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The map label for this gene is fabF [H]

Identifier: 152970329

GI number: 152970329

Start: 1958692

End: 1959966

Strand: Direct

Name: fabF [H]

Synonym: KPN_01777

Alternate gene names: 152970329

Gene position: 1958692-1959966 (Clockwise)

Preceding gene: 152970328

Following gene: 152970330

Centisome position: 36.85

GC content: 64.78

Gene sequence:

>1275_bases
ATGGGCGTTTCCGTTAAACGCATTGTCGTCACCGGGATGGGGATTGTCAGCCCGCTGGGCTGCGGCGTACAGCACGTCTG
GCAGTCGCTGCTGGCAGGTAAATCAGGGGTCACCCGGCTCAGCGAGCAGCTGGTCGCGGATATTCCCTGCAAAGTGGCCG
GCCAGGTGCCGTCCATTGACAGCGATCCGCTGCACGGCTTCGACCCGCTGGCGACCATCCCGGCGAAAGAGCGCAAAAAA
ATGGATCGCTTTATCGAGTTTGCGCTGGTCGCCGCCCGCGAAGCGCTGACCCAGGCCGGTTGGGCGCCGGCATCAATGGC
CGAACAGGAACGTACCGCCACGGTGATCGCCACCGGGATCGGTGGCTTCAGCGAGATCGCCAATGCGGTACATACCACCG
ATGAACGTGGGCCGCGTCGTCTCTCGCCGTTCACTATCCCCTCTTTTCTGGCCAACCTGGCTGCCGGGCATGTGTCTATC
GCCCACGGCTTCCGGGGCCCCATCGGCGCGCCGGTCACCGCCTGCGCAGCGGGTGCCCAGGCCATCGGCGATGCAGCGCG
GATGATCCGCAGCGGCGAGGCGGATATTGCCCTCTGCGGCGGCGCGGAAGCGGCAATTCATCGCGTTAGCCTGGCCGGGT
TTGCCGCGGCAAGGGCGCTGTCCAGCGCCTACAGCGACCAGCCGGAAAGCGCTTCCCGCCCCTTTGACCGTGACCGCGAT
GGTTTTGTGATGGGAGAAGGCGCCGGGCTTATTGTGATCGAATCTCTGGAGCACGCGCTGGCGCGCGGGGCCACGCCGCT
GGCCGAGCTGGTGGGCTACGGCACCAGCGCAGATGCTTATCACCTGACCGCAGGCCCGGAAGACGGGAACGGCGCACGTC
GGGCCATGGAGATCGCTATTCGCCAGGCCGGGGTGACCGTCGAAGAGATTGATCATATCAATGCCCACGCTACCTCGACG
CAGGTCGGTGATAAAGGCGAGCTGGCGGCGATTAAAACGCTGTTTGGCGCGCATCCGGTCGCCATTACCTCGACGAAATC
CGCCACCGGCCATCTGTTAGGCGCGGCCGGCGGGATCGAGGCCATCTTCACCATTCAGGCCCTGCGTGACCAGGTGGTGC
CGCCGACGCTGAACCTGCATCACCCCGATGAAGACGCGGCAGGCATGAACCTGGTGGCGCTGCAGGCCCGCCCGCAGAAG
ATGCGTTATGCGCTGTCGAACGGTTTTGGCTTTGGCGGCGTTAACGCCAGCCTGCTGCTGAAACGCTGGGAATAA

Upstream 100 bases:

>100_bases
GATGCTTTCTACCTCATCATGATGGGTTTTTTGCTTGCCGCGCTGCTGGTTCCCTTGATGAAAAAGCCGCCGGCACACTG
ATACTACAGGAGAGTTAACT

Downstream 100 bases:

>100_bases
TCGTCAACTCCCCCGCGGTACTGGCCGACGGGGGATTTCCACCGTTGCGGCTTTTGCCCTGCTGCTGGAGTAAATCAAGT
ACAACGCAATACCCAGGGAG

Product: putative beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MGVSVKRIVVTGMGIVSPLGCGVQHVWQSLLAGKSGVTRLSEQLVADIPCKVAGQVPSIDSDPLHGFDPLATIPAKERKK
MDRFIEFALVAAREALTQAGWAPASMAEQERTATVIATGIGGFSEIANAVHTTDERGPRRLSPFTIPSFLANLAAGHVSI
AHGFRGPIGAPVTACAAGAQAIGDAARMIRSGEADIALCGGAEAAIHRVSLAGFAAARALSSAYSDQPESASRPFDRDRD
GFVMGEGAGLIVIESLEHALARGATPLAELVGYGTSADAYHLTAGPEDGNGARRAMEIAIRQAGVTVEEIDHINAHATST
QVGDKGELAAIKTLFGAHPVAITSTKSATGHLLGAAGGIEAIFTIQALRDQVVPPTLNLHHPDEDAAGMNLVALQARPQK
MRYALSNGFGFGGVNASLLLKRWE

Sequences:

>Translated_424_residues
MGVSVKRIVVTGMGIVSPLGCGVQHVWQSLLAGKSGVTRLSEQLVADIPCKVAGQVPSIDSDPLHGFDPLATIPAKERKK
MDRFIEFALVAAREALTQAGWAPASMAEQERTATVIATGIGGFSEIANAVHTTDERGPRRLSPFTIPSFLANLAAGHVSI
AHGFRGPIGAPVTACAAGAQAIGDAARMIRSGEADIALCGGAEAAIHRVSLAGFAAARALSSAYSDQPESASRPFDRDRD
GFVMGEGAGLIVIESLEHALARGATPLAELVGYGTSADAYHLTAGPEDGNGARRAMEIAIRQAGVTVEEIDHINAHATST
QVGDKGELAAIKTLFGAHPVAITSTKSATGHLLGAAGGIEAIFTIQALRDQVVPPTLNLHHPDEDAAGMNLVALQARPQK
MRYALSNGFGFGGVNASLLLKRWE
>Mature_423_residues
GVSVKRIVVTGMGIVSPLGCGVQHVWQSLLAGKSGVTRLSEQLVADIPCKVAGQVPSIDSDPLHGFDPLATIPAKERKKM
DRFIEFALVAAREALTQAGWAPASMAEQERTATVIATGIGGFSEIANAVHTTDERGPRRLSPFTIPSFLANLAAGHVSIA
HGFRGPIGAPVTACAAGAQAIGDAARMIRSGEADIALCGGAEAAIHRVSLAGFAAARALSSAYSDQPESASRPFDRDRDG
FVMGEGAGLIVIESLEHALARGATPLAELVGYGTSADAYHLTAGPEDGNGARRAMEIAIRQAGVTVEEIDHINAHATSTQ
VGDKGELAAIKTLFGAHPVAITSTKSATGHLLGAAGGIEAIFTIQALRDQVVPPTLNLHHPDEDAAGMNLVALQARPQKM
RYALSNGFGFGGVNASLLLKRWE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=44.6300715990453, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI223972627, Length=172, Percent_Identity=47.093023255814, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI41872631, Length=433, Percent_Identity=26.3279445727483, Blast_Score=102, Evalue=7e-22,
Organism=Escherichia coli, GI1787337, Length=425, Percent_Identity=45.6470588235294, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI1788663, Length=423, Percent_Identity=37.1158392434988, Blast_Score=241, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=39.622641509434, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=45.6603773584906, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=427, Percent_Identity=25.0585480093677, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=287, Percent_Identity=24.390243902439, Blast_Score=88, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=452, Percent_Identity=39.3805309734513, Blast_Score=307, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=45.0236966824645, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI221330659, Length=428, Percent_Identity=24.5327102803738, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19920632, Length=428, Percent_Identity=24.5327102803738, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24581345, Length=426, Percent_Identity=22.5352112676056, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43945; Mature: 43814

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVSVKRIVVTGMGIVSPLGCGVQHVWQSLLAGKSGVTRLSEQLVADIPCKVAGQVPSID
CCCCEEEHEEECCHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHCCCCCCCC
SDPLHGFDPLATIPAKERKKMDRFIEFALVAAREALTQAGWAPASMAEQERTATVIATGI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCEEEEEECC
GGFSEIANAVHTTDERGPRRLSPFTIPSFLANLAAGHVSIAHGFRGPIGAPVTACAAGAQ
CCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHH
AIGDAARMIRSGEADIALCGGAEAAIHRVSLAGFAAARALSSAYSDQPESASRPFDRDRD
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GFVMGEGAGLIVIESLEHALARGATPLAELVGYGTSADAYHLTAGPEDGNGARRAMEIAI
CEEEECCCCEEEEHHHHHHHHCCCCHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHH
RQAGVTVEEIDHINAHATSTQVGDKGELAAIKTLFGAHPVAITSTKSATGHLLGAAGGIE
HHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCEEECCCCHH
AIFTIQALRDQVVPPTLNLHHPDEDAAGMNLVALQARPQKMRYALSNGFGFGGVNASLLL
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHEE
KRWE
EECC
>Mature Secondary Structure 
GVSVKRIVVTGMGIVSPLGCGVQHVWQSLLAGKSGVTRLSEQLVADIPCKVAGQVPSID
CCCEEEHEEECCHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHCCCCCCCC
SDPLHGFDPLATIPAKERKKMDRFIEFALVAAREALTQAGWAPASMAEQERTATVIATGI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCEEEEEECC
GGFSEIANAVHTTDERGPRRLSPFTIPSFLANLAAGHVSIAHGFRGPIGAPVTACAAGAQ
CCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHH
AIGDAARMIRSGEADIALCGGAEAAIHRVSLAGFAAARALSSAYSDQPESASRPFDRDRD
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GFVMGEGAGLIVIESLEHALARGATPLAELVGYGTSADAYHLTAGPEDGNGARRAMEIAI
CEEEECCCCEEEEHHHHHHHHCCCCHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHH
RQAGVTVEEIDHINAHATSTQVGDKGELAAIKTLFGAHPVAITSTKSATGHLLGAAGGIE
HHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCEEECCCCHH
AIFTIQALRDQVVPPTLNLHHPDEDAAGMNLVALQARPQKMRYALSNGFGFGGVNASLLL
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHEE
KRWE
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]