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The map label for this gene is lctP [H]

Identifier: 152974760

GI number: 152974760

Start: 1066575

End: 1068068

Strand: Direct

Name: lctP [H]

Synonym: Bcer98_0951

Alternate gene names: 152974760

Gene position: 1066575-1068068 (Clockwise)

Preceding gene: 152974757

Following gene: 152974761

Centisome position: 26.1

GC content: 37.42

Gene sequence:

>1494_bases
ATGGATGTATTACTAGCCCTTATTCCGATTCTGATGATTTTTATTTGTTTATTTCTGTTTAAACAAACATCATTAAAAGC
ATCGCTAATTTCTTATGCTATTTGTACGGGCATCGTGTTATTAACACCGATGTTTCGTCTGCAAATCGGGGAAGTAGTGC
ATGCAACGATTAAGGGTGGATTAATTTGTTTTATCGTCGGATATGTTTTGTTTTTTGGTATTCTTTTATTTCACCTCATG
AACAAAATGGGATATATTAATCAAGCGGCAAAGTTTATTAAACAAGTGACAAAAGATCGTTTGCTACAAATGTTATTCAT
GTGTTTTGGCATTTGCCCGCTTATTGAATCAGTCAGTGGATTTGGCATCGGTTTTATGGTAGCGGCACCTATTTTTCTTT
CGCTCGGTTATCAGCCGTTTCAAGCTGTTTTATTATCGTTTATCGGTTTACTAGCAAGTTCATGGGGAGCGATGGCAACG
GGAACCATTATTGGAGCACAGCTTGTTCATATATCGCTCGTTCAGTTTGGAACTAGCACAGCACTGTTCAGTATTCCTTT
CTTTGCATACTTTATTGTACTTTCCTTATATGTTGTTGGCGGATGGGAAGCAGTGAAACAAAAATGGAAAGAAGGACTCG
GCTTTTTTCTCTTATTTTCTATTTCTATTTATCTTTCAAATGCATATGTAAGTGTCGAGTTGGCCGGTATTTTAAGTTCA
ATTGTAACGATTGCATGTGGTTTGACCATAATAAAACTGACCGCGAAGCAAGAGAGTAGAATGTTATCAGAACATGCAGC
AACGATAGAGCGGGGGCCTTCCATTGTTAAGATTATGAGTCCTTATCTCTTTTTAACAGCTTGTATTTTATTATCTCGCC
TCGTTCCTACTTTCCATCATACATTACAATCTTACGCTGTTTTAAATTTACCATCTTACTCTTATAAACTAGAACTACTA
TATTCCCCGGGATTTTGGCTTGGTGTTACTTGTTTGTTTACTATTTTTGTCTTTCGTGTACCATCTGCGATTATAAAAGA
ATCATTATTTCAAACGGTAAAACAATGGATTCCGTTTGCGATTACAACGACAATGTTTATTGCCATTTCAGAACTAATGG
GAGCCGCAGGGATGCATTCCTTGTTAGCAGATGTAGCAGGAAATACATTTGGAACGTTATTTGTCTTTGTAGCACCTTTC
ATCGGTGGAATTGGCGGCTTTTTAACAGGAAGCAATGCTGGATCTAATGCGATGTTTATTAACCTGCAAATGCAAACAGC
ACAAAACGTAGGATTGCCATGGCAATATGTTACAAGTCTACAAAATACGGCATCATCAGTAGCAACCATTGCCTGTCCAT
CGCGGATTACACTTGGAGCTTACTTATGTAATGTTCCATTTCGCGAAAATGAGTTATTGAAGAAAACAACACTCATGATT
TTCGGCGCAGTGTTGATTGTAGGTATCGAGGTCCTTATTTGGTATATATTCTAA

Upstream 100 bases:

>100_bases
TAGGAGCCCCTTTTGAAAATGTATCACTCTTAGAATTGAATATTCTGACAATTGTTATATAATGGTTACAATTGTACCTT
ATAAGAAATGAGATGATAAT

Downstream 100 bases:

