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The map label for this gene is tktB [H]

Identifier: 152971330

GI number: 152971330

Start: 3066150

End: 3068144

Strand: Direct

Name: tktB [H]

Synonym: KPN_02799

Alternate gene names: 152971330

Gene position: 3066150-3068144 (Clockwise)

Preceding gene: 152971329

Following gene: 152971334

Centisome position: 57.69

GC content: 61.8

Gene sequence:

>1995_bases
ATGTCCCGAAGAGAGCTTGCCAACGCCATCCGCGCCCTGAGTATGGACGCCGTGCAGAAAGCCAACTCCGGCCACCCCGG
TGCGCCGATGGGGATGGCTGATATTGCCGAAGTGCTGTGGAACGATTTTCTCAAGCACAATCCGCAGAACCCTGACTGGG
TGGACCGCGACCGTTTCATCTTGTCCAACGGCCACGCGTCGATGCTGCTCTACAGTCTGCTGCACCTGACCGGCTACGAT
CTGCCGCTGTCTGAACTGAAGCAGTTCCGTCAGCTGCACTCTAAAACGCCCGGCCACCCGGAGCATGGCTATACCCCTGG
GGTGGAAACCACCACCGGCCCGCTGGGCCAGGGGCTGGCGAACGCCGTCGGGATGGCCATCGCCGAACGGACGCTGGCGG
CGCAGTTTAATCGCCCCGGCCATGAGATCATTGACCATCACACCTGGGTGTTCATGGGCGATGGCTGTTTGATGGAGGGG
ATCTCCCATGAGGCCTGTTCGCTGGCCGGCACGCTCGGACTGGGCAAGCTGATCGGTTTTTACGATCACAACGGCATCTC
CATCGACGGCAAAACCGAAGGCTGGTTTTCCGATGATACGGCGGAACGCTTCCGCGCCTATCACTGGCACGTCATAGGCG
ATATCGACGGCCACGATCCGCAGGCTATCAAACAGGCGATAACGGAAGCGCAGGCGGTGAAAGATAAACCGTCACTGATT
ATCTGCCGGACCATCATCGGCTTCGGTTCGCCCAACAAAGCCGGCTCAGAGGAGTCTCACGGGGCGGCGCTTGGCGAAAA
AGAGGTAGCGCTAGCCCGCCAGCAGCTTGGCTGGAAATATCCTCCGTTCGAGATCCCGAAAGAGATCTACGCGGGCTGGG
ATGCGCGTCCGCGCGGGGAAAAAGCGGAGCACGCCTGGAACGAGAAATTCGCCGCCTACCAGCAGCAGTTCCCGGAGCTG
GCCGCTGAGCTGACCCGACGTATGAATGGCGCCCTGCCGGAAGACTTTGCCGCGACCGCCCGCGACTACGTGGCGAAACT
GCAGGCCGAGCCGGCGAAAATCGCCAGTCGCAAGGCTTCGCAAAACGCGCTGAACGCCTACGGCCCGCACCTTCCGGAAC
TGCTGGGCGGTTCTGCGGATCTTGCGCCGAGTAACCTGACCATCTGGTCTGGATCGACATCGATTAAAGAAGATCCTGCG
GGCAATTATATCCACTACGGGGTGCGCGAGTTTGGCATGACCGCGGTGGCCAACGGCATTGCCCTGCACGGGGGCTTTAT
TCCTTATACCTCGACCTTCCTGATGTTTGTGGAGTACGCCCGCAACGCCGCGCGCATGGCGGCCCTGATGAAGGCCCGGC
AGATCATGGTCTATACCCATGACTCGATCGGTCTTGGGGAAGACGGGCCGACGCACCAGGCGGTGGAACAGCTGGCCAGT
CTGCGGCTGACGCCCAACTTCAGCACCTGGCGCCCCTGCGACCAGGTGGAGACCGCCGTCGCCTGGCAGGCGGCTATCGC
GCGACAGGGCGGGCCGACGGCGCTGATCCTGTCGCGACAAAACCTGGCGCAGATGCCGCGTACCCCGGAACAGGTGCAGG
ATATCGCCCGGGGTGGCTACGTGCTTAAGGATGCCGGCGGAAAACCCGACCTGATCCTCATCGCCACCGGCTCGGAAGTG
GAGATCACCGTCCTGGCCGCGGAAAAACTGTTGGCCAAAGGGGTAAATGTGCGGGTCGTCTCGCTCCCTTCCACTGATGT
GTTTGACGCCCAGGATGAGGCCTGGCGCGAATCGGTGCTGCCGTCGGACGTCAGCGCCCGGGTGGCGGTCGAAGCCGGGA
TAGCGGACTACTGGTATAAATATGTCGGCTTAAAAGGCAAGATCGTCGGCATGACCGGCTATGGCGAATCCGCCCCGGCA
GAGCAGTTGTTCCCGTTCTTTGGCTTTACGGTCGACCATATCGTCGCCACCGCCGAACAGGTGCTTAACGGGTGA

