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The map label for this gene is napA [H]

Identifier: 152974492

GI number: 152974492

Start: 753312

End: 754439

Strand: Direct

Name: napA [H]

Synonym: Bcer98_0667

Alternate gene names: 152974492

Gene position: 753312-754439 (Clockwise)

Preceding gene: 152974491

Following gene: 152974493

Centisome position: 18.43

GC content: 36.52

Gene sequence:

>1128_bases
ATGCTGTTTTACTTTGAACTAGTTGTTATTTTACTTTGTACAAAACTAGCTGGTGACATTAGTGTGAGACTTGGTCAGCC
ATCTGTATTAGGAAAATTAATTGTTGGTATTATTATTGGTCCGGCAGTTTTAGGGATTATTGATAGTTCAGAACTCATTG
ATGAGCTAAGTGAAATTGGTGTGTTACTTCTTATGTTTATGGCAGGGCTAGAAACAGACTTAGAAGAACTAAATCGTAAT
TTAAAATCATCATTTGCAGTTGCAATCGGCGGTATTATTCTTCCTTTTCTCGGTGGTTATTTAGCAGGAATTGCGTTTGG
GATGATGCAGTCACATGCCATTTTCTTAGGATTATTACTTTGTGCAACTTCCGTCAGTATTTCTGTTCAAACATTGCGTG
ATTTAGGGAAAATGAATACGAGGGAGAGCACAACCATTCTCGGAGCTGCCGTCTTTGATGATGTCATTGTTGTAATTTTA
TTAGCTTTTGTTATGAGTTTTTTAGGGACACAGGATGTGAATGTTACGCTTATGATTGCTAAAAAAGTCATCTTTTTTAG
CAGTATTGTTGTAATTGGGTGGAAAGTCGTTCCGTGGATTATGCGCATGTTAGTGCCGCTTCGCGTATCAGAAGCATTAA
TTAGTGCAGCACTTATTATTTGTTTTTCCTTTGCTTATTATAGTGAACAAATGGGGGTTGCCGGGATTATCGGAGCTTTT
GCAGCCGGAATTGCCATATCGCAAACGACATATAAGCATGAAGTAGAACATAAAATTGAACCGATTGCCTATGCTATTTT
TGTACCAGTCTTTTTTGTTAGTATCGGAATGGAAATTACATTTCAAGGGATTGGAAACCAAATTTGGTTTATCGTTTTGA
TGACGATAATCGCAATCTTGACAAAATTAGTTGGATCAGGACTAGGAGCAAGATTAACAGGATTTAATTTGAAATCGTCG
ATTGGTATTGGAGCTGGTATGGTGTCACGCGGAGAAGTAGCACTTATTATCGCGGCAAATGGATTAACCGCAAATTTATT
AGCAAAAGAGAATTTTACCTCAATCGTCATTGTTGTTATATTAACGACGATTATTACACCGCCATTGTTAAAGAAATATT
TTGTATAA

Upstream 100 bases:

>100_bases
AGAGTATTTAATGAAATAAAAATGCAACAAATAAAATGGCATTAGTAAGGAGAGACTATCGTTAGGAATAGACGTATTCT
ATAAAGTAGGAGAAGATGCT

Downstream 100 bases:

>100_bases
AAGGAAGGGCCTGTACTACTGGACGGGCTCTTTTTACATTTTTAGTAGCAGTGATTTGATGAAATTTGTCGATTGGTCGA
TATCTCATGTCGAACCGCCG

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MLFYFELVVILLCTKLAGDISVRLGQPSVLGKLIVGIIIGPAVLGIIDSSELIDELSEIGVLLLMFMAGLETDLEELNRN
LKSSFAVAIGGIILPFLGGYLAGIAFGMMQSHAIFLGLLLCATSVSISVQTLRDLGKMNTRESTTILGAAVFDDVIVVIL
LAFVMSFLGTQDVNVTLMIAKKVIFFSSIVVIGWKVVPWIMRMLVPLRVSEALISAALIICFSFAYYSEQMGVAGIIGAF
AAGIAISQTTYKHEVEHKIEPIAYAIFVPVFFVSIGMEITFQGIGNQIWFIVLMTIIAILTKLVGSGLGARLTGFNLKSS
IGIGAGMVSRGEVALIIAANGLTANLLAKENFTSIVIVVILTTIITPPLLKKYFV

Sequences:

>Translated_375_residues
MLFYFELVVILLCTKLAGDISVRLGQPSVLGKLIVGIIIGPAVLGIIDSSELIDELSEIGVLLLMFMAGLETDLEELNRN
LKSSFAVAIGGIILPFLGGYLAGIAFGMMQSHAIFLGLLLCATSVSISVQTLRDLGKMNTRESTTILGAAVFDDVIVVIL
LAFVMSFLGTQDVNVTLMIAKKVIFFSSIVVIGWKVVPWIMRMLVPLRVSEALISAALIICFSFAYYSEQMGVAGIIGAF
AAGIAISQTTYKHEVEHKIEPIAYAIFVPVFFVSIGMEITFQGIGNQIWFIVLMTIIAILTKLVGSGLGARLTGFNLKSS
IGIGAGMVSRGEVALIIAANGLTANLLAKENFTSIVIVVILTTIITPPLLKKYFV
>Mature_375_residues
MLFYFELVVILLCTKLAGDISVRLGQPSVLGKLIVGIIIGPAVLGIIDSSELIDELSEIGVLLLMFMAGLETDLEELNRN
LKSSFAVAIGGIILPFLGGYLAGIAFGMMQSHAIFLGLLLCATSVSISVQTLRDLGKMNTRESTTILGAAVFDDVIVVIL
LAFVMSFLGTQDVNVTLMIAKKVIFFSSIVVIGWKVVPWIMRMLVPLRVSEALISAALIICFSFAYYSEQMGVAGIIGAF
AAGIAISQTTYKHEVEHKIEPIAYAIFVPVFFVSIGMEITFQGIGNQIWFIVLMTIIAILTKLVGSGLGARLTGFNLKSS
IGIGAGMVSRGEVALIIAANGLTANLLAKENFTSIVIVVILTTIITPPLLKKYFV

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1789749, Length=367, Percent_Identity=27.2479564032698, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786232, Length=361, Percent_Identity=27.9778393351801, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786685, Length=383, Percent_Identity=26.8929503916449, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322367, Length=407, Percent_Identity=25.3071253071253, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 40160; Mature: 40160

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFYFELVVILLCTKLAGDISVRLGQPSVLGKLIVGIIIGPAVLGIIDSSELIDELSEIG
CHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VLLLMFMAGLETDLEELNRNLKSSFAVAIGGIILPFLGGYLAGIAFGMMQSHAIFLGLLL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CATSVSISVQTLRDLGKMNTRESTTILGAAVFDDVIVVILLAFVMSFLGTQDVNVTLMIA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHH
KKVIFFSSIVVIGWKVVPWIMRMLVPLRVSEALISAALIICFSFAYYSEQMGVAGIIGAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AAGIAISQTTYKHEVEHKIEPIAYAIFVPVFFVSIGMEITFQGIGNQIWFIVLMTIIAIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEECCCHHHHHHHHHHHHHHH
TKLVGSGLGARLTGFNLKSSIGIGAGMVSRGEVALIIAANGLTANLLAKENFTSIVIVVI
HHHHCCCCCCEEECCCCHHCCCCCCCCCCCCCEEEEEEECCCEEEHHHHCCHHHHHHHHH
LTTIITPPLLKKYFV
HHHHHCCHHHHHHCC
>Mature Secondary Structure
MLFYFELVVILLCTKLAGDISVRLGQPSVLGKLIVGIIIGPAVLGIIDSSELIDELSEIG
CHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VLLLMFMAGLETDLEELNRNLKSSFAVAIGGIILPFLGGYLAGIAFGMMQSHAIFLGLLL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CATSVSISVQTLRDLGKMNTRESTTILGAAVFDDVIVVILLAFVMSFLGTQDVNVTLMIA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHH
KKVIFFSSIVVIGWKVVPWIMRMLVPLRVSEALISAALIICFSFAYYSEQMGVAGIIGAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AAGIAISQTTYKHEVEHKIEPIAYAIFVPVFFVSIGMEITFQGIGNQIWFIVLMTIIAIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEECCCHHHHHHHHHHHHHHH
TKLVGSGLGARLTGFNLKSSIGIGAGMVSRGEVALIIAANGLTANLLAKENFTSIVIVVI
HHHHCCCCCCEEECCCCHHCCCCCCCCCCCCCEEEEEEECCCEEEHHHHCCHHHHHHHHH
LTTIITPPLLKKYFV
HHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]