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The map label for this gene is hbd [H]

Identifier: 152970605

GI number: 152970605

Start: 2250371

End: 2251294

Strand: Direct

Name: hbd [H]

Synonym: KPN_02056

Alternate gene names: 152970605

Gene position: 2250371-2251294 (Clockwise)

Preceding gene: 152970604

Following gene: 152970606

Centisome position: 42.34

GC content: 68.61

Gene sequence:

>924_bases
ATGTTTACACCACGCCTGGCGGTACTCGGCGCGGGACTGATGGGCGTCGGTATCGCCTGCCATTTCGCCCGTCACGGTCA
CGCCGTCCGCCTGTATGACACCGACCCGCAGCGTCTCGCCGAGGTTCCGGCAGTGGCCAGCGCCATCCTGTGCGAGCTGG
AGGCCAGCAGTCAACAGGATCCCGCCGACCGCGACGCGGTGCTGGCCCGTCTGACCCCCACCCCGACGCTGAATGCCCTG
GCCGATGCCACGCTGCTGATTGAAGCGATCCCCGAACGGCTGGCGCTGAAGCACGCCCTGTACGCCGAGCTGGAAACGCT
GATCGCCGACGAGGCGATTATCGCCAGCAACACCAGCGGCCTGCCGCCGGATCGGCTGGCGCAGGGCATGCGCCTCCCGG
AACGGCTACTGATCGCTCATTTCTGGCATCCGCCGCACCTGATCCCGCTGGTGGAAGTGGTGCCCGGGAGCGCCACGCTG
CCTCATCTGGCACGCCAGGTGAGCGACTTTTGCGCCGCCTGCGCGCTGGAGGCGGTGGTGCTCAACCGCGCCGCGCCGGG
CTTTGTCGGCAACCGGCTGCAGTTCGCCCTGCTGCGCGAAGCGTTGCATATCGTCCACAGCGGCATCGCTTCCCCGGAGG
TGGTGGACCAGGTGATGCGCGCCTCGCTGGGCCGCCGCTATGCGATGGTCGGCCCGCTGGAGGCTGCGGACATGACCGGC
CTGGCGACAGTCCAGGATATCTGCCAGCACCTGCTGCCGGAGCTGGCCAGCGGCACGGAGATGATGTCGCTGGTGGCGGA
GAAAGTGGCGCGAGGCGACACCGGCGCCCGCAGCGGGCAAGGCTTTTACCGCTGGGACGAAGCCCGGCACCAACGCATCC
AGTCGCGCCGGGAACACCAGCTGCGCTTCGCCCTGAAACCCTAG

Upstream 100 bases:

>100_bases
ATGAGATGCAGCGCCGGGGCGCCAGCAAAGGGCTTGCCACCCTGTGCGTCGGCGGCGGCCAGGGCATCGCCATGACTCTA
CAACGTTAACAGGAGCCACT

Downstream 100 bases:

>100_bases
TATCGCGTTCTGTACCCCTACAATAACAATGAGAGTGAGACGTCGTGATGAGTGTGATAATAGCCCTGGCCGCGCTGGCG
TTACTGATGCTGGCAGCCTA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MFTPRLAVLGAGLMGVGIACHFARHGHAVRLYDTDPQRLAEVPAVASAILCELEASSQQDPADRDAVLARLTPTPTLNAL
ADATLLIEAIPERLALKHALYAELETLIADEAIIASNTSGLPPDRLAQGMRLPERLLIAHFWHPPHLIPLVEVVPGSATL
PHLARQVSDFCAACALEAVVLNRAAPGFVGNRLQFALLREALHIVHSGIASPEVVDQVMRASLGRRYAMVGPLEAADMTG
LATVQDICQHLLPELASGTEMMSLVAEKVARGDTGARSGQGFYRWDEARHQRIQSRREHQLRFALKP

Sequences:

>Translated_307_residues
MFTPRLAVLGAGLMGVGIACHFARHGHAVRLYDTDPQRLAEVPAVASAILCELEASSQQDPADRDAVLARLTPTPTLNAL
ADATLLIEAIPERLALKHALYAELETLIADEAIIASNTSGLPPDRLAQGMRLPERLLIAHFWHPPHLIPLVEVVPGSATL
PHLARQVSDFCAACALEAVVLNRAAPGFVGNRLQFALLREALHIVHSGIASPEVVDQVMRASLGRRYAMVGPLEAADMTG
LATVQDICQHLLPELASGTEMMSLVAEKVARGDTGARSGQGFYRWDEARHQRIQSRREHQLRFALKP
>Mature_307_residues
MFTPRLAVLGAGLMGVGIACHFARHGHAVRLYDTDPQRLAEVPAVASAILCELEASSQQDPADRDAVLARLTPTPTLNAL
ADATLLIEAIPERLALKHALYAELETLIADEAIIASNTSGLPPDRLAQGMRLPERLLIAHFWHPPHLIPLVEVVPGSATL
PHLARQVSDFCAACALEAVVLNRAAPGFVGNRLQFALLREALHIVHSGIASPEVVDQVMRASLGRRYAMVGPLEAADMTG
LATVQDICQHLLPELASGTEMMSLVAEKVARGDTGARSGQGFYRWDEARHQRIQSRREHQLRFALKP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=274, Percent_Identity=30.6569343065693, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI296179429, Length=292, Percent_Identity=30.8219178082192, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=29.0102389078498, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=29.0102389078498, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI20127408, Length=297, Percent_Identity=27.6094276094276, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI296179427, Length=309, Percent_Identity=29.126213592233, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1787661, Length=291, Percent_Identity=32.9896907216495, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788682, Length=267, Percent_Identity=28.0898876404494, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1790281, Length=292, Percent_Identity=27.7397260273973, Blast_Score=82, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17553560, Length=303, Percent_Identity=30.3630363036304, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17549919, Length=294, Percent_Identity=30.6122448979592, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17563036, Length=293, Percent_Identity=27.6450511945392, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71985923, Length=312, Percent_Identity=27.2435897435897, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71985930, Length=296, Percent_Identity=26.0135135135135, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI25144276, Length=292, Percent_Identity=26.3698630136986, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17508953, Length=292, Percent_Identity=26.3698630136986, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17508951, Length=293, Percent_Identity=26.2798634812287, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI193203623, Length=179, Percent_Identity=33.5195530726257, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI115533614, Length=179, Percent_Identity=33.5195530726257, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17558304, Length=313, Percent_Identity=24.6006389776358, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129993, Length=259, Percent_Identity=33.976833976834, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI45549573, Length=245, Percent_Identity=31.8367346938775, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI19921000, Length=292, Percent_Identity=27.7397260273973, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24583077, Length=292, Percent_Identity=27.7397260273973, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24583079, Length=292, Percent_Identity=27.7397260273973, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33251; Mature: 33251

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTPRLAVLGAGLMGVGIACHFARHGHAVRLYDTDPQRLAEVPAVASAILCELEASSQQD
CCCCHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCC
PADRDAVLARLTPTPTLNALADATLLIEAIPERLALKHALYAELETLIADEAIIASNTSG
CCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCC
LPPDRLAQGMRLPERLLIAHFWHPPHLIPLVEVVPGSATLPHLARQVSDFCAACALEAVV
CCHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LNRAAPGFVGNRLQFALLREALHIVHSGIASPEVVDQVMRASLGRRYAMVGPLEAADMTG
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHH
LATVQDICQHLLPELASGTEMMSLVAEKVARGDTGARSGQGFYRWDEARHQRIQSRREHQ
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LRFALKP
HHCCCCC
>Mature Secondary Structure
MFTPRLAVLGAGLMGVGIACHFARHGHAVRLYDTDPQRLAEVPAVASAILCELEASSQQD
CCCCHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCC
PADRDAVLARLTPTPTLNALADATLLIEAIPERLALKHALYAELETLIADEAIIASNTSG
CCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCC
LPPDRLAQGMRLPERLLIAHFWHPPHLIPLVEVVPGSATLPHLARQVSDFCAACALEAVV
CCHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LNRAAPGFVGNRLQFALLREALHIVHSGIASPEVVDQVMRASLGRRYAMVGPLEAADMTG
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHH
LATVQDICQHLLPELASGTEMMSLVAEKVARGDTGARSGQGFYRWDEARHQRIQSRREHQ
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LRFALKP
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]