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The map label for this gene is yfhQ [H]

Identifier: 152974276

GI number: 152974276

Start: 497333

End: 498427

Strand: Direct

Name: yfhQ [H]

Synonym: Bcer98_0443

Alternate gene names: 152974276

Gene position: 497333-498427 (Clockwise)

Preceding gene: 152974274

Following gene: 152974277

Centisome position: 12.17

GC content: 37.26

Gene sequence:

>1095_bases
TTGACACTTGAAATATTAGATGATTTTAATATAAAGCAATTTCAAGAAGATTTAATTGATTGGTTTGAAAAAGAGCAAAG
GGACTTACCATGGCGCAAAAATAAAGATCCATATCGTGTTTGGGTGTCTGAAATTATGTTACAACAAACACGAGTGGAAG
CTGTAAAACCATATTACGCAAAATTCATGGGAAAGTTCCCGACGCTAGAAGCATTAGCAGATGCTGAAGATGAAGAAGTG
TTAAAAGCGTGGGAAGGCCTTGGGTATTACTCACGAGCAAGAAATTTACACGCGGCTGTAAAGGAAGTTAAAGAAGTATA
CGGCGGGGAAGTTCCAAGTGATGTGAAAAAAATTGAAAAATTACAAGGGATTGGCCCGTATACAAAAGGTGCTATTTTAA
GTATTGCATATGGAATACCTGAACCGGCAGTTGATGGAAACGTTATGCGTGTATTATCTCGCATTTTATCCGTTTGGGAA
GATATTGCAAAGCCGAAAACAAGAAAAATATTCGAAGATATTGTACGTGAAATTATTTCGATAGAAAACCCATCATACTT
TAATCAAGGGCTAATGGAGCTAGGAGCATTAATTTGTATCCCGAAAAACCCAGCTTGTTTACTTTGTCCTGTACGAGAGC
ATTGCCGTGGATACGCTGAAGGTGTTCAAAAAGATTTACCGGTTAAAAGTAAAGCGAAAGCTCCTAAAATGGTACCGCTT
GTTGCTGGTGTACTTCAAACAGAAGATGGTCGCTATGTGATTCATAAACGTCCAAGCGAAGGATTACTTGCAAATATGTG
GGAATTTCCAAATGTTGAAATTCGTGCAGGGATTCGGAATCAAAAACAACAACTTATTGATTATGTGAAAGAACAATTCA
ATCTTTCTGTATCAGTTAATGAATATGCGATGAATGTGCAGCATACCTTTACACATCGGACATGGGATATATTTGTATTT
TATGGAAAAGTAACAGGAGAAATTGTAGAAACAGATACTTTGAAGGTTGTAACGAAAGAAGCCTTTGAACAGTTACCTTT
TTCAAAAGCACATCGCACCATTTATGAAGAATGCGTGGAAAGACTCCAACCTTGA

Upstream 100 bases:

>100_bases
CTCAAGTCATTTGCCTTCTATTTCCTGCATTATCTTACTTAAATTTTTTCCTAAAATCTTTATAATAGTACGTATATGCA
AAAAATAAGGGGGACACGGT

Downstream 100 bases:

>100_bases
TGGTTGGAGTTTTTTCAACATAAACATAACAATAAATTACAAATATTTCATATTGTCTTAACAAATGACAAATAAAATAG
AATTTGTAGTGCAAAGGAAA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MTLEILDDFNIKQFQEDLIDWFEKEQRDLPWRKNKDPYRVWVSEIMLQQTRVEAVKPYYAKFMGKFPTLEALADAEDEEV
LKAWEGLGYYSRARNLHAAVKEVKEVYGGEVPSDVKKIEKLQGIGPYTKGAILSIAYGIPEPAVDGNVMRVLSRILSVWE
DIAKPKTRKIFEDIVREIISIENPSYFNQGLMELGALICIPKNPACLLCPVREHCRGYAEGVQKDLPVKSKAKAPKMVPL
VAGVLQTEDGRYVIHKRPSEGLLANMWEFPNVEIRAGIRNQKQQLIDYVKEQFNLSVSVNEYAMNVQHTFTHRTWDIFVF
YGKVTGEIVETDTLKVVTKEAFEQLPFSKAHRTIYEECVERLQP

Sequences:

