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The map label for this gene is ilvC

Identifier: 152974926

GI number: 152974926

Start: 1234401

End: 1235411

Strand: Direct

Name: ilvC

Synonym: Bcer98_1122

Alternate gene names: 152974926

Gene position: 1234401-1235411 (Clockwise)

Preceding gene: 152974925

Following gene: 152974927

Centisome position: 30.2

GC content: 41.15

Gene sequence:

>1011_bases
ATGGCAAAAGTTTATTATGAAAAGGATGTAATGGTAAATGTATTAAAGGGAAAGAAAGTAGCAATTGTAGGATATGGATC
GCAAGGGCACGCTCATGCACAAAACTTACGTGATAACAACTTTGATGTAGTAGTTGGTCTTCGGAAAGGAAAGTCGTGGG
AAAAGGCAAAAGAGGATGGTTTTTCCGTTTACTCTGTAGCCGAAGCGGCAGCGATGGCTGATGTAGTGATGGTTCTTCTA
CCAGATGAATTACAGCCAGAAGTATATCAGGCGGAAATTGAGTCAAACTTACAATCTGGAAATGCACTTGTATTTGCTCA
TGGTTTTAATGTTCATTTTAATCAAGTAACACCGCCGGAAGATGTAGATGTATTCCTAGTAGCACCGAAAGGACCAGGCC
ATTTAGTGCGCCGCACCTTTACTGAAGGAGGAGCTGTACCAGCGTTGTTTGCTGTATATCAAGACGCAACTGGAACAGCA
ACAGAAAAAGCATTATCCTATGCCGATGGAATTGGAGCTACAAGAGCTGGTGTGTTAGAAACGACATTTAAAGAAGAAAC
AGAAACGGATTTATTTGGAGAACAAGCTGTACTTTGTGGAGGAGTGACTGCACTTGTAAAAGCAGGATTTGAAACATTAG
TAGATGCTGGTTATCAGCCTGAACTTGCCTATTTTGAATGTTTACATGAATTAAAGCTCATTGTTGATCTTATGTATGAA
GGTGGACTTGAAAATATGAGATATTCTGTTTCTGATACAGCGCAGTGGGGAGACTTTGTATCTGGTCCGCGTGTCGTAAC
AGAACATACGAAAAAAGCAATGGGCGACGTGTTAAAGGAAATTCAAGATGGTACATTCGCAAAAGGATGGATTGCAGAGC
ATCAAGCAGGAAGGCCGCACTTTCATGCGATAAACGCAAAGGAAAATGAGCATCAAATTGAAGTAGTTGGACGGCAGTTA
CGTGAGATGATGCCGTTTGTAAAACCGAAAGTAAAGACGGGGGTTAAATAA

Upstream 100 bases:

>100_bases
TTGCAAGAACAGGTGTGACAGCTTTTACAAGAAGTATGAAAAAACAAGAGAAACAAGTAATGTTAATTCATTAATTATTT
CAATATAGGGGGAGAAGAAA

Downstream 100 bases:

>100_bases
TATGAAACAGATTTTGTTCATGGATACGACGCTTCGTGATGGGGAACAATCACCTGGAGTCAATTTAAATGAACAAGAAA
AATTACAAATTGCTCGGCAG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAKVYYEKDVMVNVLKGKKVAIVGYGSQGHAHAQNLRDNNFDVVVGLRKGKSWEKAKEDGFSVYSVAEAAAMADVVMVLL
PDELQPEVYQAEIESNLQSGNALVFAHGFNVHFNQVTPPEDVDVFLVAPKGPGHLVRRTFTEGGAVPALFAVYQDATGTA
TEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
GGLENMRYSVSDTAQWGDFVSGPRVVTEHTKKAMGDVLKEIQDGTFAKGWIAEHQAGRPHFHAINAKENEHQIEVVGRQL
REMMPFVKPKVKTGVK

Sequences:

>Translated_336_residues
MAKVYYEKDVMVNVLKGKKVAIVGYGSQGHAHAQNLRDNNFDVVVGLRKGKSWEKAKEDGFSVYSVAEAAAMADVVMVLL
PDELQPEVYQAEIESNLQSGNALVFAHGFNVHFNQVTPPEDVDVFLVAPKGPGHLVRRTFTEGGAVPALFAVYQDATGTA
TEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
GGLENMRYSVSDTAQWGDFVSGPRVVTEHTKKAMGDVLKEIQDGTFAKGWIAEHQAGRPHFHAINAKENEHQIEVVGRQL
REMMPFVKPKVKTGVK
>Mature_335_residues
AKVYYEKDVMVNVLKGKKVAIVGYGSQGHAHAQNLRDNNFDVVVGLRKGKSWEKAKEDGFSVYSVAEAAAMADVVMVLLP
DELQPEVYQAEIESNLQSGNALVFAHGFNVHFNQVTPPEDVDVFLVAPKGPGHLVRRTFTEGGAVPALFAVYQDATGTAT
EKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEG
GLENMRYSVSDTAQWGDFVSGPRVVTEHTKKAMGDVLKEIQDGTFAKGWIAEHQAGRPHFHAINAKENEHQIEVVGRQLR
EMMPFVKPKVKTGVK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=34.8122866894198, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=333, Percent_Identity=33.9339339339339, Blast_Score=158, Evalue=1e-39,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_BACCN (A7GMU0)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001374443.1
- ProteinModelPortal:   A7GMU0
- SMR:   A7GMU0
- STRING:   A7GMU0
- EnsemblBacteria:   EBBACT00000038708
- GeneID:   5344457
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1122
- eggNOG:   COG0059
- GeneTree:   EBGT00050000000943
- HOGENOM:   HBG286525
- OMA:   KDELTAG
- ProtClustDB:   PRK05479
- BioCyc:   BCER315749:BCER98_1122-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36751; Mature: 36620

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVYYEKDVMVNVLKGKKVAIVGYGSQGHAHAQNLRDNNFDVVVGLRKGKSWEKAKEDG
CCCEEECCCCEEEEECCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCHHHHHHCC
FSVYSVAEAAAMADVVMVLLPDELQPEVYQAEIESNLQSGNALVFAHGFNVHFNQVTPPE
CHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCCC
DVDVFLVAPKGPGHLVRRTFTEGGAVPALFAVYQDATGTATEKALSYADGIGATRAGVLE
CCEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLENMRYSVSDTAQWGDFVSGPRVVTEHTKKAMGDVLKEIQDGTFAKGWIAEHQAGRPH
CCCCCCEECCCCCHHHCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
FHAINAKENEHQIEVVGRQLREMMPFVKPKVKTGVK
EEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCC
>Mature Secondary Structure 
AKVYYEKDVMVNVLKGKKVAIVGYGSQGHAHAQNLRDNNFDVVVGLRKGKSWEKAKEDG
CCEEECCCCEEEEECCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCHHHHHHCC
FSVYSVAEAAAMADVVMVLLPDELQPEVYQAEIESNLQSGNALVFAHGFNVHFNQVTPPE
CHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCCC
DVDVFLVAPKGPGHLVRRTFTEGGAVPALFAVYQDATGTATEKALSYADGIGATRAGVLE
CCEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLENMRYSVSDTAQWGDFVSGPRVVTEHTKKAMGDVLKEIQDGTFAKGWIAEHQAGRPH
CCCCCCEECCCCCHHHCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
FHAINAKENEHQIEVVGRQLREMMPFVKPKVKTGVK
EEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA