The gene/protein map for NC_009648 is currently unavailable.
Definition Klebsiella pneumoniae subsp. pneumoniae MGH 78578 chromosome, complete genome.
Accession NC_009648
Length 5,315,120

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The map label for this gene is yvaG [H]

Identifier: 152971507

GI number: 152971507

Start: 3276223

End: 3277017

Strand: Direct

Name: yvaG [H]

Synonym: KPN_02980

Alternate gene names: 152971507

Gene position: 3276223-3277017 (Clockwise)

Preceding gene: 152971506

Following gene: 152971508

Centisome position: 61.64

GC content: 63.77

Gene sequence:

>795_bases
ATGAAAATTGATTTAGCGGGAAAAGTCGCGCTGATCACCGCCTCCACGGCGGGTATTGGCTTCGCCATCGCCAAAGGCCT
GGCGGAGAGCGGCGCAGAGGTTATCCTTAACGGGCGCAGCGAGCAGAGCGTGAACGCCGCGATCGCCCGGCTGCAAAATG
AGGTGCCGGGCGCGAAGGCGCGCCCCGCCATCGCCGACCTCAGCGACGCCGACGGCGCAGCGCAGCTGCTGCGGGCCGTG
ACCGGTGTCGATATTCTGGTCAATAACGCCGGAATCTATGGCCCGCAGGATTTCTACGCCACCGACGACGCGACCTGGGA
CAACTACTGGCAGACCAACGTCATGTCCGGCGTACGCCTGTCGCGGGGGCTGCTCCCGGCGATGGTCAGTAAAGGCTGGG
GGCGGGTGGTGTTTATCTCCTCAGAATCGGCGCGCAATATCCCGGCGGACATGATCCACTATGGCGTCACCAAGACCGCG
CAGCTGTCGCTGGCCCGCGGCCTGGCGAAATATGTCGCCGGCAGCGGAGTGACCGTTAACAGCGTTCTGCCAGGGCCAAC
GATTTCCGACGGCTTTGCCGAAATGCTGAAAGACGAAGTGGCGAAAACCGGTCAGTCGCTGGAGGAACTGGCGAAAGCGT
TTGTCATGACCCATCGTCCGAGCTCGGTGATCCAGCGGGCGGCCTCGGTGGCAGAGGTCGCCAATATGGTGGTCTACGTC
TGCTCGCCGCAGGCGTCAGCCACCTCCGGCGCCGCGCTGCGCGTCGACGGCGGCGTGGTGGATGATATTCTCTGA

Upstream 100 bases:

>100_bases
GCCGCTGAAAAACCTGGTCAATAAGCACGCCGGTTACTGATCCCCGGCTATATCGCCGCTGCTACGCTTAATAGGAGATC
CACAACCAGAAGGCAGGAAC

Downstream 100 bases:

>100_bases
ATCCCCTTTATGCAGGGGAGCCCCCTCCCCTGCCGCCTTCCCGGGCGCTAAAAAGCGCAAAATGTTAAAAAACAGCCGCA
AAGTCGCACAAAGTGAACAG

Product: putative short-chain dehydrogenase/reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKIDLAGKVALITASTAGIGFAIAKGLAESGAEVILNGRSEQSVNAAIARLQNEVPGAKARPAIADLSDADGAAQLLRAV
TGVDILVNNAGIYGPQDFYATDDATWDNYWQTNVMSGVRLSRGLLPAMVSKGWGRVVFISSESARNIPADMIHYGVTKTA
QLSLARGLAKYVAGSGVTVNSVLPGPTISDGFAEMLKDEVAKTGQSLEELAKAFVMTHRPSSVIQRAASVAEVANMVVYV
CSPQASATSGAALRVDGGVVDDIL

Sequences:

