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The map label for this gene is comP [H]

Identifier: 152974519

GI number: 152974519

Start: 785892

End: 788264

Strand: Direct

Name: comP [H]

Synonym: Bcer98_0696

Alternate gene names: 152974519

Gene position: 785892-788264 (Clockwise)

Preceding gene: 152974518

Following gene: 152974520

Centisome position: 19.23

GC content: 27.9

Gene sequence:

>2373_bases
ATGCCGCATGAAATGAAAAAAGATAATGAGGAGAAGTGGAGGAACAAACAATTATATTCAAAAATTAATAAGAAAGAACG
TGATGAAATGATAAGAAAAATAAGTAAGAAAAAATTTCAATATTTCATAGTAGTATTTTCTCTCCTTATTAGTGGGTATC
TTATACATTTAATTCTCACATATCCTGAGGTTGGTATAAAGCTAAATTCAAACTATATTGTAAGCGAAGTGCATAGATTT
ACTTGGGCCCATAAGCATGGGATACAAGTAGGAGATAAAATAGAAAAGATAGATGATAAATTGCCGAGTCAGCACTTTAC
AGTTTCATCCTATCATGCCATTGAACAGGCGAAAAAAATATCTATACAAAAAGATGGGCAGGTAAAAGAATATAACATTC
AATATGTTCCTTACAGTAGGCAACTTTTTTACCAGCTATTAATACCAGTTGGATTTTATATTACATGTATTTTTATGGCT
CTTTATCTTTTAATATTTGTTCCTAAAACGAATAATAGTATACAAGATTTACTATACTTTTTGATTGCGATGGGAATGAG
TTTCATTAGTATTATAGCCGCGCAACGAAAAGATGGAATTGCCTTTATTATCGCTTCTATCTCATTAGTTTCTTCCTTTA
CCTTCTTTATTAGATTTATGAAATTGTATTTTAAACATAATCAAATTAAATTTTTAACAAGAGAACAATTGAGAATTTTG
GATATAATAATGATTGTATTAATTGCAGTAAACATCGTTGTTTATATGAAGTATAATGAAATTTCCGTCATGTTTACAAT
CGCTTTAAGCATTGCTTTATTTTTATTAACAGGCTACCTTTTAGTAAGGTTTTATTTTAGAAGCAAACATAGTCATCATT
TTAAATTTATGAAGGTTATCGTGATGAGCTTTTTTGCATCTGTTATTCCGTTTATTTGTTTATTCTTAATTCCTGATATG
ATATATGGAAAAGAAATAATCAGTGTTGAAACAATTGGGATTTTCTTTTTGTTTATTCCAATATATATGTTTTATTGGGT
GATTTCAGGAGATTTATTTGATGCTAAATTTATGATTCAACGAATTCCATATTATATTATGTTGTCGATTAGTTTTACAG
GATTTGTAACTATATTGGGTATTTTTATTTTTAATGATAATGCAGATCATATATTAGATACCATTCGCTTTAGTTGTATT
ACTTTTATTGCAACAATTTTCTTTTTATTTATAAAAGATTACTTGGATTTTAAATTAAGAAAAAGTTTATATCATCATCA
AAAAAATTATCAGTTTAGTTTGTATCGATTTTTATATCAAGCAAAACATGAATATAAATTGTCAAATTTGACTTATAGCA
TACAAAGAGAATTTTCTGATGTCTTGAAAATGGAAGAGGTATGCTATGTAGAAATGAATAAGGAGAATAAATCTATTCAT
GTTTTTGAGAGTAAATATGTTCCTCCTCAATCCATATTGGACAGTTTGTTCGATTTCCAATTGGAAACATACAAAGTTGG
TTCTATGATGAAGTTGGAAGAACATTTTGGATTTGTTCTTTCTACAACGACAGAAAAAGTGATTATCTTATTGTGCAAAA
ATAATAAAAAAGAAACGTTAAACTTTGATGAGATTGTTTGGGTTGAGACATTATGTAATTATACAGATTTGCTATTAGAA
TGTTTGAATCAAATTGAAGACTTATTAAAACAATTACAAGATTTACAAAATATAGAACACCCTCCGATGTGGTTATCCCG
ACTTCTGTTCAAGTTATCGGAAAAAGAAAGAGCAAATCTTGCAAGCGATATACATGATGGGGTCTTACAAGATCAAATTC
GTTTAGTAAGAAAGTTTGAATCTTACAATAAGCATATTCAAGATGAAGAAATGAAACATATACTTCATGAAATAAAAGAA
CAATTACTCGATCATATTTACATGACTCGAGAAACATGTAATCACTTAAGGCCACCATTTTTATATGAATTAGGAATAAA
ACAAGCGTTATTAAACTTATTCAAACAAATTAACTTAAAGGCTACTTTCTTTTTTTATTATGATATTCCTGAACATATAG
TTGTACCTAGTGCAGAGCATGAACAAGCAATTTACCGGATTATACAGGAACTTCTAAATAATGCTTTGAAACATTCGAAA
GCATCGAATGTAAGTATAAAATTATTTCAAAAAGATCAGCAGTTATTTTTAACCTATACAGATAATGGAATAGGGATAGA
TTTAAAGCATTTTAATTACTCGTATAATACTTTGGGATTGTCAGGAATTATAACGAGAATTCAAAGTATTGATGGGGAAA
TAACAATAGATTCAAAACCTAACGATGGTTTACAGGTATTTGTGAAATTTTAG

