BacMap

Definition	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 chromosome, complete genome.
Accession	NC_009648
Length	5,315,120

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The map label for this gene is kduD [C]

Identifier: 152969872

GI number: 152969872

Start: 1479689

End: 1480423

Strand: Direct

Name: kduD [C]

Synonym: KPN_01319

Alternate gene names: 152969872

Gene position: 1479689-1480423 (Clockwise)

Preceding gene: 152969870

Following gene: 152969873

Centisome position: 27.84

GC content: 60.68

Gene sequence:

>735_bases
GTGACAGGTGGCAGCCGCGGCCTGGGACGCGCGACCGTCGAAGCGCTGGCACAGCGCGGCGTAAATGTAGTACTGACCTA
CAAAACGCGTCTTGCCGAGGCGAACGAGGTGGTTACACGGGTTGAAGCACTGGGCGCCCGGGCGATCGCGTTGCCTTTCA
GCGCCGGCGAAATCGACACCTTTGACGCATTTGTTAGCGCTTTTCAGGGCGCGCTGACGGAGCTGGGCGCCGATAAATTT
GATTATCTGGTCAATAATGCCGGCAACGCCAGCGGCATGGGATTTCTTAACGCCACGGAAGCGGAATTCGATGCGCTGTA
TCGCATCCACGTGAAGAGCGTTTTTTTCCTCAGCCAAAAACTATTGCCGCTGCTGGCCGATGGCGGGCGAATAGTGAATG
TTTCGTCCGGCCTCACCCGCATCGTGATGGCGAACCGGGCGCCCTATGCGATCATGAAATCCGCGGTGGAAACCCTGACT
CGCTATATGGCGTTTGAGCTGGGCAGTCGCGGGATCACGGTGAACTGCGTGGCGCCCGGCGCCATCGCCACCGATTTCAG
CGGCGGGGTGGTGCGGGATAACCCGCAGGTCGCTCAGGCGGTGGCGAATATGACGGCGCTGGGCCGACCTGGCCTGCCAG
AGGATATCGGGCCGATGATCGCCTCGCTGTTATCCGATGATCATCGCTGGGTGAATGCCCAGCGCATTGAGGTTTCCGGG
GGAATGCGCATCTGA

Upstream 100 bases:

>100_bases
GTCTTATCGTCGGCATTCAGGGGCTTATAATCGCTCATGTTTTCAGCAGAGAGAAAAGGAGAAAACATGAACAATAGCGC
AAAAATCGCCCTGGTGACAG

Downstream 100 bases:

>100_bases
GCGAAGAAAACCGGGGCTGTTTTCATCCGTAGTCAATCGATATGTCAGTGGATGCCGATATAGCGCGACGCTGTGGAGAG
ATAAGGAAATAATGATCTGC

Product: 7-alpha-hydroxysteroid dehydrogenase

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTGGSRGLGRATVEALAQRGVNVVLTYKTRLAEANEVVTRVEALGARAIALPFSAGEIDTFDAFVSAFQGALTELGADKF
DYLVNNAGNASGMGFLNATEAEFDALYRIHVKSVFFLSQKLLPLLADGGRIVNVSSGLTRIVMANRAPYAIMKSAVETLT
RYMAFELGSRGITVNCVAPGAIATDFSGGVVRDNPQVAQAVANMTALGRPGLPEDIGPMIASLLSDDHRWVNAQRIEVSG
GMRI

Sequences:

