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The map label for this gene is kynA [H]

Identifier: 152975667

GI number: 152975667

Start: 2015392

End: 2016231

Strand: Reverse

Name: kynA [H]

Synonym: Bcer98_1901

Alternate gene names: 152975667

Gene position: 2016231-2015392 (Counterclockwise)

Preceding gene: 152975668

Following gene: 152975666

Centisome position: 49.33

GC content: 36.07

Gene sequence:

>840_bases
ATGACAGAAAATGAAAAAGTAATTATGGAAAAGGGGATTTATACAGATTTCAAGGAGAATATGACATATGGAGAGTACTT
GCAGTTAGATCGCTTATTAGATAGTCAAAAAAGATTATCTAATCATCATGATGAAATGCTGTTTATTATTATTCATCAAG
CAAGTGAACTTTGGATGAAACTGATTTTACATGAATTAAATGCAGCGATTGAATCTATTCAAAATGAAAAGATGGCACCT
GCATTTAAAATGTTGGCAAGGGTGTCGAAAATTCAATCACAAATCATTCAATCGTGGGATATTCTTGCCACATTAACGCC
GTCTGAATATATTGAATTTCGCGATTCACTCGGTCAAGCATCAGGTTTTCAATCGTATCAATACCGAATGATTGAATATG
CACTTGGCTATAAAACACCGCACGCATTAAAAATTTATGAAAAAGATCCAGAACTACATGCTCGATTGCATACAGCGCTT
CATTCACCAAGCCTTTATGATGTAGCAATTCAGGCGCTTGTAAAAGAAGGATTTCCAATCAATAAAGACGTACTAGGTCG
CGATATTACGCAGCCTTACGAAGAGGATTCGACAGTTGAAGCGGCTTGGTTAGAAGTATATGCCGATGTGAAAAAATATT
GGGATTTATATCAGCTTGCAGAAAAATTAATTGATATAGAAGATTGGTTACAACAGTGGCGATTCCGTCATATGAAAACG
GTAGAACGTATCATTGGTCATAAAATGGGGACAGGTGGTTCGTCTGGTGTATCTTATTTAAAACGTGTGTTGGATCAGCG
ATTTTTCCCAGAGCTTTGGAATGTACGAACGAAATTATAA

Upstream 100 bases:

>100_bases
ACCACTTGCCTTAACAGAAGCAGATGGTAGCCCAGTTCGTGCTATAATTCGACCATTATAACAGGGGATGCATGATGCAT
AGAAAGGGTGTTACATAACG

Downstream 100 bases:

>100_bases
AAAAAATCAGCATCTCTTAGGAGAGGCTGATTTTTTTATGAAAATGTTAAGGTGAAGTTAGAAATATTTCTTTGCTTTGA
GTAGAATAGTAAGAATAAAA

Product: tryptophan 23-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTENEKVIMEKGIYTDFKENMTYGEYLQLDRLLDSQKRLSNHHDEMLFIIIHQASELWMKLILHELNAAIESIQNEKMAP
AFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQASGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTAL
HSPSLYDVAIQALVKEGFPINKDVLGRDITQPYEEDSTVEAAWLEVYADVKKYWDLYQLAEKLIDIEDWLQQWRFRHMKT
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL

Sequences:

>Translated_279_residues
MTENEKVIMEKGIYTDFKENMTYGEYLQLDRLLDSQKRLSNHHDEMLFIIIHQASELWMKLILHELNAAIESIQNEKMAP
AFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQASGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTAL
HSPSLYDVAIQALVKEGFPINKDVLGRDITQPYEEDSTVEAAWLEVYADVKKYWDLYQLAEKLIDIEDWLQQWRFRHMKT
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL
>Mature_278_residues
TENEKVIMEKGIYTDFKENMTYGEYLQLDRLLDSQKRLSNHHDEMLFIIIHQASELWMKLILHELNAAIESIQNEKMAPA
FKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQASGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTALH
SPSLYDVAIQALVKEGFPINKDVLGRDITQPYEEDSTVEAAWLEVYADVKKYWDLYQLAEKLIDIEDWLQQWRFRHMKTV
ERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=138, Percent_Identity=39.1304347826087, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17552370, Length=336, Percent_Identity=29.1666666666667, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32564651, Length=133, Percent_Identity=38.3458646616541, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17530891, Length=331, Percent_Identity=32.02416918429, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 32782; Mature: 32651

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENEKVIMEKGIYTDFKENMTYGEYLQLDRLLDSQKRLSNHHDEMLFIIIHQASELWMK
CCCCCHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHH
LILHELNAAIESIQNEKMAPAFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCC
SGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTALHSPSLYDVAIQALVKEGFPI
CCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
NKDVLGRDITQPYEEDSTVEAAWLEVYADVKKYWDLYQLAEKLIDIEDWLQQWRFRHMKT
CHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCC
>Mature Secondary Structure 
TENEKVIMEKGIYTDFKENMTYGEYLQLDRLLDSQKRLSNHHDEMLFIIIHQASELWMK
CCCCHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHH
LILHELNAAIESIQNEKMAPAFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCC
SGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTALHSPSLYDVAIQALVKEGFPI
CCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
NKDVLGRDITQPYEEDSTVEAAWLEVYADVKKYWDLYQLAEKLIDIEDWLQQWRFRHMKT
CHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA