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The map label for this gene is uxaB [H]

Identifier: 152970192

GI number: 152970192

Start: 1817022

End: 1818473

Strand: Direct

Name: uxaB [H]

Synonym: KPN_01640

Alternate gene names: 152970192

Gene position: 1817022-1818473 (Clockwise)

Preceding gene: 152970191

Following gene: 152970193

Centisome position: 34.19

GC content: 59.37

Gene sequence:

>1452_bases
GTGAAAACTTTAAACCGTCGTGATTTCCCCGGCGCGCAGTACCCTGACCGTATCATCCAGTTTGGGGAAGGTAACTTCCT
GCGCGCATTCGTTGACTGGCAGATCGACCTGCTCAACGAGCATACCGACCTGAATGCGGGCATCGTGGTCGTGCGGCCTA
TCGCCACAGATTTTCCGCCTTCGCTGAACACCCAGGATGGCCTGTACACGACTATTATTCGCGGCCTGAACGAGCAGGGC
GAAGCGGTCAGCGATGCGCGTCTTATCCGCTCGGTCAACCGGGAGATCAGCGCTTACGCAGACTTCGACGCTTTTTTACG
CCTGGCGCATAACCCGGAGATGCGGTTTGTCTTCTCCAACACCACCGAGGCGGGCATCAGCTACCATGCCGGGGATCGGT
TTGACGACGCGCCGCCGGTCAGTTATCCGGCGAAACTGACCCGTCTGTTGTTTGAGCGTTATCAGCATTTCGCCGGTGCG
GCCGACAAGGGATGGGTGATTATTCCCTGCGAGCTGATCGATTATAACGGCGAGGCGCTGCAGGCGCTGGTGCTGCGCTA
TGCTAGCGAATGGGAACTGCCGCAGGCATTTATCACCTGGCTGACCTCAGCGAATACCTTCTGTTCGACGCTGGTGGATC
GCATTGTGACCGGCTATCCGCGTGATGAAGTGGCGGCTCTCGAGGCGCAGACCGGCTATAAAGATGCTTTCCTTGATACC
GCCGAGCATTTCTACCTGTTTGTGATCCAGGGGCCTGCCTCGCTGGCGGCCGAGCTGCGTCTCGATAAACTGCCGCTGAA
TGTGCGTATTGTGGACGATATTAAGCCGTATAAAGAGCGCAAAGTGGCGATCCTCAACGGGGCGCACACCGCGCTGGTGC
CGGTGGCCTTCCAGGCCGGGATCGACACCGTGGGTGAGGCGATGAACGATGCGGAGATTTGCGCGTTTGTCGAAAAAGCG
ATTTATGACGAGATTATTCCGGTGCTGGATCTGCCGCGCGATGAGCTGGTGTCATTCGCCAGCGCCGTGACAGGGCGCTT
CCGTAATCCCTATATTAAACATCAGCTGCTCTCGATTGCGCTCAACGGCATGACCAAGTACCGCACCCGTATTCTGCCGC
AGCTGCTGGCGGGGCAGAAAGCGCATGGCGCGCTGCCGCCGCGTCTGACCTTTGCCCTGGCGGCGCTGATCGCCTTTTAC
CGGGGAGAGCGGGATGGTGAGAGCTATCCAGTACAGGATGACGCCGACTGGATATCGCGCTATCAAACGCTGTGGGCCCG
CCATCGCGATGGCCAGATGAGCACTCGCGAGCTGGTCACCGCCGTGCTCAGCGTGGCGGATCACTGGCAGCAGGATCTGA
GCCAGACCCCGGGGTTGGTGGAGCTGGTGACTGCCGACCTTGACGCTATCCTGACCTGCGGTATGCGCGACGCCGTCAAA
CCTCTGTGCTGA

Upstream 100 bases:

>100_bases
AGATTGCTTTGATCAAAACAGGGTTTCACTGGTAGAAAAACCTGATAACTTATTGGACCAATTACTCAGGTTGTATGACT
ACTATTAGAGGGAACCCATT

Downstream 100 bases:

>100_bases
TAGTCCATCTATACACCCGGCTGCGGCCGGGTTGTGCAGGATCTTTATTAGTTACAACATACTATTATACTAACCTGTAA
CAGCCGGTCAGTGGCTCCTC

Product: altronate oxidoreductase

Products: NA

Alternate protein names: Tagaturonate dehydrogenase; Tagaturonate reductase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MKTLNRRDFPGAQYPDRIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVVRPIATDFPPSLNTQDGLYTTIIRGLNEQG
EAVSDARLIRSVNREISAYADFDAFLRLAHNPEMRFVFSNTTEAGISYHAGDRFDDAPPVSYPAKLTRLLFERYQHFAGA
ADKGWVIIPCELIDYNGEALQALVLRYASEWELPQAFITWLTSANTFCSTLVDRIVTGYPRDEVAALEAQTGYKDAFLDT
AEHFYLFVIQGPASLAAELRLDKLPLNVRIVDDIKPYKERKVAILNGAHTALVPVAFQAGIDTVGEAMNDAEICAFVEKA
IYDEIIPVLDLPRDELVSFASAVTGRFRNPYIKHQLLSIALNGMTKYRTRILPQLLAGQKAHGALPPRLTFALAALIAFY
RGERDGESYPVQDDADWISRYQTLWARHRDGQMSTRELVTAVLSVADHWQQDLSQTPGLVELVTADLDAILTCGMRDAVK
PLC