>Translated_244_residues
MTGGSRGLGRATVEALAQRGVNVVLTYKTRLAEANEVVTRVEALGARAIALPFSAGEIDTFDAFVSAFQGALTELGADKF
DYLVNNAGNASGMGFLNATEAEFDALYRIHVKSVFFLSQKLLPLLADGGRIVNVSSGLTRIVMANRAPYAIMKSAVETLT
RYMAFELGSRGITVNCVAPGAIATDFSGGVVRDNPQVAQAVANMTALGRPGLPEDIGPMIASLLSDDHRWVNAQRIEVSG
GMRI
>Mature_243_residues
TGGSRGLGRATVEALAQRGVNVVLTYKTRLAEANEVVTRVEALGARAIALPFSAGEIDTFDAFVSAFQGALTELGADKFD
YLVNNAGNASGMGFLNATEAEFDALYRIHVKSVFFLSQKLLPLLADGGRIVNVSSGLTRIVMANRAPYAIMKSAVETLTR
YMAFELGSRGITVNCVAPGAIATDFSGGVVRDNPQVAQAVANMTALGRPGLPEDIGPMIASLLSDDHRWVNAQRIEVSGG
MRI

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=244, Percent_Identity=32.3770491803279, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI5031737, Length=242, Percent_Identity=29.7520661157025, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI32483357, Length=244, Percent_Identity=27.8688524590164, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=30.5555555555556, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI33667109, Length=189, Percent_Identity=30.1587301587302, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=26.6409266409266, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI66933014, Length=170, Percent_Identity=28.8235294117647, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=34.0163934426229, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=32.8, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=30.5220883534137, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=34.9593495934959, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=30.7377049180328, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=28.3400809716599, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790717, Length=247, Percent_Identity=28.3400809716599, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI2367365, Length=242, Percent_Identity=31.404958677686, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=27.7777777777778, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=26.8, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=31.5384615384615, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=29.1338582677165, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=30.9433962264151, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=28.2352941176471, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=31.8181818181818, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=245, Percent_Identity=27.3469387755102, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=31.4176245210728, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=248, Percent_Identity=27.8225806451613, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=30.7984790874525, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=32.1969696969697, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=29.9242424242424, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=195, Percent_Identity=32.3076923076923, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=27.9693486590038, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=31.1787072243346, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=249, Percent_Identity=29.718875502008, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=200, Percent_Identity=33.5, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=260, Percent_Identity=30.7692307692308, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=261, Percent_Identity=29.1187739463602, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=28.1124497991968, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=29.5019157088123, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=248, Percent_Identity=27.0161290322581, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=29.0697674418605, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=262, Percent_Identity=27.8625954198473, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=25.6809338521401, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=194, Percent_Identity=30.4123711340206, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=32.1285140562249, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643142, Length=245, Percent_Identity=30.6122448979592, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=29.0836653386454, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=32.5301204819277, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=28.6290322580645, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28571526, Length=247, Percent_Identity=32.3886639676113, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=30.5882352941176, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644337, Length=177, Percent_Identity=35.5932203389831, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 25811; Mature: 25680

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGSRGLGRATVEALAQRGVNVVLTYKTRLAEANEVVTRVEALGARAIALPFSAGEIDT
CCCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHH
FDAFVSAFQGALTELGADKFDYLVNNAGNASGMGFLNATEAEFDALYRIHVKSVFFLSQK
HHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLPLLADGGRIVNVSSGLTRIVMANRAPYAIMKSAVETLTRYMAFELGSRGITVNCVAPG
HHHHHCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
AIATDFSGGVVRDNPQVAQAVANMTALGRPGLPEDIGPMIASLLSDDHRWVNAQRIEVSG
CEEECCCCCEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECEEEEEECC
GMRI
CCCC
>Mature Secondary Structure 
TGGSRGLGRATVEALAQRGVNVVLTYKTRLAEANEVVTRVEALGARAIALPFSAGEIDT
CCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHH
FDAFVSAFQGALTELGADKFDYLVNNAGNASGMGFLNATEAEFDALYRIHVKSVFFLSQK
HHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLPLLADGGRIVNVSSGLTRIVMANRAPYAIMKSAVETLTRYMAFELGSRGITVNCVAPG
HHHHHCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
AIATDFSGGVVRDNPQVAQAVANMTALGRPGLPEDIGPMIASLLSDDHRWVNAQRIEVSG
CEEECCCCCEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECEEEEEECC
GMRI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]