>Translated_364_residues
MTLEILDDFNIKQFQEDLIDWFEKEQRDLPWRKNKDPYRVWVSEIMLQQTRVEAVKPYYAKFMGKFPTLEALADAEDEEV
LKAWEGLGYYSRARNLHAAVKEVKEVYGGEVPSDVKKIEKLQGIGPYTKGAILSIAYGIPEPAVDGNVMRVLSRILSVWE
DIAKPKTRKIFEDIVREIISIENPSYFNQGLMELGALICIPKNPACLLCPVREHCRGYAEGVQKDLPVKSKAKAPKMVPL
VAGVLQTEDGRYVIHKRPSEGLLANMWEFPNVEIRAGIRNQKQQLIDYVKEQFNLSVSVNEYAMNVQHTFTHRTWDIFVF
YGKVTGEIVETDTLKVVTKEAFEQLPFSKAHRTIYEECVERLQP
>Mature_363_residues
TLEILDDFNIKQFQEDLIDWFEKEQRDLPWRKNKDPYRVWVSEIMLQQTRVEAVKPYYAKFMGKFPTLEALADAEDEEVL
KAWEGLGYYSRARNLHAAVKEVKEVYGGEVPSDVKKIEKLQGIGPYTKGAILSIAYGIPEPAVDGNVMRVLSRILSVWED
IAKPKTRKIFEDIVREIISIENPSYFNQGLMELGALICIPKNPACLLCPVREHCRGYAEGVQKDLPVKSKAKAPKMVPLV
AGVLQTEDGRYVIHKRPSEGLLANMWEFPNVEIRAGIRNQKQQLIDYVKEQFNLSVSVNEYAMNVQHTFTHRTWDIFVFY
GKVTGEIVETDTLKVVTKEAFEQLPFSKAHRTIYEECVERLQP

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=406, Percent_Identity=31.2807881773399, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI190358497, Length=406, Percent_Identity=31.2807881773399, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI115298648, Length=406, Percent_Identity=31.2807881773399, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI115298654, Length=406, Percent_Identity=31.2807881773399, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI115298652, Length=406, Percent_Identity=31.2807881773399, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI115298650, Length=406, Percent_Identity=31.2807881773399, Blast_Score=202, Evalue=3e-52,
Organism=Escherichia coli, GI1789331, Length=333, Percent_Identity=35.7357357357357, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1787920, Length=188, Percent_Identity=26.5957446808511, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41888; Mature: 41757

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEILDDFNIKQFQEDLIDWFEKEQRDLPWRKNKDPYRVWVSEIMLQQTRVEAVKPYYA
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KFMGKFPTLEALADAEDEEVLKAWEGLGYYSRARNLHAAVKEVKEVYGGEVPSDVKKIEK
HHHCCCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LQGIGPYTKGAILSIAYGIPEPAVDGNVMRVLSRILSVWEDIAKPKTRKIFEDIVREIIS
HHCCCCCCCCHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
IENPSYFNQGLMELGALICIPKNPACLLCPVREHCRGYAEGVQKDLPVKSKAKAPKMVPL
CCCCCHHHHHHHHHCCEEEECCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
VAGVLQTEDGRYVIHKRPSEGLLANMWEFPNVEIRAGIRNQKQQLIDYVKEQFNLSVSVN
HHHHHCCCCCCEEEEECCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCEEEEH
EYAMNVQHTFTHRTWDIFVFYGKVTGEIVETDTLKVVTKEAFEQLPFSKAHRTIYEECVE
HHHHHHHHHHCCCEEEEEEEEECCCCCEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RLQP
HHCC
>Mature Secondary Structure 
TLEILDDFNIKQFQEDLIDWFEKEQRDLPWRKNKDPYRVWVSEIMLQQTRVEAVKPYYA
EEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KFMGKFPTLEALADAEDEEVLKAWEGLGYYSRARNLHAAVKEVKEVYGGEVPSDVKKIEK
HHHCCCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LQGIGPYTKGAILSIAYGIPEPAVDGNVMRVLSRILSVWEDIAKPKTRKIFEDIVREIIS
HHCCCCCCCCHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
IENPSYFNQGLMELGALICIPKNPACLLCPVREHCRGYAEGVQKDLPVKSKAKAPKMVPL
CCCCCHHHHHHHHHCCEEEECCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
VAGVLQTEDGRYVIHKRPSEGLLANMWEFPNVEIRAGIRNQKQQLIDYVKEQFNLSVSVN
HHHHHCCCCCCEEEEECCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCEEEEH
EYAMNVQHTFTHRTWDIFVFYGKVTGEIVETDTLKVVTKEAFEQLPFSKAHRTIYEECVE
HHHHHHHHHHCCCEEEEEEEEECCCCCEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RLQP
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]