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The map label for this gene is ipk

Identifier: 152970784

GI number: 152970784

Start: 2453231

End: 2454082

Strand: Direct

Name: ipk

Synonym: KPN_02237

Alternate gene names: 152970784

Gene position: 2453231-2454082 (Clockwise)

Preceding gene: 152970783

Following gene: 152970785

Centisome position: 46.16

GC content: 59.98

Gene sequence:

>852_bases
ATGATGACCCGCTGGCCCTCTCCTGCAAAACTGAATCTGTTTTTATATATCACCGGCCAGCGGGCCGATGGTTACCATAC
CCTGCAAACGCTGTTTCAGTTTCTCGATTACGGCGATACGTTGACCATCGAACCGCGTACTGACGGCCAACTGCGCCTGC
TGACGCCGGTGGCCGGCGTGCCGGACGAGGAGAATCTGATCGTTCGCGCCGCGCGTCTGCTGATGCATGCCGCCAGCGAA
AGCGATCGCCTGCCGGCGGGCAGCGGCGCCGATATCAGTATCGATAAGCGCCTGCCGATGGGCGGCGGCCTGGGCGGTGG
CTCCTCCAATGCCGCCACCGTGCTGGTGGCGCTCAACCATCTGTGGGGCTGCGGTCTCTCGGAAGATGAGCTGGCGACTC
TTGGCCTTCAGCTGGGGGCCGATGTGCCGGTTTTCGTGCGCGGCCATGCCGCCTTCGCCGAGGGGGTGGGTGAAATACTG
ACGCCGGTAGAACCCGAGGAAAAATGGTACCTGGTGGCCCACCCGGGGGTCAGTATTCCGACGCCGATCATTTTTCGCGA
TCCGGAGCTACCACGAAATACCCCGCGCCGGTCAATTAATACGTTATTAAATTGTGAATTCAGCAACGATTGCGAGCTTA
TCGCAAGAAAACGTTTTCGCGAGGTTGATGCCGCGCTTTCCTGGCTGTTAGAATATGCGCCGTCACGCCTGACCGGCACA
GGGGCCTGTGTGTTTGCTGAATTTAACACCGAATCCGCTGCCCGTCAGGTGCTGGACACTGCCCCGGCATGGCTAAATGG
CTTTGTGGCGCGCGGAGTTAACCTTTCGCCGCTCAAGCAGGCCCTGCTCTGA

Upstream 100 bases:

>100_bases
GCGGCTACACCAGCGATACCCAGCCAGCCCTACCGTCCAATGTCGAGCTGAACAATGGCGCTCAGCGCATCAAGCTGAAG
ATGGATAACTGGATCGTGAA

Downstream 100 bases:

>100_bases
ATCCTGCGCCGTGATGGCACATTGATAATGAGTCAGCCGGGGAAATTGAGTTACGGTGACAACGTCACCCTGTTCCAGAC
GTTGCATCGTGCTCTTTAAA

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MMTRWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLTIEPRTDGQLRLLTPVAGVPDEENLIVRAARLLMHAASE
SDRLPAGSGADISIDKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSEDELATLGLQLGADVPVFVRGHAAFAEGVGEIL
TPVEPEEKWYLVAHPGVSIPTPIIFRDPELPRNTPRRSINTLLNCEFSNDCELIARKRFREVDAALSWLLEYAPSRLTGT
GACVFAEFNTESAARQVLDTAPAWLNGFVARGVNLSPLKQALL

Sequences:

>Translated_283_residues
MMTRWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLTIEPRTDGQLRLLTPVAGVPDEENLIVRAARLLMHAASE
SDRLPAGSGADISIDKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSEDELATLGLQLGADVPVFVRGHAAFAEGVGEIL
TPVEPEEKWYLVAHPGVSIPTPIIFRDPELPRNTPRRSINTLLNCEFSNDCELIARKRFREVDAALSWLLEYAPSRLTGT
GACVFAEFNTESAARQVLDTAPAWLNGFVARGVNLSPLKQALL
>Mature_283_residues
MMTRWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLTIEPRTDGQLRLLTPVAGVPDEENLIVRAARLLMHAASE
SDRLPAGSGADISIDKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSEDELATLGLQLGADVPVFVRGHAAFAEGVGEIL
TPVEPEEKWYLVAHPGVSIPTPIIFRDPELPRNTPRRSINTLLNCEFSNDCELIARKRFREVDAALSWLLEYAPSRLTGT
GACVFAEFNTESAARQVLDTAPAWLNGFVARGVNLSPLKQALL

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=283, Percent_Identity=84.8056537102474, Blast_Score=480, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_KLEP7 (A6TAP2)

Other databases:

- EMBL:   CP000647
- RefSeq:   YP_001335893.1
- ProteinModelPortal:   A6TAP2
- SMR:   A6TAP2
- STRING:   A6TAP2
- GeneID:   5340024
- GenomeReviews:   CP000647_GR
- KEGG:   kpn:KPN_02237
- eggNOG:   COG1947
- HOGENOM:   HBG734593
- OMA:   LNLFLHV
- ProtClustDB:   PRK00343
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 30689; Mature: 30689

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: ACT_SITE 10-10 ACT_SITE 141-141

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTRWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLTIEPRTDGQLRLLTPVAGV
CCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCC
PDEENLIVRAARLLMHAASESDRLPAGSGADISIDKRLPMGGGLGGGSSNAATVLVALNH
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHEEEHHH
LWGCGLSEDELATLGLQLGADVPVFVRGHAAFAEGVGEILTPVEPEEKWYLVAHPGVSIP
HHCCCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
TPIIFRDPELPRNTPRRSINTLLNCEFSNDCELIARKRFREVDAALSWLLEYAPSRLTGT
CCEEEECCCCCCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GACVFAEFNTESAARQVLDTAPAWLNGFVARGVNLSPLKQALL
CEEEEEECCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure
MMTRWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLTIEPRTDGQLRLLTPVAGV
CCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCC
PDEENLIVRAARLLMHAASESDRLPAGSGADISIDKRLPMGGGLGGGSSNAATVLVALNH
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHEEEHHH
LWGCGLSEDELATLGLQLGADVPVFVRGHAAFAEGVGEILTPVEPEEKWYLVAHPGVSIP
HHCCCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
TPIIFRDPELPRNTPRRSINTLLNCEFSNDCELIARKRFREVDAALSWLLEYAPSRLTGT
CCEEEECCCCCCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GACVFAEFNTESAARQVLDTAPAWLNGFVARGVNLSPLKQALL
CEEEEEECCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA