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The map label for this gene is hipA [H]

Identifier: 152970220

GI number: 152970220

Start: 1843332

End: 1844654

Strand: Direct

Name: hipA [H]

Synonym: KPN_01668

Alternate gene names: 152970220

Gene position: 1843332-1844654 (Clockwise)

Preceding gene: 152970219

Following gene: 152970229

Centisome position: 34.68

GC content: 61.45

Gene sequence:

>1323_bases
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACACTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Upstream 100 bases:

>100_bases
TGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCCGATAAC
AACACGGACCTTGACTGGTA

Downstream 100 bases:

>100_bases
CAGAGCCGGCTGGCGGCTAGCTCTGCGGCTGCCCCCAGCGGCTGCGCAAATAGTTAACCGCCTGCCGGGTTTGCGGCTGA
TTGAGGTTGTTTTCGCGGAA

Product: persistence to inhibition of murein or DNA biosynthesis, DNA-binding regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Sequences:

>Translated_440_residues
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
>Mature_439_residues
ATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQA
RSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTALL
RMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRWA
QEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLLP
GGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVPQ
AIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=435, Percent_Identity=70.1149425287356, Blast_Score=647, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 49112; Mature: 48981

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHY
CCCHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCCEEEEECCEECCCHHHHHHHH
FDNLLPDSPQVRDRIVRRYQARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTL
HHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHCCCCCCCC
DEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTALLRMGEQWCIPQGATPTTHII
CHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCHHHHHHHHCCCHHCCCCCCCCCCEEE
KLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
ECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCHHEEECCCHHHHHHHHHHHHH
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMV
HHCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
FQWLTGATDGHAKNFSIYLLPGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATK
HHHHHCCCCCCCCCEEEEEEECCCEECCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCC
GRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVPQAIESARRTLPADFSSHVWQ
CCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AITENMLKLHARLQQGLQAL
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHY
CCHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCCEEEEECCEECCCHHHHHHHH
FDNLLPDSPQVRDRIVRRYQARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTL
HHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHCCCCCCCC
DEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTALLRMGEQWCIPQGATPTTHII
CHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCHHHHHHHHCCCHHCCCCCCCCCCEEE
KLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
ECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCHHEEECCCHHHHHHHHHHHHH
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMV
HHCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
FQWLTGATDGHAKNFSIYLLPGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATK
HHHHHCCCCCCCCCEEEEEEECCCEECCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCC
GRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVPQAIESARRTLPADFSSHVWQ
CCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AITENMLKLHARLQQGLQAL
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]