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The map label for this gene is gltR [H]

Identifier: 152974121

GI number: 152974121

Start: 322675

End: 323526

Strand: Direct

Name: gltR [H]

Synonym: Bcer98_0280

Alternate gene names: 152974121

Gene position: 322675-323526 (Clockwise)

Preceding gene: 152974119

Following gene: 152974125

Centisome position: 7.9

GC content: 35.45

Gene sequence:

>852_bases
ATGAATTTACAAGATTTTGTAGCTTTTTATATGGTTGCGCAAGAGAAGAGCATTTCAAAAGCAGCAGTTCGTCTTAATTT
TGTCCAATCGAATGTAACAGCTAAAATAAAAAGATTAGAAGTAGAATACGAAACACAGTTGTTTTATCGCCATCGAAATG
GGGTGACATTAACACATGCAGGAGAAAAGTTACTAATATATGCTGAAAAAATGATTCAATTATTGAATGAGTCAAAAAGA
GATATTAAATATACGATTTTACCAGGGGGGACATTAAAGATTGGAGCGATGGAAACGGCAGCAGCAGTTAGACTGCCAAA
CATTCTTTCTAATTATCATACAAAATATCCAGAAGTTGAGATTGCGCTTCAAACGAATAGCACGGAAGAATTAACGAAAA
AGGTGCTTTTGCATGAGCTTGAAGGAGCATTTGTAGCAAATTGTATAGATGATCCAGCACTCGAAAAAATTGAAGTATTT
CAAGAAGAAATGATGCTGCTGTCAAAGAAAAGTTTGTTACTGGACCATAAGTATATGGAAAATCAGTCGTTTATTGTTTT
CCAATCGGGCTGTTTTTATAGAAAAGTATTGGAAGAATGGCTATTGTCAGAAGGAATTGTTCCGAGGAAAGTGATGGAGT
TAAATTCTTTGGATGGTATTATCGGCTGTGTAAAAGCTGGGCTTGGGGTATCTATACTCCCGAGAGAAGTAGCAGAGCAG
TTCGATTCTCATCAAGAGCTCGTTCGGAAACCGTTATTAAATGAAAATAGATTTATTCCAACGTATTTTATTTATCGGAA
GGATAGTGTGAAAACCGCTACATTTAATGAATTTATCAGACTTCTCGTATAG

Upstream 100 bases:

>100_bases
CTCTTAATACATATGATAGTGGAATATACATAGTGCGTAAAATACTGTTTTTCAATATGTAATATCAAAAATAATGATAT
GAATGAAAGGATGAGAAAAA

Downstream 100 bases:

>100_bases
TATAGGAGAGATAGGGGTTCTAAAATTACTCTTATACTTTTGGAAATTCGATAATTGAAGAGAAGAGACTATATTCATCT
TTAATCATCGCATAGGCAAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MNLQDFVAFYMVAQEKSISKAAVRLNFVQSNVTAKIKRLEVEYETQLFYRHRNGVTLTHAGEKLLIYAEKMIQLLNESKR
DIKYTILPGGTLKIGAMETAAAVRLPNILSNYHTKYPEVEIALQTNSTEELTKKVLLHELEGAFVANCIDDPALEKIEVF
QEEMMLLSKKSLLLDHKYMENQSFIVFQSGCFYRKVLEEWLLSEGIVPRKVMELNSLDGIIGCVKAGLGVSILPREVAEQ
FDSHQELVRKPLLNENRFIPTYFIYRKDSVKTATFNEFIRLLV

Sequences:

>Translated_283_residues
MNLQDFVAFYMVAQEKSISKAAVRLNFVQSNVTAKIKRLEVEYETQLFYRHRNGVTLTHAGEKLLIYAEKMIQLLNESKR
DIKYTILPGGTLKIGAMETAAAVRLPNILSNYHTKYPEVEIALQTNSTEELTKKVLLHELEGAFVANCIDDPALEKIEVF
QEEMMLLSKKSLLLDHKYMENQSFIVFQSGCFYRKVLEEWLLSEGIVPRKVMELNSLDGIIGCVKAGLGVSILPREVAEQ
FDSHQELVRKPLLNENRFIPTYFIYRKDSVKTATFNEFIRLLV
>Mature_283_residues
MNLQDFVAFYMVAQEKSISKAAVRLNFVQSNVTAKIKRLEVEYETQLFYRHRNGVTLTHAGEKLLIYAEKMIQLLNESKR
DIKYTILPGGTLKIGAMETAAAVRLPNILSNYHTKYPEVEIALQTNSTEELTKKVLLHELEGAFVANCIDDPALEKIEVF
QEEMMLLSKKSLLLDHKYMENQSFIVFQSGCFYRKVLEEWLLSEGIVPRKVMELNSLDGIIGCVKAGLGVSILPREVAEQ
FDSHQELVRKPLLNENRFIPTYFIYRKDSVKTATFNEFIRLLV

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787806, Length=284, Percent_Identity=29.5774647887324, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI87082132, Length=288, Percent_Identity=26.3888888888889, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI157672245, Length=280, Percent_Identity=24.2857142857143, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI145693105, Length=288, Percent_Identity=25.6944444444444, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788748, Length=240, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787128, Length=131, Percent_Identity=34.3511450381679, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787879, Length=278, Percent_Identity=25.5395683453237, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790208, Length=249, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787601, Length=281, Percent_Identity=25.2669039145907, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788887, Length=295, Percent_Identity=23.0508474576271, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788481, Length=255, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787589, Length=282, Percent_Identity=27.3049645390071, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081904, Length=305, Percent_Identity=23.2786885245902, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790399, Length=247, Percent_Identity=22.6720647773279, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI2367136, Length=289, Percent_Identity=23.8754325259516, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1788297, Length=248, Percent_Identity=21.7741935483871, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32502; Mature: 32502

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQDFVAFYMVAQEKSISKAAVRLNFVQSNVTAKIKRLEVEYETQLFYRHRNGVTLTHA
CCHHHHHHHHHHHHHHHHHHHHHEEHHHHHCHHEEHHHEEEEHHHEEEEEECCCEEEEEC
GEKLLIYAEKMIQLLNESKRDIKYTILPGGTLKIGAMETAAAVRLPNILSNYHTKYPEVE
CCEEEEEHHHHHHHHCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEE
IALQTNSTEELTKKVLLHELEGAFVANCIDDPALEKIEVFQEEMMLLSKKSLLLDHKYME
EEEECCCHHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NQSFIVFQSGCFYRKVLEEWLLSEGIVPRKVMELNSLDGIIGCVKAGLGVSILPREVAEQ
CCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHH
FDSHQELVRKPLLNENRFIPTYFIYRKDSVKTATFNEFIRLLV
HHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MNLQDFVAFYMVAQEKSISKAAVRLNFVQSNVTAKIKRLEVEYETQLFYRHRNGVTLTHA
CCHHHHHHHHHHHHHHHHHHHHHEEHHHHHCHHEEHHHEEEEHHHEEEEEECCCEEEEEC
GEKLLIYAEKMIQLLNESKRDIKYTILPGGTLKIGAMETAAAVRLPNILSNYHTKYPEVE
CCEEEEEHHHHHHHHCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEE
IALQTNSTEELTKKVLLHELEGAFVANCIDDPALEKIEVFQEEMMLLSKKSLLLDHKYME
EEEECCCHHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NQSFIVFQSGCFYRKVLEEWLLSEGIVPRKVMELNSLDGIIGCVKAGLGVSILPREVAEQ
CCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHH
FDSHQELVRKPLLNENRFIPTYFIYRKDSVKTATFNEFIRLLV
HHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]