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The map label for this gene is prpR [H]

Identifier: 152971519

GI number: 152971519

Start: 3292260

End: 3294047

Strand: Direct

Name: prpR [H]

Synonym: KPN_02992

Alternate gene names: 152971519

Gene position: 3292260-3294047 (Clockwise)

Preceding gene: 152971513

Following gene: 152971521

Centisome position: 61.94

GC content: 65.77

Gene sequence:

>1788_bases
GTGGCAGGCAATCCCTTTCTTCTCGCACCAGAGGTTAATGCGAATCCCCTGCTGAGCGATTCGTGGTCTCGCTGCCAGCG
CTACGGGCTGGATCCCGCCACCGAGGATTTTCCCCGCCTCGGCGCCGGCGAGCTGGCGGACCGGCTCGCCAGCCACCGCG
GCCTGCAGCAGCTGGCGCAGCCGGTGGTGGAAGCCCTGTCGCGCCAGGTCGCAGACCTGCAGTCGGTGGTGATCCTTTCC
GACCCCGACGGCCTGGTGCTGCATACTCTCGGCGATACCCAGGCGCTGCAAAAGGCCCAGCGCGTGGCGCTGGCTCCCGG
CAATCTGTGGAGTGAAAGCGGGCGCGGGACCAACGCCATCGGCACCGCGCTGGCGATTGACGATGGCTGCGAGATCGATG
GCCGTCAGCACTTTCTTACCCGCAACCAGAATCTGTACTGCGCGGCGATGCCGCTCCAGCGACCGGACGGAAGCATCGCC
GGGGTGCTGGATATCTCCGGCCCGGCGAATTTTCCCCACCAGCACACCTTTGGCTGGGTAAAAGCGGCGGCAAAGCAAAT
TGAATATCTGTGGGTGAAACAGAGTATGCATCCTGAGCAGTGGCTGATGAGCCTGCACCGGCAGGTGGACAAACTCGACA
GCGTCGAGGAGCTGCTGCTGGTCTTTTCCGACAACGTCCTCACCGCCGGCAACCGGCTGGCGATGCGCGAGTTCGGCCTG
AGCGCGGCGCAGTTTGGCCAGCTCACCTTTGCCTCGCTTTTTCCGACGCTGACGCAAACGGCGGTCAGCGTCCCGCTGCC
GCTGACCACGCCGCAGGGCCGCTACCATTATCGCCTGCGGGCGCCCACCCGCCGCCGGGTGGCGGTAAGCGCCCCGCCGG
CCATGCATCTCCCCTTTACCAGCCCGCGCGAAGGCGAAAAGCTGCTGCGGCTGCTCAACGCCGGCATCGCGCTCTGTATT
GAGGGGGAAACCGGCAGCGGCAAAGAGTATGTCAGCCGCACGCTGCATCAGCACAGCCGCTGGCGCAGTGGCAAATTTGT
CGCCATCAACTGCGCGGCCATCCCGGAATCGCTGATCGAATCCGAGCTCTTCGGCTACCAGCCGGGGGCGTTTACCGGCG
CCAGCAAAAATGGCTATATCGGTAAAATCCGCGAGGCTGACGGCGGGGTGCTGTTTCTTGATGAGATCGGCGATATGCCG
CTGGCGCTGCAGACCCGCCTCCTGCGCGTCCTGCAGGAGAAAGAGGTCGCTCCGCTGGGCGCCAGCCGCAGCGTGCCGGT
GAATTTCGCCTTGATCTGCGCCACCCACCGCAACCTGACCCAGCGGGTCAGCGCCGGAGAATTCCGTGAAGATCTGCTGT
GGCGTCTGCGGGAATACGCCCTGGCGCTGCCTCCGCTGCGCGAGTGGCCGGCGCTGGAAACCTTTATCGCCACCCTGTGG
CACGACCTGGGCGGTGCTTCACGCCGGGTGACGCTTTCAAACGCGCTGCTGGTTCACCTCAGCCAGCTGCCGTGGCCGGG
AAACGTACGCCAGCTGCAGAGCGTCCTGAAGGTAATGCTGGCTCTCGCCGATGAGGGCGACACGCTGACGCCCGACGCGC
TGCCGGAGGCTTATCGCGCCGCGCCTGCGCCGTTGCCGCGCGGGGGATTGCAGGCCCATGATGAGCAGTTGATTGTCGAT
ACCCTGGCCAGGGTCAACGGCAACGTCAGCCGGGCGGCGCAGATACTGGGTATCGCCCGCAGCACGTTGTACCGCCGTGC
CGCCCGTGCCGGACGGCCTCGTCGCTGA

Upstream 100 bases:

