGIKALAKGGDTLLQHAALVVLPEQKMAAAVLSSGGSSMTNQLLATKLLLAALKEKGTIKDIKPDK
SFGKPVKAKMPQAVAKKAGFYGNSYSHFKIEITKKGELFLPSNREEKYVYTADGSFINEKGTSKLNFVTEKNGRTYLMES
TYKSTPGLGQDVLTHYLAEKLEDNVLSKKTAAVWTDREGGKFYLVNEKFSSMDYLVQLIPLTKQITRQEGLKGYWDGRKI
TGPNTAAHQIQIPVMDGRDTTEARFYTEGGKEYMQIDSSLYVSESNVKPLETGQSSKVTLQSNGHAKWFTIPYAAAGKTM
TVELPSKSSFAVYDEKGVCVNFTVVSNNNKVKLPKNGTVVFAGAPNSEFTVTLN

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI26051233, Length=88, Percent_Identity=39.7727272727273, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI26051231, Length=88, Percent_Identity=39.7727272727273, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786574, Length=290, Percent_Identity=28.2758620689655, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1790593, Length=248, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17550934, Length=285, Percent_Identity=27.0175438596491, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115533026, Length=339, Percent_Identity=25.9587020648968, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 76602; Mature: 76602

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKRFGVLVATLALTMILPTGAIASSSTKTPIVASQEVASKELEKIAAENAALLTKSYE
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHHCCCEEEEECCC
TTSVQYALIDNGKLILSDQTGKNDMEGKQPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKV
CCEEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCC
DLDTPVVRYIPEFKMKDKRYKRITTRMLLNHSSGLQGTTLNNSFLFKDNDTYTHDILLRQ
CCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEECCEEEEECCCCHHHHHHHHH
LSTQSLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQQFTKPLKLNHTKTPQDKW
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHCCCCEECCCCCCCHHHC
EDEKRAGLYFPTYQGQLPIETVNVIGTGGISSTAEDVVRFSQLFMGQGKGILSNKAVKEM
CCHHHCCEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EQEEYKKGMWPGAGDYVFNYGLGWDSVKLYPFNRYGIKALAKGGDTLLQHAALVVLPEQK
HHHHHHHCCCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHCCCHHHHHCCEEEEECCHH
MAAAVLSSGGSSMTNQLLATKLLLAALKEKGTIKDIKPDKSFGKPVKAKMPQAVAKKAGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHCHHHHHHHCCC
YGNSYSHFKIEITKKGELFLPSNREEKYVYTADGSFINEKGTSKLNFVTEKNGRTYLMES
CCCCCCEEEEEEEECCCEECCCCCCCCEEEECCCCEECCCCCCEEEEEEECCCCEEEEEC
TYKSTPGLGQDVLTHYLAEKLEDNVLSKKTAAVWTDREGGKFYLVNEKFSSMDYLVQLIP
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHH
LTKQITRQEGLKGYWDGRKITGPNTAAHQIQIPVMDGRDTTEARFYTEGGKEYMQIDSSL
HHHHHHHHCCCCEECCCEEECCCCCCCEEEEEEEECCCCCCCEEEEECCCCEEEEECCEE
YVSESNVKPLETGQSSKVTLQSNGHAKWFTIPYAAAGKTMTVELPSKSSFAVYDEKGVCV
EEECCCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCEEEEECCCCCCEEEEECCCEEE
NFTVVSNNNKVKLPKNGTVVFAGAPNSEFTVTLN
EEEEEECCCEEEECCCCEEEEEECCCCCEEEEEC
>Mature Secondary Structure
MENKRFGVLVATLALTMILPTGAIASSSTKTPIVASQEVASKELEKIAAENAALLTKSYE
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHHCCCEEEEECCC
TTSVQYALIDNGKLILSDQTGKNDMEGKQPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKV
CCEEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCC
DLDTPVVRYIPEFKMKDKRYKRITTRMLLNHSSGLQGTTLNNSFLFKDNDTYTHDILLRQ
CCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEECCEEEEECCCCHHHHHHHHH
LSTQSLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQQFTKPLKLNHTKTPQDKW
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHCCCCEECCCCCCCHHHC
EDEKRAGLYFPTYQGQLPIETVNVIGTGGISSTAEDVVRFSQLFMGQGKGILSNKAVKEM
CCHHHCCEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EQEEYKKGMWPGAGDYVFNYGLGWDSVKLYPFNRYGIKALAKGGDTLLQHAALVVLPEQK
HHHHHHHCCCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHCCCHHHHHCCEEEEECCHH
MAAAVLSSGGSSMTNQLLATKLLLAALKEKGTIKDIKPDKSFGKPVKAKMPQAVAKKAGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHCHHHHHHHCCC
YGNSYSHFKIEITKKGELFLPSNREEKYVYTADGSFINEKGTSKLNFVTEKNGRTYLMES
CCCCCCEEEEEEEECCCEECCCCCCCCEEEECCCCEECCCCCCEEEEEEECCCCEEEEEC
TYKSTPGLGQDVLTHYLAEKLEDNVLSKKTAAVWTDREGGKFYLVNEKFSSMDYLVQLIP
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHH
LTKQITRQEGLKGYWDGRKITGPNTAAHQIQIPVMDGRDTTEARFYTEGGKEYMQIDSSL
HHHHHHHHCCCCEECCCEEECCCCCCCEEEEEEEECCCCCCCEEEEECCCCEEEEECCEE
YVSESNVKPLETGQSSKVTLQSNGHAKWFTIPYAAAGKTMTVELPSKSSFAVYDEKGVCV
EEECCCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCEEEEECCCCCCEEEEECCCEEE
NFTVVSNNNKVKLPKNGTVVFAGAPNSEFTVTLN
EEEEEECCCEEEECCCCEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]