Click here to switch to the map view.

The map label for this gene is livF [H]

Identifier: 152970172

GI number: 152970172

Start: 1801437

End: 1801859

Strand: Direct

Name: livF [H]

Synonym: KPN_01620

Alternate gene names: 152970172

Gene position: 1801437-1801859 (Clockwise)

Preceding gene: 152970171

Following gene: 152970174

Centisome position: 33.89

GC content: 64.54

Gene sequence:

>423_bases
GTGGAAGAAAACCTGCTGATGGGGCTGTCGCGCTTTCCCGCCCGCGAAGCGCAGCAGGTGCCGGAGGAGATCTACCAGCT
TTTCCCGGTGCTCAGGACCATGAAGCAGCGGCGAGGCGGTGACTTATCCGGCGGCCAGCAGCAGCAGCTGGCGATTGGCC
GCGCGCTGGCCAGCCGCCCACAGCTGCTGATCCTTGATGAACCCACCGAGGGGATCCAGCCCTCGGTCATCAAAGAGATT
GGCGAGGTGATCCGCCAGCTGGCGAGCCGCGGAGACATGGCGATCCTGCTGGTGGAGCAGTTCTATGACTTTGCCGCCGG
ACTGGCGGACCACTACCTGGTGATGTCGCGCGGCGCCATCGTCCAGCAAGGCAAGGGTGGTGATATGGAGAGCGACGGCG
TGCGCGCCATGGTGACCATCTGA

Upstream 100 bases:

>100_bases
GCTGGCAGGATCAGAACATCACCCATCGCAAACCGCACCAGCGGGTGCAGGCCGGGGTCGCCTACGTCCCCCAGGGGCGC
GAGATATTTCCGCGCTGACG

Downstream 100 bases:

>100_bases
CCATGCCGGCGGCGGTCGCGCCGCCGGTTTGCGGCCTATTTGCGCAGCAGCCGCTGCAGGCGCGCCTGGCGCCAGTTTTT
AATCCATTCGCCGAACACGA

Product: ATP-binding component of leucine transport

Products: ADP; phosphate; L-leucine [Cytoplasm]; ADP; L-valine [Cytoplasm]; L-iso-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein F [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MEENLLMGLSRFPAREAQQVPEEIYQLFPVLRTMKQRRGGDLSGGQQQQLAIGRALASRPQLLILDEPTEGIQPSVIKEI
GEVIRQLASRGDMAILLVEQFYDFAAGLADHYLVMSRGAIVQQGKGGDMESDGVRAMVTI

Sequences:

>Translated_140_residues
MEENLLMGLSRFPAREAQQVPEEIYQLFPVLRTMKQRRGGDLSGGQQQQLAIGRALASRPQLLILDEPTEGIQPSVIKEI
GEVIRQLASRGDMAILLVEQFYDFAAGLADHYLVMSRGAIVQQGKGGDMESDGVRAMVTI
>Mature_140_residues
MEENLLMGLSRFPAREAQQVPEEIYQLFPVLRTMKQRRGGDLSGGQQQQLAIGRALASRPQLLILDEPTEGIQPSVIKEI
GEVIRQLASRGDMAILLVEQFYDFAAGLADHYLVMSRGAIVQQGKGGDMESDGVRAMVTI

Specific function: Component of the leucine-specific transport system [H]

COG id: COG0410

COG function: function code E; ABC-type branched-chain amino acid transport systems, ATPase component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI87082268, Length=127, Percent_Identity=45.6692913385827, Blast_Score=94, Evalue=2e-21,
Organism=Escherichia coli, GI1788225, Length=91, Percent_Identity=40.6593406593407, Blast_Score=74, Evalue=3e-15,
Organism=Escherichia coli, GI1789672, Length=104, Percent_Identity=36.5384615384615, Blast_Score=72, Evalue=1e-14,
Organism=Escherichia coli, GI1790190, Length=128, Percent_Identity=34.375, Blast_Score=70, Evalue=6e-14,
Organism=Escherichia coli, GI1786398, Length=84, Percent_Identity=36.9047619047619, Blast_Score=68, Evalue=3e-13,
Organism=Escherichia coli, GI1788644, Length=83, Percent_Identity=36.144578313253, Blast_Score=66, Evalue=9e-13,
Organism=Escherichia coli, GI1788761, Length=125, Percent_Identity=35.2, Blast_Score=66, Evalue=9e-13,
Organism=Escherichia coli, GI1787029, Length=86, Percent_Identity=37.2093023255814, Blast_Score=65, Evalue=1e-12,
Organism=Escherichia coli, GI1786872, Length=83, Percent_Identity=39.7590361445783, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1787089, Length=97, Percent_Identity=36.0824742268041, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1789864, Length=89, Percent_Identity=32.5842696629214, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1788472, Length=81, Percent_Identity=41.9753086419753, Blast_Score=63, Evalue=6e-12,
Organism=Escherichia coli, GI1788450, Length=104, Percent_Identity=33.6538461538462, Blast_Score=62, Evalue=1e-11,
Organism=Escherichia coli, GI1790162, Length=94, Percent_Identity=35.1063829787234, Blast_Score=62, Evalue=1e-11,
Organism=Escherichia coli, GI1788506, Length=90, Percent_Identity=32.2222222222222, Blast_Score=62, Evalue=1e-11,
Organism=Escherichia coli, GI48994997, Length=83, Percent_Identity=38.5542168674699, Blast_Score=60, Evalue=6e-11,
Organism=Escherichia coli, GI87081709, Length=88, Percent_Identity=35.2272727272727, Blast_Score=60, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 15427; Mature: 15427

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEENLLMGLSRFPAREAQQVPEEIYQLFPVLRTMKQRRGGDLSGGQQQQLAIGRALASRP
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
QLLILDEPTEGIQPSVIKEIGEVIRQLASRGDMAILLVEQFYDFAAGLADHYLVMSRGAI
CEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC
VQQGKGGDMESDGVRAMVTI
EECCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MEENLLMGLSRFPAREAQQVPEEIYQLFPVLRTMKQRRGGDLSGGQQQQLAIGRALASRP
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
QLLILDEPTEGIQPSVIKEIGEVIRQLASRGDMAILLVEQFYDFAAGLADHYLVMSRGAI
CEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC
VQQGKGGDMESDGVRAMVTI
EECCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-leucine [Periplasm]; H2O; ATP; L-valine [Periplasm]; L-iso-leucine [Periplasm] [C]

Specific reaction: ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]