>100_bases
CTGTCGCACGGGTTTCCACTTATGTGTTGCAAATCGCAACACCAAATAAACCAAATGGCTACAATATTGCAACACAGCAA
CATCGACCCAGAGGTGCCCT

Downstream 100 bases:

>100_bases
GGCTATGGCGTAAAGCGCGCCGGTAGCTTGCACGCTGTCGGAAAACCTCCGCCGCCATAGATGGCGGTTATTTCTCTCTG
CGCTAACCAGGTGTTGCGGT

Product: putative helix-turn-helix, Fis-type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MAGNPFLLAPEVNANPLLSDSWSRCQRYGLDPATEDFPRLGAGELADRLASHRGLQQLAQPVVEALSRQVADLQSVVILS
DPDGLVLHTLGDTQALQKAQRVALAPGNLWSESGRGTNAIGTALAIDDGCEIDGRQHFLTRNQNLYCAAMPLQRPDGSIA
GVLDISGPANFPHQHTFGWVKAAAKQIEYLWVKQSMHPEQWLMSLHRQVDKLDSVEELLLVFSDNVLTAGNRLAMREFGL
SAAQFGQLTFASLFPTLTQTAVSVPLPLTTPQGRYHYRLRAPTRRRVAVSAPPAMHLPFTSPREGEKLLRLLNAGIALCI
EGETGSGKEYVSRTLHQHSRWRSGKFVAINCAAIPESLIESELFGYQPGAFTGASKNGYIGKIREADGGVLFLDEIGDMP
LALQTRLLRVLQEKEVAPLGASRSVPVNFALICATHRNLTQRVSAGEFREDLLWRLREYALALPPLREWPALETFIATLW
HDLGGASRRVTLSNALLVHLSQLPWPGNVRQLQSVLKVMLALADEGDTLTPDALPEAYRAAPAPLPRGGLQAHDEQLIVD
TLARVNGNVSRAAQILGIARSTLYRRAARAGRPRR

Sequences:

>Translated_595_residues
MAGNPFLLAPEVNANPLLSDSWSRCQRYGLDPATEDFPRLGAGELADRLASHRGLQQLAQPVVEALSRQVADLQSVVILS
DPDGLVLHTLGDTQALQKAQRVALAPGNLWSESGRGTNAIGTALAIDDGCEIDGRQHFLTRNQNLYCAAMPLQRPDGSIA
GVLDISGPANFPHQHTFGWVKAAAKQIEYLWVKQSMHPEQWLMSLHRQVDKLDSVEELLLVFSDNVLTAGNRLAMREFGL
SAAQFGQLTFASLFPTLTQTAVSVPLPLTTPQGRYHYRLRAPTRRRVAVSAPPAMHLPFTSPREGEKLLRLLNAGIALCI
EGETGSGKEYVSRTLHQHSRWRSGKFVAINCAAIPESLIESELFGYQPGAFTGASKNGYIGKIREADGGVLFLDEIGDMP
LALQTRLLRVLQEKEVAPLGASRSVPVNFALICATHRNLTQRVSAGEFREDLLWRLREYALALPPLREWPALETFIATLW
HDLGGASRRVTLSNALLVHLSQLPWPGNVRQLQSVLKVMLALADEGDTLTPDALPEAYRAAPAPLPRGGLQAHDEQLIVD
TLARVNGNVSRAAQILGIARSTLYRRAARAGRPRR
>Mature_594_residues
AGNPFLLAPEVNANPLLSDSWSRCQRYGLDPATEDFPRLGAGELADRLASHRGLQQLAQPVVEALSRQVADLQSVVILSD
PDGLVLHTLGDTQALQKAQRVALAPGNLWSESGRGTNAIGTALAIDDGCEIDGRQHFLTRNQNLYCAAMPLQRPDGSIAG
VLDISGPANFPHQHTFGWVKAAAKQIEYLWVKQSMHPEQWLMSLHRQVDKLDSVEELLLVFSDNVLTAGNRLAMREFGLS
AAQFGQLTFASLFPTLTQTAVSVPLPLTTPQGRYHYRLRAPTRRRVAVSAPPAMHLPFTSPREGEKLLRLLNAGIALCIE
GETGSGKEYVSRTLHQHSRWRSGKFVAINCAAIPESLIESELFGYQPGAFTGASKNGYIGKIREADGGVLFLDEIGDMPL
ALQTRLLRVLQEKEVAPLGASRSVPVNFALICATHRNLTQRVSAGEFREDLLWRLREYALALPPLREWPALETFIATLWH
DLGGASRRVTLSNALLVHLSQLPWPGNVRQLQSVLKVMLALADEGDTLTPDALPEAYRAAPAPLPRGGLQAHDEQLIVDT
LARVNGNVSRAAQILGIARSTLYRRAARAGRPRR

