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The map label for this gene is ndk [H]

Identifier: 152975038

GI number: 152975038

Start: 1348142

End: 1348588

Strand: Direct

Name: ndk [H]

Synonym: Bcer98_1238

Alternate gene names: 152975038

Gene position: 1348142-1348588 (Clockwise)

Preceding gene: 152975037

Following gene: 152975039

Centisome position: 32.99

GC content: 38.03

Gene sequence:

>447_bases
ATGGAAAAAACATTTCTAATGGTAAAACCAGACGGCGTACAACGTGCCTTCATTGGGGAAATTGTAGCTCGTTTTGAGAA
AAAGGGCTTTCAATTGGTTGGTGCGAAATTAATGCAAGTTACTCCAGAAATTGCAAAGCAACATTATGCTGAGCATGTGG
AAAAGCCTTTCTTTGGTGAATTAGTAGATTTTATTACATCTGGACCGGTGTTTGCAATGGTATGGCAAGGAGAAGGTGTA
GTAAATACTGCTCGTAACATGATGGGGAAAACAAGACCACATGAAGCGGCACCAGGTACAATTCGTGGCGATTTCGGTTT
AACAGTTGAGAAAAATGTAATCCACGGTTCTGATTCTTTAGAAAGTGCTGAACGTGAGATTGGTATTTTCTTCAAAGAAG
AAGAGTTAGTAGATTATTCAAAACTAATGAATCAATGGATTTATTAA

Upstream 100 bases:

>100_bases
CTCTCTATTTCAAAACTATTGCACAATTACGATAAGGGTGTTAATATGTGTGTGGGGATATACAATTACATACATAATTC
AGAAGTGGAGAGATTTTTTT

Downstream 100 bases:

>100_bases
TTATTTTAAAATAATTTGTAAACGCTTTAATCACTGTGATAATAGTGAAAAGTGCAAGAGGATGATGATTTCCTTCTTGC
ACTTTTTTCGTTTCTAATAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAKQHYAEHVEKPFFGELVDFITSGPVFAMVWQGEGV
VNTARNMMGKTRPHEAAPGTIRGDFGLTVEKNVIHGSDSLESAEREIGIFFKEEELVDYSKLMNQWIY

Sequences:

>Translated_148_residues
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAKQHYAEHVEKPFFGELVDFITSGPVFAMVWQGEGV
VNTARNMMGKTRPHEAAPGTIRGDFGLTVEKNVIHGSDSLESAEREIGIFFKEEELVDYSKLMNQWIY
>Mature_148_residues
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAKQHYAEHVEKPFFGELVDFITSGPVFAMVWQGEGV
VNTARNMMGKTRPHEAAPGTIRGDFGLTVEKNVIHGSDSLESAEREIGIFFKEEELVDYSKLMNQWIY

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI38045913, Length=148, Percent_Identity=56.0810810810811, Blast_Score=188, Evalue=1e-48,
Organism=Homo sapiens, GI4557797, Length=148, Percent_Identity=56.0810810810811, Blast_Score=188, Evalue=2e-48,
Organism=Homo sapiens, GI37693993, Length=147, Percent_Identity=57.1428571428571, Blast_Score=187, Evalue=4e-48,
Organism=Homo sapiens, GI66392227, Length=148, Percent_Identity=54.0540540540541, Blast_Score=181, Evalue=2e-46,
Organism=Homo sapiens, GI66392205, Length=148, Percent_Identity=54.0540540540541, Blast_Score=181, Evalue=2e-46,
Organism=Homo sapiens, GI4505409, Length=148, Percent_Identity=54.0540540540541, Blast_Score=181, Evalue=2e-46,
Organism=Homo sapiens, GI66392192, Length=148, Percent_Identity=54.0540540540541, Blast_Score=181, Evalue=2e-46,
Organism=Homo sapiens, GI66392203, Length=148, Percent_Identity=54.0540540540541, Blast_Score=181, Evalue=2e-46,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=49.6402877697842, Blast_Score=159, Evalue=9e-40,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=36.4963503649635, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=35.3383458646617, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=35.3383458646617, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=30.6569343065693, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=30.7142857142857, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=28.1481481481481, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=46.0992907801418, Blast_Score=137, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17506807, Length=148, Percent_Identity=49.3243243243243, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6322783, Length=147, Percent_Identity=55.1020408163265, Blast_Score=184, Evalue=4e-48,
Organism=Drosophila melanogaster, GI45549037, Length=147, Percent_Identity=52.3809523809524, Blast_Score=176, Evalue=7e-45,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=33.0882352941176, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 16726; Mature: 16726

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAKQHYAEHVEKPFFGE
CCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHH
LVDFITSGPVFAMVWQGEGVVNTARNMMGKTRPHEAAPGTIRGDFGLTVEKNVIHGSDSL
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCEEECCEECCCCHH
ESAEREIGIFFKEEELVDYSKLMNQWIY
HHHHHHHCEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAKQHYAEHVEKPFFGE
CCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHH
LVDFITSGPVFAMVWQGEGVVNTARNMMGKTRPHEAAPGTIRGDFGLTVEKNVIHGSDSL
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCEEECCEECCCCHH
ESAEREIGIFFKEEELVDYSKLMNQWIY
HHHHHHHCEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]