Upstream 100 bases:

>100_bases
GAAAAGCTAGCGGAGGGGATCCGCCTGTTCGCCGTCGATCAGCGCAAACTGGAAGATCTGCTTGCCGCCAAACTGTCACT
TTAGTCTCACGGAGAAAAAT

Downstream 100 bases:

>100_bases
TCCACAGCGTGGGCCAGGCATCTGGCCCCTGCCAGTTGTCGCACGTCGGCTGCTGCGCGTAGCGGGAGAGGCTGAACCGC
TGGCCGTCAAAACGCCAGCG

Product: transketolase

Products: NA

Alternate protein names: TK 2 [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MSRRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPQNPDWVDRDRFILSNGHASMLLYSLLHLTGYD
LPLSELKQFRQLHSKTPGHPEHGYTPGVETTTGPLGQGLANAVGMAIAERTLAAQFNRPGHEIIDHHTWVFMGDGCLMEG
ISHEACSLAGTLGLGKLIGFYDHNGISIDGKTEGWFSDDTAERFRAYHWHVIGDIDGHDPQAIKQAITEAQAVKDKPSLI
ICRTIIGFGSPNKAGSEESHGAALGEKEVALARQQLGWKYPPFEIPKEIYAGWDARPRGEKAEHAWNEKFAAYQQQFPEL
AAELTRRMNGALPEDFAATARDYVAKLQAEPAKIASRKASQNALNAYGPHLPELLGGSADLAPSNLTIWSGSTSIKEDPA
GNYIHYGVREFGMTAVANGIALHGGFIPYTSTFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
LRLTPNFSTWRPCDQVETAVAWQAAIARQGGPTALILSRQNLAQMPRTPEQVQDIARGGYVLKDAGGKPDLILIATGSEV
EITVLAAEKLLAKGVNVRVVSLPSTDVFDAQDEAWRESVLPSDVSARVAVEAGIADYWYKYVGLKGKIVGMTGYGESAPA
EQLFPFFGFTVDHIVATAEQVLNG

Sequences:

>Translated_664_residues
MSRRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPQNPDWVDRDRFILSNGHASMLLYSLLHLTGYD
LPLSELKQFRQLHSKTPGHPEHGYTPGVETTTGPLGQGLANAVGMAIAERTLAAQFNRPGHEIIDHHTWVFMGDGCLMEG
ISHEACSLAGTLGLGKLIGFYDHNGISIDGKTEGWFSDDTAERFRAYHWHVIGDIDGHDPQAIKQAITEAQAVKDKPSLI
ICRTIIGFGSPNKAGSEESHGAALGEKEVALARQQLGWKYPPFEIPKEIYAGWDARPRGEKAEHAWNEKFAAYQQQFPEL
AAELTRRMNGALPEDFAATARDYVAKLQAEPAKIASRKASQNALNAYGPHLPELLGGSADLAPSNLTIWSGSTSIKEDPA
GNYIHYGVREFGMTAVANGIALHGGFIPYTSTFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
LRLTPNFSTWRPCDQVETAVAWQAAIARQGGPTALILSRQNLAQMPRTPEQVQDIARGGYVLKDAGGKPDLILIATGSEV
EITVLAAEKLLAKGVNVRVVSLPSTDVFDAQDEAWRESVLPSDVSARVAVEAGIADYWYKYVGLKGKIVGMTGYGESAPA
EQLFPFFGFTVDHIVATAEQVLNG
>Mature_663_residues
SRRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPQNPDWVDRDRFILSNGHASMLLYSLLHLTGYDL
PLSELKQFRQLHSKTPGHPEHGYTPGVETTTGPLGQGLANAVGMAIAERTLAAQFNRPGHEIIDHHTWVFMGDGCLMEGI
SHEACSLAGTLGLGKLIGFYDHNGISIDGKTEGWFSDDTAERFRAYHWHVIGDIDGHDPQAIKQAITEAQAVKDKPSLII
CRTIIGFGSPNKAGSEESHGAALGEKEVALARQQLGWKYPPFEIPKEIYAGWDARPRGEKAEHAWNEKFAAYQQQFPELA
AELTRRMNGALPEDFAATARDYVAKLQAEPAKIASRKASQNALNAYGPHLPELLGGSADLAPSNLTIWSGSTSIKEDPAG
NYIHYGVREFGMTAVANGIALHGGFIPYTSTFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLASL
RLTPNFSTWRPCDQVETAVAWQAAIARQGGPTALILSRQNLAQMPRTPEQVQDIARGGYVLKDAGGKPDLILIATGSEVE
ITVLAAEKLLAKGVNVRVVSLPSTDVFDAQDEAWRESVLPSDVSARVAVEAGIADYWYKYVGLKGKIVGMTGYGESAPAE
QLFPFFGFTVDHIVATAEQVLNG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=585, Percent_Identity=27.1794871794872, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI4507521, Length=585, Percent_Identity=27.1794871794872, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI133778974, Length=681, Percent_Identity=25.697503671072, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI225637459, Length=671, Percent_Identity=23.0998509687034, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI225637461, Length=567, Percent_Identity=24.3386243386243, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI225637463, Length=567, Percent_Identity=23.9858906525573, Blast_Score=105, Evalue=2e-22,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=83.8368580060423, Blast_Score=1176, Evalue=0.0,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=77.7609682299546, Blast_Score=1097, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=672, Percent_Identity=24.8511904761905, Blast_Score=158, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=667, Percent_Identity=47.8260869565217, Blast_Score=583, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=45.3055141579732, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45551847, Length=597, Percent_Identity=26.9681742043551, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI45550715, Length=597, Percent_Identity=26.9681742043551, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24645119, Length=563, Percent_Identity=26.4653641207815, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24666278, Length=585, Percent_Identity=25.6410256410256, Blast_Score=142, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72170; Mature: 72039