>100_bases
TAAATTATTTGAAAAAATCCTCTGCCACAGGAGGATTTTCTTTTTGCAATGAATAATTTATAAAAGAACAAACGTTTCTA
TTAAACAAAGAGGAGAGGAT

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MDVLLALIPILMIFICLFLFKQTSLKASLISYAICTGIVLLTPMFRLQIGEVVHATIKGGLICFIVGYVLFFGILLFHLM
NKMGYINQAAKFIKQVTKDRLLQMLFMCFGICPLIESVSGFGIGFMVAAPIFLSLGYQPFQAVLLSFIGLLASSWGAMAT
GTIIGAQLVHISLVQFGTSTALFSIPFFAYFIVLSLYVVGGWEAVKQKWKEGLGFFLLFSISIYLSNAYVSVELAGILSS
IVTIACGLTIIKLTAKQESRMLSEHAATIERGPSIVKIMSPYLFLTACILLSRLVPTFHHTLQSYAVLNLPSYSYKLELL
YSPGFWLGVTCLFTIFVFRVPSAIIKESLFQTVKQWIPFAITTTMFIAISELMGAAGMHSLLADVAGNTFGTLFVFVAPF
IGGIGGFLTGSNAGSNAMFINLQMQTAQNVGLPWQYVTSLQNTASSVATIACPSRITLGAYLCNVPFRENELLKKTTLMI
FGAVLIVGIEVLIWYIF

Sequences:

>Translated_497_residues
MDVLLALIPILMIFICLFLFKQTSLKASLISYAICTGIVLLTPMFRLQIGEVVHATIKGGLICFIVGYVLFFGILLFHLM
NKMGYINQAAKFIKQVTKDRLLQMLFMCFGICPLIESVSGFGIGFMVAAPIFLSLGYQPFQAVLLSFIGLLASSWGAMAT
GTIIGAQLVHISLVQFGTSTALFSIPFFAYFIVLSLYVVGGWEAVKQKWKEGLGFFLLFSISIYLSNAYVSVELAGILSS
IVTIACGLTIIKLTAKQESRMLSEHAATIERGPSIVKIMSPYLFLTACILLSRLVPTFHHTLQSYAVLNLPSYSYKLELL
YSPGFWLGVTCLFTIFVFRVPSAIIKESLFQTVKQWIPFAITTTMFIAISELMGAAGMHSLLADVAGNTFGTLFVFVAPF
IGGIGGFLTGSNAGSNAMFINLQMQTAQNVGLPWQYVTSLQNTASSVATIACPSRITLGAYLCNVPFRENELLKKTTLMI
FGAVLIVGIEVLIWYIF
>Mature_497_residues
MDVLLALIPILMIFICLFLFKQTSLKASLISYAICTGIVLLTPMFRLQIGEVVHATIKGGLICFIVGYVLFFGILLFHLM
NKMGYINQAAKFIKQVTKDRLLQMLFMCFGICPLIESVSGFGIGFMVAAPIFLSLGYQPFQAVLLSFIGLLASSWGAMAT
GTIIGAQLVHISLVQFGTSTALFSIPFFAYFIVLSLYVVGGWEAVKQKWKEGLGFFLLFSISIYLSNAYVSVELAGILSS
IVTIACGLTIIKLTAKQESRMLSEHAATIERGPSIVKIMSPYLFLTACILLSRLVPTFHHTLQSYAVLNLPSYSYKLELL
YSPGFWLGVTCLFTIFVFRVPSAIIKESLFQTVKQWIPFAITTTMFIAISELMGAAGMHSLLADVAGNTFGTLFVFVAPF
IGGIGGFLTGSNAGSNAMFINLQMQTAQNVGLPWQYVTSLQNTASSVATIACPSRITLGAYLCNVPFRENELLKKTTLMI
FGAVLIVGIEVLIWYIF

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=556, Percent_Identity=23.7410071942446, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790031, Length=542, Percent_Identity=23.8007380073801, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 54431; Mature: 54431

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10809684 [H]