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The map label for this gene is uge [C]

Identifier: 152971031

GI number: 152971031

Start: 2719961

End: 2720965

Strand: Direct

Name: uge [C]

Synonym: KPN_02492

Alternate gene names: 152971031

Gene position: 2719961-2720965 (Clockwise)

Preceding gene: 152971022

Following gene: 152971037

Centisome position: 51.17

GC content: 55.22

Gene sequence:

>1005_bases
ATGAAGTTTTTGGTCACTGGTGCCGCAGGTTTTATCGGCTTCCATATCGCGCAGCGCCTGCTGAATGAAGGGCATAATGT
TGTCGGAATCGACAACATGAACGACTATTATGACGTCAGCCTGAAGCAGGCCCGTCTGGATCGCCTGGCATATCCGGCAT
TCCATTTCCAGCAGCTGGATCTGGCCGACCGCGAAGGTATGGCAAAGCTGTTCGCCACAGAGCAATTTGATCGTGTGATC
CACCTGGCCGCCCAGGCCGGTGTGCGCTACTCGCTGGAAAACCCGTATGCCTACGCAGACGCTAACCTGATGGGGTATCT
GAACATTCTGGAAGGCTGCCGTCATACCAAGGTGAAACACCTGGTGTACGCCTCCTCCAGCTCGGTTTACGGCCTTAACC
GTAAAATGCCGTTCTCCACCGAAGATTCCGTCGATCATCCGGTCTCCCTGTATGCCGCCACCAAGAAAGCTAATGAGCTG
ATGGCGCACACCTATTCCCACCTGTACGGCATCCCGACTACCGGGCTGCGCTTCTTTACAGTGTATGGTCCGTGGGGTCG
CCCGGATATGGCGCTGTTCAAGTTCACGAAAGCGATGCTGGAAGGAAAAAGCATCGACGTTTACAACTACGGCAAAATGA
AGCGCGACTTCACCTATATCGACGACATCGTCGAGGCGGTGGTTCGGGTGCTGGATGTGATCCCGCAGGCCAATGCCGAC
TGGACCGTTGAGAGCGGTTCCCCGGCCACCAGCTCCGCGCCGTACAGGGTATATAACATTGGCAACAGCTCACCAGTGGA
ACTGATGGACTACATCACTGCCCTGGAAGAGGCGCTGGGGATGGAAGCGCAGAAGAATATGATGCCGATCCAGCCGGGAG
ATGTGCTGGACACCAGCGCAGACACCCAACCGCTGTATGACCTGGTGGGCTTTAAGCCGCAAACTTCAGTGAAGGACGGC
GTGAAGAACTTCGTGGACTGGTACAAGGATTACTATCAGATCTAA

Upstream 100 bases:

>100_bases
AACTCACATCCTGCAACTGTAAAGCAAGTGATCCCAACCGCAAGCCAGTGTAAAATCGGCACTTATGTAGAACGGGATAT
CCACACCCCGGAGGAAAAAT

Downstream 100 bases:

>100_bases
TCCCCCTGCCCTGCCGCAATCGTCAGATTGCGGCACCTCTTCTATGGAACCTCCGTTATCCGGGCTATATGTCGACTGAA
TGCACATTCATTATTTTATA

Product: uridine diphosphate galacturonate 4-epimerase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKFLVTGAAGFIGFHIAQRLLNEGHNVVGIDNMNDYYDVSLKQARLDRLAYPAFHFQQLDLADREGMAKLFATEQFDRVI
HLAAQAGVRYSLENPYAYADANLMGYLNILEGCRHTKVKHLVYASSSSVYGLNRKMPFSTEDSVDHPVSLYAATKKANEL
MAHTYSHLYGIPTTGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIVEAVVRVLDVIPQANAD
WTVESGSPATSSAPYRVYNIGNSSPVELMDYITALEEALGMEAQKNMMPIQPGDVLDTSADTQPLYDLVGFKPQTSVKDG
VKNFVDWYKDYYQI

Sequences:

>Translated_334_residues
MKFLVTGAAGFIGFHIAQRLLNEGHNVVGIDNMNDYYDVSLKQARLDRLAYPAFHFQQLDLADREGMAKLFATEQFDRVI
HLAAQAGVRYSLENPYAYADANLMGYLNILEGCRHTKVKHLVYASSSSVYGLNRKMPFSTEDSVDHPVSLYAATKKANEL
MAHTYSHLYGIPTTGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIVEAVVRVLDVIPQANAD
WTVESGSPATSSAPYRVYNIGNSSPVELMDYITALEEALGMEAQKNMMPIQPGDVLDTSADTQPLYDLVGFKPQTSVKDG
VKNFVDWYKDYYQI
>Mature_334_residues
MKFLVTGAAGFIGFHIAQRLLNEGHNVVGIDNMNDYYDVSLKQARLDRLAYPAFHFQQLDLADREGMAKLFATEQFDRVI
HLAAQAGVRYSLENPYAYADANLMGYLNILEGCRHTKVKHLVYASSSSVYGLNRKMPFSTEDSVDHPVSLYAATKKANEL
MAHTYSHLYGIPTTGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIVEAVVRVLDVIPQANAD
WTVESGSPATSSAPYRVYNIGNSSPVELMDYITALEEALGMEAQKNMMPIQPGDVLDTSADTQPLYDLVGFKPQTSVKDG
VKNFVDWYKDYYQI

Specific function: DTDP-L-RHAMNOSE BIOSYNTHESIS WITHIN THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE BIOSYNTHESIS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=342, Percent_Identity=26.6081871345029, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI42516563, Length=338, Percent_Identity=22.7810650887574, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI56237023, Length=350, Percent_Identity=23.7142857142857, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI56118217, Length=350, Percent_Identity=23.7142857142857, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI189083684, Length=350, Percent_Identity=23.7142857142857, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1788353, Length=355, Percent_Identity=25.9154929577465, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI48994969, Length=349, Percent_Identity=26.9340974212034, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1786974, Length=308, Percent_Identity=25, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788589, Length=248, Percent_Identity=27.4193548387097, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788366, Length=205, Percent_Identity=29.2682926829268, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71982035, Length=351, Percent_Identity=25.9259259259259, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71982038, Length=353, Percent_Identity=25.4957507082153, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17568069, Length=232, Percent_Identity=29.7413793103448, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17539532, Length=339, Percent_Identity=24.7787610619469, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI133901786, Length=245, Percent_Identity=27.3469387755102, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539424, Length=245, Percent_Identity=27.7551020408163, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133901790, Length=245, Percent_Identity=26.9387755102041, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539422, Length=245, Percent_Identity=26.9387755102041, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133901788, Length=245, Percent_Identity=26.9387755102041, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507723, Length=245, Percent_Identity=26.1224489795918, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532424, Length=340, Percent_Identity=22.0588235294118, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=351, Percent_Identity=25.6410256410256, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI19923002, Length=347, Percent_Identity=26.5129682997118, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21356223, Length=341, Percent_Identity=23.7536656891496, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 37584; Mature: 37584

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLVTGAAGFIGFHIAQRLLNEGHNVVGIDNMNDYYDVSLKQARLDRLAYPAFHFQQLD
CEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHCC
LADREGMAKLFATEQFDRVIHLAAQAGVRYSLENPYAYADANLMGYLNILEGCRHTKVKH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHE
LVYASSSSVYGLNRKMPFSTEDSVDHPVSLYAATKKANELMAHTYSHLYGIPTTGLRFFT
EEEECCCCEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
VYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIVEAVVRVLDVIPQANAD
EECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
WTVESGSPATSSAPYRVYNIGNSSPVELMDYITALEEALGMEAQKNMMPIQPGDVLDTSA
EEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCC
DTQPLYDLVGFKPQTSVKDGVKNFVDWYKDYYQI
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFLVTGAAGFIGFHIAQRLLNEGHNVVGIDNMNDYYDVSLKQARLDRLAYPAFHFQQLD
CEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHCC
LADREGMAKLFATEQFDRVIHLAAQAGVRYSLENPYAYADANLMGYLNILEGCRHTKVKH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHE
LVYASSSSVYGLNRKMPFSTEDSVDHPVSLYAATKKANELMAHTYSHLYGIPTTGLRFFT
EEEECCCCEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
VYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIVEAVVRVLDVIPQANAD
EECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
WTVESGSPATSSAPYRVYNIGNSSPVELMDYITALEEALGMEAQKNMMPIQPGDVLDTSA
EEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCC
DTQPLYDLVGFKPQTSVKDGVKNFVDWYKDYYQI
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.019 {NAD+}} 0.034 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: TDP; TTP [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7682279 [H]