Upstream 100 bases:

>100_bases
TTATAAACGTAATTAAATGATATTCATTTAGAAAAAGCAGGCATGTATATAAACAGAAAAGCGATTATTCTTTCTTTTTT
TAGAGAGCTTAATTGATACT

Downstream 100 bases:

>100_bases
GATATGTGATAATGCTAAAGGATAGAGAAAGGATGAAAGTGATGATTTCTGTACTAATAGTAGACGATCATGTAGCTGTA
GGTTTGGGAACAAAAGCATT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 790; Mature: 789

Protein sequence:

>790_residues
MPHEMKKDNEEKWRNKQLYSKINKKERDEMIRKISKKKFQYFIVVFSLLISGYLIHLILTYPEVGIKLNSNYIVSEVHRF
TWAHKHGIQVGDKIEKIDDKLPSQHFTVSSYHAIEQAKKISIQKDGQVKEYNIQYVPYSRQLFYQLLIPVGFYITCIFMA
LYLLIFVPKTNNSIQDLLYFLIAMGMSFISIIAAQRKDGIAFIIASISLVSSFTFFIRFMKLYFKHNQIKFLTREQLRIL
DIIMIVLIAVNIVVYMKYNEISVMFTIALSIALFLLTGYLLVRFYFRSKHSHHFKFMKVIVMSFFASVIPFICLFLIPDM
IYGKEIISVETIGIFFLFIPIYMFYWVISGDLFDAKFMIQRIPYYIMLSISFTGFVTILGIFIFNDNADHILDTIRFSCI
TFIATIFFLFIKDYLDFKLRKSLYHHQKNYQFSLYRFLYQAKHEYKLSNLTYSIQREFSDVLKMEEVCYVEMNKENKSIH
VFESKYVPPQSILDSLFDFQLETYKVGSMMKLEEHFGFVLSTTTEKVIILLCKNNKKETLNFDEIVWVETLCNYTDLLLE
CLNQIEDLLKQLQDLQNIEHPPMWLSRLLFKLSEKERANLASDIHDGVLQDQIRLVRKFESYNKHIQDEEMKHILHEIKE
QLLDHIYMTRETCNHLRPPFLYELGIKQALLNLFKQINLKATFFFYYDIPEHIVVPSAEHEQAIYRIIQELLNNALKHSK
ASNVSIKLFQKDQQLFLTYTDNGIGIDLKHFNYSYNTLGLSGIITRIQSIDGEITIDSKPNDGLQVFVKF

Sequences:

