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The map label for this gene is sipS [H]

Identifier: 152974234

GI number: 152974234

Start: 455971

End: 456501

Strand: Direct

Name: sipS [H]

Synonym: Bcer98_0400

Alternate gene names: 152974234

Gene position: 455971-456501 (Clockwise)

Preceding gene: 152974233

Following gene: 152974236

Centisome position: 11.16

GC content: 31.64

Gene sequence:

>531_bases
ATGGAAAAGAAAAAACATTTTCGTGAATTGTTTGAAGTATTTGCGATTGCATGTTTACTAGCTTTTTTAGCAAAAGTGTT
TTTATTTTTTCCGACCACTGTAAATGGGGCATCAATGAGACCGGCTTTGGAAGATGGTGATAAGGTCATTATTAATAAAT
TAGCAAAGAGATTTGAAAGCTATGATAGGGAAGATATTATTGTAGTGAAGACAGATAATTTTTATGTGAAGAGAGTGATT
GGATTACCGGGAGATGTAATTGAGATGAAAAATGATCAATTATATATTAATCATCAAGTGCATAGTGAACCGTATTTAGA
GAAAAATCGAAAACATGCTAAGCAACTCCTTGTTCATTTAACAGAAGACTTTGGGCCAATTACTGTACCAAAAAATAAAA
TCTTTGTTATGGGAGATAATCGTTTAATTAGTAGAGACAGTCGGAATGGTTTAGGGTTTATTGATAAGAAGCAAGTATTA
GGGACACTGGTTGCTATTTATTATCCTTTTCATCATATGAAAATTATATAG

Upstream 100 bases:

>100_bases
AAAGAAGAAGGACTGCGAGTGAAGTAGTCCTTTTTGTAGCGAGATACCGAATTATAAGGAATATAGAAACAAATATGGAT
GGGGGAGAAAGGGGAAGGAG

Downstream 100 bases:

>100_bases
AAATGATAGAAAGAATCCCCCAAACAATTCTGAAGAATTGCTTGGGGGCATATTTAAGTAGTTGGAACTTCATGATGTCC
CTTTCTATTTAACATAAATT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MEKKKHFRELFEVFAIACLLAFLAKVFLFFPTTVNGASMRPALEDGDKVIINKLAKRFESYDREDIIVVKTDNFYVKRVI
GLPGDVIEMKNDQLYINHQVHSEPYLEKNRKHAKQLLVHLTEDFGPITVPKNKIFVMGDNRLISRDSRNGLGFIDKKQVL
GTLVAIYYPFHHMKII

Sequences:

>Translated_176_residues
MEKKKHFRELFEVFAIACLLAFLAKVFLFFPTTVNGASMRPALEDGDKVIINKLAKRFESYDREDIIVVKTDNFYVKRVI
GLPGDVIEMKNDQLYINHQVHSEPYLEKNRKHAKQLLVHLTEDFGPITVPKNKIFVMGDNRLISRDSRNGLGFIDKKQVL
GTLVAIYYPFHHMKII
>Mature_176_residues
MEKKKHFRELFEVFAIACLLAFLAKVFLFFPTTVNGASMRPALEDGDKVIINKLAKRFESYDREDIIVVKTDNFYVKRVI
GLPGDVIEMKNDQLYINHQVHSEPYLEKNRKHAKQLLVHLTEDFGPITVPKNKIFVMGDNRLISRDSRNGLGFIDKKQVL
GTLVAIYYPFHHMKII

Specific function: Not essential for cell viability, but required for efficient secretion of many proteins [H]

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 20422; Mature: 20422

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKKHFRELFEVFAIACLLAFLAKVFLFFPTTVNGASMRPALEDGDKVIINKLAKRFES
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHHHC
YDREDIIVVKTDNFYVKRVIGLPGDVIEMKNDQLYINHQVHSEPYLEKNRKHAKQLLVHL
CCCCCEEEEECCCEEEEEEECCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
TEDFGPITVPKNKIFVMGDNRLISRDSRNGLGFIDKKQVLGTLVAIYYPFHHMKII
HHCCCCEECCCCEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEC
>Mature Secondary Structure
MEKKKHFRELFEVFAIACLLAFLAKVFLFFPTTVNGASMRPALEDGDKVIINKLAKRFES
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHHHC
YDREDIIVVKTDNFYVKRVIGLPGDVIEMKNDQLYINHQVHSEPYLEKNRKHAKQLLVHL
CCCCCEEEEECCCEEEEEEECCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
TEDFGPITVPKNKIFVMGDNRLISRDSRNGLGFIDKKQVLGTLVAIYYPFHHMKII
HHCCCCEECCCCEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1639057; 7934829; 7876097; 9384377; 8951809; 9823656 [H]