>Translated_264_residues
MKIDLAGKVALITASTAGIGFAIAKGLAESGAEVILNGRSEQSVNAAIARLQNEVPGAKARPAIADLSDADGAAQLLRAV
TGVDILVNNAGIYGPQDFYATDDATWDNYWQTNVMSGVRLSRGLLPAMVSKGWGRVVFISSESARNIPADMIHYGVTKTA
QLSLARGLAKYVAGSGVTVNSVLPGPTISDGFAEMLKDEVAKTGQSLEELAKAFVMTHRPSSVIQRAASVAEVANMVVYV
CSPQASATSGAALRVDGGVVDDIL
>Mature_264_residues
MKIDLAGKVALITASTAGIGFAIAKGLAESGAEVILNGRSEQSVNAAIARLQNEVPGAKARPAIADLSDADGAAQLLRAV
TGVDILVNNAGIYGPQDFYATDDATWDNYWQTNVMSGVRLSRGLLPAMVSKGWGRVVFISSESARNIPADMIHYGVTKTA
QLSLARGLAKYVAGSGVTVNSVLPGPTISDGFAEMLKDEVAKTGQSLEELAKAFVMTHRPSSVIQRAASVAEVANMVVYV
CSPQASATSGAALRVDGGVVDDIL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI5031737, Length=259, Percent_Identity=35.5212355212355, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=33.206106870229, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI33667109, Length=199, Percent_Identity=37.6884422110553, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=34.4086021505376, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI126723750, Length=262, Percent_Identity=30.9160305343511, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI7705925, Length=260, Percent_Identity=26.5384615384615, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI19923817, Length=263, Percent_Identity=25.8555133079848, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI66933014, Length=258, Percent_Identity=26.7441860465116, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI109715829, Length=254, Percent_Identity=25.9842519685039, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI142976729, Length=211, Percent_Identity=26.0663507109005, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI7705855, Length=185, Percent_Identity=29.1891891891892, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI10190704, Length=264, Percent_Identity=28.030303030303, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI20149619, Length=156, Percent_Identity=32.6923076923077, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=261, Percent_Identity=30.6513409961686, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787905, Length=266, Percent_Identity=29.6992481203008, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=31.0861423220974, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=27.5193798449612, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI2367365, Length=256, Percent_Identity=29.296875, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786812, Length=262, Percent_Identity=28.6259541984733, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788459, Length=260, Percent_Identity=28.4615384615385, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789378, Length=268, Percent_Identity=29.8507462686567, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789208, Length=259, Percent_Identity=25.0965250965251, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367175, Length=261, Percent_Identity=29.8850574712644, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787820, Length=187, Percent_Identity=28.3422459893048, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789057, Length=263, Percent_Identity=25.8555133079848, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=32.6923076923077, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17561402, Length=266, Percent_Identity=30.8270676691729, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=30.4511278195489, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=30.9433962264151, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=263, Percent_Identity=26.615969581749, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=28.4644194756554, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=26.953125, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=271, Percent_Identity=28.0442804428044, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=27.5471698113208, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17558006, Length=205, Percent_Identity=30.7317073170732, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=270, Percent_Identity=29.2592592592593, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=29.9625468164794, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=269, Percent_Identity=30.1115241635688, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=28.1853281853282, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=273, Percent_Identity=30.4029304029304, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=259, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=268, Percent_Identity=27.9850746268657, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=220, Percent_Identity=30.4545454545455, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992402, Length=208, Percent_Identity=28.3653846153846, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32565532, Length=141, Percent_Identity=29.0780141843972, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=193, Percent_Identity=24.8704663212435, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=31.7829457364341, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21355319, Length=264, Percent_Identity=31.4393939393939, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24644339, Length=263, Percent_Identity=30.4182509505703, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=30.7392996108949, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24643142, Length=258, Percent_Identity=29.4573643410853, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=30.859375, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20129347, Length=210, Percent_Identity=30, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21358495, Length=191, Percent_Identity=29.8429319371728, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639444, Length=262, Percent_Identity=27.4809160305344, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24584748, Length=183, Percent_Identity=29.5081967213115, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161076933, Length=183, Percent_Identity=29.5081967213115, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24647946, Length=198, Percent_Identity=28.7878787878788, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45553409, Length=198, Percent_Identity=28.7878787878788, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24647948, Length=198, Percent_Identity=28.7878787878788, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640442, Length=194, Percent_Identity=31.9587628865979, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24644337, Length=261, Percent_Identity=27.5862068965517, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI18859837, Length=196, Percent_Identity=27.5510204081633, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27349; Mature: 27349

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MKIDLAGKVALITASTAGIGFAIAKGLAESGAEVILNGRSEQSVNAAIARLQNEVPGAKA
CEECCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCC
RPAIADLSDADGAAQLLRAVTGVDILVNNAGIYGPQDFYATDDATWDNYWQTNVMSGVRL
CCCCCCCCCCCHHHHHHHHHHCHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SRGLLPAMVSKGWGRVVFISSESARNIPADMIHYGVTKTAQLSLARGLAKYVAGSGVTVN
HHCHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEE
SVLPGPTISDGFAEMLKDEVAKTGQSLEELAKAFVMTHRPSSVIQRAASVAEVANMVVYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEE
CSPQASATSGAALRVDGGVVDDIL
ECCCCCCCCCCEEEECCCHHHHCC
>Mature Secondary Structure
MKIDLAGKVALITASTAGIGFAIAKGLAESGAEVILNGRSEQSVNAAIARLQNEVPGAKA
CEECCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCC
RPAIADLSDADGAAQLLRAVTGVDILVNNAGIYGPQDFYATDDATWDNYWQTNVMSGVRL
CCCCCCCCCCCHHHHHHHHHHCHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SRGLLPAMVSKGWGRVVFISSESARNIPADMIHYGVTKTAQLSLARGLAKYVAGSGVTVN
HHCHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEE
SVLPGPTISDGFAEMLKDEVAKTGQSLEELAKAFVMTHRPSSVIQRAASVAEVANMVVYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEE
CSPQASATSGAALRVDGGVVDDIL
ECCCCCCCCCCEEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]