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The map label for this gene is yfnC [H]

Identifier: 152975234

GI number: 152975234

Start: 1538265

End: 1539473

Strand: Direct

Name: yfnC [H]

Synonym: Bcer98_1437

Alternate gene names: 152975234

Gene position: 1538265-1539473 (Clockwise)

Preceding gene: 152975232

Following gene: 152975235

Centisome position: 37.64

GC content: 38.46

Gene sequence:

>1209_bases
ATGCAGGCAATTTCAAAAGAAAATGTAGTGACGACGCCAACGATATATCGCATTTTATTTGCAATTAGTTTCGGTCATTT
TTTGAATGATTCTATGCAAGCTGTTGTGCCGGCATTGTTTCCAATTTTAGAAAAAACGATGAATTTATCTTATATGCAAG
TCGGATGGATTGCGTTTGCGCTAAATATGACGTCATCTGTTATGCAACCGGTATTTGGGATGTATTCAGATAAGAAGCCA
TCCCCATTTTTACTACCGCTCGGTATGTTCTCAAGCATGCTTGGAATGATTGGTCTTGCATTTGCACCAAACTTTATTAT
TGTTATTATTTCTGTTTTATTTATCGGATTAGGTTCAGCAGTCTTTCATCCAGAAGGAGCCCGCGTTGCGTATATGGCAT
CTGGTACGAAGCGTGGATTAGCACAAGCGATTTATCAAGTAGGGGGGAATACTGGTAATTCACTTGCTCCAATTTTTACA
GCAGTAATTTTCGTTCCTCTTGGTCAAAAAGGTTCGCTTGGTTTTACGGCTTTTGCAGCAGTAGGGATTCTATTATTAAT
GTATGTGTCAAAGTGGTATAAAAATGAATTAGTAAGCGGTGCTGTAAAAAGCAAGAAACGAGCTGCACTTGAGGCTGAAA
ATGCAATTGTAAGTGCGCATATTAAATTTGTTATCGTTCTCCTTATCTTTTTAACATTTGTTCGTTCGTGGTATGGAGCT
GGTATTGGGAACTTCTATCAATTTTATTTGATTGAGCATTATGGTTTATCGATAAAGAATGCGCAATATTTTGTATTTGC
TTTTATGATTTCCGGCGTACTGGGAACATTTTTTGGAGGACCGCTCGCAGATCGATTTGGTAAGAAAAATATTATTGTGT
TCTCCATGCTAGGTTCTGCGCCGCTTGCACTTTTATTACCGCATGTTTCTCTTTTATGGGTTGTGCCACTATTTTTATGT
ATCGGTTTCATTAGTTCCAGTAGCTTTAGTGTGATTGTTGTATATGCCCAAGAACTTGTGCCAGGGAAAGTAGGGATGGT
ATCAGGATTAATTGTCGGTCTTGCATTTGGTCTTGGCGCGCTAGGTGCTGTCGTTCTTGGGAAATTAGCTGACATATATA
GTCTGCAGTTCATTATGGTATTATGTAGTTGTTTACCATTAATTGGACTTACTTCCTGGTTACTGCCGAGTGATAAAAAA
TCCGTATAG

Upstream 100 bases:

>100_bases
GAAAAAGAGATAAAATCAGTATAGAATAGAAATGTTTCAAAAGTCAGAAGTGATGATACCCGCATAAAAATATATGTTGT
AAGGAGGGTGAAATTCAAAT

Downstream 100 bases:

>100_bases
AATAGGGGATGCGCTATGAAACTATGCAAAAATGTTACAGAATTAATAGGGGATACACCTGTCGTGCGATTATCTAAATT
TGTTCCGAAAGATGCGGCGG

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MQAISKENVVTTPTIYRILFAISFGHFLNDSMQAVVPALFPILEKTMNLSYMQVGWIAFALNMTSSVMQPVFGMYSDKKP
SPFLLPLGMFSSMLGMIGLAFAPNFIIVIISVLFIGLGSAVFHPEGARVAYMASGTKRGLAQAIYQVGGNTGNSLAPIFT
AVIFVPLGQKGSLGFTAFAAVGILLLMYVSKWYKNELVSGAVKSKKRAALEAENAIVSAHIKFVIVLLIFLTFVRSWYGA
GIGNFYQFYLIEHYGLSIKNAQYFVFAFMISGVLGTFFGGPLADRFGKKNIIVFSMLGSAPLALLLPHVSLLWVVPLFLC
IGFISSSSFSVIVVYAQELVPGKVGMVSGLIVGLAFGLGALGAVVLGKLADIYSLQFIMVLCSCLPLIGLTSWLLPSDKK
SV

Sequences:

>Translated_402_residues
MQAISKENVVTTPTIYRILFAISFGHFLNDSMQAVVPALFPILEKTMNLSYMQVGWIAFALNMTSSVMQPVFGMYSDKKP
SPFLLPLGMFSSMLGMIGLAFAPNFIIVIISVLFIGLGSAVFHPEGARVAYMASGTKRGLAQAIYQVGGNTGNSLAPIFT
AVIFVPLGQKGSLGFTAFAAVGILLLMYVSKWYKNELVSGAVKSKKRAALEAENAIVSAHIKFVIVLLIFLTFVRSWYGA
GIGNFYQFYLIEHYGLSIKNAQYFVFAFMISGVLGTFFGGPLADRFGKKNIIVFSMLGSAPLALLLPHVSLLWVVPLFLC
IGFISSSSFSVIVVYAQELVPGKVGMVSGLIVGLAFGLGALGAVVLGKLADIYSLQFIMVLCSCLPLIGLTSWLLPSDKK
SV
>Mature_402_residues
MQAISKENVVTTPTIYRILFAISFGHFLNDSMQAVVPALFPILEKTMNLSYMQVGWIAFALNMTSSVMQPVFGMYSDKKP
SPFLLPLGMFSSMLGMIGLAFAPNFIIVIISVLFIGLGSAVFHPEGARVAYMASGTKRGLAQAIYQVGGNTGNSLAPIFT
AVIFVPLGQKGSLGFTAFAAVGILLLMYVSKWYKNELVSGAVKSKKRAALEAENAIVSAHIKFVIVLLIFLTFVRSWYGA
GIGNFYQFYLIEHYGLSIKNAQYFVFAFMISGVLGTFFGGPLADRFGKKNIIVFSMLGSAPLALLLPHVSLLWVVPLFLC
IGFISSSSFSVIVVYAQELVPGKVGMVSGLIVGLAFGLGALGAVVLGKLADIYSLQFIMVLCSCLPLIGLTSWLLPSDKK
SV

Specific function: Confers The Resistance Against Fosmidomycin. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=387, Percent_Identity=43.4108527131783, Blast_Score=297, Evalue=7e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43309; Mature: 43309

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]