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The map label for this gene is comA [H]

Identifier: 152974520

GI number: 152974520

Start: 788276

End: 788962

Strand: Direct

Name: comA [H]

Synonym: Bcer98_0697

Alternate gene names: 152974520

Gene position: 788276-788962 (Clockwise)

Preceding gene: 152974519

Following gene: 152974521

Centisome position: 19.29

GC content: 30.13

Gene sequence:

>687_bases
ATGCTAAAGGATAGAGAAAGGATGAAAGTGATGATTTCTGTACTAATAGTAGACGATCATGTAGCTGTAGGTTTGGGAAC
AAAAGCATTAATTGAGCAATATAATGATATAACAGTTGATGTATTACACGAAAGTGATAAAGTGATAGAAAGACTTCAAA
GTAAAACGTATGATGTGTATTTAATTGATTTACAAATGCCGAATATAAATGGTTTGGAGCTTTCTAAGAAAATATTAACA
ATCCATCCAGAAGCATCTATTTTGATTTTCACTGGATATGATGTGTTATCACATTATAATTTATTAATTGACAATGGAGT
TCTTGGTGTATTAAGTAAGACATATTTCGAAGAACAAATTATAGATGCGATTCGGCATGCCGTAAAAAAAGAAGTTGTTT
TACCACATCAGCTTATTCAGCAGTTGAGAATTAAAGAGAGTGTATCGAATATAAATGAACAAGAGCAAGTAGAAAATGTA
GTTTCCTTAACTGAAGAAGAAAAGAAAATTTTAATTGAAGTAAGTAAAGGAAAAACGAATAGAGAACTGGCTGAAATTTT
ACATTTAAGTCAAAGAGCTGTAGAGTACAAATTAACTGATATATTTCATAAATTAAAAGTAACTTCTCGAATGACAGCTG
TTCAGAGGGCAAAAGAGTTGAAGATAATTGCTTTTCTTGATTTGTAA

Upstream 100 bases:

>100_bases
GAATTATAACGAGAATTCAAAGTATTGATGGGGAAATAACAATAGATTCAAAACCTAACGATGGTTTACAGGTATTTGTG
AAATTTTAGGATATGTGATA

Downstream 100 bases:

>100_bases
GAACAGTTTCATAATATTGAGTCGTAAATAGAAAGAAAAAAAGAGATCCTGTTCCAATTTATATGGGGCAAGATCTCTTT
TTTATATTTTGCGTGAAGAC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Competence protein A [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MLKDRERMKVMISVLIVDDHVAVGLGTKALIEQYNDITVDVLHESDKVIERLQSKTYDVYLIDLQMPNINGLELSKKILT
IHPEASILIFTGYDVLSHYNLLIDNGVLGVLSKTYFEEQIIDAIRHAVKKEVVLPHQLIQQLRIKESVSNINEQEQVENV
VSLTEEEKKILIEVSKGKTNRELAEILHLSQRAVEYKLTDIFHKLKVTSRMTAVQRAKELKIIAFLDL

Sequences:

>Translated_228_residues
MLKDRERMKVMISVLIVDDHVAVGLGTKALIEQYNDITVDVLHESDKVIERLQSKTYDVYLIDLQMPNINGLELSKKILT
IHPEASILIFTGYDVLSHYNLLIDNGVLGVLSKTYFEEQIIDAIRHAVKKEVVLPHQLIQQLRIKESVSNINEQEQVENV
VSLTEEEKKILIEVSKGKTNRELAEILHLSQRAVEYKLTDIFHKLKVTSRMTAVQRAKELKIIAFLDL
>Mature_228_residues
MLKDRERMKVMISVLIVDDHVAVGLGTKALIEQYNDITVDVLHESDKVIERLQSKTYDVYLIDLQMPNINGLELSKKILT
IHPEASILIFTGYDVLSHYNLLIDNGVLGVLSKTYFEEQIIDAIRHAVKKEVVLPHQLIQQLRIKESVSNINEQEQVENV
VSLTEEEKKILIEVSKGKTNRELAEILHLSQRAVEYKLTDIFHKLKVTSRMTAVQRAKELKIIAFLDL

Specific function: Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, d

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=198, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1788521, Length=203, Percent_Identity=31.0344827586207, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26152; Mature: 26152

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKDRERMKVMISVLIVDDHVAVGLGTKALIEQYNDITVDVLHESDKVIERLQSKTYDVY
CCCHHHHHHHHHHEEEEECCEEECCCHHHHHHHCCCCEEEEECCCHHHHHHHHCCCEEEE
LIDLQMPNINGLELSKKILTIHPEASILIFTGYDVLSHYNLLIDNGVLGVLSKTYFEEQI
EEEEECCCCCCCEECCEEEEECCCCCEEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IDAIRHAVKKEVVLPHQLIQQLRIKESVSNINEQEQVENVVSLTEEEKKILIEVSKGKTN
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCCCH
RELAEILHLSQRAVEYKLTDIFHKLKVTSRMTAVQRAKELKIIAFLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECC
>Mature Secondary Structure
MLKDRERMKVMISVLIVDDHVAVGLGTKALIEQYNDITVDVLHESDKVIERLQSKTYDVY
CCCHHHHHHHHHHEEEEECCEEECCCHHHHHHHCCCCEEEEECCCHHHHHHHHCCCEEEE
LIDLQMPNINGLELSKKILTIHPEASILIFTGYDVLSHYNLLIDNGVLGVLSKTYFEEQI
EEEEECCCCCCCEECCEEEEECCCCCEEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IDAIRHAVKKEVVLPHQLIQQLRIKESVSNINEQEQVENVVSLTEEEKKILIEVSKGKTN
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCCCH
RELAEILHLSQRAVEYKLTDIFHKLKVTSRMTAVQRAKELKIIAFLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2507523; 9274030; 9384377 [H]