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The map label for this gene is sdaA [H]

Identifier: 152970877

GI number: 152970877

Start: 2551481

End: 2552779

Strand: Direct

Name: sdaA [H]

Synonym: KPN_02330

Alternate gene names: 152970877

Gene position: 2551481-2552779 (Clockwise)

Preceding gene: 152970876

Following gene: 152970878

Centisome position: 48.0

GC content: 59.74

Gene sequence:

>1299_bases
ATGAAGGCCGGAAAACAGTTCGTCGATGACCTGGTCGAAAAAGGATTGCTTAATGCAGTGACTCGTGTGGCGGTTGACGT
CTACGGTTCACTGTCATTAACCGGCAAAGGCCACCATACGGACATCGCCATTATCATGGGACTGGCGGGCAATCAGCCCG
ATACGGTCGATATTGACGCGATCCCGGCTTTTATCCGTGACGTCGAAGCGCGCGGTCGTCTGCTGCTGGCCAACGGCCAG
CACGAGGTCGACTTCCCGGCGGATGACGGCATGCGTTTTCGTAGCGACAACCTGCCGCTGCACGAAAACGGCATGACCAT
TCACGCCTGGGCCGGCGAGAAAGAGATCTACTGCAAGACCTACTACTCGATCGGCGGCGGCTTTATTGTCGACGAAGAGC
ACTTCGGCAAGGAAAACGCCAACGAACTGCAGGTGCCCTACCCATTTAAATCGGCGCAGGAAATGCTGGCCTACTGCAAA
GAGACTGGCCTGTCGCTCTCCGGGATGGTGATGCAGAACGAGTTGGCTCTGCACAGCAAAAAAGAGATCGAGGATTATTT
CGCCAACGTCTGGCAGACCATGCGCGCCTGTATCGACCGCGGGATGAACACCGAGGGCGTGCTGCCTGGCCCGCTGCGCG
TACCGCGTCGCGCCTCGGCGCTGCGTCGTCTGCTGGTGGCCAGCGATAAGCTCTCCAGCGATCCAATGAACGTTGTTGAC
TGGGTCAATATGTTCGCGCTGGCGGTCAATGAAGAGAACGCCGCCGGCGGTCGCGTGGTAACCGCGCCGACCAACGGCGC
CTGCGGCATCGTTCCGGCGGTACTCGCCTATTACGATCACTTTATCGAGTCCGTCAGCCCGGAGATCTATATTCGCTACT
TTATGGCCTGCGGGGCGATCGGCGCGCTGTATAAGATGAATGCGTCCATTTCCGGCGCGGAAGTCGGCTGTCAGGGCGAG
GTGGGCGTCGCCTGCTCGATGGCGGCGGCGGGACTGGCTGAACTGCTCGGCGCCAGCCCGGAACAGGTTTGCGTGGCAGC
GGAGATCGGCATGGAACACAACCTCGGCCTGACCTGTGATCCGGTCGCCGGTCAGGTGCAGGTGCCATGCATTGAACGTA
ACGCCATCGCCTCCGTCAAGGCGATCAACGCCGCGCGAATGGCGATGCGCCGCACCAGCGAACCGCGCGTCTCGCTCGAT
AAGGTGATCGAGACCATGTATGAAACCGGTAAAGACATGAACGCCAAGTACCGCGAAACCTCGCGCGGCGGCCTGGCGAT
TAAAGTTCAGTGTGACTAA

Upstream 100 bases:

>100_bases
CCGCACCCGCGGTAACCCTGTCAGGAGTATTATCGTGATTAGTCTATTCGACATGTTCAAGGTGGGGATTGGTCCCTCAT
CTTCCCACACTGTTGGCCCG

Downstream 100 bases:

>100_bases
ACTTTTCGTGCCCCTCTGCGCCCGCAAAGCGCGCAGGGGGATAACCCTGGTGACTGAAATCTCCCTGATGCGCCTTCAAC
GGCGCATTTTCTTTTTTCTA

Product: L-serine deaminase

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKAGKQFVDDLVEKGLLNAVTRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNQPDTVDIDAIPAFIRDVEARGRLLLANGQ
HEVDFPADDGMRFRSDNLPLHENGMTIHAWAGEKEIYCKTYYSIGGGFIVDEEHFGKENANELQVPYPFKSAQEMLAYCK
ETGLSLSGMVMQNELALHSKKEIEDYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRASALRRLLVASDKLSSDPMNVVD
WVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPEIYIRYFMACGAIGALYKMNASISGAEVGCQGE
VGVACSMAAAGLAELLGASPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIASVKAINAARMAMRRTSEPRVSLD
KVIETMYETGKDMNAKYRETSRGGLAIKVQCD

Sequences:

>Translated_432_residues
MKAGKQFVDDLVEKGLLNAVTRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNQPDTVDIDAIPAFIRDVEARGRLLLANGQ
HEVDFPADDGMRFRSDNLPLHENGMTIHAWAGEKEIYCKTYYSIGGGFIVDEEHFGKENANELQVPYPFKSAQEMLAYCK
ETGLSLSGMVMQNELALHSKKEIEDYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRASALRRLLVASDKLSSDPMNVVD
WVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPEIYIRYFMACGAIGALYKMNASISGAEVGCQGE
VGVACSMAAAGLAELLGASPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIASVKAINAARMAMRRTSEPRVSLD
KVIETMYETGKDMNAKYRETSRGGLAIKVQCD
>Mature_432_residues
MKAGKQFVDDLVEKGLLNAVTRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNQPDTVDIDAIPAFIRDVEARGRLLLANGQ
HEVDFPADDGMRFRSDNLPLHENGMTIHAWAGEKEIYCKTYYSIGGGFIVDEEHFGKENANELQVPYPFKSAQEMLAYCK
ETGLSLSGMVMQNELALHSKKEIEDYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRASALRRLLVASDKLSSDPMNVVD
WVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPEIYIRYFMACGAIGALYKMNASISGAEVGCQGE
VGVACSMAAAGLAELLGASPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIASVKAINAARMAMRRTSEPRVSLD
KVIETMYETGKDMNAKYRETSRGGLAIKVQCD

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=432, Percent_Identity=88.8888888888889, Blast_Score=806, Evalue=0.0,
Organism=Escherichia coli, GI1789161, Length=433, Percent_Identity=76.905311778291, Blast_Score=705, Evalue=0.0,
Organism=Escherichia coli, GI48994925, Length=431, Percent_Identity=71.9257540603248, Blast_Score=635, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 46707; Mature: 46707

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAGKQFVDDLVEKGLLNAVTRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNQPDTVDIDA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEEEEEEECCCCCCEEEHHH
IPAFIRDVEARGRLLLANGQHEVDFPADDGMRFRSDNLPLHENGMTIHAWAGEKEIYCKT
HHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEECCCCCEECCCCEEEEECCCCEEEEEE
YYSIGGGFIVDEEHFGKENANELQVPYPFKSAQEMLAYCKETGLSLSGMVMQNELALHSK
EEECCCCEEEEHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCEECEEEHHHHHHHHH
KEIEDYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRASALRRLLVASDKLSSDPMNVVD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
WVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPEIYIRYFMACGAI
HHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGASPEQVCVAAEIGMEHNLGLTCD
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCEEEC
PVAGQVQVPCIERNAIASVKAINAARMAMRRTSEPRVSLDKVIETMYETGKDMNAKYRET
CCCCCEECCEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHCC
SRGGLAIKVQCD
CCCCEEEEEEEC
>Mature Secondary Structure
MKAGKQFVDDLVEKGLLNAVTRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNQPDTVDIDA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEEEEEEECCCCCCEEEHHH
IPAFIRDVEARGRLLLANGQHEVDFPADDGMRFRSDNLPLHENGMTIHAWAGEKEIYCKT
HHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEECCCCCEECCCCEEEEECCCCEEEEEE
YYSIGGGFIVDEEHFGKENANELQVPYPFKSAQEMLAYCKETGLSLSGMVMQNELALHSK
EEECCCCEEEEHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCEECEEEHHHHHHHHH
KEIEDYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRASALRRLLVASDKLSSDPMNVVD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
WVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPEIYIRYFMACGAI
HHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGASPEQVCVAAEIGMEHNLGLTCD
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCEEEC
PVAGQVQVPCIERNAIASVKAINAARMAMRRTSEPRVSLDKVIETMYETGKDMNAKYRET
CCCCCEECCEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHCC
SRGGLAIKVQCD
CCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]