Specific function: Acts as a transcriptional activator of the acoABCL operon encoding the acetoin dehydrogenase complex [H]

COG id: COG3284

COG function: function code QK; Transcriptional activator of acetoin/glycerol metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1789233, Length=296, Percent_Identity=39.1891891891892, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1786524, Length=291, Percent_Identity=42.9553264604811, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI87082117, Length=304, Percent_Identity=42.4342105263158, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI1789087, Length=288, Percent_Identity=42.3611111111111, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1790299, Length=315, Percent_Identity=39.0476190476191, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI1788905, Length=297, Percent_Identity=39.3939393939394, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1790437, Length=282, Percent_Identity=39.7163120567376, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI1788550, Length=290, Percent_Identity=36.2068965517241, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI87082152, Length=290, Percent_Identity=37.9310344827586, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI87081872, Length=291, Percent_Identity=35.3951890034364, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787583, Length=287, Percent_Identity=33.7979094076655, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI87081858, Length=636, Percent_Identity=23.5849056603774, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1789828, Length=223, Percent_Identity=37.219730941704, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078 [H]

Pfam domain/function: PF02954 HTH_8; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 65142; Mature: 65011

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGNPFLLAPEVNANPLLSDSWSRCQRYGLDPATEDFPRLGAGELADRLASHRGLQQLAQ
CCCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHH
PVVEALSRQVADLQSVVILSDPDGLVLHTLGDTQALQKAQRVALAPGNLWSESGRGTNAI
HHHHHHHHHHHHHHEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHH
GTALAIDDGCEIDGRQHFLTRNQNLYCAAMPLQRPDGSIAGVLDISGPANFPHQHTFGWV
CEEEEECCCCCCCCCHHHEECCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHH
KAAAKQIEYLWVKQSMHPEQWLMSLHRQVDKLDSVEELLLVFSDNVLTAGNRLAMREFGL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCC
SAAQFGQLTFASLFPTLTQTAVSVPLPLTTPQGRYHYRLRAPTRRRVAVSAPPAMHLPFT
CHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEECCCC
SPREGEKLLRLLNAGIALCIEGETGSGKEYVSRTLHQHSRWRSGKFVAINCAAIPESLIE
CCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCHHHHH
SELFGYQPGAFTGASKNGYIGKIREADGGVLFLDEIGDMPLALQTRLLRVLQEKEVAPLG
HHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCC
ASRSVPVNFALICATHRNLTQRVSAGEFREDLLWRLREYALALPPLREWPALETFIATLW
CCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHH
HDLGGASRRVTLSNALLVHLSQLPWPGNVRQLQSVLKVMLALADEGDTLTPDALPEAYRA
HHHCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCHHHHHC
APAPLPRGGLQAHDEQLIVDTLARVNGNVSRAAQILGIARSTLYRRAARAGRPRR
CCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AGNPFLLAPEVNANPLLSDSWSRCQRYGLDPATEDFPRLGAGELADRLASHRGLQQLAQ
CCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHH
PVVEALSRQVADLQSVVILSDPDGLVLHTLGDTQALQKAQRVALAPGNLWSESGRGTNAI
HHHHHHHHHHHHHHEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHH
GTALAIDDGCEIDGRQHFLTRNQNLYCAAMPLQRPDGSIAGVLDISGPANFPHQHTFGWV
CEEEEECCCCCCCCCHHHEECCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHH
KAAAKQIEYLWVKQSMHPEQWLMSLHRQVDKLDSVEELLLVFSDNVLTAGNRLAMREFGL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCC
SAAQFGQLTFASLFPTLTQTAVSVPLPLTTPQGRYHYRLRAPTRRRVAVSAPPAMHLPFT
CHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEECCCC
SPREGEKLLRLLNAGIALCIEGETGSGKEYVSRTLHQHSRWRSGKFVAINCAAIPESLIE
CCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCHHHHH
SELFGYQPGAFTGASKNGYIGKIREADGGVLFLDEIGDMPLALQTRLLRVLQEKEVAPLG
HHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCC
ASRSVPVNFALICATHRNLTQRVSAGEFREDLLWRLREYALALPPLREWPALETFIATLW
CCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHH
HDLGGASRRVTLSNALLVHLSQLPWPGNVRQLQSVLKVMLALADEGDTLTPDALPEAYRA
HHHCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCHHHHHC
APAPLPRGGLQAHDEQLIVDTLARVNGNVSRAAQILGIARSTLYRRAARAGRPRR
CCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377; 10368162 [H]