Click here to switch to the map view.

The map label for this gene is folE [H]

Identifier: 152975034

GI number: 152975034

Start: 1344773

End: 1345342

Strand: Direct

Name: folE [H]

Synonym: Bcer98_1234

Alternate gene names: 152975034

Gene position: 1344773-1345342 (Clockwise)

Preceding gene: 152975033

Following gene: 152975035

Centisome position: 32.9

GC content: 42.46

Gene sequence:

>570_bases
ATGGCAAAAGTTAACTTAGAGCAAATTGAACATGCAGTGCGCCTTATTTTAGAGGCGATTGGTGATGATCCAAATCGTGA
GGGAGTACTGGATACACCAAGACGAGTTGCAAAGATGTATGCAGAAGTATTTTCAGGAATGCATGAGGACCCAAAAGAAC
ATTTACATAAAGTATTTGGGGAAGATCATGAAGAACTGGTATTAGTAAAAGATATTCCATTTTACTCAATGTGTGAGCAT
CACCTTGTTCCGTTTTATGGAGTTGCGCATGTGGCATATATCCCACGTGGCGGAAAAGTAACGGGCTTAAGTAAGTTAGC
TCGTACTGTAGACACGATTGCGCGCCGTCCACAGCTGCAAGAGCGTATTACATCAACAGTAGCAGACTCTATCATGGAAG
TGTTAGAACCGCATGGTGTTATGGTCGTGGTGGAAGCAGAACATATGTGTATGACAATGCGCGGTGTGAAAAAGCCGGGT
GCTAAAACAGTAACCACAGCTGTACGTGGTGTATTAGAAAACGATGCAGCAGCACGCAGTGAAATTTTGTCTTTTATTAA
GTCTAAGTAA

Upstream 100 bases:

>100_bases
GAAGAGTTTCCTTTTAGGAGGCTCTTCTTTTTGCTTTTAAAAACATAAATATGCTAGAATGTGTTCGTATCATTTTTAGG
TTTCTTGGGAGGGCTAGCGG

Downstream 100 bases:

>100_bases
AGAAAAGCGGGAAACTGCTTTTCTTTTTTATTTATGAGTAGTGGAAATTAGTGAGGAATGAAGAACAACGTACATGAATG
AATGCTTCACTTTATTTGAG

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MAKVNLEQIEHAVRLILEAIGDDPNREGVLDTPRRVAKMYAEVFSGMHEDPKEHLHKVFGEDHEELVLVKDIPFYSMCEH
HLVPFYGVAHVAYIPRGGKVTGLSKLARTVDTIARRPQLQERITSTVADSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPG
AKTVTTAVRGVLENDAAARSEILSFIKSK

Sequences:

>Translated_189_residues
MAKVNLEQIEHAVRLILEAIGDDPNREGVLDTPRRVAKMYAEVFSGMHEDPKEHLHKVFGEDHEELVLVKDIPFYSMCEH
HLVPFYGVAHVAYIPRGGKVTGLSKLARTVDTIARRPQLQERITSTVADSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPG
AKTVTTAVRGVLENDAAARSEILSFIKSK
>Mature_188_residues
AKVNLEQIEHAVRLILEAIGDDPNREGVLDTPRRVAKMYAEVFSGMHEDPKEHLHKVFGEDHEELVLVKDIPFYSMCEHH
LVPFYGVAHVAYIPRGGKVTGLSKLARTVDTIARRPQLQERITSTVADSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPGA
KTVTTAVRGVLENDAAARSEILSFIKSK

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=187, Percent_Identity=48.1283422459893, Blast_Score=175, Evalue=2e-44,
Organism=Homo sapiens, GI4503949, Length=187, Percent_Identity=48.1283422459893, Blast_Score=175, Evalue=2e-44,
Organism=Homo sapiens, GI66932970, Length=155, Percent_Identity=45.1612903225806, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI66932972, Length=145, Percent_Identity=47.5862068965517, Blast_Score=131, Evalue=3e-31,
Organism=Escherichia coli, GI1788476, Length=179, Percent_Identity=36.8715083798883, Blast_Score=104, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17560486, Length=185, Percent_Identity=46.4864864864865, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6321706, Length=167, Percent_Identity=49.1017964071856, Blast_Score=167, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24656782, Length=185, Percent_Identity=45.945945945946, Blast_Score=163, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24656796, Length=185, Percent_Identity=45.945945945946, Blast_Score=162, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24656791, Length=185, Percent_Identity=45.945945945946, Blast_Score=162, Evalue=1e-40,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 21064; Mature: 20933

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVNLEQIEHAVRLILEAIGDDPNREGVLDTPRRVAKMYAEVFSGMHEDPKEHLHKVFG
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHC
EDHEELVLVKDIPFYSMCEHHLVPFYGVAHVAYIPRGGKVTGLSKLARTVDTIARRPQLQ
CCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHH
ERITSTVADSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPGAKTVTTAVRGVLENDAAARS
HHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHH
EILSFIKSK
HHHHHHHCC
>Mature Secondary Structure 
AKVNLEQIEHAVRLILEAIGDDPNREGVLDTPRRVAKMYAEVFSGMHEDPKEHLHKVFG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHC
EDHEELVLVKDIPFYSMCEHHLVPFYGVAHVAYIPRGGKVTGLSKLARTVDTIARRPQLQ
CCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHH
ERITSTVADSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPGAKTVTTAVRGVLENDAAARS
HHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHH
EILSFIKSK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA