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The map label for this gene is fumC [H]

Identifier: 152975214

GI number: 152975214

Start: 1511318

End: 1512706

Strand: Direct

Name: fumC [H]

Synonym: Bcer98_1415

Alternate gene names: 152975214

Gene position: 1511318-1512706 (Clockwise)

Preceding gene: 152975213

Following gene: 152975216

Centisome position: 36.98

GC content: 38.66

Gene sequence:

>1389_bases
ATGGAGTATAGAATTGAAAGAGATACATTAGGAGAAATGAAGGTTCCAGCTGACAAATTATGGGCAGCCCAAACGCAGCG
TAGTAAAGAGAACTTTCCGATTGGCACTGAGCGTATGCCACTTGAAATTGTAAAGGCGTTTGCTATTTTAAAGAAAAGTG
CTGCGATTAGTAATCAAAAATTAGGAAAATTAGCTGAAGAAAAAGCAGAAGCGATTGTACAAGCAGCTGATGAAATTATG
GAAGGGAAATGGAATGAACACTTCCCTCTTGTTGTATGGCAAACAGGTAGTGGTACACAATCAAATATGAATGTGAATGA
AGTGATTGCGAATCGCGGGAATCAAATTTTGAAAGAAAAAGGGATTGATGTACATATTCATCCAAATGACGATGTAAATA
TGTCTCAAAGTTCAAATGATACATTTCCAACAGCTCTTCATGTAGCTTGCGTAATGGCAGTGGAAGAGCATGTATTACCA
GCTATTGCGAAGTTAAAAGGTACATTAGCAGAAAAGGTAACCGCTTTTCAACATATTATTAAAATTGGTCGTACACATTT
GCAAGATGCTACGCCGCTTACATTAGGACAAGAAATTAGTGGATGGCATCGTATGCTTGAAAAAACGGAGCGCATGATTG
CAGAGAGTAATACATATATGAAAGAGTTAGCAATTGGTGGTACTGCAGTGGGAACAGGGATTAATGCTCATCCTAAATTC
GGTGAGATGGTAGCGGCAGAAATTAGCCAATTTACAGGCAAACAGTTCGTTTCTGCGCCGAACAAGTTCCATGCGTTAAC
AAGTCATGATGAAGTTGTATTTGCACATGGTGCACTAAAAGCATTAGCTGCTGATTTAATGAAGATTGCAAACGATGTGC
GCTGGCTTGCAAGTGGTCCGCGCAGTGGTCTTGGCGAAATTATTATTCCAGCAAATGAACCGGGTAGCTCTATTATGCCG
GGTAAGGTAAACCCAACACAAAGTGAAGCTATAACAATGGTAGCAGCACAAGTAATGGGAAATGATGCAACAATTGGATT
TGCGGCTAGCCAAGGGAACTTTGAGTTAAATGTATTTAAACCGGTTATTGCCTATAATTTCTTACAATCTGCTCACTTAT
TAGCGGATGCCATGGTTTCATTCAATGATAAATGTGCAGTTGGTATTGAAGCGAACGAAGAAGTAATTAAGCAAAATGTG
AATCGTTCTTTAATGCTTGTAACAGCATTAAATCCGCATATTGGATATGAAAATGCAGCAAAAATTGCAAAGCACGCACA
TAAAGAGGGATTAACTTTAAAAGAAGCAGCATTACAGTCAGGATTATTAACAGAAGAACAATTTGACGAAATTGTTGATC
CGGAGAAAATGATTGCTCCGAAAGAATAA

Upstream 100 bases:

>100_bases
TTCCATTTTATTTAGGTACTGAAGTGAGAATTCTTATCATTTGATTGGAATTCTGCTAAAATAAGAAATGTAGATATTTT
ATTTTCAAGGGGATGAAAAA

Downstream 100 bases:

>100_bases
AAATTTTAAATTGAAATATTCTATCATAGAAGCGAATAAGAGCACTGTCCTACTTATAATAAAAGTGAGACAGTGCTCTT
ATTTTTAATTTACGTGTCTA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MEYRIERDTLGEMKVPADKLWAAQTQRSKENFPIGTERMPLEIVKAFAILKKSAAISNQKLGKLAEEKAEAIVQAADEIM
EGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGIDVHIHPNDDVNMSQSSNDTFPTALHVACVMAVEEHVLP
AIAKLKGTLAEKVTAFQHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVAAEISQFTGKQFVSAPNKFHALTSHDEVVFAHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEAITMVAAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAMVSFNDKCAVGIEANEEVIKQNV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPEKMIAPKE

Sequences:

>Translated_462_residues
MEYRIERDTLGEMKVPADKLWAAQTQRSKENFPIGTERMPLEIVKAFAILKKSAAISNQKLGKLAEEKAEAIVQAADEIM
EGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGIDVHIHPNDDVNMSQSSNDTFPTALHVACVMAVEEHVLP
AIAKLKGTLAEKVTAFQHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVAAEISQFTGKQFVSAPNKFHALTSHDEVVFAHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEAITMVAAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAMVSFNDKCAVGIEANEEVIKQNV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPEKMIAPKE
>Mature_462_residues
MEYRIERDTLGEMKVPADKLWAAQTQRSKENFPIGTERMPLEIVKAFAILKKSAAISNQKLGKLAEEKAEAIVQAADEIM
EGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGIDVHIHPNDDVNMSQSSNDTFPTALHVACVMAVEEHVLP
AIAKLKGTLAEKVTAFQHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVAAEISQFTGKQFVSAPNKFHALTSHDEVVFAHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEAITMVAAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAMVSFNDKCAVGIEANEEVIKQNV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPEKMIAPKE

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=60.3896103896104, Blast_Score=536, Evalue=1e-152,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=62.280701754386, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=39.4793926247288, Blast_Score=331, Evalue=6e-92,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=59.6529284164859, Blast_Score=546, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=59.1463414634146, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=57.7006507592191, Blast_Score=535, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.6810344827586, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.6810344827586, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=55.1724137931034, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=53.9784946236559, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=46.8817204301075, Blast_Score=425, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50292; Mature: 50292

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRIERDTLGEMKVPADKLWAAQTQRSKENFPIGTERMPLEIVKAFAILKKSAAISNQK
CCEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGKLAEEKAEAIVQAADEIMEGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCHHHHHHC
GIDVHIHPNDDVNMSQSSNDTFPTALHVACVMAVEEHVLPAIAKLKGTLAEKVTAFQHII
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHCCCCCCCCCCH
GEMVAAEISQFTGKQFVSAPNKFHALTSHDEVVFAHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEAITMVAAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAMVSFNDKCAVGIEANEEVIKQNVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPEKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MEYRIERDTLGEMKVPADKLWAAQTQRSKENFPIGTERMPLEIVKAFAILKKSAAISNQK
CCEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGKLAEEKAEAIVQAADEIMEGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCHHHHHHC
GIDVHIHPNDDVNMSQSSNDTFPTALHVACVMAVEEHVLPAIAKLKGTLAEKVTAFQHII
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHCCCCCCCCCCH
GEMVAAEISQFTGKQFVSAPNKFHALTSHDEVVFAHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEAITMVAAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAMVSFNDKCAVGIEANEEVIKQNVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPEKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]