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The map label for this gene is hisA

Identifier: 152974935

GI number: 152974935

Start: 1244688

End: 1245407

Strand: Direct

Name: hisA

Synonym: Bcer98_1132

Alternate gene names: 152974935

Gene position: 1244688-1245407 (Clockwise)

Preceding gene: 152974934

Following gene: 152974936

Centisome position: 30.45

GC content: 39.58

Gene sequence:

>720_bases
ATGGAAATCCTCCCAGCTATCGATTTAAAAGAAGGACGATGTGTTCGGCTTTATCAAGGAGAGTTCAACAAAGAAACAGT
TGTGAATGAACATCCAGTTGCACAAGCGATGATATTTGAAAAAATGGGAGCGAACAGGCTACATATTGTTGACTTAGATG
GTGCAGTCTTGGGAAAATCAGCAAACTTATCTACCATTGAAGATATATGTAAAGCTGTTCGGATTTCGGTGCAAGCTGGC
GGGGGGATTCGATCGCTTTCAGCTGTTGAAATGTTGCTATCAATAGGGGTAGAAAAAGTGATTTTAGGAACAGCTGCTTT
GCATAATCGCTCATTTTTAGAAGAAGTAATTCGTCTATATGGAGAGAAGATTATTGTTGGAATTGATGCCAAAAATGGCT
ATGTGGCGACAAGAGGATGGCTTGATATGTCGGAAATTTCTTACATTGAACTCGCGAAACAAATGGAAGCAGTAGGCGTA
CAAACAATTATTTTTACTGATATTTCGAAAGATGGAACGCTTATGGGCCCCAATTTTGCGCAACTGCAATTGTTACAAGA
AGAAGTATCGCTTCGTATTATCGCTTCAGGCGGCATTTCTTCATTGCAAGATGTAGAACAATTACAGGCAATGAATATGT
ACGGTGTGATTATTGGAAAAGCGCTGTACGAAAAAACAATGGATCTACAAGAAGTATTGCGGGTGACAAAGTCATGTTAG

Upstream 100 bases:

>100_bases
TTGTTGCAAAAGGAAATATATTTGGAGCGCAATTTCATCCTGAAAAGAGTGGGGAAATCGGAATACAAATGCTTGCAAAT
TTCAAAGGAGTGGTGAAACA

Downstream 100 bases:

>100_bases
CAAAGCGAATTATTCCCTGCTTAGATGTGAAAGCGGGCCGCGTTGTGAAGGGAGTCAATTTTATCGGATTACAAGATATA
GGAGACCCTGTTGAAATAGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MEILPAIDLKEGRCVRLYQGEFNKETVVNEHPVAQAMIFEKMGANRLHIVDLDGAVLGKSANLSTIEDICKAVRISVQAG
GGIRSLSAVEMLLSIGVEKVILGTAALHNRSFLEEVIRLYGEKIIVGIDAKNGYVATRGWLDMSEISYIELAKQMEAVGV
QTIIFTDISKDGTLMGPNFAQLQLLQEEVSLRIIASGGISSLQDVEQLQAMNMYGVIIGKALYEKTMDLQEVLRVTKSC

Sequences:

>Translated_239_residues
MEILPAIDLKEGRCVRLYQGEFNKETVVNEHPVAQAMIFEKMGANRLHIVDLDGAVLGKSANLSTIEDICKAVRISVQAG
GGIRSLSAVEMLLSIGVEKVILGTAALHNRSFLEEVIRLYGEKIIVGIDAKNGYVATRGWLDMSEISYIELAKQMEAVGV
QTIIFTDISKDGTLMGPNFAQLQLLQEEVSLRIIASGGISSLQDVEQLQAMNMYGVIIGKALYEKTMDLQEVLRVTKSC
>Mature_239_residues
MEILPAIDLKEGRCVRLYQGEFNKETVVNEHPVAQAMIFEKMGANRLHIVDLDGAVLGKSANLSTIEDICKAVRISVQAG
GGIRSLSAVEMLLSIGVEKVILGTAALHNRSFLEEVIRLYGEKIIVGIDAKNGYVATRGWLDMSEISYIELAKQMEAVGV
QTIIFTDISKDGTLMGPNFAQLQLLQEEVSLRIIASGGISSLQDVEQLQAMNMYGVIIGKALYEKTMDLQEVLRVTKSC

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=242, Percent_Identity=33.4710743801653, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1788336, Length=242, Percent_Identity=21.4876033057851, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_BACCN (A7GMU9)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001374452.1
- ProteinModelPortal:   A7GMU9
- SMR:   A7GMU9
- STRING:   A7GMU9
- EnsemblBacteria:   EBBACT00000039557
- GeneID:   5344516
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1132
- eggNOG:   COG0106
- GeneTree:   EBGT00050000001074
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- BioCyc:   BCER315749:BCER98_1132-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26160; Mature: 26160

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILPAIDLKEGRCVRLYQGEFNKETVVNEHPVAQAMIFEKMGANRLHIVDLDGAVLGKS
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEECCC
ANLSTIEDICKAVRISVQAGGGIRSLSAVEMLLSIGVEKVILGTAALHNRSFLEEVIRLY
CCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHC
GEKIIVGIDAKNGYVATRGWLDMSEISYIELAKQMEAVGVQTIIFTDISKDGTLMGPNFA
CCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEECCCHH
QLQLLQEEVSLRIIASGGISSLQDVEQLQAMNMYGVIIGKALYEKTMDLQEVLRVTKSC
HHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MEILPAIDLKEGRCVRLYQGEFNKETVVNEHPVAQAMIFEKMGANRLHIVDLDGAVLGKS
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEECCC
ANLSTIEDICKAVRISVQAGGGIRSLSAVEMLLSIGVEKVILGTAALHNRSFLEEVIRLY
CCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHC
GEKIIVGIDAKNGYVATRGWLDMSEISYIELAKQMEAVGVQTIIFTDISKDGTLMGPNFA
CCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEECCCHH
QLQLLQEEVSLRIIASGGISSLQDVEQLQAMNMYGVIIGKALYEKTMDLQEVLRVTKSC
HHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA