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The map label for this gene is nrdE [H]

Identifier: 152974878

GI number: 152974878

Start: 1186607

End: 1187308

Strand: Direct

Name: nrdE [H]

Synonym: Bcer98_1074

Alternate gene names: 152974878

Gene position: 1186607-1187308 (Clockwise)

Preceding gene: 152974877

Following gene: 152974879

Centisome position: 29.03

GC content: 36.89

Gene sequence:

>702_bases
TTGCGACACATTGAACTGAATAATGAAATCACGCAAATGCAAGATGGTTTCTATCAGCTTCATAAAGATAAAGAAGCACT
GGAAGTCTTTATGGAAGAAGCGAGAGCAAATACCATTCATTTTGATAGCGTGGCAGAACGAATAAAGTATATGATTGAAC
ATGATTATTATTACAATGTTTTGGACGAGTATAAGTTGGAGGAAATAGAAGCAGTATACGATATTGCGTACGGAGAAAAC
TTTAAGTTCCAATCTTATATGGCAGCATCTAAGTTTTATAAAGATTATGCGCTCAAAACAAATGATCAAAAGCAATATTT
AGAAAGCTATGAAGATCGTGTAGCAATTGTATCCTTATATTTGGGACGCGGTGATGTGAAAAAGGCAAAACAATTTGCGA
GCATGATTGTTAAACAAAACTACCAACCAGCGACACCAACCTTTTTAAATGCCGGCAGAAGCAGAAGAGGAGAAATGGTG
TCTTGTTTCTTGTTAGAGATGGATGATAGTTTAAATTCGATTGGATTTAATATTAATACGGCGATGCAGCTATCAAAAAT
CGGTGGCGGAGTAGCCTTGAACTTATCTAAGCTGCGTGCACGTGGTGAACAAATTAAAGGTATCGAGAACGCAGCAAGCG
GTGTTGTACCAGTTATGAAATTACTTGAAGATTCGTTTTCATATGCGAATCAGTTGGGTTAA

Upstream 100 bases:

>100_bases
GATAAAATTTCAATGAAATACGAAGTACCTATTGTATCAAAATTTGAGTTATCTGGAACAAATAAGGATGTAGAATATTT
TAAGGAAAGGGTGCGGGAGA

Downstream 100 bases:

>100_bases
CTTATGGCTCAACTATAAAACCGGGTCAATTGCTGGAACGCCTGAGTATATCGAGGTAGGATACTACGAAGAAATTACGT
AGCGCCCCCTAAAAAACCAA

Product: ribonucleoside-diphosphate reductase

Products: NA

Alternate protein names: Ribonucleotide reductase large subunit [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MRHIELNNEITQMQDGFYQLHKDKEALEVFMEEARANTIHFDSVAERIKYMIEHDYYYNVLDEYKLEEIEAVYDIAYGEN
FKFQSYMAASKFYKDYALKTNDQKQYLESYEDRVAIVSLYLGRGDVKKAKQFASMIVKQNYQPATPTFLNAGRSRRGEMV
SCFLLEMDDSLNSIGFNINTAMQLSKIGGGVALNLSKLRARGEQIKGIENAASGVVPVMKLLEDSFSYANQLG

Sequences:

>Translated_233_residues
MRHIELNNEITQMQDGFYQLHKDKEALEVFMEEARANTIHFDSVAERIKYMIEHDYYYNVLDEYKLEEIEAVYDIAYGEN
FKFQSYMAASKFYKDYALKTNDQKQYLESYEDRVAIVSLYLGRGDVKKAKQFASMIVKQNYQPATPTFLNAGRSRRGEMV
SCFLLEMDDSLNSIGFNINTAMQLSKIGGGVALNLSKLRARGEQIKGIENAASGVVPVMKLLEDSFSYANQLG
>Mature_233_residues
MRHIELNNEITQMQDGFYQLHKDKEALEVFMEEARANTIHFDSVAERIKYMIEHDYYYNVLDEYKLEEIEAVYDIAYGEN
FKFQSYMAASKFYKDYALKTNDQKQYLESYEDRVAIVSLYLGRGDVKKAKQFASMIVKQNYQPATPTFLNAGRSRRGEMV
SCFLLEMDDSLNSIGFNINTAMQLSKIGGGVALNLSKLRARGEQIKGIENAASGVVPVMKLLEDSFSYANQLG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase large chain family [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=160, Percent_Identity=28.75, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1789030, Length=220, Percent_Identity=47.7272727272727, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17555242, Length=160, Percent_Identity=28.75, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320914, Length=184, Percent_Identity=27.7173913043478, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322123, Length=180, Percent_Identity=27.2222222222222, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17352481, Length=187, Percent_Identity=25.668449197861, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926
- InterPro:   IPR013554 [H]

Pfam domain/function: PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN; PF08343 RNR_N [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 26727; Mature: 26727

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHIELNNEITQMQDGFYQLHKDKEALEVFMEEARANTIHFDSVAERIKYMIEHDYYYNV
CCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCHHHHH
LDEYKLEEIEAVYDIAYGENFKFQSYMAASKFYKDYALKTNDQKQYLESYEDRVAIVSLY
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEHHH
LGRGDVKKAKQFASMIVKQNYQPATPTFLNAGRSRRGEMVSCFLLEMDDSLNSIGFNINT
HCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEEEEEECCCCHHHCCCCCHH
AMQLSKIGGGVALNLSKLRARGEQIKGIENAASGVVPVMKLLEDSFSYANQLG
HHHHHHCCCCEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRHIELNNEITQMQDGFYQLHKDKEALEVFMEEARANTIHFDSVAERIKYMIEHDYYYNV
CCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCHHHHH
LDEYKLEEIEAVYDIAYGENFKFQSYMAASKFYKDYALKTNDQKQYLESYEDRVAIVSLY
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEHHH
LGRGDVKKAKQFASMIVKQNYQPATPTFLNAGRSRRGEMVSCFLLEMDDSLNSIGFNINT
HCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEEEEEECCCCHHHCCCCCHH
AMQLSKIGGGVALNLSKLRARGEQIKGIENAASGVVPVMKLLEDSFSYANQLG
HHHHHHCCCCEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969495; 9384377 [H]