Sequences:

>Translated_483_residues
MKTLNRRDFPGAQYPDRIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVVRPIATDFPPSLNTQDGLYTTIIRGLNEQG
EAVSDARLIRSVNREISAYADFDAFLRLAHNPEMRFVFSNTTEAGISYHAGDRFDDAPPVSYPAKLTRLLFERYQHFAGA
ADKGWVIIPCELIDYNGEALQALVLRYASEWELPQAFITWLTSANTFCSTLVDRIVTGYPRDEVAALEAQTGYKDAFLDT
AEHFYLFVIQGPASLAAELRLDKLPLNVRIVDDIKPYKERKVAILNGAHTALVPVAFQAGIDTVGEAMNDAEICAFVEKA
IYDEIIPVLDLPRDELVSFASAVTGRFRNPYIKHQLLSIALNGMTKYRTRILPQLLAGQKAHGALPPRLTFALAALIAFY
RGERDGESYPVQDDADWISRYQTLWARHRDGQMSTRELVTAVLSVADHWQQDLSQTPGLVELVTADLDAILTCGMRDAVK
PLC
>Mature_483_residues
MKTLNRRDFPGAQYPDRIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVVRPIATDFPPSLNTQDGLYTTIIRGLNEQG
EAVSDARLIRSVNREISAYADFDAFLRLAHNPEMRFVFSNTTEAGISYHAGDRFDDAPPVSYPAKLTRLLFERYQHFAGA
ADKGWVIIPCELIDYNGEALQALVLRYASEWELPQAFITWLTSANTFCSTLVDRIVTGYPRDEVAALEAQTGYKDAFLDT
AEHFYLFVIQGPASLAAELRLDKLPLNVRIVDDIKPYKERKVAILNGAHTALVPVAFQAGIDTVGEAMNDAEICAFVEKA
IYDEIIPVLDLPRDELVSFASAVTGRFRNPYIKHQLLSIALNGMTKYRTRILPQLLAGQKAHGALPPRLTFALAALIAFY
RGERDGESYPVQDDADWISRYQTLWARHRDGQMSTRELVTAVLSVADHWQQDLSQTPGLVELVTADLDAILTCGMRDAVK
PLC

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxaB subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994885, Length=483, Percent_Identity=84.472049689441, Blast_Score=858, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=368, Percent_Identity=26.6304347826087, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788497, Length=490, Percent_Identity=24.4897959183673, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1790779, Length=493, Percent_Identity=23.7322515212982, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324401, Length=430, Percent_Identity=23.7209302325581, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320765, Length=430, Percent_Identity=23.7209302325581, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.58 [H]

Molecular weight: Translated: 54042; Mature: 54042

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLNRRDFPGAQYPDRIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVVRPIATDFPP
CCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEEEEHEECCCCCCCCCCEEEEEECCCCCCC
SLNTQDGLYTTIIRGLNEQGEAVSDARLIRSVNREISAYADFDAFLRLAHNPEMRFVFSN
CCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECC
TTEAGISYHAGDRFDDAPPVSYPAKLTRLLFERYQHFAGAADKGWVIIPCELIDYNGEAL
CCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHH
QALVLRYASEWELPQAFITWLTSANTFCSTLVDRIVTGYPRDEVAALEAQTGYKDAFLDT
HHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHC
AEHFYLFVIQGPASLAAELRLDKLPLNVRIVDDIKPYKERKVAILNGAHTALVPVAFQAG
CCCEEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCHHHCEEEEEECCCHHHHHHHHHHC
IDTVGEAMNDAEICAFVEKAIYDEIIPVLDLPRDELVSFASAVTGRFRNPYIKHQLLSIA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LNGMTKYRTRILPQLLAGQKAHGALPPRLTFALAALIAFYRGERDGESYPVQDDADWISR
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
YQTLWARHRDGQMSTRELVTAVLSVADHWQQDLSQTPGLVELVTADLDAILTCGMRDAVK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHC
PLC
CCC
>Mature Secondary Structure
MKTLNRRDFPGAQYPDRIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVVRPIATDFPP
CCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEEEEHEECCCCCCCCCCEEEEEECCCCCCC
SLNTQDGLYTTIIRGLNEQGEAVSDARLIRSVNREISAYADFDAFLRLAHNPEMRFVFSN
CCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECC
TTEAGISYHAGDRFDDAPPVSYPAKLTRLLFERYQHFAGAADKGWVIIPCELIDYNGEAL
CCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHH
QALVLRYASEWELPQAFITWLTSANTFCSTLVDRIVTGYPRDEVAALEAQTGYKDAFLDT
HHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHC
AEHFYLFVIQGPASLAAELRLDKLPLNVRIVDDIKPYKERKVAILNGAHTALVPVAFQAG
CCCEEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCHHHCEEEEEECCCHHHHHHHHHHC
IDTVGEAMNDAEICAFVEKAIYDEIIPVLDLPRDELVSFASAVTGRFRNPYIKHQLLSIA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LNGMTKYRTRILPQLLAGQKAHGALPPRLTFALAALIAFYRGERDGESYPVQDDADWISR
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
YQTLWARHRDGQMSTRELVTAVLSVADHWQQDLSQTPGLVELVTADLDAILTCGMRDAVK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHC
PLC
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA