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The map label for this gene is phoP [H]

Identifier: 152970615

GI number: 152970615

Start: 2264472

End: 2265209

Strand: Direct

Name: phoP [H]

Synonym: KPN_02066

Alternate gene names: 152970615

Gene position: 2264472-2265209 (Clockwise)

Preceding gene: 152970611

Following gene: 152970616

Centisome position: 42.6

GC content: 46.48

Gene sequence:

>738_bases
ATGCATGTTGTCATCAGCACTGTGGAAGAAAATATGAACAACAACAATCTGATTATCGTCGCAGAAGACGATGATGACAT
CGCTGCCATACTGACAGGCTATTTACGTAAGGCAGGTATGAAAACCTTAAGAGCCGAAGACGGTGAGCAGGCAATCAATC
TTACCCGTCTGAACAAGCCTGATCTCCTGCTATTGGACATCCACCTGCCCGTGTACGATGGCTGGAATGTTCTCACCACG
TTAAGAAAGGAAACGAATGTACCGGTCATCATGGTGACAGCACTGGATCAAGACGTTGATAAACTGATGGGGCTACGGCT
CGGGGCTGACGACTATGTGATAAAACCCTTCAATCCATCTGAGGTTATTGCCCGGGTTGAAGCTGTGCTTCGCAGAACCA
GACCGGTTGCAGAGTCTACACATTCACGGCCTTTAAGAACGCCTTTTTTAACGATTTATCCTGATGAGTTTTACGTTGAA
ATCACTGCACAAGGTGAGGTTTCCACGCCAGTATTAACCACCACTGAGTTTAAGCTTTTAACCTATTTGGCGAGAAACCC
GAGAAAAGTCTGTTCACGTGAAGAGTTACTCGATGCGTGTTTACCTGAGGGAGACTCGCTGGATCGTACTGTAGACAGTC
ATATGAGTAAACTTCGGAAAAAGCTTGAACATGCCGGATTGAAGGGCATTCCGGAAAGCATCCGAGGATTAGGCTACCGG
TTGGGTGACAAAAAATGA

Upstream 100 bases:

>100_bases
TTCCAAAAAGTACCTGTCAAAAGACATCAAATTGAAAATTAATGTTTGTAATTGAGTTAAAGAGCTTTAAGCATGACGAT
AAAAGTGCTTTCAGGGTAAA

Downstream 100 bases:

>100_bases
ACAAAGAAACGATTCTGAGCCGTCAGATTTTGACATATATGTTGTTGTTAACGTTTGTTATTATTGCCATTGCAATACTC
GGTTCCTACCTATTTTATAG

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MHVVISTVEENMNNNNLIIVAEDDDDIAAILTGYLRKAGMKTLRAEDGEQAINLTRLNKPDLLLLDIHLPVYDGWNVLTT
LRKETNVPVIMVTALDQDVDKLMGLRLGADDYVIKPFNPSEVIARVEAVLRRTRPVAESTHSRPLRTPFLTIYPDEFYVE
ITAQGEVSTPVLTTTEFKLLTYLARNPRKVCSREELLDACLPEGDSLDRTVDSHMSKLRKKLEHAGLKGIPESIRGLGYR
LGDKK

Sequences:

>Translated_245_residues
MHVVISTVEENMNNNNLIIVAEDDDDIAAILTGYLRKAGMKTLRAEDGEQAINLTRLNKPDLLLLDIHLPVYDGWNVLTT
LRKETNVPVIMVTALDQDVDKLMGLRLGADDYVIKPFNPSEVIARVEAVLRRTRPVAESTHSRPLRTPFLTIYPDEFYVE
ITAQGEVSTPVLTTTEFKLLTYLARNPRKVCSREELLDACLPEGDSLDRTVDSHMSKLRKKLEHAGLKGIPESIRGLGYR
LGDKK
>Mature_245_residues
MHVVISTVEENMNNNNLIIVAEDDDDIAAILTGYLRKAGMKTLRAEDGEQAINLTRLNKPDLLLLDIHLPVYDGWNVLTT
LRKETNVPVIMVTALDQDVDKLMGLRLGADDYVIKPFNPSEVIARVEAVLRRTRPVAESTHSRPLRTPFLTIYPDEFYVE
ITAQGEVSTPVLTTTEFKLLTYLARNPRKVCSREELLDACLPEGDSLDRTVDSHMSKLRKKLEHAGLKGIPESIRGLGYR
LGDKK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=36.5217391304348, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1786599, Length=234, Percent_Identity=36.7521367521368, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=34.468085106383, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=35.9649122807018, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=36.3636363636364, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=32.7354260089686, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=31.6964285714286, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=32.0512820512821, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.8947368421053, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=30.0884955752212, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=30.6034482758621, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=35.2173913043478, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787229, Length=212, Percent_Identity=32.0754716981132, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790552, Length=182, Percent_Identity=33.5164835164835, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=36.6071428571429, Blast_Score=71, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27534; Mature: 27534

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVVISTVEENMNNNNLIIVAEDDDDIAAILTGYLRKAGMKTLRAEDGEQAINLTRLNKP
CEEEEEEHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
DLLLLDIHLPVYDGWNVLTTLRKETNVPVIMVTALDQDVDKLMGLRLGADDYVIKPFNPS
CEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCEECCCCEEECCCCHH
EVIARVEAVLRRTRPVAESTHSRPLRTPFLTIYPDEFYVEITAQGEVSTPVLTTTEFKLL
HHHHHHHHHHHHCCCHHHCCCCCCCCCCEEEEECCEEEEEEEECCCCCCCEEECHHHHHH
TYLARNPRKVCSREELLDACLPEGDSLDRTVDSHMSKLRKKLEHAGLKGIPESIRGLGYR
HHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHH
LGDKK
CCCCC
>Mature Secondary Structure
MHVVISTVEENMNNNNLIIVAEDDDDIAAILTGYLRKAGMKTLRAEDGEQAINLTRLNKP
CEEEEEEHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
DLLLLDIHLPVYDGWNVLTTLRKETNVPVIMVTALDQDVDKLMGLRLGADDYVIKPFNPS
CEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCEECCCCEEECCCCHH
EVIARVEAVLRRTRPVAESTHSRPLRTPFLTIYPDEFYVEITAQGEVSTPVLTTTEFKLL
HHHHHHHHHHHHCCCHHHCCCCCCCCCCEEEEECCEEEEEEEECCCCCCCEEECHHHHHH
TYLARNPRKVCSREELLDACLPEGDSLDRTVDSHMSKLRKKLEHAGLKGIPESIRGLGYR
HHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHH
LGDKK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]