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The map label for this gene is lldD [H]

Identifier: 152970692

GI number: 152970692

Start: 2346553

End: 2347737

Strand: Direct

Name: lldD [H]

Synonym: KPN_02143

Alternate gene names: 152970692

Gene position: 2346553-2347737 (Clockwise)

Preceding gene: 152970683

Following gene: 152970697

Centisome position: 44.15

GC content: 63.88

Gene sequence:

>1185_bases
ATGATTGTTTCAGCCCCCAGCGATTATCGCGAAGCCGCTCGTCGTCGTCTGCCCCGCTTCCTTTTCGATTATATTGACGG
TGGCGCGGTGGCGGAAAACACCATGAACGCCAACGCCGCCGAGCTTGCCTCGGTAGCTCTTCGCCAGCGCGTACTGTGCG
GGGCCGGCGAACCGACGCTGGCGACCACGATCCTTGATGCCCCATGGGCGATGCCCGTGGCGCTGGGGCCCGTCGGCGCC
ACCGGGATGTACGCCCGCCGCGGCGAAGTCCAGGCGGCCCGCGCCGCCTCCCGCGCCGGGATCCCGTACACCTTATCCAC
CGTGTCGGTCTGCTCGATTGAAGAGGTGGCGAGCCACGCCAGCGGCGCGCTCTGGTCCCAGCTGTACGTGCTCAAAGATC
GCGGCTATATGCGTAACGCGCTGGAGCGCGCCTGGGCCGCTGGCATGAAAACCCTGGTATTTACCGTCGATATGCCAATC
CCCGGCTCGCGGTATCGCGATAACCGCTCAGGGATGTCCGGGCCGCACGCCACCCTGCGACAATATCTCCAGGCTTGCAC
CCATCCGCGCTGGGCGATGAACGTCGGGCTGGCGGGCAGACCCCTGTCGTTTGGTAATATCGAAGCCTACACCGGCCACA
AAATGACCATGGACGACTATATGGGGTTCATCAGCAACAACTTCGACCCGTCCATCGCCTGGCACGATCTGGAGTGGATC
CGCGACAGCTGGCAAGGAAAATTAATCATCAAAGGGATCCTCGATGCCGACGATGCGCGCAATGCCGTGCGGCTGGGCGC
CGATGGTATTGTGGTGTCAAATCATGGCGGCAGACAGCTCGATGGCGCCATCCCCACCGCCCGGGCGCTGCCCAGGGTGG
TGGATGCGGTCGGCGACGATCTGACAGTGCTTGCCGATTCCGGGGTGCGCTCCGGCGTGGACGTTATACGTCTGCTGGCC
CTCGGCGCGAAAGGCGTGCTGCTCGGTCGGGCCTATATTTATGCCCTGGCCGCGGCGGGCGAAGCGGGCGTGGCGCATCT
GCTGCGCTTATTTGCCGAGGATATGAAGGTTACCATGACCCTCACCGGCGCGACCTCGCCATCGGCCATCAGCCTCGATT
GCCTTGATCGCCTCGAACAGGATCAACACCGCACCCATGCGGTGCCGGTATCCTTACCCGCCTGA

Upstream 100 bases:

>100_bases
CTGGAATGCTAATATTTCATTTCCTCGCCGGTTTTTAGAGGCCTATAGTTTTTTTACCTGCAGAACATCCACTAAGGTTA
AAAAACATAAGGACATAATA

Downstream 100 bases:

>100_bases
CCCTGCCCGGGACCTGGCCTGGCCATGTGCCTCGCCCAGGTCCGGCAAAGTGGAATTACCTCTGAAGGTGCAACTCTGTC
TGTTGTACCGTGTTCTCCGG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MIVSAPSDYREAARRRLPRFLFDYIDGGAVAENTMNANAAELASVALRQRVLCGAGEPTLATTILDAPWAMPVALGPVGA
TGMYARRGEVQAARAASRAGIPYTLSTVSVCSIEEVASHASGALWSQLYVLKDRGYMRNALERAWAAGMKTLVFTVDMPI
PGSRYRDNRSGMSGPHATLRQYLQACTHPRWAMNVGLAGRPLSFGNIEAYTGHKMTMDDYMGFISNNFDPSIAWHDLEWI
RDSWQGKLIIKGILDADDARNAVRLGADGIVVSNHGGRQLDGAIPTARALPRVVDAVGDDLTVLADSGVRSGVDVIRLLA
LGAKGVLLGRAYIYALAAAGEAGVAHLLRLFAEDMKVTMTLTGATSPSAISLDCLDRLEQDQHRTHAVPVSLPA

Sequences:

>Translated_394_residues
MIVSAPSDYREAARRRLPRFLFDYIDGGAVAENTMNANAAELASVALRQRVLCGAGEPTLATTILDAPWAMPVALGPVGA
TGMYARRGEVQAARAASRAGIPYTLSTVSVCSIEEVASHASGALWSQLYVLKDRGYMRNALERAWAAGMKTLVFTVDMPI
PGSRYRDNRSGMSGPHATLRQYLQACTHPRWAMNVGLAGRPLSFGNIEAYTGHKMTMDDYMGFISNNFDPSIAWHDLEWI
RDSWQGKLIIKGILDADDARNAVRLGADGIVVSNHGGRQLDGAIPTARALPRVVDAVGDDLTVLADSGVRSGVDVIRLLA
LGAKGVLLGRAYIYALAAAGEAGVAHLLRLFAEDMKVTMTLTGATSPSAISLDCLDRLEQDQHRTHAVPVSLPA
>Mature_394_residues
MIVSAPSDYREAARRRLPRFLFDYIDGGAVAENTMNANAAELASVALRQRVLCGAGEPTLATTILDAPWAMPVALGPVGA
TGMYARRGEVQAARAASRAGIPYTLSTVSVCSIEEVASHASGALWSQLYVLKDRGYMRNALERAWAAGMKTLVFTVDMPI
PGSRYRDNRSGMSGPHATLRQYLQACTHPRWAMNVGLAGRPLSFGNIEAYTGHKMTMDDYMGFISNNFDPSIAWHDLEWI
RDSWQGKLIIKGILDADDARNAVRLGADGIVVSNHGGRQLDGAIPTARALPRVVDAVGDDLTVLADSGVRSGVDVIRLLA
LGAKGVLLGRAYIYALAAAGEAGVAHLLRLFAEDMKVTMTLTGATSPSAISLDCLDRLEQDQHRTHAVPVSLPA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=367, Percent_Identity=35.6948228882834, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI54234014, Length=372, Percent_Identity=33.8709677419355, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI7705393, Length=372, Percent_Identity=33.8709677419355, Blast_Score=195, Evalue=5e-50,
Organism=Escherichia coli, GI1790033, Length=375, Percent_Identity=64.5333333333333, Blast_Score=494, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI193208036, Length=385, Percent_Identity=31.6883116883117, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI32566217, Length=288, Percent_Identity=30.5555555555556, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=396, Percent_Identity=28.2828282828283, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI281363140, Length=373, Percent_Identity=33.2439678284182, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI78707190, Length=373, Percent_Identity=33.2439678284182, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI78707188, Length=373, Percent_Identity=33.2439678284182, Blast_Score=195, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42243; Mature: 42243

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVSAPSDYREAARRRLPRFLFDYIDGGAVAENTMNANAAELASVALRQRVLCGAGEPTL
CEECCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHH
ATTILDAPWAMPVALGPVGATGMYARRGEVQAARAASRAGIPYTLSTVSVCSIEEVASHA
HHEECCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEECHHHHHHHHHHHHHH
SGALWSQLYVLKDRGYMRNALERAWAAGMKTLVFTVDMPIPGSRYRDNRSGMSGPHATLR
CCHHHHHEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHH
QYLQACTHPRWAMNVGLAGRPLSFGNIEAYTGHKMTMDDYMGFISNNFDPSIAWHDLEWI
HHHHHHCCCCEEEECCCCCCCCCCCCEEEECCCEEEHHHHHHHHHCCCCCCEEHHHHHHH
RDSWQGKLIIKGILDADDARNAVRLGADGIVVSNHGGRQLDGAIPTARALPRVVDAVGDD
HHCCCCEEEEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
LTVLADSGVRSGVDVIRLLALGAKGVLLGRAYIYALAAAGEAGVAHLLRLFAEDMKVTMT
EEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEE
LTGATSPSAISLDCLDRLEQDQHRTHAVPVSLPA
EECCCCCCEEEHHHHHHHHHHHHHHEECEEECCC
>Mature Secondary Structure
MIVSAPSDYREAARRRLPRFLFDYIDGGAVAENTMNANAAELASVALRQRVLCGAGEPTL
CEECCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHH
ATTILDAPWAMPVALGPVGATGMYARRGEVQAARAASRAGIPYTLSTVSVCSIEEVASHA
HHEECCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEECHHHHHHHHHHHHHH
SGALWSQLYVLKDRGYMRNALERAWAAGMKTLVFTVDMPIPGSRYRDNRSGMSGPHATLR
CCHHHHHEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHH
QYLQACTHPRWAMNVGLAGRPLSFGNIEAYTGHKMTMDDYMGFISNNFDPSIAWHDLEWI
HHHHHHCCCCEEEECCCCCCCCCCCCEEEECCCEEEHHHHHHHHHCCCCCCEEHHHHHHH
RDSWQGKLIIKGILDADDARNAVRLGADGIVVSNHGGRQLDGAIPTARALPRVVDAVGDD
HHCCCCEEEEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
LTVLADSGVRSGVDVIRLLALGAKGVLLGRAYIYALAAAGEAGVAHLLRLFAEDMKVTMT
EEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEE
LTGATSPSAISLDCLDRLEQDQHRTHAVPVSLPA
EECCCCCCEEEHHHHHHHHHHHHHHEECEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA