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The map label for this gene is pcaI [H]

Identifier: 152970090

GI number: 152970090

Start: 1709539

End: 1710225

Strand: Direct

Name: pcaI [H]

Synonym: KPN_01538

Alternate gene names: 152970090

Gene position: 1709539-1710225 (Clockwise)

Preceding gene: 152970088

Following gene: 152970091

Centisome position: 32.16

GC content: 62.59

Gene sequence:

>687_bases
ATGATTGATAAAAGCGTATCGACGCTGAGCGAGGCCATCGCCGGGATCCACGATGGGGCGACTATTATGATCGGCGGCTT
TGGCCCCGCCGGCCAGCCGACCTTTCTGATTGACGCCCTGATTGACCAGGGCGCTCGCGACCTGACCATCATAAATAACA
ACGCCGGCAACGGGGAAGTGGGTCTCGCGGCGCTGCTCAAGGCGGGCCGGGTGCGCAAAATGATCTGCTCCTTTCCGCGC
CAGGTGGATTCTCAGATTTTCGATGATCTCTACCGTCGCGGCAAAGTGGAACTGGAGCTGGTGCCGCAGGGCAACCTCGC
GGCGCGGATCCAGGCGGCTGGCGCCGGGCTGGGGGCGGTATTTACCCCCACCGGCTACGGCACGCCGCTGGCGGAAGGCA
AGGAGACACGGGAAATCGACGGTCGCCACTACGTGCTGGAGTACCCGATCAAAGCCGATTTCGCGCTGATTAAAGCTCAC
CAGGGCGACCGCTGGGGCAACCTGGTCTATCGCAAGGCGGCGCGCAACTTTGGCCCGATCATGGCGACAGCGGCGAAAAC
CACCATCGTAGAGGTCTCGCAGCTGGTGGCGCTGGGCGACCTCGACCCGGAAAACATCATCACCCCCGGCATTTTCGTCC
AGCGCGTCTTCTCGCTGGAAAACCTGACTGCCGCACAACGCGCCTGA

Upstream 100 bases:

>100_bases
ATATTTCGATTATCGCCCTTGACCGACATCGTTAAGCGGGTCACATTTTGTGCGAACAACGAATAAAAGTGCGATTACCG
CACATCACTGGAGCGACCTG

Downstream 100 bases:

>100_bases
GGAGCCCGACATGCAAAAACTGACCCGTGACGAAATGGCCCAGCGCGTGGCCCGCGATATTCCCGAAGGCGCTTACGTCA
ACCTCGGCATCGGCCTGCCG

Product: acetyl-CoA:acetoacetyl-CoA transferase alpha subunit

Products: NA

Alternate protein names: Beta-ketoadipate:succinyl-CoA transferase subunit A [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MIDKSVSTLSEAIAGIHDGATIMIGGFGPAGQPTFLIDALIDQGARDLTIINNNAGNGEVGLAALLKAGRVRKMICSFPR
QVDSQIFDDLYRRGKVELELVPQGNLAARIQAAGAGLGAVFTPTGYGTPLAEGKETREIDGRHYVLEYPIKADFALIKAH
QGDRWGNLVYRKAARNFGPIMATAAKTTIVEVSQLVALGDLDPENIITPGIFVQRVFSLENLTAAQRA

Sequences:

>Translated_228_residues
MIDKSVSTLSEAIAGIHDGATIMIGGFGPAGQPTFLIDALIDQGARDLTIINNNAGNGEVGLAALLKAGRVRKMICSFPR
QVDSQIFDDLYRRGKVELELVPQGNLAARIQAAGAGLGAVFTPTGYGTPLAEGKETREIDGRHYVLEYPIKADFALIKAH
QGDRWGNLVYRKAARNFGPIMATAAKTTIVEVSQLVALGDLDPENIITPGIFVQRVFSLENLTAAQRA
>Mature_228_residues
MIDKSVSTLSEAIAGIHDGATIMIGGFGPAGQPTFLIDALIDQGARDLTIINNNAGNGEVGLAALLKAGRVRKMICSFPR
QVDSQIFDDLYRRGKVELELVPQGNLAARIQAAGAGLGAVFTPTGYGTPLAEGKETREIDGRHYVLEYPIKADFALIKAH
QGDRWGNLVYRKAARNFGPIMATAAKTTIVEVSQLVALGDLDPENIITPGIFVQRVFSLENLTAAQRA

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=229, Percent_Identity=43.6681222707424, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI11545841, Length=226, Percent_Identity=43.8053097345133, Blast_Score=174, Evalue=8e-44,
Organism=Escherichia coli, GI1788551, Length=214, Percent_Identity=43.9252336448598, Blast_Score=179, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17531517, Length=236, Percent_Identity=41.1016949152542, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21358325, Length=229, Percent_Identity=40.6113537117904, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24655794, Length=229, Percent_Identity=40.6113537117904, Blast_Score=172, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012792
- InterPro:   IPR004165
- InterPro:   IPR004163 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: =2.8.3.6 [H]

Molecular weight: Translated: 24359; Mature: 24359

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS01273 COA_TRANSF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKSVSTLSEAIAGIHDGATIMIGGFGPAGQPTFLIDALIDQGARDLTIINNNAGNGEV
CCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHH
GLAALLKAGRVRKMICSFPRQVDSQIFDDLYRRGKVELELVPQGNLAARIQAAGAGLGAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCEE
FTPTGYGTPLAEGKETREIDGRHYVLEYPIKADFALIKAHQGDRWGNLVYRKAARNFGPI
ECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCH
MATAAKTTIVEVSQLVALGDLDPENIITPGIFVQRVFSLENLTAAQRA
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDKSVSTLSEAIAGIHDGATIMIGGFGPAGQPTFLIDALIDQGARDLTIINNNAGNGEV
CCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHH
GLAALLKAGRVRKMICSFPRQVDSQIFDDLYRRGKVELELVPQGNLAARIQAAGAGLGAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCEE
FTPTGYGTPLAEGKETREIDGRHYVLEYPIKADFALIKAHQGDRWGNLVYRKAARNFGPI
ECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCH
MATAAKTTIVEVSQLVALGDLDPENIITPGIFVQRVFSLENLTAAQRA
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1624453; 6780551 [H]