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The map label for this gene is xanP [H]

Identifier: 152970216

GI number: 152970216

Start: 1840620

End: 1841999

Strand: Direct

Name: xanP [H]

Synonym: KPN_01664

Alternate gene names: 152970216

Gene position: 1840620-1841999 (Clockwise)

Preceding gene: 152970214

Following gene: 152970217

Centisome position: 34.63

GC content: 61.45

Gene sequence:

>1380_bases
ATGTCTGACGAACATCACAGTGGCCTGCTTTACGGCCTTGAACAGCGGATCCCACCGCTTCCGGCCTTTTTCAGCGCTCT
CCAGCATGTGCTGGCGGGCCTGGTGGGGATCATCACGCCGCCGCTGATCATCGGTGCTACCCTCGGGCTTGGCGACTGGC
TGCCGTATCTCATCAGTATGTCGCTGCTGGCCTCGGGCATTGGCACTTTTCTGCAGTCCAATCGGGTATGGGGCATCGGC
GCCGGGATGATCTGCATGCAGGGCACCAGTTTTGCCTTCCTCGGCGTGACGGTGGCCGGAGGGATGTGGGTAAAAGCCCA
GGGCGGCGGGCCGCAGGATATGATGGCGATGCTGTTTGGCGTTAACTTTGTCGCCGCTCTGGTGCCGGTGATTGTCAGCC
GCTTTATCGAACCGCTGAAGAAAATCTTTACTCCCATCATTACCGGCAGCGTGATTGCGCTGATCGGCATCAGCCTGATC
AAGGTCAGCGTCATCAACTGGTGCGGTGGGGAAAAGGCCGAGGATTTCGCCAGCATGAGCAATATCGCGCTCGGGGCGGG
CACCCTCGGGGTTATCGTCCTGCTGAGCTGCGCCAAAAACCGCTGGCTGCGGCTCTCCTCGGTGGTGGTGGGCATTGCCG
TGGGCTGCATCGCAGCGGGGCTGAGCGGTCAGTTCCATCTTCACAGCCTGGGCGACACTCTGTTTCGCCTGCCGACGCTG
TTTCCGTTCGGCTTTCAGTTTAACAGCGCGATATTTCTGCCGGTCGCCCTGGTGTCGCTGGTCTGTATTCTGGAGGCGGT
GGGCGATCTGACGGCCAACTCGCTGATTTCGCAACAGTCTGTTGACGATCGCGCTTTTCGTAACCGGCTGAAGGGCGGTA
TCCTGGCGGATGGCGTCAGCTGTATGGTGGCGGCCATGCTCTGTGCTTTTCCGAACACCACCTTCGCGCAGAACAACGGC
GTGATCCAGATGACCGGGGTGGCCAGCCGCTATGTCGGACGCTACATTGGCGTGATTCTGATCCTGCTCGGGCTGTTCCC
CCCGGTGGGCGAACTGCTGCGGCAGATCCCGGCGCCGGTGCTGGGGGGCGCCACGATGGTGATGTTTGGCTGCGTGGTGG
CGGCCGGGATCCGGATTATTACCCAGACCCCGCTGAGCCGTCGCGATGTGCTGATCGTGGGGCTGGCGTTTGGCGCGGGT
CTTGGCGTGGAGTCGGTGCCGGCGTTTCTCAGCCATTTTCCGCCGATGGTCGGCGATCTGTTCGGTTCGGCGGCCACCAG
CGGTGGGCTGGTAGCGATAGCGCTGAACCTTATTCTGCCGCAGGAGCAGGCGGCGACGAAAACGATAAGGAGTCAGGATG
ATCGCGCTGAGTCAGTTTAA

Upstream 100 bases:

>100_bases
ATGATTTTGGAGTGATAATAAATTTATTGGTGCCCTTTTGTCGTCTCTGGCCTGCTTTGTGCACAAGCCCATGCACTTCT
CTTTACTACGGGATATCACT

Downstream 100 bases:

>100_bases
CAGCCTGAGTAAAGATGAGGCGGCGGGGCTGCTGGCCCCCTGCGTGGCGCTCCCGGCCTGGGGCGAGACGCTGGTGAGCT
TGCGACCTTTCGCCAGCCGC

Product: guanine/xanthin permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSDEHHSGLLYGLEQRIPPLPAFFSALQHVLAGLVGIITPPLIIGATLGLGDWLPYLISMSLLASGIGTFLQSNRVWGIG
AGMICMQGTSFAFLGVTVAGGMWVKAQGGGPQDMMAMLFGVNFVAALVPVIVSRFIEPLKKIFTPIITGSVIALIGISLI
KVSVINWCGGEKAEDFASMSNIALGAGTLGVIVLLSCAKNRWLRLSSVVVGIAVGCIAAGLSGQFHLHSLGDTLFRLPTL
FPFGFQFNSAIFLPVALVSLVCILEAVGDLTANSLISQQSVDDRAFRNRLKGGILADGVSCMVAAMLCAFPNTTFAQNNG
VIQMTGVASRYVGRYIGVILILLGLFPPVGELLRQIPAPVLGGATMVMFGCVVAAGIRIITQTPLSRRDVLIVGLAFGAG
LGVESVPAFLSHFPPMVGDLFGSAATSGGLVAIALNLILPQEQAATKTIRSQDDRAESV

Sequences:

>Translated_459_residues
MSDEHHSGLLYGLEQRIPPLPAFFSALQHVLAGLVGIITPPLIIGATLGLGDWLPYLISMSLLASGIGTFLQSNRVWGIG
AGMICMQGTSFAFLGVTVAGGMWVKAQGGGPQDMMAMLFGVNFVAALVPVIVSRFIEPLKKIFTPIITGSVIALIGISLI
KVSVINWCGGEKAEDFASMSNIALGAGTLGVIVLLSCAKNRWLRLSSVVVGIAVGCIAAGLSGQFHLHSLGDTLFRLPTL
FPFGFQFNSAIFLPVALVSLVCILEAVGDLTANSLISQQSVDDRAFRNRLKGGILADGVSCMVAAMLCAFPNTTFAQNNG
VIQMTGVASRYVGRYIGVILILLGLFPPVGELLRQIPAPVLGGATMVMFGCVVAAGIRIITQTPLSRRDVLIVGLAFGAG
LGVESVPAFLSHFPPMVGDLFGSAATSGGLVAIALNLILPQEQAATKTIRSQDDRAESV
>Mature_458_residues
SDEHHSGLLYGLEQRIPPLPAFFSALQHVLAGLVGIITPPLIIGATLGLGDWLPYLISMSLLASGIGTFLQSNRVWGIGA
GMICMQGTSFAFLGVTVAGGMWVKAQGGGPQDMMAMLFGVNFVAALVPVIVSRFIEPLKKIFTPIITGSVIALIGISLIK
VSVINWCGGEKAEDFASMSNIALGAGTLGVIVLLSCAKNRWLRLSSVVVGIAVGCIAAGLSGQFHLHSLGDTLFRLPTLF
PFGFQFNSAIFLPVALVSLVCILEAVGDLTANSLISQQSVDDRAFRNRLKGGILADGVSCMVAAMLCAFPNTTFAQNNGV
IQMTGVASRYVGRYIGVILILLGLFPPVGELLRQIPAPVLGGATMVMFGCVVAAGIRIITQTPLSRRDVLIVGLAFGAGL
GVESVPAFLSHFPPMVGDLFGSAATSGGLVAIALNLILPQEQAATKTIRSQDDRAESV

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790087, Length=451, Percent_Identity=41.2416851441242, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI87082178, Length=465, Percent_Identity=41.9354838709677, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI87082181, Length=446, Percent_Identity=29.5964125560538, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI87081818, Length=415, Percent_Identity=26.5060240963855, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788843, Length=396, Percent_Identity=28.2828282828283, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=450, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17541904, Length=516, Percent_Identity=23.6434108527132, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71993493, Length=219, Percent_Identity=27.3972602739726, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 47950; Mature: 47818

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEHHSGLLYGLEQRIPPLPAFFSALQHVLAGLVGIITPPLIIGATLGLGDWLPYLISM
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHH
SLLASGIGTFLQSNRVWGIGAGMICMQGTSFAFLGVTVAGGMWVKAQGGGPQDMMAMLFG
HHHHHHHHHHHHCCCEEEECCCHHEECCCCEEEEHEEEECCEEEEECCCCHHHHHHHHHH
VNFVAALVPVIVSRFIEPLKKIFTPIITGSVIALIGISLIKVSVINWCGGEKAEDFASMS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
NIALGAGTLGVIVLLSCAKNRWLRLSSVVVGIAVGCIAAGLSGQFHLHSLGDTLFRLPTL
HHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
FPFGFQFNSAIFLPVALVSLVCILEAVGDLTANSLISQQSVDDRAFRNRLKGGILADGVS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHCCHH
CMVAAMLCAFPNTTFAQNNGVIQMTGVASRYVGRYIGVILILLGLFPPVGELLRQIPAPV
HHHHHHHHHCCCCCEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
LGGATMVMFGCVVAAGIRIITQTPLSRRDVLIVGLAFGAGLGVESVPAFLSHFPPMVGDL
CCHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEHHCCCCCHHHHHHHHHHCCHHHHHH
FGSAATSGGLVAIALNLILPQEQAATKTIRSQDDRAESV
HHHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SDEHHSGLLYGLEQRIPPLPAFFSALQHVLAGLVGIITPPLIIGATLGLGDWLPYLISM
CCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHH
SLLASGIGTFLQSNRVWGIGAGMICMQGTSFAFLGVTVAGGMWVKAQGGGPQDMMAMLFG
HHHHHHHHHHHHCCCEEEECCCHHEECCCCEEEEHEEEECCEEEEECCCCHHHHHHHHHH
VNFVAALVPVIVSRFIEPLKKIFTPIITGSVIALIGISLIKVSVINWCGGEKAEDFASMS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
NIALGAGTLGVIVLLSCAKNRWLRLSSVVVGIAVGCIAAGLSGQFHLHSLGDTLFRLPTL
HHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
FPFGFQFNSAIFLPVALVSLVCILEAVGDLTANSLISQQSVDDRAFRNRLKGGILADGVS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHCCHH
CMVAAMLCAFPNTTFAQNNGVIQMTGVASRYVGRYIGVILILLGLFPPVGELLRQIPAPV
HHHHHHHHHCCCCCEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
LGGATMVMFGCVVAAGIRIITQTPLSRRDVLIVGLAFGAGLGVESVPAFLSHFPPMVGDL
CCHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEHHCCCCCHHHHHHHHHHCCHHHHHH
FGSAATSGGLVAIALNLILPQEQAATKTIRSQDDRAESV
HHHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]