>Translated_790_residues
MPHEMKKDNEEKWRNKQLYSKINKKERDEMIRKISKKKFQYFIVVFSLLISGYLIHLILTYPEVGIKLNSNYIVSEVHRF
TWAHKHGIQVGDKIEKIDDKLPSQHFTVSSYHAIEQAKKISIQKDGQVKEYNIQYVPYSRQLFYQLLIPVGFYITCIFMA
LYLLIFVPKTNNSIQDLLYFLIAMGMSFISIIAAQRKDGIAFIIASISLVSSFTFFIRFMKLYFKHNQIKFLTREQLRIL
DIIMIVLIAVNIVVYMKYNEISVMFTIALSIALFLLTGYLLVRFYFRSKHSHHFKFMKVIVMSFFASVIPFICLFLIPDM
IYGKEIISVETIGIFFLFIPIYMFYWVISGDLFDAKFMIQRIPYYIMLSISFTGFVTILGIFIFNDNADHILDTIRFSCI
TFIATIFFLFIKDYLDFKLRKSLYHHQKNYQFSLYRFLYQAKHEYKLSNLTYSIQREFSDVLKMEEVCYVEMNKENKSIH
VFESKYVPPQSILDSLFDFQLETYKVGSMMKLEEHFGFVLSTTTEKVIILLCKNNKKETLNFDEIVWVETLCNYTDLLLE
CLNQIEDLLKQLQDLQNIEHPPMWLSRLLFKLSEKERANLASDIHDGVLQDQIRLVRKFESYNKHIQDEEMKHILHEIKE
QLLDHIYMTRETCNHLRPPFLYELGIKQALLNLFKQINLKATFFFYYDIPEHIVVPSAEHEQAIYRIIQELLNNALKHSK
ASNVSIKLFQKDQQLFLTYTDNGIGIDLKHFNYSYNTLGLSGIITRIQSIDGEITIDSKPNDGLQVFVKF
>Mature_789_residues
PHEMKKDNEEKWRNKQLYSKINKKERDEMIRKISKKKFQYFIVVFSLLISGYLIHLILTYPEVGIKLNSNYIVSEVHRFT
WAHKHGIQVGDKIEKIDDKLPSQHFTVSSYHAIEQAKKISIQKDGQVKEYNIQYVPYSRQLFYQLLIPVGFYITCIFMAL
YLLIFVPKTNNSIQDLLYFLIAMGMSFISIIAAQRKDGIAFIIASISLVSSFTFFIRFMKLYFKHNQIKFLTREQLRILD
IIMIVLIAVNIVVYMKYNEISVMFTIALSIALFLLTGYLLVRFYFRSKHSHHFKFMKVIVMSFFASVIPFICLFLIPDMI
YGKEIISVETIGIFFLFIPIYMFYWVISGDLFDAKFMIQRIPYYIMLSISFTGFVTILGIFIFNDNADHILDTIRFSCIT
FIATIFFLFIKDYLDFKLRKSLYHHQKNYQFSLYRFLYQAKHEYKLSNLTYSIQREFSDVLKMEEVCYVEMNKENKSIHV
FESKYVPPQSILDSLFDFQLETYKVGSMMKLEEHFGFVLSTTTEKVIILLCKNNKKETLNFDEIVWVETLCNYTDLLLEC
LNQIEDLLKQLQDLQNIEHPPMWLSRLLFKLSEKERANLASDIHDGVLQDQIRLVRKFESYNKHIQDEEMKHILHEIKEQ
LLDHIYMTRETCNHLRPPFLYELGIKQALLNLFKQINLKATFFFYYDIPEHIVVPSAEHEQAIYRIIQELLNNALKHSKA
SNVSIKLFQKDQQLFLTYTDNGIGIDLKHFNYSYNTLGLSGIITRIQSIDGEITIDSKPNDGLQVFVKF

Specific function: Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=204, Percent_Identity=30.3921568627451, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 93523; Mature: 93392

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHEMKKDNEEKWRNKQLYSKINKKERDEMIRKISKKKFQYFIVVFSLLISGYLIHLILT
CCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YPEVGIKLNSNYIVSEVHRFTWAHKHGIQVGDKIEKIDDKLPSQHFTVSSYHAIEQAKKI
CCCCCEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHC
SIQKDGQVKEYNIQYVPYSRQLFYQLLIPVGFYITCIFMALYLLIFVPKTNNSIQDLLYF
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHH
LIAMGMSFISIIAAQRKDGIAFIIASISLVSSFTFFIRFMKLYFKHNQIKFLTREQLRIL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHH
DIIMIVLIAVNIVVYMKYNEISVMFTIALSIALFLLTGYLLVRFYFRSKHSHHFKFMKVI
HHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VMSFFASVIPFICLFLIPDMIYGKEIISVETIGIFFLFIPIYMFYWVISGDLFDAKFMIQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RIPYYIMLSISFTGFVTILGIFIFNDNADHILDTIRFSCITFIATIFFLFIKDYLDFKLR
HCCEEEEEEEHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLYHHQKNYQFSLYRFLYQAKHEYKLSNLTYSIQREFSDVLKMEEVCYVEMNKENKSIH
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEE
VFESKYVPPQSILDSLFDFQLETYKVGSMMKLEEHFGFVLSTTTEKVIILLCKNNKKETL
EEECCCCCHHHHHHHHHHCCHHHEECCCHHHHHHHCCEEEEECCCEEEEEEECCCCCCCC
NFDEIVWVETLCNYTDLLLECLNQIEDLLKQLQDLQNIEHPPMWLSRLLFKLSEKERANL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ASDIHDGVLQDQIRLVRKFESYNKHIQDEEMKHILHEIKEQLLDHIYMTRETCNHLRPPF
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LYELGIKQALLNLFKQINLKATFFFYYDIPEHIVVPSAEHEQAIYRIIQELLNNALKHSK
HHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCCC
ASNVSIKLFQKDQQLFLTYTDNGIGIDLKHFNYSYNTLGLSGIITRIQSIDGEITIDSKP
CCCCEEEEEECCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEECCCC
NDGLQVFVKF
CCCCEEEEEC
>Mature Secondary Structure 
PHEMKKDNEEKWRNKQLYSKINKKERDEMIRKISKKKFQYFIVVFSLLISGYLIHLILT
CCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YPEVGIKLNSNYIVSEVHRFTWAHKHGIQVGDKIEKIDDKLPSQHFTVSSYHAIEQAKKI
CCCCCEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHC
SIQKDGQVKEYNIQYVPYSRQLFYQLLIPVGFYITCIFMALYLLIFVPKTNNSIQDLLYF
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHH
LIAMGMSFISIIAAQRKDGIAFIIASISLVSSFTFFIRFMKLYFKHNQIKFLTREQLRIL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHH
DIIMIVLIAVNIVVYMKYNEISVMFTIALSIALFLLTGYLLVRFYFRSKHSHHFKFMKVI
HHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VMSFFASVIPFICLFLIPDMIYGKEIISVETIGIFFLFIPIYMFYWVISGDLFDAKFMIQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RIPYYIMLSISFTGFVTILGIFIFNDNADHILDTIRFSCITFIATIFFLFIKDYLDFKLR
HCCEEEEEEEHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLYHHQKNYQFSLYRFLYQAKHEYKLSNLTYSIQREFSDVLKMEEVCYVEMNKENKSIH
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEE
VFESKYVPPQSILDSLFDFQLETYKVGSMMKLEEHFGFVLSTTTEKVIILLCKNNKKETL
EEECCCCCHHHHHHHHHHCCHHHEECCCHHHHHHHCCEEEEECCCEEEEEEECCCCCCCC
NFDEIVWVETLCNYTDLLLECLNQIEDLLKQLQDLQNIEHPPMWLSRLLFKLSEKERANL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ASDIHDGVLQDQIRLVRKFESYNKHIQDEEMKHILHEIKEQLLDHIYMTRETCNHLRPPF
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LYELGIKQALLNLFKQINLKATFFFYYDIPEHIVVPSAEHEQAIYRIIQELLNNALKHSK
HHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCCC
ASNVSIKLFQKDQQLFLTYTDNGIGIDLKHFNYSYNTLGLSGIITRIQSIDGEITIDSKP
CCCCEEEEEECCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEECCCC
NDGLQVFVKF
CCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2116363; 9274030; 9384377; 1715859 [H]