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPQNPDWVDRDRFI
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
LSNGHASMLLYSLLHLTGYDLPLSELKQFRQLHSKTPGHPEHGYTPGVETTTGPLGQGLA
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
NAVGMAIAERTLAAQFNRPGHEIIDHHTWVFMGDGCLMEGISHEACSLAGTLGLGKLIGF
HHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHE
YDHNGISIDGKTEGWFSDDTAERFRAYHWHVIGDIDGHDPQAIKQAITEAQAVKDKPSLI
ECCCCEEECCCCCCCCCCCHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEE
ICRTIIGFGSPNKAGSEESHGAALGEKEVALARQQLGWKYPPFEIPKEIYAGWDARPRGE
EEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCC
KAEHAWNEKFAAYQQQFPELAAELTRRMNGALPEDFAATARDYVAKLQAEPAKIASRKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
QNALNAYGPHLPELLGGSADLAPSNLTIWSGSTSIKEDPAGNYIHYGVREFGMTAVANGI
HHHHHHCCCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHCCE
ALHGGFIPYTSTFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHH
LRLTPNFSTWRPCDQVETAVAWQAAIARQGGPTALILSRQNLAQMPRTPEQVQDIARGGY
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHCCCCHHHHHHHHHCCE
VLKDAGGKPDLILIATGSEVEITVLAAEKLLAKGVNVRVVSLPSTDVFDAQDEAWRESVL
EEECCCCCCCEEEEEECCCEEEEEEEHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHCC
PSDVSARVAVEAGIADYWYKYVGLKGKIVGMTGYGESAPAEQLFPFFGFTVDHIVATAEQ
CCCCCHHEEEHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
VLNG
HHCC
>Mature Secondary Structure 
SRRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPQNPDWVDRDRFI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
LSNGHASMLLYSLLHLTGYDLPLSELKQFRQLHSKTPGHPEHGYTPGVETTTGPLGQGLA
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
NAVGMAIAERTLAAQFNRPGHEIIDHHTWVFMGDGCLMEGISHEACSLAGTLGLGKLIGF
HHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHE
YDHNGISIDGKTEGWFSDDTAERFRAYHWHVIGDIDGHDPQAIKQAITEAQAVKDKPSLI
ECCCCEEECCCCCCCCCCCHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEE
ICRTIIGFGSPNKAGSEESHGAALGEKEVALARQQLGWKYPPFEIPKEIYAGWDARPRGE
EEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCC
KAEHAWNEKFAAYQQQFPELAAELTRRMNGALPEDFAATARDYVAKLQAEPAKIASRKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
QNALNAYGPHLPELLGGSADLAPSNLTIWSGSTSIKEDPAGNYIHYGVREFGMTAVANGI
HHHHHHCCCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHCCE
ALHGGFIPYTSTFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHH
LRLTPNFSTWRPCDQVETAVAWQAAIARQGGPTALILSRQNLAQMPRTPEQVQDIARGGY
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHCCCCHHHHHHHHHCCE
VLKDAGGKPDLILIATGSEVEITVLAAEKLLAKGVNVRVVSLPSTDVFDAQDEAWRESVL
EEECCCCCCCEEEEEECCCEEEEEEEHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHCC
PSDVSARVAVEAGIADYWYKYVGLKGKIVGMTGYGESAPAEQLFPFFGFTVDHIVATAEQ
CCCCCHHEEEHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
VLNG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8396116; 9205837; 9278503 [H]